Davood A.,Islamic Azad University at Tehran |
Iman M.,Mashad University of Medical science
Medicinal Chemistry Research | Year: 2011
β-Phenylethylidenehydrazine (PEH) derivatives have been recognized as Gamma-aminobutyric acid aminotransferase (GABA-AT) inhibitors. In this research a group of newly synthesized of PEH analogs, possessing a variety of substituents (Me, OMe, Cl, and CF3) at the 2-, 3-, and 4-position of the phenyl ring, were subjected to docking study and quantitative structure activity relationship (QSAR) analysis. PEH analogs were built by HYPERCHEM program, and conformational studies were performed through semi-empirical method followed by PM3 method. QSAR descriptors were obtained from the EDRAGON and HYPERCHEM, and equations were derived from multilinear regression (MLR) method. The sums of the JGI2, H6m, and E2s were identified as the most significant descriptors. This simple equation can be used to estimate the GABA-AT inhibitory activity for new derivatives of this series of compounds. Docking study was performed by using AutoDock4 program on the all compounds. The obtained results show that the phenyl ring is inserted into the lipophilic pocket and that the NHNH2moiety is situated in a mainly polar region of the enzyme. These computational studies can offer some useful references for understanding the action mechanism and performing the molecular design or modification of this series of GABA-AT inhibitors. © Springer Science+Business Media, LLC 2010.
Bakhshaee M.,Mashhad University of Medical Sciences |
Naderi H.R.,Imam Reza University |
Ghazvini K.,Mashad University of Medical science |
Sotoudeh K.,Tehran University of Medical Sciences |
And 2 more authors.
European Archives of Oto-Rhino-Laryngology | Year: 2012
Exposure to tobacco smoke may be associated with higher risk of nasopharyngeal colonization and infection by Streptococcus pneumoniae (SP), Haemophilus influenzae (HI), and Moraxella catarrhalis (MC). This study was done to determine the influence of passive smoking on S. pneumoniae, H. influenzae, and M. catarrhalis colonization rates among children. This is a prospective cross-sectional study. Tertiary referral centers with accredited otorhinolaryngology-head and neck surgery and Microbiology Departments. In this cross-sectional study, 2-6 years old children in 10 randomly selected daycare centers in northeast of Iran (Mashad) were studied. Smoking exposure and medical history were recorded. Carriage rates for aforementioned bacteria were analyzed on the basis of smoking exposure. 1,125 children (Female/ Male: 597/528) with the mean age of 5.05 ± 0.98 years were studied. Carriage rates of S. pneumoniae, H. influenzae and M. catarrhalis among children were 10.1, 8.8 and 6.7%, respectively. Mixed colonization was found in 2.7%. There was a significant difference in carriage rates between children who live in smoking families compare to those with nonsmoking families for M. catarrhalis (P = 0.001) but not for S. pneumoniae, and H. influenza (P = 0.798 and P = 0.117, respectively). It seems exposure to tobacco smoke is associated with increased carriage rate of M. catarrhalis in day-care children. © 2011 Springer-Verlag.
Davood A.,Islamic Azad University at Tehran |
Iman M.,Mashad University of Medical science |
Nematollahi A.,Islamic Azad University at Tehran |
Shafiee A.,Tehran University of Medical Sciences
Medicinal Chemistry Research | Year: 2012
1,4-Dihydropyridine (1,4-DHP) derivatives have been recognized as calcium channel blocker (CCB) agent. In this research, a newly synthesized dihydropyridine, containing 4-[4(5)-chloro-2-methyl-5(4)-imidazolyl] moiety, as subjected to docking study and QSAR analysis. DHPs were built by HYPERCHEM program, and conformational studies were performed through semi-empirical method followed by PM3 method. QSAR descriptors were obtained from the EDRAGON and HYPERCHEM. QSAR equations were derived from multilinear regression method. This simple equation can be used to estimate the CCB's activity for new derivatives of this series of compounds. The sums of the HATS2v, Mor09p, Mor06p, and CIC5 were identified as the most significant descriptors. Docking study was performed using AutoDock4 program on all of the compounds. The results show that experimental pIC50 values agree with docking results for potent compounds. These computational studies can offer useful references for understanding the action mechanism and molecular design or modification of this series of the CCB agents. © Springer Science+Business Media, LLC 2010.
Ellen Sy M.,University of California at Los Angeles |
Ramirez-Miranda A.,Institute Oftalmologia |
Zarei-Ghanavati S.,Mashad University of Medical science |
Engle J.,Aurora University |
And 2 more authors.
Journal of Refractive Surgery | Year: 2013
PURPOSE: To compare the maximum posterior elevation (MPE) measurements before and after LASIK using a dual rotating Scheimpflug (DRS) imaging system (Galilei, Ziemer Ophthalmic Systems, Port, Switzerland) and a scanning slit-beam (SSB) imaging system (Orbscan IIz, Bausch & Lomb, Rochester, NY). METHODS: This retrospective study included 78 eyes from 78 patients who underwent myopic LASIK. Preoperative and postoperative data collected included anterior and posterior best-fit sphere radius and axial curvature readings, posterior central elevation (PCE), and MPE relative to a best-fit sphere using a 7.8-mm region of interest. Data were compared using paired t test analysis. RESULTS: Mean preoperative PCE (5.06 ± 2.29 μm with the DRS system and 12.78 ± 6.90 μm with the SSB system) and MPE (4.87 ± 4 μm with the DRS system and 15.44 ± 9.78 μm with the SSB system) were statistically different (P < .001). Mean postoperative PCE (4.55 ± 2.34 μm with the DRS system and 20.59 ± 8.11 μm with the SSB system) and MPE (4.90 ± 3.35 μm with the DRS system and 24.95 ± 10.15 μm with the SSB system) were statistically different (P < .001). The difference between preoperative and postoperative MPE measurements by DRS was not statistically significant (P = .953), whereas the difference measured by SSB was statistically significant (P < .001). CONCLUSIONS: The consistency of DRS measurements suggests that the posterior surface of the cornea does not change appreciably after keratorefractive surgery and is imaged more accurately using DRS compared with SSB. The DRS system affords confidence in interpreting data that are useful for discerning morphologic abnormalities of the cornea, both before and after keratorefractive surgery. Copyright © SLACK Incorporated.
Sedaghat M.,Mashad University of Medical Science |
Naderi M.,Baqiyatallah Medical Sciences University |
Zarei-Ghanavati M.,Mashad University of Medical Science
Journal of Cataract and Refractive Surgery | Year: 2010
Purpose: To compare 2 corneal biomechanical parameters - corneal hysteresis (CH) and corneal resistance factor (CRF) - before and after collagen crosslinking (CXL) for keratoconus. Setting: Eye Research Center of Mashhad University of Medical Sciences, Khatam-al-Anbia Eye Hospital, Mashhad, and Department of Ophthalmology, Baqiyatallah University of Medical Science, Tehran, Iran. Design: Case series study. Methods: Topical riboflavin was applied to the deepithelialized cornea every 3 minutes for 30 minutes and every 5 minutes during ultraviolet-A irradiation of the cornea. Corneal hysteresis and CRF were measured by biomechanical waveform analysis (Ocular Response Analyzer) before and 6 months after CXL. The values were compared using the paired Student t test. Results: The study comprised 51 patients (56 eyes). The mean age of the patients was 23.27 years ± 6.3 (SD). Before CXL, the mean CH was 7.9 ± 1.5 mm Hg and the mean CRF was 7.3 ± 1.4 mm Hg. Six months after CXL, the mean values were 8.20 ± 1.5 mm Hg and 7.59 ± 1.5 mm Hg, respectively. The changes in CH and CRF were not statistically significant (P>.05). The changes in central corneal thickness and Goldmann-correlated intraocular pressure (IOP) between preoperatively and postoperatively were not statistically significant, although the change in corneal-compensated IOP was (P<.05). Conclusion: Although previous in vitro studies found a change in corneal rigidity, this study found no significant change in CH or CHF measured by biomechanical waveform analysis. © 2010 ASCRS and ESCRS.
Zarei-Ghanavati S.,Eye Research Center |
Zarei-Ghanavati M.,Eye Research Center |
Sheibani S.,Mashad University of Medical science
Cornea | Year: 2010
Purpose: To describe a case of traumatic wound dehiscence after deep anterior lamellar keratoplasty. Method: Observational case report. Case report:: A 31-year-old man who had undergone deep anterior lamellar keratoplasty using big-bubble technique for keratoconus 3 months earlier presented to emergency room after blunt trauma. On examination, visual acuity was counting fingers at 2 m. The corneal graft wound dehisced from 12 to 3 o'clock (90 degrees) with localized suture ruptures, but the anterior chamber was deep and the Seidel test was negative. Surprisingly, there was intact Descemet membrane prolapsed through the corneal wound gap. Conclusions: This case indicates that intact Descemet membrane remaining after big-bubble technique might reduce the severity of ocular injury after traumatic wound dehiscence. © 2010 by Lippincott Williams & Wilkins.
Naseri M.,Dr Sheikh Children Hospital |
Naseri M.,Mashad University of Medical science |
Hiradfar M.,Dr Sheikh Children Hospital
Indian Pediatrics | Year: 2012
Reduced nocturnal bladder capacity has been suggested in the pathogenesis of nocturnal enuresis. This study was conducted to define frequency of bladder dysfunction in enuretic children and determine parameters which might predict bladder dysfunction. 60 children were enrolled. Full urodynamic study (UDS) was done in case of abnormal uroflowmetry, abnormal bladder ultrasound, daytime incontinence and age 10 years. Of 60 patients ultrasound 48 underwent complete UDS. In 11, results of UDS were unreliable. The results were normal in 10 (20.8%) and 27 (56.2%) had abnormal UDS .The study revealed that abnormal UDS is common in enuretic children and overactive bladder is the most common findings. No clinical feature were found, which could identify children requiring UDS.
Heravi F.,Mashad University of Medical science
Oral health & preventive dentistry | Year: 2011
The aim of this study was to assess the relationship between untreated malocclusions and oral health-related quality of life (OHRQOL) in male adolescents of Mashad (Iran) high schools. In this observational cross-sectional descriptive study, 120 male students were randomly selected among Mashad (Iran) high schools. These students filled out an oral health-related quality of life questionnaire (the modified version of CPQ), and then they were clinically examined to determine their malocclusions according to the Index of Complexity, Outcome and Need (ICON), and finally the relationship between these two variables was assessed with the Pearson correlation test. There was a statistically significant relationship between ICON scores and the quality of life levels (P < 0.01). The assessment of four sections of the questionnaire showed that among these four sections (oral symptoms, functional limitations, emotional well-being, social well-being), only oral symptoms were significantly correlated with the ICON score (P < 0.05). Malocclusion plays an important role in the oral health-related quality of life. However, the relationship between emotional well-being, social well-being and malocclusions was not as strong as in previous studies.
Ebrahimzadeh M.H.,Mashad University of Medical science |
Amadzadeh-Chabock H.,Mashad University of Medical science |
Ring D.,Mashad University of Medical science
Journal of Hand Surgery | Year: 2010
Trauma can render the elbow unstable via a combination of bone and ligament injuries. Some of these injuries feature subluxation rather than dislocation of the elbow. Effective treatment centers on restoring enough of the bony and ligamentous structures to keep the elbow in joint so that recovery can proceed as for a simple elbow dislocation. Recognition of distinct patterns of injury can help determine the structures injured and the best methods for repairing them. © 2010.
Golmohammadzadeh S.,Mashad University of Medical science |
Jaafari M.R.,Mashad University of Medical science |
Hosseinzadeh H.,Mashad University of Medical science
Iranian Journal of Pharmaceutical Research | Year: 2010
The objective of this study was to investigate the effects of saffron as a natural sunscreen and moisturizer. The pollens of the saffron were dried and powdered in a grinder. The experimental formulations included a homosalate (8%) lotion reference, lotions with 2, 4 and 8% of grinded saffron, and the control lotion base without saffron. The lotions containing saffron were prepared like homosalate lotion reference according to FDA. The sun protection factors (SPFs) of the formulations were determined by an in vitro spectrophotometry method. The moisture contents of the skin before application and after 30 min and 3, 5 and 7 h post-application of the formulations were measured in human volunteers using Corneometer. The results indicated that, there was no signifcant difference between the SPF values of the 4% saffron lotion and the homosalate lotion reference. However, the SPF of 8% saffron lotion was signifcantly more than that of homosalate lotion reference. These results showed that in equal concentrations saffron lotion could act as a better antisolar agent compared to homosalate. Furthermore, there were no signifcant differences in skin moisture saffron lotions and the control lotion without saffron during the 7 h post-application period. Saffron can be used as a natural UV absorbing agent. The 4% saffron lotion showed an SPF value equivalent to the 8% homosalate lotion reference by an in vitro method. There were no signifcant differences of skin moisture contents after application of the saffron lotions and the control base lotion without saffron. © 2010 by School of Pharmacy.