Maternal and Child Health Hospital of Fujian Province

Fuzhou, China

Maternal and Child Health Hospital of Fujian Province

Fuzhou, China

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Zhu Y.,Zhejiang University | Lu S.,Zhejiang University | Bian X.,Peking Union Medical College | Wang H.,University of Sichuan | And 10 more authors.
Taiwanese Journal of Obstetrics and Gynecology | Year: 2016

Objective: This study aimed to determine the rates of different fetal chromosomal abnormalities among women of advanced maternal age in China and to discuss the possible misdiagnosis risks of newer molecular techniques, for selection of appropriate prenatal screening and diagnostic technologies. Materials and Methods: Second trimester amniocentesis and fetal karyotype results of 46,258 women were retrospectively reviewed. All women were ≥ 35 years old with singleton pregnancies. The rates of clinically significant chromosomal abnormalities (CSCAs), incidence of chromosomal abnormalities, and correlations with age were determined. Results: From 2001 to 2010, the proportion of women of advanced maternal age undergoing prenatal diagnosis increased from 20% to 46%. The mean age was 37.4 years (range, 35-46 years). A total of 708 cases of CSCAs, with a rate of 1.53% were found. Trisomy 21 was the most common single chromosome abnormality and accounted for 55.9% of all CSCAs with an incidence of 0.86%. Trisomy 13, trisomy 18, and trisomy 21, the most common chromosome autosomal aneuploidies, accounted for 73.6% of all CSCAs, with a rate of 1.13%. As a group, the most common chromosomal aneuploidies (13/18/21/X/Y) accounted for 93.9% of all abnormalities, with a rate of 1.44%. The incidence of trisomy 21, trisomy 13/18/21 as a group, and 13/18/21/X/Y as a group was significantly greater in women aged 39 years and older (p < 0.001), but was not different between women aged 35 years, 36 years, 37 years, and 38 years. Conclusion: These findings may assist in genetic counseling of advanced maternal age pregnant women, and provide a basis for the selection of prenatal screening and diagnostic technologies. © 2016.


Tang S.-P.,Fujian Medical University | Liu Y.-L.,Fujian Medical University | Wang S.-B.,Maternal and Child Health Hospital of Fujian Province | Weng S.-F.,Beijing Geriatric Hospital | And 7 more authors.
Journal of Asthma | Year: 2015

Objective: The prevalence of asthma in children age 0-14 years in Fuzhou, a city in Southeast China, was 1.57% in 1990 and 3.28% in 2000. The aim of this study was to investigate the asthma prevalence and risk factors in children in the same city in 2010. Methods: This was a cross-sectional study with a two-stage, clustered, stratified random sample design. Parents of 12 235 children 0-14 years of age in Fuzhou were surveyed using a questionnaire. Children with history and/or symptoms of asthma were then interviewed by pediatricians in a nearby clinic to confirm the diagnosis of asthma, and a second questionnaire listing reported risk factors of asthma was completed by the parents in the clinic. Results: About 11 738 questionnaires were completed with a response rate of 95.9%. Among the responders, 648 children had history and/or symptoms of asthma but only 485 (4.13%) were confirmed with asthma. The prevalence was 1.83%, 7.64% and 6.27% in the age groups of 0-1 years, 3-4 years and 13-14 years, respectively. The most significant (binary logistic regression test) factors associated with asthma were presence of atopic or allergic diseases (OR = 21.5, 95% CI: 12-38.5), family history of allergy or asthma (OR = 29.4, 95% CI: 12.6-68.6), use of at least one course of antibiotics in the first year of life (OR = 7.61, 95% CI: 3.4-17.06), supplementary protein feedings before 6 months (OR = 1.90, 95% CI: 1.23-2.95). Natural ventilation at home (versus frequent use of air-conditioning) appeared to be a protective factor (OR = 0.5, 95% CI: 0.3-0.8). Conclusion: The prevalence of asthma in childhood has increased significantly during the past 20 years in Fuzhou. © 2014 Informa Healthcare USA, Inc.


Pan X.Y.,Fujian Normal University | Pan X.Y.,Jilin Medical College | Zhang Z.H.,Fujian Normal University | Wu L.X.,Maternal and Child Health Hospital of Fujian Province | Wang Z.C.,Fujian Normal University
Genetics and Molecular Research | Year: 2015

The corpus luteum is a temporary endocrine structure in mammals that plays an important role in the female reproductive cycle and is formed from a ruptured and ovulated follicle with rapid angiogenesis. Vascular endothelial growth factor (VEGF) is thought to be vital in normal and abnormal angiogenesis in the ovary, but the molecular regulation of luteal VEGF expression during corpus luteum development in vivo is still poorly understood at present. Therefore, we examined whether hypoxia-inducible factor-1a (HIF-1a) is induced and regulates VEGF expression and luteal function in vivo using a pseudopregnant rat model treated with a small-molecule inhibitor of HIF-1a, echinomycin. Corpus luteum development in the pseudopregnant rat ovary was determined after measuring plasma progesterone concentration and ovarian prostaglandin F2a content to reflect changes in HIF-1a and VEGF on different days of this developmental process. At day 7, the corpus luteum was formed and the expression of HIF- 1a/VEGF reached a maximum, while a significant decrease in HIF-1a/VEGF expression was observed when luteolysis occurred at day 13. Additionally, echinomycin blocked luteal development by inhibiting VEGF expression mediated by HIF-1a and following luteal function by detecting the progesterone changes at day 7. These results demonstrated that HIF-1a-mediated VEGF expression might be an important mechanism regulating ovarian luteal development in mammals in vivo, which may provide new strategies for fertility control and for treating some types of ovarian dysfunction, such as polycystic ovarian syndrome, ovarian hyperstimulation syndrome, and ovarian neoplasia. © FUNPEC-RP.


PubMed | Maternal and Child Health Hospital of Fujian Province and Fujian Normal University
Type: Journal Article | Journal: Genetics and molecular research : GMR | Year: 2015

The corpus luteum is a temporary endocrine structure in mammals that plays an important role in the female reproductive cycle and is formed from a ruptured and ovulated follicle with rapid angiogenesis. Vascular endothelial growth factor (VEGF) is thought to be vital in normal and abnormal angiogenesis in the ovary, but the molecular regulation of luteal VEGF expression during corpus luteum development in vivo is still poorly understood at present. Therefore, we examined whether hypoxia-inducible factor-1a (HIF-1a) is induced and regulates VEGF expression and luteal function in vivo using a pseudopregnant rat model treated with a small-molecule inhibitor of HIF-1a, echinomycin. Corpus luteum development in the pseudopregnant rat ovary was determined after measuring plasma progesterone concentration and ovarian prostaglandin F2a content to reflect changes in HIF-1a and VEGF on different days of this developmental process. At day 7, the corpus luteum was formed and the expression of HIF- 1a/VEGF reached a maximum, while a significant decrease in HIF-1a/ VEGF expression was observed when luteolysis occurred at day 13. Additionally, echinomycin blocked luteal development by inhibiting VEGF expression mediated by HIF-1a and following luteal function by detecting the progesterone changes at day 7. These results demonstrated that HIF-1a-mediated VEGF expression might be an important mechanism regulating ovarian luteal development in mammals in vivo, which may provide new strategies for fertility control and for treating some types of ovarian dysfunction, such as polycystic ovarian syndrome, ovarian hyperstimulation syndrome, and ovarian neoplasia.


Pan X.-X.,Fuzhou University | Ye D.-Y.,Fuzhou University | Yan J.-Y.,Maternal and Child Health Hospital of Fujian Province | Zhang D.,Fuzhou University | Yang D.-L.,Maternal and Child Health Hospital of Fujian Province
Moshi Shibie yu Rengong Zhineng/Pattern Recognition and Artificial Intelligence | Year: 2015

Due to inconspicuous clinical characteristics of placenta accreta, there is no prenatal diagnosis methods with high sensitivity and specificity in clinical medicine. In this paper, feature selection method is introduced into the prenatal diagnosis of placenta accreta. From the view of feature correlation, a multi-objective feature optimization problem is formulated to extract features with effective medical meaning for the prenatal diagnosis of placenta accreta, and then an improved non-dominated sorting genetic algorithm II (NSGA-II) is described to solve this problem. The computational result based on real clinical data for placenta accreta shows that the proposed method can extract placenta accreta features with effective medical meaning from complex clinical data of placenta accreta. The analysis based on receiver operating characteristic (ROC) curve shows that medical meaning of the extracted features has high diagnostic values, and it can be an effective decision tool for obstetricians to study the pathogenesis of placenta accreta and to make a timely prenatal diagnosis. The study reveals that some biochemistry characteristics in real diagnosis are very important and it can provide a reliable criterion for the prenatal diagnosis of placenta accreta. ©, 2015, Journal of Pattern Recognition and Artificial Intelligence. All right reserved.


Chen H.,Huazhong University of Science and Technology | Li H.,Huazhong University of Science and Technology | Cao F.,Huazhong University of Science and Technology | Zhen L.,Maternal and Child Health Hospital of Fujian Province | And 3 more authors.
Journal of Huazhong University of Science and Technology - Medical Science | Year: 2012

This study examined the ability of 1,2,3,4,6-penta-O-galloyl-β-D- glucose (β-PGG) to induce the expression of heme oxygenase-1 (HO-1) in the PC12 cells and its regulation in the PC12 cells. One week before treatment with the drug, nerve growth factor (NGF) was added to the cultures at a final concentration of 50 ng/mL to induce neuronal differentiation. After drug treatment, HO-1 gene transcription was analyzed by reverse transcription polymerase chain reaction (RT-PCR). Expression of HO-1 and NF-E2-related factor2 (Nrf2) and activation of extracellular signal-regulated kinase (ERK) and Akt were detected by Western blotting. The viability of the PC12 cells treated with different medicines was examined by MTT assay. The oxidative stress in the PC12 cells was evaluated qualitatively and quantitatively by DCFH-DA. The results showed that β-PGG up-regulated HO-1 expression and this increased expression provided neuroprotection against MPP+-induced oxidative injury. Moreover, β-PGG induced Nrf2 nuclear translocation, which was found to be upstream of β-PGG-induced HO-1 expression, and the activation of ERK and Akt, a pathway that is involved in β-PGG-induced Nrf2 nuclear translocation, HO-1 expression and neuroprotection. In conclusion, β-PGG up-regulates HO-1 expression by stimulating Nrf2 nuclear translocation in an ERK- and Akt-dependent manner, and HO-1 expression by β-PGG may provide the PC12 cells with an acquired antioxidant defense capacity to survive the oxidative stress. © Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2012.

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