Time filter

Source Type

Mashhad, Iran

Mashhad University of Medical science is a medical school in Iran. Located in Razavi Khorasan province in the city of Mashhad, it was established in 1949 with Ferdowsi University of Mashad and separated in 1986 from its parent institution by national legislation.The university is currently ranked as one of the best in the Middle East. In 2001, its department of Medicine was ranked first among the Iranian universities. The latest rankings put Mashhad University in 3rd place nationally.MUMS has 8 faculties, operates 32 hospitals plus 179 rural and 147 urban health care centers. Its faculty include 600 teaching staff, 1700 physicians, 140 dentists, 130 pharmacists, and 25,402 staff employees. In 2001, 7,000 students were enrolled full-time. Wikipedia.

Genetic factors can substantially contribute to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). A missense Pro12Ala substitution in the PPARγ2 gene (rs1801282) has been studied in relation with NAFLD risk in different ethnic groups, but findings have been inconclusive. The aim of this was to evaluate the association between rs1801282 and NAFLD through meta-analysis of all relevant published evidence. A systematic search to find eligible studies was performed in Medline, HuGE Navigator, and SCOPUS databases. The strength of association was evaluated using odds ratios with 95% confidence intervals obtained from a random effect approach and under additive, dominant, co-dominant, recessive, and allelic contrast models. Seven studies comprising 1474 cases and 2259 controls met the eligibility criteria and included in the meta-analysis. Combined results did not indicate any predisposing or protective effect for rs1801282 under any of the assessed modes of inheritance. The rate of heterogeneity was generally high due to the inter-study variations in terms of age, gender, and ethnicity. Evidence from the current meta-analysis indicated that rs1801282 variants are not associated with NAFLD risk. Future large-scale studies are required to substantiate the present findings. © Copyright 2013, Mary Ann Liebert, Inc. 2013. Source

Azarpazhooh M.R.,Mashhad University of Medical Sciences
AIDS research and human retroviruses

Human T-lymphotropic virus type 1 (HTLV-I) is an important global health problem in the world mainly in the endemic areas of HTLV-I infection. It was previously reported that Mashhad, in northeastern Iran, is a new endemic region of HTLV-I. The aim of this study was to examine the prevalence and phylogenetic analysis of HTLV-I in Sabzevar, located in the southeast of Mashhad. In this cross-sectional study 1445 individuals were selected by multistage cluster sampling. Serum samples were screened for anti-HTLV-I antibody using enzyme-linked immunosorbent assay (ELISA); all of the ELISA-positive samples were confirmed by polymerase chain reaction (PCR). Long terminal repeat (LTR) sequencing was carried out to determine the type of HTLV-I in Sabzevar. In the primary screening by ELISA, 26/1445 (1.8%) of those sampled were reactive for HTLV-I antibody. Twenty-four out of 26 samples were confirmed HTLV-I infection by PCR (24/1445). The overall prevalence of HTLV-I infection in Sabzevar is 1.66%. The prevalence of the virus infection in men and women was 2.42% (11/455) and 1.31% (13/989), respectively. Seroprevalence was associated with age, increasing significantly among those older than 30 years (p=0.015), and a history of surgery (p=0.002), imprisonment (p=0.018), and hospitalization (p=0.005). Three out of 24 positive HTLV-I samples were selected for sequencing and phylogenetic analysis of LTR. The results showed that HTLV-I in Sabzevar belonged to the cosmopolitan subtype. The present study showed Sabzevar is a new endemic area for HTLV-I infection. Our study emphasizes that systemic HTLV-I screening of blood donors in Sabzevar and other cities in Khorasan province is important and should be taken into account. Source

A systematic review and meta-analysis of available evidence was conducted to obtain a conclusive result on the lipid-modulating effects of resveratrol. Seven randomized controlled trials with a total of 282 subjects (141 in each group) met the eligibility criteria. Overall, resveratrol supplementation had no significant effect on any of the lipid parameters assessed: total cholesterol (weighted mean difference [WMD] -8.70; 95% confidence interval [95% CI] -21.54-4.14; P=0.18), low-density lipoprotein cholesterol (WMD -3.22; 95% CI -12.56-6.12); P=0.50), high-density lipoprotein cholesterol (WMD -0.26; 95% CI -4.25-3.73; P=0.90), and triglycerides (WMD -4.30; 95% CI -20.22-11.63; P=0.60). These results were robust in sensitivity analysis and were not dependent on the resveratrol dose, the duration of supplementation, or the cardiovascular risk status of the population studied. While future large-scale, well-designed trials are warranted, the current evidence suggests that mechanisms other than hypolipidemic effects account for the established cardioprotective properties of resveratrol. © 2013 International Life Sciences Institute. Source

Ghorbani A.,Mashhad University of Medical Sciences
Clinical Lipidology

Diabetes is often associated with dyslipidemia, a main risk factor for cardiovascular diseases. According to the traditional recommendations and experimental studies, numerous phytochemicals have been suggested for dyslipidemia. In most cases, however, limited evidence exists regarding their clinical usefulness. This review focuses on phytochemicals that have been investigated in clinical trials, particularly their hypolipidemic actions in diabetic patients. Proposed mechanisms for the hypolipidemic effects of such phytochemicals and their potential side effects are discussed. According to the evidence currently available, Allium sativum, Cyamopsis tetragonolobus, Psyllium, Silybum marianum and Trigonella foenum-graecum have acquired enough reputation for treatment of diabetic dyslipidemia. These herbs have demonstrated hypolipidemic and in some cases hypoglycemic activity in diabetic patients. Therefore, their consumption may improve the management of dyslipidemia and reduce cardiovascular risk in diabetic patients. © 2013 Future Medicine Ltd. Source

Malaekeh-Nikouei B.,Mashhad University of Medical Sciences
Current drug delivery

In the present work a series of imprinted (MIPs) and non-imprinted (NIPs) hydrogels were prepared using 2-hydroxyethyl methacrylate (HEMA) as a backbone monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linker monomer, methacrylic acid (MAA) as a functional monomer and dorzolamide (DZD) as the template molecule. Different concentrations of MAA (0, 100, 200, 400 mM) were used for preparation of NIPs. Two DZD: MAA molar ratios (1:8 and 1:4) and 400 mM MAA were also applied in imprinting process. The hydrogels (0.4 mm thickness) were synthesized by thermal polymerization at 50°C in 24h in a polypropylene mould. Then, the swelling and binding properties of hydrogels were evaluated in water. Their loading and releasing properties were also studied in NaCl 0.9% and artificial lachrymal fluid. The results showed that using MAA as co-monomer and applying molecular imprinting technique increased loading capacity of hydrogels. The optimized imprinted hydrogel (MIP1:4), prepared with 400 mM MAA and DZD: MAA molar ratio of 1:4, had the highest affinity for DZD and the greatest ability to control the release process in aqueous media. Our data indicated that the use of suitable co-monomer and applying a molecular imprinting technique had important influence on loading and releasing properties of hydrogels. Source

Discover hidden collaborations