Cambridge, MA, United States

Massachusetts Institute of Technology
Cambridge, MA, United States

The Massachusetts Institute of Technology is a private research university in Cambridge, Massachusetts. Founded in 1861 in response to the increasing industrialization of the United States, MIT adopted a European polytechnic university model and stressed laboratory instruction in applied science and engineering. Researchers worked on computers, radar, and inertial guidance during World War II and the Cold War. Post-war defense research contributed to the rapid expansion of the faculty and campus under James Killian. The current 168-acre campus opened in 1916 and extends over 1 mile along the northern bank of the Charles River basin.MIT, with five schools and one college which contain a total of 32 departments, is traditionally known for research and education in the physical science and engineering, and more recently in biology, economics, linguistics, and management as well. The "Engineers" sponsor 31 sports, most teams of which compete in the NCAA Division III's New England Women's and Men's Athletic Conference; the Division I rowing programs compete as part of the EARC and EAWRC.MIT is often cited as among the world's top universities. As of 2014, 81 Nobel laureates, 52 National Medal of Science recipients, 45 Rhodes Scholars, 38 MacArthur Fellows, and 2 Fields Medalists have been affiliated with MIT. MIT has a strong entrepreneurial culture and the aggregated revenues of companies founded by MIT alumni would rank as the eleventh-largest economy in the world. Wikipedia.

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Massachusetts Institute of Technology | Date: 2017-03-01

Embodiments related to cation-disordered lithium metal oxide compounds, their methods of manufacture, and use are described. In one embodiment, a cation-disordered lithium metal oxide includes LiMMO_(2) with a greater than 1. M includes at least one redox-active species with a first oxidation state n and an oxidation state n greater than n, and M is chosen such that a lithium-M oxide having a formula LiMO_(2) forms a cation-disordered rocksalt structure. M includes at least one charge-compensating species that has an oxidation state y that is greater than n.

The Broad Institute Inc., Massachusetts Institute of Technology and Harvard University | Date: 2017-03-22

The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR-Cas system.

The General Hospital Corporation and Massachusetts Institute of Technology | Date: 2017-01-24

The present embodiments relate to compositions and methods for treating the inflammatory response in a tissue or organ, such as the liver, by contacting the tissue with a tissue-specific gap junction inhibitor; and compositions and methods of reducing the toxicity of an agent by administering a gap junction inhibitor either simultaneously or sequentially with exposure to the agent. For example, inhibition of the liver-specific gap junction connexin 32 by 2-aminoethyoxydiphenyl-borate, effectively treats and/or prevents hepatotoxicity.

Massachusetts Institute of Technology | Date: 2017-01-18

A light emitting device includes a semiconductor nanocrystal and a charge transporting layer that includes an inorganic material. The charge transporting layer can be a hole or electron transporting layer. The inorganic material can be an inorganic semiconductor.

Massachusetts Institute of Technology and Boston College | Date: 2017-01-05

The present invention relates generally to catalysts and processes for the Z-selective formation of internal olefin(s) from terminal olefin(s) via homo-metathesis reactions.

Massachusetts Institute of Technology, Brigham and Women's Hospital | Date: 2017-04-19

Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

Disclosed herein is a portable gas stove equipped with a dual-layered cover (110). The portable gas stove includes a gas can reception unit (100) configured to include the dual-layered cover (110) having a top surface portion formed of a dual layer (111) in such a way as to be open or closed and to have a gas can attached to or detached from the gas can reception unit (100) and a burner unit (200) configured to be ignited by fuel supplied by the gas can mounted on the gas can reception unit (100). One side of the dual layer (111) which comes into contact with the burner unit (200) is sealed, and one or more first through holes (115) are formed on the other side of the dual layer (111) so that heat within the dual layer (111) is discharged to the first through holes (115). Accordingly, the upper side of a gas can can be prevented from being overheated by heat from an excessive hot grill when the excessive hot grill is used in the portable gas stove.

Ebert M.S.,Massachusetts Institute of Technology
Cell | Year: 2012

Biological systems use a variety of mechanisms to maintain their functions in the face of environmental and genetic perturbations. Increasing evidence suggests that, among their roles as posttranscriptional repressors of gene expression, microRNAs (miRNAs) help to confer robustness to biological processes by reinforcing transcriptional programs and attenuating aberrant transcripts, and they may in some network contexts help suppress random fluctuations in transcript copy number. These activities have important consequences for normal development and physiology, disease, and evolution. Here, we will discuss examples and principles of miRNAs that contribute to robustness in animal systems. Copyright © 2012 Elsevier Inc. All rights reserved.

Guarente L.,Massachusetts Institute of Technology
Genes and Development | Year: 2013

Calorie or dietary restriction (CR) has attracted attention because it is the oldest and most robust way to extend rodent life span. The idea that the nutrient sensors, termed sirtuins, might mediate effects of CR was proposed 13 years ago and has been challenged in the intervening years. This review addresses these challenges and draws from a great body of new data in the sirtuin field that shows a systematic redirection of mammalian physiology in response to diet by sirtuins. The prospects for drugs that can deliver at least a subset of the benefits of CR seems very real. © 2013 Guarente.

Nocera D.G.,Massachusetts Institute of Technology
Accounts of Chemical Research | Year: 2012

To convert the energy of sunlight into chemical energy, the leaf splits water via the photosynthetic process to produce molecular oxygen and hydrogen, which is in a form of separated protons and electrons. The primary steps of natural photosynthesis involve the absorption of sunlight and its conversion into spatially separated electron-hole pairs. The holes of this wireless current are captured by the oxygen evolving complex (OEC) of photosystem II (PSII) to oxidize water to oxygen. The electrons and protons produced as a byproduct of the OEC reaction are captured by ferrodoxin of photosystem I. With the aid of ferrodoxin-NADP + reductase, they are used to produce hydrogen in the form of NADPH. For a synthetic material to realize the solar energy conversion function of the leaf, the light-absorbing material must capture a solar photon to generate a wireless current that is harnessed by catalysts, which drive the four electron/hole fuel-forming water-splitting reaction under benign conditions and under 1 sun (100 mW/cm 2) illumination.This Account describes the construction of an artificial leaf comprising earth-abundant elements by interfacing a triple junction, amorphous silicon photovoltaic with hydrogen- and oxygen-evolving catalysts made from a ternary alloy (NiMoZn) and a cobalt-phosphate cluster (Co-OEC), respectively. The latter captures the structural and functional attributes of the PSII-OEC. Similar to the PSII-OEC, the Co-OEC self-assembles upon oxidation of an earth-abundant metal ion from 2+ to 3+, may operate in natural water at room temperature, and is self-healing. The Co-OEC also activates H 2O by a proton-coupled electron transfer mechanism in which the Co-OEC is increased by four hole equivalents akin to the S-state pumping of the Kok cycle of PSII. X-ray absorption spectroscopy studies have established that the Co-OEC is a structural relative of Mn 3CaO 4-Mn cubane of the PSII-OEC, where Co replaces Mn and the cubane is extended in a corner-sharing, head-to-tail dimer.The ability to perform the oxygen-evolving reaction in water at neutral or near-neutral conditions has several consequences for the construction of the artificial leaf. The NiMoZn alloy may be used in place of Pt to generate hydrogen. To stabilize silicon in water, its surface is coated with a conducting metal oxide onto which the Co-OEC may be deposited. The net result is that immersing a triple-junction Si wafer coated with NiMoZn and Co-OEC in water and holding it up to sunlight can effect direct solar energy conversion via water splitting. By constructing a simple, stand-alone device composed of earth-abundant materials, the artificial leaf provides a means for an inexpensive and highly distributed solar-to-fuels system that employs low-cost systems engineering and manufacturing. Through this type of system, solar energy can become a viable energy supply to those in the non-legacy world. © 2012 American Chemical Society.

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