Arlington Heights, IL, United States

Materials Development, Inc.

www.matsdev.com
Arlington Heights, IL, United States

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Han G.,National University of Singapore | Chung T.-S.,National University of Singapore | Toriida M.,Materials Development, Inc. | Tamai S.,Materials Development, Inc.
Journal of Membrane Science | Year: 2012

In this work, a novel sulphonated poly(ether ketone) (SPEK) polymer with super-hydrophilic nature was designed as the substrate material to fabricate high performance thin-film composite (TFC) membranes for desalination via forward osmosis (FO). m-Phenylenediamine (MPD) and 1,3,5-trimesoylchloride (TMC) were employed as the monomers for the interfacial polymerization reaction to form a thin aromatic polyamide selective layer. It has been demonstrated that blending a certain SPEK material into the polysulfone (PSU) substrate of TFC-FO membranes not only plays the key role to form a fully sponge-like structure, but also enhances membrane hydrophilicity and reduces structure parameter. The TFC-FO membrane comprising 50. wt% SPEK in the substrate shows the highest water flux of 50 LMH against deionized water and 22 LMH against the 3.5. wt% NaCl model solution, respectively, when using 2. M NaCl as the draw solution tested under the pressure retarded osmosis (PRO) mode (draw solution flows against the selective layer). It is found that the hydrophilicity and thickness of the substrates for TFC-FO membranes play much stronger roles in facilitating high water flux in FO for desalination compared to those made from hydrophobic substrates full of finger-like structures. Moreover, the reduced membrane structural parameter indicates that the internal concentration polarization (ICP) can be remarkably reduced via blending a hydrophilic material into the membrane substrates. Thermal treatment of TFC-FO membranes with optimized conditions can also improve the membrane performance and mechanical strength. © 2012 Elsevier B.V.


Zhang J.,Tohoku University | Kumagai H.,Materials Development, Inc. | Yamamura K.,Materials Development, Inc. | Ohara S.,Tohoku University | And 6 more authors.
Nano Letters | Year: 2011

Herein we demonstrate the extra-low-temperature oxygen storage capacity (OSC) of cerium oxide nanocrystals with cubic (100) facets. A considerable OSC occurs at 150 °C without active species loading. This temperature is 250 °C lower than that of irregularly shaped cerium oxide. This result indicates that cubic (100) facets of cerium oxide have the characteristics to be a superior low-temperature catalyst. © 2011 American Chemical Society.


Grant
Agency: Department of Energy | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 150.00K | Year: 2016

Recent advances in the generation and focusing of synchrotron x-ray beams enable new types of measurements. Pending upgrades to Advanced Photon Source (APS-U) in the US, SPring8 in Japan and ESRF in Europe and commissioning of NSLS-II will provide unprecedented x-ray flux density. In combination with these developments in sources, modern detector technologies and extreme sample environments enable important new research with a high scientific and commercial impact. There is a need to seamlessly combine small and wide angle x-ray scattering methods to understand nanostructure and structural evolution in materials. This approach can revolutionize the way that x-ray data can be analyzed to study large structures in real space. Sample holders and containers severely limit the ability to study materials by nucleating crystals and interfering with the scattered x-ray signal. Materials Development will combine advanced x-ray optics, a novel detector geometry and aerodynamic levitation to achieve completely contact-free processing of samples and generation of data over a Q range from 0.03-20 Å-1. This approach will access pristine materials and avoid contributions from sample holders to the measured signal and provide a pair distribution function over a wide length scale range. During the Phase I R&D Materials Development will validate the proposed solution and design an optimized system. The main technical objectives of the Phase I research will be to: (i) investigate processing using the aerodynamic levitator, (ii) investigate hardware and software for combining small and wide angle detector technologies on a high energy beamline, (iii) evaluate requirements for incident beam optics, flight path and beam stops, (iv) evaluate requirements for an integrated system that will be developed during the Phase II research, and (v) present and/or publish results. Successful demonstration of the proposed technology in Phase I will lead to development of a commercial capability for synchrotron-enabled research on materials during the Phase II R&D. The proposed project will advance the application of x-rays to solving important energy-related and industrial problems in materials. These include developing enabling materials for advanced fuel, nuclear, photonic and aerospace products. Commercial Applications/Benefits: The product of this R&D will be an x-ray facility sample environment/detector instrument that will be marketed by direct interaction with customers. The proposed system has immediate applications in synchrotron facilities such as APS, NSLS- II, ESRF, SPring-8 and many other smaller synchrotrons. The sample environment capability has important commercial applications in basic and applied materials research. Prior sales of extreme environment instruments is several M$.


Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 138.93K | Year: 2013

DESCRIPTION (provided by applicant): Advanced Image Plates for Dental X-ray Diagnostics The proposed research and development project will enhance medical imaging technology for use in dental imaging. This overall objective provides an important opportunity to enhance the technical quality and patient experience in dental care. The RandD will investigate the use of high-resolution Transparent Storage Phosphor (TSP) materials in dental imaging applications. The work will include fabrication of image plates,testing and evaluation of imaging performance using phantoms and contrast test plates, and development of a detailed plan that will lead to manufacturing of commercially competitive imaging components for the dental market. The RandD team is skilled in thedevelopment of advanced TSP medical imaging materials and it has the facilities and knowledge needed to make significant advances in the application of the technology to dental imaging. The proposed innovation will enable higher quality dental imaging under well-defined and controlled exposure conditions. The advantages of the new technology will be obtained by using equipment that is compatible with existing dental x-ray generators. The novelty of the approach is to develop optimized imaging performance and packaging to meet the specific requirements of the dental market. These innovations include: (i) Consistent high resolution imaging with lower x-ray doses, (ii) image plates compatible with current x-ray systems, and (iii) potential for development of shaped imaging plates designed specifically for intra-oral use. The proposed RandD will be completed in a period of 6 months. Completion of the proposed project will demonstrate the value of the proposed approach, secure know-how and lay the foundation forfuture successful commercialization of the technology. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: The specific aims of the proposed RandD are to: (i) Demonstrate the use of advanced Transparent Storage Phosphor (TSP) materials for dentalimaging, (ii) Evaluate the performance of the TSP materials compared to current dental imaging methods, and (iii) Establish requirements for providing TSP image plates to the dental market.


Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase II | Award Amount: 999.99K | Year: 2010

This Phase II focuses on moving a new transparent storage phosphor imaging plate technology from the laboratory to a clinical prototype product. In Phase I methods to make, polish, heat treat, and characterize ~6 x 8 cm glass plates that provide superior resolution compared to the current best were developed. Potential customers need better plates to improve imaging performance in CR systems and enable them to compete with DR technologies, particularly in the area of mammography. The outcome of the proposed RandD will be a new image plate product based on proprietary technology that is tested and verified to a pre-clinical level. The proposed research has five components: (i) Perfect/make glass plates, (ii) Characterize plates, (iii) Package and integrate plates, (iv) Measure imaging performance, and (v) Construct a prototype product. Glass production will be perfected by increasing the scale of processing and improving process control to obtain consistent products that meet target perfromance requirements, including values of MTF, DQE, and readout speed. Imaging performance will be measured in the laboratory and using standard test phantoms to benchmark reading accuracy by experienced clinical radiologists. The resulting products will be packaged in cassettes designed to operate within existing medical imaging infrastructure.


Grant
Agency: Department of Energy | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 150.00K | Year: 2012

Extreme temperatures and non-equilibrium materials are both central to DOEs mission of addressing grand challenges in emerging energy and advanced materials technologies. Processing and solidifying liquids and molten materials is a critical value adding step in manufacturing semiconductors, glasses, optical materials, metals and in the operation of many energy conversion and medical devices. Accessing extreme temperatures and non- equilibrium states is technically challenging in large part due to reactions with containers. Containerless techniques, also called levitation, are emerging as an effective solution to the container problem in beamline research. This project will lead to development of a novel sample manipulation techniques that will enable studies of materials under extreme conditions that relate to production of semiconductors, optical glasses, medical device and energy conversion materials. Research will be performed jointly by the small business and the Advanced Photon Source at Argonne National Laboratory. The proposed solution is to integrate a novel containerless sample manipulator, laser beam heating, and an advanced data acquisition and management system with a high flux, high energy x-ray beamline. The R & amp;D will: (i) evaluate instrument requirements, (ii) design and construct a test instrument that integrates an advanced containerless sample environment with a beamline, (iii) implement test experiments including in-situ measurements, and (iv) analyze results and prepare a plan for development of the instrument to be constructed, tested, and delivered in Phase II and offered for sale as a commercial research product. Commercial Applications/Benefits: The product of this R & amp;D will be a beamline facility instrument that will be marketed by direct interaction with beamline customers. The proposed system has immediate applications in x-ray facilities such as APS, NSLS-II, Diamond, Spring-8 and ESRF. The proposed solution is also suitable for marketing to laboratories where there are additional markets for instruments used in advanced materials research. Prior sales of extreme environment instruments is several M$.


Grant
Agency: Department of Energy | Branch: | Program: SBIR | Phase: Phase II | Award Amount: 999.98K | Year: 2013

Extreme temperature and non-equilibrium processes are both central to DOEs mission of addressing grand challenges in emerging energy and advanced materials; they are also crucial steps in the manufacture of many high value-add industrial products. MDI is advancing the ability to process and study materials at extreme temperatures and in non-equilibrium conditions by developing a novel containerless processing technology. Containerless techniques, also called `levitation, are emerging as a very effective tool to access and characterize materials at the extreme end of the temperature/stability range. This project is developing, optimizing and benchmarking new sample manipulation techniques that will enable studies of materials under extreme conditions, particularly using high energy synchrotron radiation. The R & amp;D impacts critical technology areas including the manufacture of optical glasses, semiconductors, medical products, and energy conversion materials. Research will be performed jointly by the small business and the Advanced Photon Source at Argonne National Laboratory. The proposed solution integrates a novel containerless sample manipulator, laser beam heating, and advanced data acquisition and management with a high flux, high energy x-ray beamline. The R & amp;D will: (i) specify, optimize and construct a prototype instrument; (ii) test and characterize the instrument, including making in-situ measurements, (iii) leverage the SBIR investment to sell instruments to clients in the industrial glass and materials, basic research, and beamline instrumentation markets. The Phase I research was completed on-time and on-budget. Results demonstrated the feasibility of the proposed approach using materials at temperatures up to 3200C and temperature dependent measurements of melt structure. The R & amp;D defined precise requirements for an advanced instrument that will be developed in Phase II to meet customers clearly identified needs. In Phase II the R & amp;D will complete the advanced instrument design based on the Phase I results. A test instrument will be constructed, fully characterized, and perfected through detailed experiments, modeling, and testing at high energy synchrotron beamlines. The Phase II commercialization plan will be implemented to sell instruments to customers who have expressed interest acquiring the new capabilities. Commercial Applications and Other Benefits: The product of this R & amp;D will be a beamline facility instrument that will be marketed directly to beamline customers. The proposed system has immediate applications in X-ray facilities such as APS, NSLS-II, Diamond, Spring-8 and ESRF. MDI is an equipment developer, manufacturer, and seller which will work directly with customers to install instruments in their facilities and to expand the market. Prior sales of extreme environment instruments is several millions of dollars.


Grant
Agency: Department of Energy | Branch: | Program: SBIR | Phase: Phase II | Award Amount: 999.89K | Year: 2011

Research on advanced materials is hampered by difficulty in accessing short-lived metastable states that play a crucial role in determining the material & apos;s ultimate structure, properties and performance. In combination with advanced sample environments, DOEs high flux neutron sources such as SNS provide an opportunity to revolutionize advanced materials research by helping to understand how materials function during processing. The capability is valuable in developing competitive new materials for high value applications. The proposed solution is to integrate a novel containerless sample environment and an event-based data acquisition system with a high flux neutron beam line. The project is developing a novel sample environment and event-based data processing that enable studies of materials under extreme conditions that relate to production of semiconductors, optical glasses, medical device materials and energy conversion materials. Showed the technical feasibility of the proposed approach, made measurements using a test instrument and established technical basis for Phase II R & amp;D. Measurements were made in the lab and at SNS and discussions were held with potential customers to define critical design parameters. Optimize instrument design and performance, construct test instrument, investigate and refine operation to meet customer requirements. Work will include design analyses, laboratory and beamline experiments, and collaborative research with potential customers. Commercial Applications and Other Benefits: The product of this R & amp;D will be a new instrument that will be marketed by direct interaction with customers. The proposed system has applications in neutron facilities such as SNS, HFIR, ILL, ISIS and other sources. Prior sales of extreme environment instruments has been several M$.


Grant
Agency: Department of Energy | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 100.00K | Year: 2010

In combination with advanced sample environments, the emerging generation of high flux neutron sources such as SNS provide an opportunity to revolutionize advanced materials research. Processing and solidifying liquids is a critical value adding step in manufacturing semiconductors, optical materials, metals and in the operation of many energy conversion and medical devices. Research on advanced materials is hampered by difficulty in accessing short-lived metastable states that play a crucial role in determining the material's ultimate structure and properties. This project will lead to development of a novel sample environment and event-based data processing technologies that will enable studies of materials under extreme conditions that relate to production of semiconductors, optical glasses, medical device materials and energy conversion materials. Research will be performed jointly by the small business and the Spallation Neutron Source at Oak Ridge National Laboratory. The proposed solution is to integrate a novel containerless sample environment and an event-based data acquisition system with a high flux neutron beam line. The R&D will: (i) evaluate instrument requirements, (ii) design and construct a test instrument that integrates an advanced containerless sample environment with a beamline, (iii) implement test experiments including event-based measurements, and (iv) analyze results and prepare a plan for development of the instrument that will be constructed, tested, and delivered in Phase II and offered for sale as a commercial research product. Commercial Applications and Other Benefits: The product of this R&D will be a beamline facility instrument that will be marketed by direct interaction with beamline customers. The proposed system has direct applications in neutron facilities such as SNS, HFIR, ISIS and other sources. The approach is also suitable for marketing to X-ray facilities where there are additional markets for instruments based on the proposed technology. Prior sales of extreme environment instruments has been several M$.


Grant
Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase I | Award Amount: 150.00K | Year: 2016

DESCRIPTION provided by applicant The objective of the proposed project is to advance the development a tool for research on amorphous pharmaceutical screening production towards a commercial product Commercialization will be through sales of research instruments and potentially drug screening services to pharmaceutical companies Many emerging drugs cannot be used in their naturally insoluble crystalline forms In some cases amorphous forms made using conventional methods contain residual crystal nuclei and consequently have short shelf lives before they crystallize The novel use of the proposed containerless method avoids nucleation allowing completely amorphous materials to be synthesized is sufficient quantities for research This capability is important for benchmarking products understanding drug biner phase relationships and in the optimization of large scale production methods such as spray drying In addition to benchmarking and synthesis of small quantities of drugs the proposed device is useful for characterizing the behavior of drug solutions of the type that are used in spray drying The principal goals of the proposed Randamp D are to i demonstrate key performance benchmarks by comparing data on test drugs representative of commercial pharmaceutical compounds made using MDIandapos s instrument and standard rotovap synthesis and ii optimize the capability to meet commercial drug research requirements The long term objective is to provide a new laboratory scale process platform and a tool that can be used to optimize drug production using conventional manufacturing methods such as spray drying The proposed research has five main technical objectives that are targeted to achieving the project goals and that will lead to development of a commercially viable non contact pharmaceutical research and screening technology The work will include instrumentation research measurements on selected drug and drug polymer materials and analysis benchmarking of the performance of the method The project will be performed by an experienced team of scientists and engineers who are expert in the areas of the proposed research During the Phase I MDI will be working with Merck SSCI and a process engineer scientist as documented in the letters of support included with the proposal PUBLIC HEALTH RELEVANCE The proposed technology can revolutionize drug discovery and screening The most important goal of medical care is to optimize patient outcomes through the effective administration of treatments Many emerging drugs cannot be used in their naturally insoluble crystalline forms The new patented containerless processing method that will be commercially developed as a result of the proposed research is an essential tool for next generation drug development that enables the development and optimization of high solubility amorphous drug forms As a result of the new process advanced drug formulations can become available to treat a variety of diseases more effectively

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