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Shiojiri, Japan

Matsumoto Dental University is a private university in Shiojiri, Nagano, Japan, established in 1972. Wikipedia.

Kobayashi Y.,Matsumoto Dental University
Clinical calcium | Year: 2012

Wnts, palmitoylated and glycosylated molecules play a central role in the early development of organs and tissues. Wnts bind to receptor complexes of frizzled and low density lipoprotein-related protein 5/6, which in turn, activate theβ-catenin-dependent canonical pathway. Wnt5a, a typical non-canonical ligand, activates theβ-catenin-independent noncanonical pathways such as the Wnt/Ca pathway and the Wnt/planar cell polarity pathway. Recent studies have established that Wnt-mediated signals are crucial for bone formation and resorption. This review summarizes the current knowledge of the roles of Wnt signaling in bone formation and resorption. Source

Sahara N.,Matsumoto Dental University
Anatomical Record | Year: 2014

The horse is a grazing herbivore whose cheek teeth are hypsodon; that is, they possess long crowns that are completely covered by coronal cement at eruption. For elucidation of the sequential events in the formation of this coronal cementum in the mandibular horse cheek teeth, in the present study the lower 3rd permanent premolar teeth (PM4) from 3.5-, 4-, and 5-year-old horses were compared by using radiography, microcomputed tomography (Miro-CT), light microscopy (LM), and scanning electron microscopy (SEM). The present study clearly showed that prior to coronal cementogenesis tartrate-resistant acid phosphatase (TRAP)-positive odontoclasts resorbed on the enamel surface of the reserve crown in horse cheek tooth. Enamel resorption areas were relatively narrow, and started from the cuspal tips, and moved in the apical direction during tooth development. A primary cementum was initially deposited on the irregularly pitted enamel-cementum junction (ECJ) of the infolding and peripheral enamel. The infolding cementum filled grooves completely by the time of tooth eruption. On the other hand, in the peripheral cementum, the secondary and tertiary cementum layers were sequentially deposited on the primary cementum. These two cementum layers were sites for the insertion of the periodontal ligaments, and were continually laid down on the primary cementum coronally rather than apically throughout the life. The results of the present study suggest that the coronal cementum of horse cheek teeth is a multistructural and multifunctional tissue, meeting the requirements of its many different functions. Anat Rec, 297:716-730, 2014. © 2014 Wiley Periodicals, Inc. Source

Yamazoe M.,Matsumoto Dental University
Dental Materials Journal | Year: 2010

Metal ions released in 1% lactic acid solution from combinations of titanium fixtures with superstructures made of dental precious metal alloys (dental alloys) and titanium and differences based on the fixing method were investigated. In combinations of titanium with dental alloys, the level of Ti release was influenced by micro-structure of titanium: it was lower when the grain size was smaller. In titanium-titanium combinations, differences in the micro-structure of metal also markedly influenced the dissolution: the level of release increased when the micro-structure of titanium was different. The Ti and V release levels were higher in combination with titanium alloy and titanium than with titanium alloy and dental alloys. Regarding the superstructure-fixture fixing method, the level of Ti release was significantly lower in cement than in direct fixation. Source

Takahashi N.,Matsumoto Dental University
Advances in Experimental Medicine and Biology | Year: 2010

How are sites suitable for osteoclastogenesis determined? We addressed this issue using in vivo and in vitro experimental systems. We first examined the formation of osteoclasts in ectopic bone induced by BMP-2. When collagen disks which contained BMP-2 BMP-2-disks) or vehicle control-disks) were implanted into wild-type mice osteoclasts and osteoblasts appeared in the BMP-2-disks but not in the control disks. RANKL-deficient RANKL-/-) mice exhibited osteopetrosis with an absence of osteoclasts. BMP-2 and control disks were implanted into RANKL-/- mice which were intraperitoneally injected with RANKL. Osteoclasts formed in the BMP-2-disks but not in the control disks. In the BMP-2-disks osteoclasts were observed in the vicinity of osteoblasts. Cell cycle-arrested quiescent osteoclast precursors QOP) were identified as the committed osteoclast precursors in vitro. Experiments in vivo showed that QOPs survived for several weeks and differentiated into osteoclasts in response to M-CSF and RANKL. QOPs were identified as RANK and c-Fms double-positive cells and detected along bone surfaces in the vicinity of osteoblasts in RANKL-/- mice. QOPs were also observed in the ectopic bone induced by BMP-2 implanted into RANKL -/- mice suggesting that QOPs were circulating. These results imply that osteoblasts support the homing of QOPs to bone tissues. In response to bone-resorbing stimuli QOPs promptly differentiate into osteoclasts. Therefore the distribution of QOPs appears to determine the correct site of osteoclastic development. © 2010 Springer Science+Business Media LLC. Source

Nakamura M.,Matsumoto Dental University
Clinical calcium | Year: 2014

Osteoclasts, the multinucleated cells that resorb bone, originate from monocyte-macrophage lineage cells. Various hormones, cytokines and growth factors are involved in osteoclastogenesis, via interaction with osteoblasts. In this review, we summarize the regulatory mechanism of bone resorption by various cytokines derived from osteoblasts and hematopoietic inflammatory cells. Source

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