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Peters B.D.,Rivierduinen | Blaas J.,Materials Innovation Institute M2i | de Haan L.,Academic Psychiatric Center
Journal of Psychiatric Research | Year: 2010

The dysconnectivity model suggests that disturbed integration of neural communication is central to schizophrenia. The integrity of macro-structural brain circuits can be examined with diffusion tensor imaging (DTI), an MRI application sensitive to microstructural abnormalities of brain white matter. DTI studies in first-episode schizophrenia patients and individuals at high-risk of psychosis can provide insight into the role of structural dysconnectivity in the liability, onset and early course of psychosis. This review discusses (i) views on the role of white matter abnormalities in schizophrenia, (ii) DTI and its application in schizophrenia, (iii) DTI findings in first-episode patients and subjects at high-risk of psychosis; their timing, anatomical location and early course, (iv) the hypothesized underlying pathological substrate and possible causes of DTI white matter alterations, including effects of adolescent cannabis use, and (v) some methodological issues and future recommendations. In summary, there is evidence that DTI abnormalities convey a liability for psychosis and additional abnormalities occur around onset of psychosis. However, findings in first-episode patients are less robust than in chronic patients, and progression of disturbances may occur in the early course of poor-outcome patients. In addition, acceleration of the normal aging process may occur. Adolescent cannabis use has specific effects on DTI measures. An unresolved issue is the underlying pathology of DTI abnormalities, and combining DTI with other MRI indices can provide more insight. More research is needed on which genetic and environmental factors play a role in the variability of current results. © 2010 Elsevier Ltd. Source

Topuz A.I.,Materials Innovation Institute M2i
Computational Materials Science | Year: 2014

In this study, a dimension reduction procedure of defect properties is proposed together with a two dimensional dislocation dynamics framework in order to simulate tensile response of the materials at different levels of external conditions such as radiation. This procedure delivers ordered pairs of strength and line density according to the changes in the geometrical properties of the defects. Plain strain deformation of irradiated oxygen-free high conductivity copper is investigated by using experimental information about the evolution of stacking-fault tetrahedra at the irradiation doses of 0-0.2 dpa. © 2014 Elsevier B.V. All rights reserved. Source

Gupta D.,Materials Innovation Institute M2i | Gupta D.,TU Eindhoven | Wienk M.M.,TU Eindhoven | Janssen R.A.J.,TU Eindhoven
Advanced Energy Materials | Year: 2013

Solution processed polymer:fullerene solar cells on opaque substrates have been fabricated in conventional and inverted device configurations. Opaque substrates, such as insulated steel and metal covered glass, require a transparent conducting top electrode. We demonstrate that a high conducting (900 S cm-1) PEDOT:PSS layer, deposited by a stamp-transfer lamination technique using a PDMS stamp, in combination with an Ag grid electrode provides a proficient and versatile transparent top contact. Lamination of large size PEDOT:PSS films has been achieved on variety of surfaces resulting in ITO-free solar cells. Power conversion efficiencies of 2.1% and 3.1% have been achieved for P3HT:PCBM layers in inverted and conventional polarity configurations, respectively. The power conversion efficiency is similar to conventional glass/ITO-based solar cells. The high fill factor (65%) and the unaffected open-circuit voltage that are consistently obtained in thick active layer inverted geometry devices, demonstrate that the laminated PEDOT:PSS top electrodes provide no significant potential or resistive losses. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

Agency: Cordis | Branch: H2020 | Program: CSA | Phase: NMP-36-2014 | Award Amount: 496.22K | Year: 2015

This proposal for a Coordination Action aims at improving visibility for essential stakeholders, most notably national/regional programming and funding authorities, on programming synergetic actions between the European Union and member states in the NMP Program. This shall be done by organising a forum and collecting road maps focused in particular on the use of the new ERANET instrument in the NMP area. In doing so, the CSA shall acknowledge that the NMP program has an important role in translating result from flagships towards industrial application and in facilitating key enabling technologies towards the Grand Societal Challenges. It shall also take into account the methodology of technology readiness levels is leading the programmation of the NMP work program. Programming should also acknowledge that industrial leadership, for SMEs in particular is an important objective. This objective should result in a road-map with the aim to increase visibility on themes to program. In exploiting synergies, the new ERANET Instrument is an important tool. In order to operationalize it in Horizon2020 visibility should be improved on best practices in using the ERANET under FP7 as well collecting a database on projects funded through it. This shall give input to a forum to discuss future opportunities and identify critical mass of funding agencies willing to support it. Synergies shall often require alignment of European, National and Regional funding. In fact operational programs under ERDF demand these synergies. In NMP many topics demand an alignment of proposals with regional Smart Specialisation Strategies. How these synergies can be organised is an explicit objective, with the aim, to enlarge the number of funding agencies (national or regional) able to use it. Therefore particular attention in this project shall be given to reach out to as many regions as possible.

Agency: Cordis | Branch: H2020 | Program: ERA-NET-Cofund | Phase: NMP-14-2015 | Award Amount: 49.69M | Year: 2016

M-ERA.NET 2 aims at coordinating the research efforts of the participating EU Member States, Associated States and Regions as well as of selected global partners in materials research and innovation, including materials for low carbon energy technologies and related production technologies. A large network of 43 national and regional funding organisations from 23 EU Members States and Associated States and 5 countries outside Europe will implement joint calls to fund excellent innovative transnational RTD cooperation, including one call for proposals with EU co-funding and additional non-cofunded calls. Continuing the activities started under the predecessor project M-ERA.NET (2/2012-1/2016), the M-ERA.NET 2 consortium will support relevant thematic areas, such as -for example- surfaces, coatings, composites, additive manufacturing or computational materials engineering. Research on materials enabling low carbon energy technologies will be particularly highlighted as a main target of the cofunded call (Call 2016) with a view to implementing relevant parts of the Materials Roadmap Enabling Low Carbon Energy Technologies (SEC(2011)1609), and relevant objectives of the SET-Plan (COM (2009)519). The appropriate scope of the cofunded call and the additional joint calls will be defined in cooperation with relevant stakeholders including national and regional RTD communities, the EC and the EMIRI (Energy Materials Industrial Research Initiative) as well as an external Strategic Experts Group. M-ERA.NET 2 will support the whole innovation chain, clarifying for each topic the appropriate Technology Readiness Levels (TRLs) to be addressed through the transnational RTD projects. The consortium will be aware of the TRLs which are covered by the EC through Horizon 2020 topics as well as by other schemes. Gaps will be identified and M-ERA.NET 2 will aim at offering a complementary support scheme.

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