Entity

Time filter

Source Type


Borovskaja T.G.,Russian Academy of Medical Sciences | Sergeeva S.A.,Materia Medica Holding Research and Production Company | Udut V.V.,Russian Academy of Medical Sciences | Fomina T.I.,Russian Academy of Medical Sciences | And 5 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2011

Specific effects of ultra-low doses of antibodies to prostate-specific antigen obtained from laboratory rats of late reproductive age with sulpiride model of benign prostatic hyperplasia were compared with the results of clinical application of the preparation. Clinical reproducibility of experimental data was proven, which suggests that the developed model is adequate for pilot testing of the effects of pharmacotherapy of this disease. © 2011 Springer Science+Business Media, Inc. Source


Kheyfets I.A.,Materia Medica Holding Research and Production Company | Vorob'Eva T.M.,Ukrainian Academy of Sciences | Veselovskaya E.V.,Ukrainian Academy of Sciences | Shlyahova A.V.,Ukrainian Academy of Sciences | And 5 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2013

We estimated the efficacy of Brizantin preparation in suppressing nicotine dependence in rats. It was shown that nicotine-dependent rats in the situation of choice between the chamber with smoke or the chamber with food more frequently entered the chamber with tobacco smoke and stayed there longer. The rats that received Brizantin demonstrated significantly fewer visits to the chamber with smoke and spent there less time. Reduced locomotor activity and orientation and exploratory behavior in rats against the background of Brizantin administration also suggest reduced motivation for smoke inhalation. Thus, Brizantin effectively diminished nicotine dependence in rats in the model of nicotine addiction. © 2013 Springer Science+Business Media New York. Source


Borovskaya T.G.,Russian Academy of Medical Sciences | Fomina T.I.,Russian Academy of Medical Sciences | Pakhomova A.V.,Russian Academy of Medical Sciences | Ermolaeva L.A.,Russian Academy of Medical Sciences | And 5 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2012

We compared the efficacy of Impaza (antibodies against endothelial NO-synthase in ultra-low doses) and Serenoa repens on the rat model of chronic aseptic prostatic inflammation. Administration of Serenoa repens in a dose of 50 mg/kg for 1.5 months prevented the development of prostate sclerosis and increased luminal area, but did delay the development of atrophic processes. In animals treated with Impaza (3 ml/kg for 1.5 months), atrophic changes in the prostate gland were practically absent. These findings indicate that Impaza can be used in complex therapy of abacterial prostatitis. © 2012 Springer Science+Business Media New York. Source


Petrov V.I.,S M Kirov Military Medical Academy | Bugaeva L.I.,S M Kirov Military Medical Academy | Lebedeva S.A.,S M Kirov Military Medical Academy | Lavrova E.V.,S M Kirov Military Medical Academy | And 5 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2010

Chronic treatment of rats with kardosten for 6 months had a positive effect on some ECG values and behavior without disordering the hepatorenal functions. All effects of the drug observed during a course of treatment were leveled and the parameters reached the basal values within 2 weeks after drug discontinuation, this confi rming its safety. © 2010 Springer Science+Business Media, Inc. Source


Zhavbert E.S.,Materia Medica Holding Research and Production Company | Dugina J.L.,Materia Medica Holding Research and Production Company | Sergeeva S.A.,Materia Medica Holding Research and Production Company | Kheyfets I.A.,Materia Medica Holding Research and Production Company | Epstein O.I.,Materia Medica Holding Research and Production Company
Bulletin of Experimental Biology and Medicine | Year: 2011

Experiments on different models for sexual behavior (seasonal and age-related inhibition of sexual function, animals with initially reduced sexual function) showed that ultra-low doses of anti-NO-synthase antibodies (Impaza) stimulate sexual motivation and copulative behavior in rats. The effects of the drug on different aspects of sexual behavior depend on the chosen model. © 2011 Springer Science+Business Media, Inc. Source

Discover hidden collaborations