Maternal and Fetal Health Research Center

Manchester, United Kingdom

Maternal and Fetal Health Research Center

Manchester, United Kingdom
SEARCH FILTERS
Time filter
Source Type

Gurol-Urganci I.,London School of Hygiene and Tropical Medicine | Gurol-Urganci I.,Office for Research and Clinical Audit | Cromwell D.A.,London School of Hygiene and Tropical Medicine | Cromwell D.A.,Office for Research and Clinical Audit | And 6 more authors.
BMC Pregnancy and Childbirth | Year: 2011

Background: Objective: To compare the risk of placenta previa at second birth among women who had a cesarean section (CS) at first birth with women who delivered vaginally.Methods: Retrospective cohort study of 399,674 women who gave birth to a singleton first and second baby between April 2000 and February 2009 in England. Multiple logistic regression was used to adjust the estimates for maternal age, ethnicity, deprivation, placenta previa at first birth, inter-birth interval and pregnancy complications. In addition, we conducted a meta-analysis of the reported results in peer-reviewed articles since 1980.Results: The rate of placenta previa at second birth for women with vaginal first births was 4.4 per 1000 births, compared to 8.7 per 1000 births for women with CS at first birth. After adjustment, CS at first birth remained associated with an increased risk of placenta previa (odds ratio = 1.60; 95% CI 1.44 to 1.76). In the meta-analysis of 37 previously published studies from 21 countries, the overall pooled random effects odds ratio was 2.20 (95% CI 1.96-2.46). Our results from the current study is consistent with those of the meta-analysis as the pooled odds ratio for the six population-based cohort studies that analyzed second births only was 1.51 (95% CI 1.39-1.65).Conclusions: There is an increased risk of placenta previa in the subsequent pregnancy after CS delivery at first birth, but the risk is lower than previously estimated. Given the placenta previa rate in England and the adjusted effect of previous CS, 359 deliveries by CS at first birth would result in one additional case of placenta previa in the next pregnancy. © 2011 Gurol-Urganci et al; licensee BioMed Central Ltd.


Heazell A.,Maternal and Fetal Health Research Center
Anaesthesia and Intensive Care Medicine | Year: 2013

Perinatal death or cerebral palsy are devastating outcomes of pregnancy for families. In an attempt to prevent these outcomes fetal wellbeing is assessed by a variety of means in the antenatal and intrapartum settings. In this review, the most common means to confirm fetal wellbeing, the rationale for their use and evidence of their efficacy in each of these settings are discussed. With respect to labour, the indications for continuous electronic fetal monitoring are presented, together with a guide to interpretation of cardiotocograph (CTG) or fetal blood samples (FBS). © 2013 Published by Elsevier Ltd.

Loading Maternal and Fetal Health Research Center collaborators
Loading Maternal and Fetal Health Research Center collaborators