Brockton, MA, United States
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Oguma A.Y.,University of Louisiana at Lafayette | Oguma A.Y.,Massasoit Community College | Klerks P.L.,University of Louisiana at Lafayette
Ecotoxicology | Year: 2015

Much work has focused on the effects of metal-contaminated sediment on benthic community structure, but effects on ecosystem functions have received far less attention. Decomposition has been widely used as an integrating metric of ecosystem function in lotic systems, but not for lentic ones. We assessed the relationship between low-level sediment lead (Pb) contamination and leaf-litter decomposition in a lentic system. We measured 30-day weight loss in 30 litter-bags that were deployed along a Pb-contamination gradient in a cypress-forested lake. At each deployment site we also quantified macrobenthos abundance, dissolved oxygen, water depth, sediment organic content, sediment silt/clay content, and both total sediment and porewater concentrations of Cd, Cu, Ni, Pb and Zn. Principal components (PC) analysis revealed a negative relationship between Pb concentration and benthic macroinvertebrate abundance, and this covariation dominated the first PC axis (PC1). Subsequent correlation analyses revealed a negative relationship between PC1 and percent leaf-litter loss. Our results indicate that leaf-litter decomposition was related to sediment Pb and benthic macroinvertebrate abundance. They also showed that ecosystem function may be affected even where sediment Pb concentrations are mostly below threshold-effects sediment quality guidelines—a finding with potential implications for sediment risk assessment. Additionally, the litter-bag technique used in this study showed promise as a tool in risk assessments of metal-contaminated sediments in lentic systems. © 2015, Springer Science+Business Media New York.


News Article | October 28, 2016
Site: www.prweb.com

Leading online higher education resource provider AffordableCollegesOnline.org has released its rankings of the Best Online Colleges in Massachusetts for 2016-2017. A two- and four-year school list was created for each state, with the following receiving top honors: University of Massachusetts - Lowell, Amherst and Dartmouth campuses, Westfield State University and Lesley University for four-year schools; Bunker Hill Community College, Holyoke Community College, Middlesex Community College, Massasoit Community College and Greenfield Community College for two-year schools. "The Massachusetts Department of Education has been steadily working on initiatives to ramp up college completion numbers by 2025,” said Dan Schuessler, CEO and Founder of AffordableCollegesOnline.org. "These colleges are examples of how higher education in Massachusetts is becoming more flexible, offering affordable, top-quality online learning programs to help more students earn degrees.” To earn a spot on the Best Online Colleges in Massachusetts’s list, schools are required to meet several stringent base qualifications. Each institution must be an accredited, public or private not-for-profit college or university. Schools must also fall within specific affordability guidelines, offering in-state tuition rates below $5,000 annually at two-year schools and below $25,000 annually at four-year schools. A complete lists of colleges on the two- and four-year lists are included below. To learn more about where each specifically falls in the ranking and find more details about the data analysis and methodology used to score each state, visit the following link: The two-year schools honored as the Best Online Colleges in Massachusetts for 2016 are: Berkshire Community College Bristol Community College Bunker Hill Community College Greenfield Community College Holyoke Community College Massachusetts Bay Community College Massasoit Community College Middlesex Community College Northern Essex Community College Roxbury Community College The four-year schools honored as the Best Online Colleges in Massachusetts for 2016 are: Fitchburg State University Framingham State University Hebrew College Lesley University Massachusetts Maritime Academy National Graduate School of Quality Management Salem State University University of Massachusetts - Amherst University of Massachusetts - Boston University of Massachusetts - Dartmouth University of Massachusetts - Lowell Westfield State University AffordableCollegesOnline.org began in 2011 to provide quality data and information about pursuing an affordable higher education. Our free community resource materials and tools span topics such as financial aid and college savings, opportunities for veterans and people with disabilities, and online learning resources. We feature higher education institutions that have developed online learning environments that include highly trained faculty, new technology and resources, and online support services to help students achieve educational and career success. We have been featured by nearly 1,100 postsecondary institutions and nearly 120 government organizations.


Truong-Bolduc Q.C.,Harvard University | Hsing L.C.,Harvard University | Hsing L.C.,Far Eastern Memorial Hospital | Villet R.,Harvard University | And 4 more authors.
Journal of Bacteriology | Year: 2012

We previously showed that at acid pH, the transcription of norB, encoding the NorB efflux pump, increases due to a reduction in the phosphorylation level of MgrA, which in turn leads to a reduction in bacterial killing by moxifloxacin, a substrate of the NorB efflux pump. In this study, we demonstrated that reduced oxygen levels did not affect the transcript levels of mgrA but modified the dimerization of the MgrA protein, which remained mostly in its monomeric form. Under reduced aeration, we also observed a 21.7-fold increase in the norB transcript levels after 60 min of growth that contributed to a 4-fold increase in the MICs of moxifloxacin and sparfloxacin for Staphylococcus aureus RN6390. The relative proportions of MgrA in monomeric and dimeric forms were altered by treatment with H2O2, but incubation of purified MgrA with extracts of cells grown under reduced but not normal aeration prevented MgrA from being converted to its dimeric DNA-binding form. This modification was associated with cleavage of a fragment of the dimerization domain of MgrA without change in MgrA phosphorylation and an increase in transcript levels of genes encoding serine proteases in cells incubated at reduced aeration. Taken together, these data suggest that modification of MgrA by proteases underlies the reversal of its repression of norB and increased resistance to NorB substrates in response to reduced-aeration conditions, illustrating a third mechanism of posttranslational modification, in addition to oxidation and phosphorylation, that modulates the regulatory activities of MgrA. © 2012, American Society for Microbiology.


Mills-Robles H.A.,Massasoit Community College | Desikan V.,Massasoit Community College | Golen J.A.,University of Massachusetts Dartmouth | Manke D.R.,University of Massachusetts Dartmouth
Acta Crystallographica Section E: Crystallographic Communications | Year: 2015

The title compound, C8H10O3, has two planar molecules in the asymmetric unit possessing mean deviations from planarity of 0.051 and 0.071Å. In the crystal, there are two distinct infinite chains, both along [010]. The chains are formed by O - H⋯O interactions between the phenol and both the 3-methoxy and the 4-methoxy groups.


McDonald K.J.,Massasoit Community College | Desikan V.,Massasoit Community College | Golen J.A.,University of Massachusetts Dartmouth | Manke D.R.,University of Massachusetts Dartmouth
Acta Crystallographica Section E: Crystallographic Communications | Year: 2015

The title compound, C6H5Cl2NO, has a single planar molecule in the asymmetric unit with the non-H atoms possessing a mean deviation from planarity of 0.020 Å. In the crystal, O-H⋯N hydrogen bonds lead to the formation of infinite chains along [101] which are further linked by N-H⋯O hydrogen bonds, forming (010) sheets. © 2015, International Union of Crystallography. All rights reserved.


Truong-Bolduc Q.C.,Harvard University | Bolduc G.R.,Massasoit Community College | Okumura R.,Harvard University | Okumura R.,Daiichi Sankyo | And 4 more authors.
Antimicrobial Agents and Chemotherapy | Year: 2011

Staphylococcus aureus is an important pathogen that adapts and survives in low-pH environments. One component of this adaptation involves the regulation of genes encoding bacterial transporters that could affect response to antibiotics under these conditions. We previously demonstrated that the transcriptional regulator MgrA in its phosphorylated form (MgrA-P) represses the expression of norB, encoding the NorB multidrug resistance efflux pump. In this study, we focused on changes in the expression of mgrA at the transcriptional and posttranslational levels, following a shift from pH 7.0 to pH 4.5. We then correlated those changes with modifications in transcript levels of norB and to resistance to moxifloxacin, a substrate of NorB. At pH 4.5, S. aureus MgrA increased 2-fold and MgrA-P decreased 4-fold, associated with an 8-fold increase in norB transcripts and a 6-fold reduction in bacterial killing by moxifloxacin, and the phenomenon was dependent on intact mgrA. Taken together, these new data showed that phosphoregulation of MgrA at low pH reverses its repression of norB expression, conferring resistance to moxifloxacin. Copyright © 2011, American Society for Microbiology. All Rights Reserved.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: ADVANCED TECH EDUCATION PROG | Award Amount: 199.94K | Year: 2012

This project is establishing a new biotechnology degree option and a new biotechnology certificate to respond to life science, allied health and biotechnology industry needs for more highly skilled, entry level laboratory technicians and is working closely with industry partners and industry associations to develop these programs. The new biotechnology degree option and biotechnology certificate are designed to incorporate relevant, real world applications of laboratory techniques that are required skills for biotechnicians. The courses being developed have sufficient rigor to also offer transfer credit to a four-year program.

Intellectual Merit: Early undergraduate research has been shown to improve retention and academic success in science, technology, engineering, and mathematics (STEM) disciplines and workforce competitiveness; however, the community college students this project targets are often at a disadvantage in gaining these experiences due to lack of institutional capacity or financial and time constraints common among students at community colleges. To overcome this gap, the college is infusing courses developed in support of this project, along with existing science and mathematics curriculum, with inquiry-based learning methodologies and research like laboratory exercises that promote success in biotechnology studies and other STEM disciplines. The college is also creating new opportunities for students to engage in workplace internships and on campus summer research that provide more intensive experiences and build practical skills. Professional development for faculty enhances teaching capacity to integrate inquiry based learning into science and mathematics curriculum. Acquisition of industry standard equipment provides the laboratory configuration necessary to deliver the biotechnology programs and develop industry required competencies in students. New courses developed in support of these programs and revitalized curricula throughout the Division of Science and Mathematics are grounded in research-like experiences that provide a means to engage students in learning in a way that helps them to be academically successful and teaches them the scientific inquiry skills needed for a truly comprehensive technical training.

Broader Impact: This undergraduate research program is a model for other community colleges that are similarly challenged to provide research driven education to biotechnology and STEM students. To ensure the broader impact of the project, the college has developed a thorough dissemination plan to inform stakeholders at the local, regional, and national level on outcomes related to this initiative. Regional and state distribution channels include membership in consortia of community colleges and state universities that have the established goals of sharing experiences and promoting best practices between institutions and among colleagues. As the recipient of a model program endorsement from the Massachusetts Governors STEM Advisory Council for its work in improving retention, graduation, and transfer rates among science majors, the college has the established credentials and support from appropriate authorities to ensure that findings from this project are both heard and heeded by institutions across the Commonwealth. On a national level, the plan is to promote the findings through accessible channels such as the annual NSF ATE conference and ATE Central, as well as seek opportunities to present findings through presentations and posters at academic conferences.


PubMed | University of Massachusetts Dartmouth and Massasoit Community College
Type: Journal Article | Journal: Acta crystallographica. Section E, Crystallographic communications | Year: 2016

The title compound, C8H10O3, has two planar mol-ecules in the asymmetric unit possessing mean deviations from planarity of 0.051 and 0.071. In the crystal, there are two distinct infinite chains, both along [010]. The chains are formed by O-HO inter-actions between the phenol and both the 3-meth-oxy and the 4-meth-oxy groups.


PubMed | University of Massachusetts Dartmouth and Massasoit Community College
Type: Journal Article | Journal: Acta crystallographica. Section E, Crystallographic communications | Year: 2016

The title compound, C10H15NO, has two mol-ecules in the asymmetric unit. Each mol-ecule has a near-planar C8NO unit excluding H atoms and the terminal methyl groups on the di-ethyl-amino groups, with mean deviations from planarity of 0.036 and 0.063. In the crystal, hydrogen bonding leads to four-membered O-HO-HO-H rings. No - inter-actions were observed in the structure.


PubMed | University of Kansas Medical Center, University of Montréal, University of Texas Southwestern Medical Center and Massasoit Community College
Type: Journal Article | Journal: Neurorehabilitation and neural repair | Year: 2016

Cortical stimulation (CS) combined with rehabilitative training (RT) has proven effective for enhancing poststroke functional recovery in rats, but human clinical trials have had mixed outcomes.To assess the efficacy of CS/RT versus RT in a nonhuman primate model of cortical ischemic stroke.Squirrel monkeys learned a pellet retrieval task, then received an infarct to the distal forelimb (DFL) representation of primary motor cortex. A subdural monopolar electrode was implanted over the spared DFL representation in dorsal premotor cortex (PMD). Seven weeks postinfarct, monkeys underwent 4 to 6 weeks of RT (n = 8) or CS/RT (n = 7; 100 Hz, cathodal current) therapy. Behavioral performance was assessed before and after infarct, prior to therapy, and 1 and 12 weeks posttherapy (follow-up). The primary outcome measure was motor performance at 1 week posttherapy. Secondary outcomes included follow-up performance at 12 weeks and treatment-related changes in neurophysiological maps of spared DFL representations.While postinfarct performance deficits were found in all monkeys, both groups demonstrated similar recovery profiles, with no difference in motor recovery between the RT and CS/RT groups. Posttherapy, PMD DFL area was significantly expanded in the RT group but not the CS/RT group. A significant relationship was found between motor recovery and DFL expansion in premotor cortex.Results suggest that the specific parameters utilized here were not optimal for promoting behavioral recovery in nonhuman primates. Though CS/RT has consistently shown efficacy in rat stroke models, the present finding has cautionary implications for translation of CS/RT therapy to clinical populations.

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