Masaryk University is the second largest university in the Czech Republic, a member of the Compostela Group and the Utrecht Network. Founded in 1919 in Brno as the third Czech university , it now consists of nine faculties and 35,115 students. It is named after Tomáš Garrigue Masaryk, the first president of an independent Czechoslovakia as well as the leader of the movement for a third Czech university.In 1960 the university was renamed Jan Evangelista Purkyně University after Jan Evangelista Purkyně, a Czech biologist. In 1990, following the Velvet Revolution it regained its original name. Since 1922, over 171,000 students graduated from the university. Wikipedia.
Masaryk University | Date: 2015-06-17
The invention provides compounds represented by the structural formula (1): wherein R^(1), R^(2), R^(3 )and R^(4 )are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.
Masaryk University | Date: 2017-05-31
The present invention provides a device for detection of halogenated aliphatic hydrocarbons which contains a carrier with at least one indicator of presence of halogenated aliphatic hydrocarbons, and at least one haloalkane dehalogenase (EC 22.214.171.124) immobilized on the surface of said carrier. Further provided is a method of detecting at least one halogenated aliphatic hydrocarbon in a sample or environment, wherein the sample or environment is contacted with said device which is pre-treated by hydration, and the chemical change of the indicator of presence of halogenated aliphatic hydrocarbons is evaluated.
Masaryk University | Date: 2015-04-29
The invention relates to furo[3,2-b]pyridines substituted at least in position 5 as inhibitors of protein kinases, regulators or modulators, methods of preparation thereof, pharmaceutical compositions containing the compounds, and pharmaceutical use of the compounds and compositions in the treatment of the diseases such as, for example, cancer or neurodegenerative diseases.
Agency: European Commission | Branch: H2020 | Program: ERA-NET-Cofund | Phase: SC5-15-2015 | Award Amount: 52.36M | Year: 2016
In the last decade a significant number of projects and programmes in different domains of environmental monitoring and Earth observation have generated a substantial amount of data and knowledge on different aspects related to environmental quality and sustainability. Big data generated by in-situ or satellite platforms are being collected and archived with a plethora of systems and instruments making difficult the sharing of data and knowledge to stakeholders and policy makers for supporting key economic and societal sectors. The overarching goal of ERA-PLANET is to strengthen the European Research Area in the domain of Earth Observation in coherence with the European participation to Group on Earth Observation (GEO) and the Copernicus. The expected impact is to strengthen the European leadership within the forthcoming GEO 2015-2025 Work Plan. ERA-PLANET will reinforce the interface with user communities, whose needs the Global Earth Observation System of Systems (GEOSS) intends to address. It will provide more accurate, comprehensive and authoritative information to policy and decision-makers in key societal benefit areas, such as Smart cities and Resilient societies; Resource efficiency and Environmental management; Global changes and Environmental treaties; Polar areas and Natural resources. ERA-PLANET will provide advanced decision support tools and technologies aimed to better monitor our global environment and share the information and knowledge in different domain of Earth Observation.
Agency: European Commission | Branch: H2020 | Program: COFUND-EJP | Phase: SC1-PM-05-2016 | Award Amount: 74.06M | Year: 2017
The overarching goal of the European Human Biomonitoring Initiative (HBM4EU) is to generate knowledge to inform the safe management of chemicals and so protect human health. We will use human biomonitoring to understand human exposure to chemicals and resulting health impacts and will communicate with policy makers to ensure that our results are exploited in the design of new chemicals policies and the evaluation of existing measures. Key objectives include: Harmonizing procedures for human biomonitoring across 26 countries, to provide policy makers with comparable data on human internal exposure to chemicals and mixtures of chemicals at EU level; Linking data on internal exposure to chemicals to aggregate external exposure and identifying exposure pathways and upstream sources. Information on exposure pathways is critical to the design of targeted policy measures to reduce exposure; Generating scientific evidence on the causal links between human exposure to chemicals and negative health outcomes; and Adapting chemical risk assessment methodologies to use human biomonitoring data and account for the contribution of multiple external exposure pathways to the total chemical body burden. We will achieve these objectives by harmonizing human biomonitoring initiatives in 26 countries, drawing on existing expertise and building new capacities. By establishing National Hubs in each country to coordinate activities, we will create a robust Human Biomonitoring Platform at European level. This initiative contributes directly to the improvement of health and well-being for all age groups, by investigating how exposure to chemicals affects the health of different groups, such as children, pregnant women, foetuses and workers. We will also investigate how factor such as behavior, lifestyle and socio-economic status influence internal exposure to chemicals across the EU population. This knowledge will support policy action to reduce chemical exposure and protect health.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: REV-INEQUAL-06-2016 | Award Amount: 5.00M | Year: 2017
ISOTIS addresses the nature, causes and impact of early emerging social and educational inequalities in the context of socioeconomic, cultural and institutional processes. The aim is to contribute to effective policy and practice development to combat inequalities. Quasi-panels and pooled longitudinal datasets will be used to examine the variation in early educational gaps and developmental trajectories across countries, systems and time. To disentangle the complex interactions between characteristics of systems and target groups, ISOTIS will study significant immigrant, indigenous ethnic-cultural and low-income native groups, associated with persistent educational disadvantages. ISOTIS will examine current resources, experiences, aspirations, needs and well-being of children and parents in these groups in the context of acculturation and integration, and in relation to local and national policies. ISOTIS aims to contribute to effective policy and practice development by generating recommendations and concrete tools for (1) supporting disadvantaged families and communities in using their own cultural and linguistic resources to create safe and stimulating home environments for their children; for (2) creating effective and inclusive pedagogies in early childhood education and care centres and primary schools; for (3) professionalization of staff, centres and schools to improve quality and inclusiveness; for (4) establishing inter-agency coordination of support services to children and families; and for (5) developing policies to combat educational inequalities. ISOTIS will develop inter-linked programmes for parents, classrooms and professionals using Virtual Learning Environments for working in linguistically diverse contexts. All this work together is expected to support the education practice and policy field in Europe in meeting the challenges of reducing social and educational inequalities.
Agency: European Commission | Branch: H2020 | Program: ECSEL-RIA | Phase: ECSEL-07-2015 | Award Amount: 20.53M | Year: 2016
Embedded systems have significantly increased in technical complexity towards open, interconnected systems. This has exacerbated the problem of ensuring dependability in the presence of human, environmental and technological risks. The rise of complex Cyber-Physical Systems (CPS) has led to many initiatives to promote reuse and automation of labor-intensive activities. Two large-scale projects are OPENCOSS and SafeCer, which dealt with assurance and certification of software-intensive critical systems using incremental and model-based approaches. OPENCOSS defined a Common Certification Language (CCL), unifying concepts from different industries to build a harmonized approach to reduce time and cost overheads, via facilitating the reuse of certification assets. SafeCer developed safety-oriented process lines, a component model, contract-based verification techniques, and process/product-based model-driven safety certification for compositional development and certification of CPSs. AMASS will create and consolidate a de-facto European-wide assurance and certification open tool platform, ecosystem and self-sustainable community spanning the largest CPS vertical markets. We will start by combining and evolving the OPENCOSS and SafeCer technological solutions towards end-user validated tools, and will enhance and perform further research into new areas not covered by those projects. The ultimate aim is to lower certification costs in face of rapidly changing product features and market needs. This will be achieved by establishing a novel holistic and reuse-oriented approach for architecture-driven assurance (fully compatible with standards e.g. AUTOSAR and IMA), multi-concern assurance (compliance demonstration, impact analyses, and compositional assurance of security and safety aspects), and for seamless interoperability between assurance/certification and engineering activities along with third-party activities (external assessments, supplier assurance).
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: INFRADEV-03-2016-2017 | Award Amount: 3.95M | Year: 2017
Instruct-Ultra aims to advance the scope and efficiency of implementation of Instruct and consolidate the foundations for long-term sustainability. This will be achieved through specific objectives: expand Instruct membership to new Member States and increase global links; engage new user communities; improve efficiencies in service delivery; improve data capture and management; adjust the scale and reliability of the infrastructure. Instruct-Ultra will deliver these alongside the transition to ERIC legal status and rapid developments in, and increased demand for, integrated structural biology infrastructure. These advances in the scale and speed of delivery will earn further trust within the life science community. One focus will to expand membership to Eastern European states and EFTA countries, integrating their structural biology communities into Instruct and providing new opportunities to support research excellence and raise standards. Opportunities for engaging with industrialised and developing countries outside the ERA will build on existing cooperative work between Instruct and Asian, African and South American countries to establish strong bilateral programmes of benefit to both parties, giving Instruct better engagement in emerging global challenges and positioning Instruct as a trusted global resource for high quality structural biology services. Starting from baseline operations four years ago Instruct has now identified key areas of service which should be expanded, new potential user groups, and opportunities for more reliable, efficient and sometimes remotely used workflows. Instruct-Ultra will therefore test new modes of access and pilot new service methods in high demand areas to accelerate access for more users. Instruct-Ultra will reinforce Instruct operations by updating and expanding the business plan and structural biology roadmap, whilst improving the interface with academia and industry as a strategy to sustainability.
Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2016 | Award Amount: 1.01M | Year: 2017
The overall vision of INTERWASTE is to develop scientific understanding of issues related to environmental contamination with toxic organic chemicals (specifically flame retardants (FRs) and pharmaceutical and personal care products (PPCPs)) arising from their presence in the waste stream. Specific research objectives include: (a) exchange of knowledge of and best practice in methods for rapid and cost-effective identification of waste items containing restricted FRs; (b) developing scientific understanding of environmental contamination due to processing of waste items containing FRs; and (c) furthering understanding of the sources of PPCPs and FRs in the sewerage system. To facilitate such research on the global level required, INTERWASTE will exchange best practice in the analytical chemistry techniques required to study FRs and PPCPs, and evaluate the measurement capability of INTERWASTE participants via an interlaboratory comparison. INTERWASTEs vision will be achieved via a co-ordinated programme of collaboration and research secondments between world-leading research groups both within and outside the EU; coupled with annual workshops to discuss the latest findings. The research programme will exploit the complementary expertise of the consortium members, and in so doing foster synergies. Cross-sectoral interaction and knowledge sharing will be achieved via the participation of beneficiaries and partner organisations from both academic and non-academic sectors. All secondments and workshops will be conducted within a framework designed to maximise the training and career development benefits to participating staff by providing them with opportunities for knowledge and skills acquisition, with a particular (but not exclusive) focus on early career researchers. INTERWASTEs research and training programme is complemented by communication activities that will both disseminate project findings to scientific stakeholders, and engage the general public.
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.98M | Year: 2017
Clean drinking water is crucial to human health and wellbeing. The ambition of the NaToxAq ETN network is to expand the research basis for EUs leading role in securing high quality drinking waters for its citizens. Focus is on natural toxins a large group of emerging contaminants with unknown impact on drinking water resources. Both known toxins, like cyanotoxins, cyanogenic glucosides and terpenes and not yet explored toxins will be investigated. Twenty leading universities, research institutions, and water enterprises will pioneer the field through joint training of 15 ESRs investigating natural toxin emission via water reservoirs to water works and consumers. The natural toxin challenge is addressed by the concerted work of the ESRs within 4 scientific work packages comprising origin, distribution, fate and remediation. Priority toxins are selected using in silico approaches accompanied by novel non-targeted and targeted analyses to map natural toxins along vegetation and climatic gradients in Europe. Invasion of alien species, toxin emission, leaching and dissipation will be under strong influence of climate change. Data collected for toxin emission, properties and fate will be used to model effects of climate, land use, and design of remediation actions. Special attention will be paid to toxin removal at water works including development of new technologies tailored to remove natural toxins. The results will contribute to strengthening of European policies and regulation of drinking water, while new business opportunities within the fields of water supply and treatment, chemical monitoring and sensing, and the consulting sector will arise from academia-indstry collaborations. The urgency of the challenge, its eminent knowledge gaps, its multifaceted and multidisciplinary nature, and the need for scientific and public awareness to be communicated by ESRs in a balanced way makes the topic ideal for a European mobility and training network.