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Cummings P.L.,University of California at Los Angeles | Welch S.B.,Mary Ann And J Milburn Smith Child Health Research Program | Mason M.,Mary Ann And J Milburn Smith Child Health Research Program | Mason M.,Northwestern University | And 4 more authors.
Preventive Medicine | Year: 2014

Objective: To compare changes in nutrient levels of school meals before and after implementation of nutrition interventions at five school districts in two, large U.S. counties. School menu changes were compared against national school meal recommendations. Methods: A large urban school district in Los Angeles County (LAC), California and four school districts in suburban Cook County (SCC), Illinois implemented school meal nutrition interventions. Nutrition analyses were conducted for school breakfast and lunch before and after changes were made to the meal programs. Means, % change, and net calories (kilocalories or kcal) offered as a result of the nutrition interventions were calculated. Results: School districts in both counties made district-wide changes in their school breakfast and lunch menus. Menu changes resulted in a net reduction of calories, sugar, and sodium content offered in the meals. Net fewer calories offered as a result of the nutrition interventions were estimated to be about 64,075. kcal per student per year for LAC and 22,887. kcal per student per year for SCC. Conclusions: Nutrition interventions can have broad reach through changes in menu offerings to school-aged children and adolescents. However, further research is needed to examine how these changes affect student food selection and consumption. •School-based nutrition interventions were implemented in LA County and Cook County.•Reduced calories, sugar, and sodium content in school meals were achieved.•About 688,197 students were affected by the menu changes. © 2014 Elsevier Inc.

Zhu X.,Peking Union Medical College | He F.,CAS Beijing Institute of Genomics | Zeng H.,Peking Union Medical College | Ling S.,CAS Beijing Institute of Genomics | And 42 more authors.
Nature Genetics | Year: 2014

Acute leukemia characterized by chromosomal rearrangements requires additional molecular disruptions to develop into full-blown malignancy, yet the cooperative mechanisms remain elusive. Using whole-genome sequencing of a pair of monozygotic twins discordant for MLL (also called KMT2A) gene-rearranged leukemia, we identified a transforming MLL-NRIP3 fusion gene and biallelic mutations in SETD2 (encoding a histone H3K36 methyltransferase). Moreover, loss-of-function point mutations in SETD2 were recurrent (6.2%) in 241 patients with acute leukemia and were associated with multiple major chromosomal aberrations. We observed a global loss of H3K36 trimethylation (H3K36me3) in leukemic blasts with mutations in SETD2. In the presence of a genetic lesion, downregulation of SETD2 contributed to both initiation and progression during leukemia development by promoting the self-renewal potential of leukemia stem cells. Therefore, our study provides compelling evidence for SETD2 as a new tumor suppressor. Disruption of the SETD2-H3K36me3 pathway is a distinct epigenetic mechanism for leukemia development. © 2014 Nature America, Inc. © 2014 Nature America, Inc.

LaBella C.R.,Northwestern University | LaBella C.R.,Institute for Sports Medicine | Huxford M.R.,Institute for Sports Medicine | Grissom J.,Institute for Sports Medicine | And 4 more authors.
Archives of Pediatrics and Adolescent Medicine | Year: 2011

Objective: To determine the effectiveness of coach-led neuromuscular warm-up on reducing lower extremity (LE) injuries in female athletes in a mixed-ethnicity, predominantly low-income, urban population. Design: Cluster randomized controlled trial. Setting: Chicago public high schools. Participants: Of 258 coaches invited to participate, 95 (36.8%) enrolled (1558 athletes). Ninety coaches and 1492 athletes completed the study. Interventions: We randomized schools to intervention and control groups. We trained intervention coaches to implement a 20-minute neuromuscular warm-up. Control coaches used their usual warm-up. Main Outcome Measures: Coach compliance was tracked by self-report and direct observation. Coaches reported weekly athlete exposures (AEs) and LE injuries causing a missed practice or game. Research assistants interviewed injured athletes. Injury rates were compared between the control and intervention groups using χ 2 and Fisher exact tests. Significance was set at P<.05. Poisson regression analysis adjusted for clustering and covariates in an athlete subset reporting personal information (n=855; 57.3%). Results: There were 28 023 intervention AEs and 22 925 control AEs. Intervention coaches used prescribed warm-up in 1425 of 1773 practices (80.4%). Intervention athletes had lower rates per 1000 AEs of gradual-onset LE injuries (0.43 vs 1.22, P<.01), acute-onset noncontact LE injuries (0.71 vs 1.61, P<.01), noncontact ankle sprains (0.25 vs 0.74, P=.01), and LE injuries treated surgically (0 vs 0.17, P=.04). Regression analysis showed significant incidence rate ratios for acute-onset noncontact LE injuries (0.33;95% CI, 0.17-0.61), noncontact ankle sprains (0.38; 95% CI, 0.15-0.98), noncontact knee sprains (0.30; 95% CI, 0.10- 0.86), and noncontact anterior cruciate ligament injuries (0.20; 95% CI, 0.04-0.95). Conclusion: Coach-led neuromuscular warm-up reduces noncontact LE injuries in female high school soccer and basketball athletes from a mixed-ethnicity, predominantly low-income, urban population. Trial Registration: clinicaltrials.org Identifier: NCT01092286. ©2011 American Medical Association. All rights reserved.

Lavigne J.V.,Northwestern University | Lavigne J.V.,Mary Ann And J Milburn Smith Child Health Research Program | Saps M.,Northwestern University | Bryant F.B.,Loyola University Chicago
Journal of Pediatric Psychology | Year: 2014

Objective To examine whether somatization mediates the relationship of coping styles and internalizing problems with abdominal pain. Methods 230 school children (M age = 11.80 years; 43.8% male; 21.3% White) completed measures of coping style, anxiety, and depression early in the school year, and subsequently reported abdominal pain symptoms weekly. Results The results showed (a) the association of anxiety and depression with abdominal pain may be mediated by somatization; (b) there are similarities and differences in the association of coping styles with pain for models including anxiety versus depression. Significant indirect effects showed higher levels of passive coping were associated with more pain via somatization and either anxiety or depression. For active coping, results differed for models including anxiety versus depression. Accommodative coping showed no independent relationship with abdominal pain. Conclusions Somatization may mediate the relationship of internalizing symptoms and coping styles with pain. Treatment implications are discussed. © 2013 The Author 2013.

Lavigne J.V.,Childrens Memorial Hospital | Lavigne J.V.,Mary Ann And J Milburn Smith Child Health Research Program | Saps M.,Childrens Memorial Hospital | Bryant F.B.,Loyola University Chicago
Journal of Pediatric Psychology | Year: 2012

Objective Pediatric somatization studies have used the 35-item Child Somatization Inventory (CSI-35) or psychometrically refined 24-item CSI (CSI-24). Exploratory factor analysis of the CSI-24 has identified a single factor that did not show good model fit in confirmatory factor analysis (CFA). Further evaluation of the CSI-24 factor structure is needed. Methods The present study examined alternative factor structures of the CSI-24 in a community sample (N=233, ages 8-15). Results The CFA showed good fit for a single CSI-24 factor, better fit for multiple factor models, and best fit for a single, six-item factor. Construct validity for that factor was found in significant correlations with anxiety, depression, functional disability, and quality of life. Conclusions Results are consistent with a single somatization factor, but research is needed to verify the factor structure in different, race/ethnic/demographic, and clinical groups. © 2011 The Author.

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