Matesy GmbH

Jena, Germany

Matesy GmbH

Jena, Germany
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Dietzel C.T.,Jena University Hospital | Dietzel C.T.,TomoTherapy | Richert H.,Innovent Jena | Richert H.,Matesy GmbH | And 4 more authors.
Journal of Controlled Release | Year: 2012

Human absorption studies are used to test new drug candidates for their bioavailability in different regions of the gastrointestinal tract. In order to replace invasive techniques (e.g. oral or rectal intubation) a variety of externally controlled capsule-based drug release systems has been developed. Most of these use ionizing radiation, internal batteries, heating elements or even chemicals for the localization and disintegration process of the capsule. This embodies potential harms for volunteers and patients. We report about a novel technique called Magnetic Active Agent Release System (MAARS), which uses purely magnetic effects for this purpose. In our trial thirteen healthy volunteers underwent a complete monitoring and release procedure of 250 mg acetylsalicylic acid (ASA) targeting the flexura duodenojejunalis and the mid-part of the jejunum. During all experiments MAARS initiated a sufficient drug release and was well tolerated. Beside this we also could show that the absorption of ASA is about two times faster in the more proximal region of the flexura duodenojejunalis with a tmax of 47 ± 13 min compared to the more distal jejunum with tmax values of 100 ± 10 min (p = 0.031). © 2012 Elsevier B.V.


Reuter T.,Fzmb GmbH | Beck M.,Fzmb GmbH | Lindner S.,Matesy GmbH | Richert H.,Matesy GmbH | And 3 more authors.
Biomedizinische Technik | Year: 2014

Current research at the fzmb deals with the development of a monitoring system for the continuous pH-measurement in vivo in the rumen of cattle in order to optimize the feed application and improve animal health in cattle farming. Here, an important aspect is the position of the pH-measuring bolus in the rumen. Within the scope of this work the movement pattern of the bolus depending on the bolus density (1.5-3g/cm3) was evaluated and recorded with a 3D magnetic monitoring system for 50 minutes during feeding. © 2014 by Walter de Gruyter Berlin Boston.


Beck M.,Fzmb GmbH | Reuter T.,Fzmb GmbH | Lindner S.,Matesy GmbH | Richert H.,Matesy GmbH | Hoffmann M.,Fzmb GmbH
Biomedizinische Technik | Year: 2013

Current research at the fzmb deals with the development of a monitoring system to the continuous pH-measurement in vivo in the rumen of cattle for the optimisation of the feed application and for the improvement of the animal health in cattle farming. Here, an important aspect is the position of the pH-measuring bolus in the rumen. Within the scope of this work the movement pattern of the pH-measuring bolus was evaluated and recorded with a 3D magnetic detector system for one hour during feeding. © 2013 by Walter de Gruyter.


Richert H.,Matesy GmbH | Schmidt H.,TU Chemnitz | Lindner S.,Matesy GmbH | Lindner M.,Innovent Jena | And 3 more authors.
Steel Research International | Year: 2016

Magneto-optical imaging with magneto-optical indicator films (MOIF) is a versatile method to characterize magnetic field distributions especially for material development and quality control. Magnetic domains and grains in grain-oriented electrical steel can be visualized, and quantified without removing the isolation layer. The combination of MOIF with digital high-speed camera technology enables temporally resolved investigations of the magnetization processes. In contrast to Kerr-effect measurements MOIF imaging works without sample preparation and even in the presence of industrial insulation coatings. Optical resolution of 25 microns and temporal resolution of 1 ms in single-shot mode could be demonstrated. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Koschny M.,Matesy GmbH | Lindner M.,Innovent Jena
Advanced Materials and Processes | Year: 2012

Magneto-optical (MO) sensor technology offers entirely new perspectives in the field of magnetic measurement and testing. Parameter-measurement capabilities depend on sensor design, and are altered depending on the properties of the applied magnetic field. MO-sensors have the technical benefit of immediately obtaining measurement data directly above the surface of the magnetic material depending on the sensor size. Thus, real-time investigations of the magnet field distribution can be performed without the need for time-consuming, point-to-point scans. Illumination and detection taking place on the same side of the sensor provides a technical benefit where the functional side can be used for quick, easy test object positioning. MO-sensors can be saturated depending on the strength of the external applied magnet field. MO-sensors offer a wide variety of application opportunities for research tasks regarding magnetic domain analysis and investigation.

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