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Wang X.,Chongqing Medical University | Qin J.,Maternal and Child Care Service Center | Wang L.,Chongqing Medical University | Chen J.,Chongqing Medical University | And 2 more authors.
Archives of Gynecology and Obstetrics | Year: 2013

Background: Uterine fibroids are the most common benign tumors in women. As a new minimally invasive clinical technology, high-intensity focused ultrasound (HIFU) has been widely applied to the treatment of uterine fibroids, but no study using objective criteria has evaluated the effect of HIFU on sexual function. Methods: A total of 100 premenopausal patients were enrolled in this randomized clinical trial (RCT). The brief index of sexual functioning (BISF-W) was used to evaluate changes in sexual function. Differences in the outcome were calculated for each individual before treatment and at 3 and 6 months after treatment, and changes were compared between the HIFU group (HIFUG) and the myomectomy group (MYG). Results: Preoperative BISF-W scores were similar in both groups (P < 0.05). No significant differences were found between the two groups at 3 and 6 month after treatment. Within the groups, patients reported less arousal and less problems at 3 month compared to baseline. There was a trend toward improved sexual satisfaction and overall quality of sexual life in both groups 6 months after treatment compared with the baseline, although it failed to reach statistical significance except for the dimensions of relational satisfaction and problems affecting sexuality. Conclusions: Sexual function improved on average to some degree after both HIFU and conventional myomectomy. © 2013 Springer-Verlag Berlin Heidelberg.


Jianyu L.,Library Information Center | Juzhi Z.,Library Information Center | Huanli R.,Library Information Center | Guichai L.,Maternal and Child Care Service Center
Journal of Medical Imaging and Health Informatics | Year: 2016

The current paper analyzes existing problems in health information services and discussed the importance and urgency of promoting health information literacy (HIL) of the public in China. It is suggested to establish a big data age-featured innovative health information services model in university libraries through transforming their traditional role, constructing a patient-oriented, network-sharing health information resources bank, and forging full-time and part-time HIL service teams. © 2016 American Scientific Publishers All rights reserved.


Zhang Q.,Anhui Medical University | He L.,Anhui Medical University | He L.,Maternal and Child Care Service Center | Kong L.,Anhui Medical University | And 12 more authors.
Journal of Parasitology | Year: 2015

Toxoplasma gondii induces polarization of mouse macrophages, including both classically activated macrophages (M1) and alternatively activated macrophages (M2) in a genotype-related manner. Here we present a novel result that the Wh6 strain with type Chinese 1, which is predominantly prevalent in China, induces Arg1 expression in a STAT6-dependent manner in primary rat peritoneal macrophages as compared to the PRU stain with type II, which elicited a high expression of Arg1 in a C/EBPβ-dependent manner. In addition, dexamethasone inhibited Arg1 expression in rat macrophages in both treatments. Our data suggest that Arg1 expression, which is abundant in polarized M2 cells, is associated with strain/genotype differences from different pathways. © 2015 American Society of Parasitologists.


Xu D.,Chongqing Medical University | Xu D.,Maternal and Child Care Service Center | Li R.,Chongqing Medical University | Wang H.,Chongqing Medical University | And 3 more authors.
Chinese Journal of Clinical Oncology | Year: 2012

Objective: To investigate the administration of neoadjuvant chemotherapy (NACT) for controlling pelvic node metastasis by inducing tumor cell apoptosis in patients with cervical cancer. Methods: Immunohistochemical SP staining and in situ terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) were employed to assay the pelvic lymph node apoptotic status in 104 patients with cervical cancer, i.e., 54 NACT cases with stage IB and HB cervical cancer awaiting surgery and 50 cases with stage IB and IA cervical cancer who have undergone immediate surgery. Among these cases, 54 (27 treated with NACT before surgery and 27 who underwent immediate surgery) were assessed for the apoptotic status of the in situ diseased regions simultaneously. Results: The total response rate of the chemotherapy to NACT was 74.07% in the 54 cases (40/54), with a lower incidence of pelvic node involvement (11/54, 20.37%) than the immediate surgery group (20/50, 40%). Both pelvic nodes and in situ diseased regions in the NACT group had a much higher caspase-3 expression and apoptotic index (AI) (P < 0.05) than those in the control or immediate surgery group. Additionally, the AI value in the pelvic nodes was significantly correlated with that in the in situ lesions (r = 0.316, P = 0.01). Conclusion: NACT is efficient in controlling pelvic node metastasis by inducing tumor cell apoptosis in patients with regionally advanced cervical cancer.


Xiaojuan Q.,Maternal and Child Care Service Center
African Journal of Biotechnology | Year: 2010

Our previous studies have shown that Baicalin could effectively inhibit Chlamydia trachomatis in vitro. In this study, Baicalin was tested for potential antichlamydial activity using a murine genital Chlamydia trachomatis infection model. It was demonstrated that Baicalin significantly reduced C. trachomatis loading in BALB/c mice that were vaginally infected with the pathogen. On the basis of these data and our previous observations, we concluded that further evaluation of Baicalin for prevention and treatment of sexually transmitted chlamydial infection is warranted. © 2010 Academic Journals.

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