Mashhad Medical University

Mashhad, Iran

Mashhad Medical University

Mashhad, Iran
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Saedi R.,Health Chancellery Mashhad Medical University | Ahmadian M.,Mashhad Medical University | Ghalibaf M.B.,Hakim Sabzevari University | Hashemian M.,Health Chancellery Mashhad Medical University
Iranian Journal of Neonatology | Year: 2013

Introduction weight in delivery is simplest and current health indication for assessment infant statues in each country. Purpose of this study is assessment correlation to unplan pregnancy and low birth weight in new infants also some key factors influencing on low birth weight. Materials and Methods in this study 838 pregnant mothers in two group wanted and unwanted performed. This study is descriptive and analytically based on cohort study. Sample size was all mothers who refer to nine health clinics in mashhad province in 2012. Questionnaire completed based on interview to mothers and observe health records. For analyzing data used chisquare and T-student tests. Results finding showed that in wanted group ( n=602) and unwanted (n=236) , 10.3 % of infants are LWB, in wanted group 11% and unwanted group 8.5% reported however there was no significant relation between two groups. There was a significant relationship between two groups in number of pregnancy and time of first reference to health clinic and duration between recent and previous visit (p=0.05). T-STUDENT test showed that thre is a signigicant relationship between the mean of mothers age and number of pregnancy in two groups(p=0.05) also chi square test showed that some factors like lodging of mother, mothers job, mothers education and her husband education had significant difference between two groups of wanted and unwanted pregnancy . Some factors like unwanted pregnancy and hypertension, diabetes, smoking, separately had studied but the result showed that only drug abuse had a significant effect on LBW , however in mothers with drug abuse 40% and mothers without drugabuse 9.7% cause to LWB. Conclusion considering the importance of birth weight in health of infants and advers of unplanned pregnancy on it specialy in cases with high risk behaviours, pre-pregnancy caring and increase knowledge of mothersabout the importance of this cares are necessary.


Taghavi S.M.,Mashhad Medical University | Fatemi S.S.,Mashhad Medical University | Rokni H.,Mashhad Medical University
Medical Journal of Malaysia | Year: 2012

Ergot-derived dopamine D2 receptor agonists are the usual treatment of hyperprolactinemia and Parkinson's disease and recently bromocriptine has been approved for the treatment of type 2 diabetes. The aim of this study was the evaluation of short-term effect of cabergoline in poorly controlled diabetic patients with oral agent failure who refused insulin therapy. Methods: This study was performed in 17 overweight women and men with type 2 diabetes with persistent hyperglycemia in spite of treatment with maximum dose of sulfonylurea, metformin and pioglitazone. 10 patients (group I) randomized to be treated with cabergoline 0.5 mg weekly for 3 months and 7 patients (group II) with placebo. Fasting and postprandial plasma glucose concentration and HbA1c measured in beginning and end of the study. Results: FBS decreased from 210.70± 21.29 to 144.90± 26.56 mg/dl in cabergoline group whereas it decreased in placebo group insignificantly. Postprandial blood glucose decreased from 264.2±28 mg/dl to 203.6±34.34 mg/dl in cabergoline group whereas it increased in placebo group insignificantly.HbA1c decreased in cabergoline group from 8.48±0.44 to 7.7±0.11 whereas in control group it increased insignificantly from 8.7±0.33 to 8.8±0.16. Conclusion: Cabergoline improves glycemic control in type 2 diabetic patients with oral agent failure. It reduces both fasting and postprandial plasma glucose levels and causes 0.45-1.11 reduction in HbA1c.


Bakhtiyari S.,Ilam University | Haghani K.,Tarbiat Modares University | Farhadi E.,Iranian Blood Transfusion Organization IBTO | Soukhtanloo M.,Mashhad Medical University | And 2 more authors.
Hybridoma | Year: 2010

Mycobacterium contains several immunologically active substances, which play a principal role in mycobacterial diseases. The majority of the highly antigenic proteins present in mycobacterial homogenates are components of the A60 complex. In this study, A60 antigen was prepared from cytoplasm of Mycobacterium bovis Bacillus Calmette-Guerin (BCG). Cytoplasm was fractionated by passage through the column of sepharose 6B and ConA-sepharose 4B. After purification of spleen cells of the immunized mice, the cells were fused with SP2/0 myeloma cells. Four clone cell lines producing antibody against A60 antigens were established and each clone was tested for immunoreactivity against purified A60 by ELISA and immunoblotting. The clone designated DEB7 reacted strongly with A60. Immunoblotting using MAb DEB7 showed that this MAb binds to a single protein of A60 subunit with a molecular weight of 65kDa. This subunit of A60 M. bovis recognized by DEB7 MAb could be used to increase the sensitivity and specificity of immunoassay or other potential roles in mycobacterium infection. © Copyright 2010, Mary Ann Liebert, Inc..


Morteza Taghavi S.,Mashhad Medical University | Rokni H.,Mashhad Medical University | Fatemi S.,Mashhad Medical University
Diabetes and Vascular Disease Research | Year: 2011

Objective: To assess the effect of metformin administration on thyroid function in overweight women with polycystic ovarian syndrome (PCOS). Methods: Twenty-seven overweight women with PCOS and hypothyroidism were selected. Fifteen patients (group I) were treated with metformin 1500 mg/day for 6 months and 12 patients (group II) with placebo. Serum thyrotropin (TSH), free T3 and free T4 were measured at baseline and 6 months after the beginning of the study. Results: A significant decrease (p<0.001) in TSH levels was observed in group I but not in group II subjects after 6 months of metformin treatment. No significant change in free T3 and free T4 was observed throughout the study in any group. Conclusion: In obese PCOS patients with primary hypothyroidism, metformin results in a significant fall and sometimes normalisation of TSH, without causing any reciprocal changes in other thyroid function parameters. © The Author(s) 2011.


Vahabi S.,Shahid Beheshti University | Amirizadeh N.,Iranian Blood Transfusion Organization | Shokrgozar M.A.,Pasteur Institute of Iran | Mofeed R.,Shahid Beheshti University | And 4 more authors.
Chang Gung Medical Journal | Year: 2012

Background: Recently, tissue engineering has been introduced as a regenerative treatment for bone defects. There is some evidence showing bone regeneration from mesenchymal stem cells (MSC) loaded on hydroxyapatite β-tricalcium phosphate (HA/TCP) as a scaffold in large defects. This study aimed to compare the quality and quantity of regenerated bone using Bio-Oss, HA/TCP and MSC loaded HA/TCP scaffolds. Methods: Mesenchymal stem cells were aspirated from iliac crest bone marrow after extracting the first, second and third premolars and the first molar in five mature hybrid dogs. The cells were cultured and their osteogenic differentiation potential was evaluated after the third cell passage using Alizarin red staining in experimental conditions. The HA/TCP scaffold (3 x 3 x 3 mm) was loaded with undifferentiated mesenchymal stem cells. Bilateral bone defects were then prepared in the jaws using trephine burs. The defects were randomly filled with HA/TCP, Bio-Oss, or HA/TCP + MSCs. One defect served as a control and was left as an empty cavity. All defects except the control defect were covered with an absorbable membrane. Histological and histomorphometric evaluations were conducted after 6 weeks and data were subjected to analysis of variance (ANOVA) (p < 0.05). Results: The empty cavity demonstrated more bone formation (60.80%) than the HA/TCP (44.93%) and Bio-Oss (40.60%) (p < 0.05) groups. However, the difference from the HA/TCP + MSCs group was not significant (46.38%) (p > 0.05). Conclusion: An MSC-loaded HA/TCP scaffold is a more effective alternative than Bio- OSS or HA/TCP in inducing bone regeneration.


Saedi R.,Mashhad University of Medicine | Rahmani S.,Mashhad Medical University
Iranian Journal of Neonatology | Year: 2013

This case is a bout a neonate with respiratory distress and primary diagnosis of Pneumothorax who had Congenital Lobar Emphysema. This case was the basis to review the topic of Congenital Lobar Emphysema (CLE) and the corresponding literature, considering that this is an uncommon disease and although congenital lobar emphysema is rare, clinical awareness of this condition is important for early diagnosis and effective surgical treatment. Due to the severity of respiratory symptoms, congenital lobar emphysema often requires surgical treatment in the early stages of life.


Ahmadi Hosseini S.M.,Mashhad University of Medical Sciences | Ahmadi Hosseini S.M.,Mashhad Medical University | Abolbashari F.,Mashhad University of Medical Sciences | Abolbashari F.,Mashhad Medical University | And 4 more authors.
Contact Lens and Anterior Eye | Year: 2014

Aim: To determine the efficacy of corneal thickness parameters and corneal biomechanical properties (CBPs) in discriminating between normal and keratoconus eyes. Method: After performing a comprehensive ophthalmic examination, 50 mild to moderate keratoconus and 50 age and sex matched myopic astigmatism eyes were prospectively included in the study. The corneal topographic maps and CBP were obtained by Pentacam and Ocular response analyser, respectively. Central corneal thickness (CCT), thinnest corneal thickness (TCT), corneal thickness (CT) and percentage thickness increase (PTI) at 1, 3 and 5. mm from the thinnest point and corneal volume (CV) at 3, 5, 7 and 10 centred on thinnest point, corneal hysteresis (CH) and corneal resistance factor (CRF) were recorded. Independent t-test and receiver operating characteristic (ROC) were done with SPSS software (version 15.0, SPSS, Inc.). Results: CCT, TCT, CT at 1, 3 and 5, CV at 3, 5, 7 and 10. mm, CH and CRF were significantly lower in keratoconus eyes compared to controls (p<. 0.001). In addition, PTI at 1, 3 and 5. mm from the thinnest point showed significantly higher values in keratoconus group. ROC analysis demonstrated good predictive accuracy for cut-off point values. However, the centrally located indices had higher predictive accuracy compared to the peripherally located indices. Conclusion: Although good sensitivity and specificity were found for the mentioned parameters, the centrally located indices had higher predictive accuracy compared to peripherally located indices. It is suggested to use a combination of corneal pachymetry together with CBP for more accurate detection of keratoconus. © 2013 British Contact Lens Association.


Hiradfar M.,Mashhad Medical University | Zabolinejad N.,Mashhad Medical University | Shojaeian R.,Mashhad Medical University | Saeedi P.,Mashhad Medical University | And 5 more authors.
Pediatric Surgery International | Year: 2012

Clear cell sarcoma of the kidney (CCSK) is an uncommon neoplasm that accounts for almost 3 % of pediatric renal tumors. Cavoatrial tumor thrombosis is very rare and because of poor response to chemotherapy, invasive surgical interventions such as open heart surgery may be indicated. A 6-year-old girl with CCSK of right kidney was treated with neoadjuvant chemotherapy. According to poor chemosensitivity, surgical intervention was planned. Right atriotomy was done, but intra-atrial part of tumor was very firm and unsuctionable; so the procedure was completed by laparotomy and en bloc resection of tumoral kidney and its cavoatrial extension through a limited venotomy on inferior vena cava. Although radical resection of CCSK with intracaval involvement should be considered as a multidisciplinary approach and intensive care and supports should be provided, atriocaval tumor in growth in CCSK is firm, non friable and non-adherent, and tumor en bloc resection may be possible through a limited venotomy via primary abdominal approach. © Springer-Verlag 2012.


PubMed | Mashhad Medical University
Type: Journal Article | Journal: Diabetes & vascular disease research | Year: 2011

To assess the effect of metformin administration on thyroid function in overweight women with polycystic ovarian syndrome (PCOS).Twenty-seven overweight women with PCOS and hypothyroidism were selected. Fifteen patients (group I) were treated with metformin 1500 mg/day for 6 months and 12 patients (group II) with placebo. Serum thyrotropin (TSH), free T3 and free T4 were measured at baseline and 6 months after the beginning of the study.A significant decrease (p<0.001) in TSH levels was observed in group I but not in group II subjects after 6 months of metformin treatment. No significant change in free T3 and free T4 was observed throughout the study in any group.In obese PCOS patients with primary hypothyroidism, metformin results in a significant fall and sometimes normalisation of TSH, without causing any reciprocal changes in other thyroid function parameters.


PubMed | Mashhad Medical University
Type: Journal Article | Journal: Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences | Year: 2011

Despite well-described histopathologic criteria, the distinction of spontaneous abortion from hydatidiform mole and complete hydatidiform mole from partial hydatidiform mole remains a problem because of interobserver and intraobserver variability. The aim of this study was to evaluate the value of two immunohistochemical markers in the differential diagnosis of subgroups of lesions of villous trophoblasts and spontaneous abortions.Immunohistochemistry with the P63 and Ki-67 antibody was performed in formalin-fixed paraffinembedded samples of non hydropic abortion (n = 14), partial hydatidiform mole (n = 12), complete hydatidiform mole (n = 12) and choriocarcinoma (n = 12). The Ki-67 and P63 labeling index (number of positive nuclei/total number of nuclei) for villous stromal cells, cytotrophoblasts and syncytiotrophoblasts were evaluated separately by counting 100 cells of each population. Statistical analysis was carried out by (2) analysis, and the Mann-Whitney U test. Statistical significance was determined at p < 0.05 on the basis of 2-tailed tests.None of nonhydropic spontaneous abortions analyzed exhibited positive cytotrotrophoblastic and syncytiotrophoblastic cells for P63. The syncytiotrophoblastic cells were negative for p63 in all of choriocarcinomas. All of choriocarcinomas analyzed exhibited severe expression of Ki-67 in cytotrotrophoblastic cells. None of abortions and partial moles was diffusely labeled with Ki-67.Ki-67 labeling index in cytotrophoblastic cells is the best index to differentiate between abortion and subgroups of lesions of villous trophoblasts as well as between different subgroups of lesions of villous trophoblasts. Ki-67 is a better marker than P63 to attain this goal.

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