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Columbia, MD, United States

Grant
Agency: National Science Foundation | Branch: | Program: SBIR | Phase: Phase II | Award Amount: 202.00K | Year: 1988

THE PRODUCTION OF DEUTERIUM-SUBSTITUTED OILS BY AUTOTROPHIC GROWTH OF CERTAIN ALGAL SPECIES IN DEUTERIUM OXIDE WILL BE INVESTIGATED. DUE TO THE INCREASED CARBON- DEUTERIUM BOND STRENGTH, DEUTERATED LUBRICANT OILS AND GREASES EXHIBIT SUPERIOR CAPABILITIES UNDER TEMPERATURE AND PRESSURE EXTREMES COMPARED TO THE EQUIVALENT HYDROCARBONS. THE INCREASED FUNCTIONAL LIFETIMES OF THESE COMPOUNDS HAVE MADE THEM A STRATEGIC COMMODITY IN EQUIPMENT WITH A RAPID LUBRICANT FAILURE. THE HIGH COST OF CHEMICAL DEUTERATION HAS RESULTED IN A HIGH COST PRODUCT WITH ITS USE LIMITED TO EQUIPMENT WHOSE "DOWN-TIME" IS EITHER EXPENSIVE, OR THREATENING TO THE COUNTRY'S NATIONAL SECURITY. MANY UNICELLULAR ALGAE PRODUCE LARGE QUANTITIES OF OILS AS FOOD STORAGE COMPOUNDS AND CAN BE GROWN AUTOTROPHICALLY IN CULTURE REQUIRING ONLY LIGHT CARBON DIOXIDE WATER AND A FEW MINERALS. WE PROPOSE TO GROW THESE ALGAL SPECIES AUTOTROPHICALLY IN THE PRESENCE OF 99.7% DEUTERIUM OXIDE (D2O), THEREBY REPLACING ALL THE CELLULAR HYDROGEN WITH DEUTERIUM AND BILOGICALLY PRODUCING PERDEUTERATED HYDROCARBONS. OUR PROGRAM OBJECTIVES ARE FOURFOLD: DEFINE OPTIMAL CULTURE CONDITIONS AND SELECT STRAINS OF OIL-PRODUCING ALGAE WHICH EXHIBIT EXCEPTIONAL GROWTH IN 99.7% D2O. IDENTIFY PROCEDURES FOR EFFICIENT HARVEST OF THE CULTURES, EXTRACTION OF THE PERDEUTERATED OILS AND RECYCLING OF THE D2O. CHARACTERIZE THE LIPID COMPONENTS PRODUCED BY THE PIL-PRODUCING ALGAE DURING CULTURE IN D2O. DESIGN A TEST BED FOR COMPARISON OF THE LUBRICATION CAPABILITIES OF THE OILS EXTRACTED FROM THE ALGAE. THE POTENTIAL COST REDUCTION OF THE DEUTERATED LUBRICANTS WHEN PRODUCED BIOLOGICALLY WILL UNDOUBTEDLY INCREASE THE SCOPE FOR THE USE OF THESE HIGH PERFORMANCE COMPOUNDS.


Grant
Agency: National Science Foundation | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 47.00K | Year: 1988

MOST SYNTHETIC COLORS ARE COAL TAR DERIVATIVES AND HAVE BEEN TARGETTED AS POTENTIAL CAUSATIVE AGENTS OF HYPERACTIVITY AND LEARNING DISABILITIES IN CHILDREN, CANCER,EMBRYOTOXICITY AND ALLERGENICITY. ALTERNATIVELY, NATURAL COLORS (E.G., CAROTENOIDS) DO NOT EXHIBIT THESE NEGATIVE ATTRIBUTES, AND MAY HAVE A POSITIVE HEALTH BENEFIT, PRESUMABLY DUE TO THEIR ROLE AS LIPID ANTIOXIDANTS, FREE RADICAL TRAPS AND QUENCHERS OF SINGLET OXYGEN. THERE IS, THEREFORE, A MAJOR CONSUMER-DRIVEN DEMAND FOR NATURAL COLORSTO MINIMIZE EXPOSURE TO POTENTIAL TOXINS. IN THE AREA OF NATURAL COLORS PRODUCTION, MICROALGAE ARE A GREATLY UNDERUTILIZED RESOURCE. ALGAE PRODUCE PIGMENTS OF POTENTIAL VALUE AS COLORANTS OF FOOD, COSMETICS AND PHARMACEUTICALS. INITIALLY, CAROTENOID PRODUCING STRAINS WILL BE STUDIED TO DETERMINE THE FEASIBILITY OF PRODUCING NATURAL COLORS FROM ALGAE USING THE FOLLOWING APPROACH: ESTABLISH, IN PURE CULTURE, SEVERAL ALGAL SPECIES THAT PRODUCE HIGH LEVELS OF CAROTENOIDS IN WHICH A SINGLE COMPONENT FORMS THE BULK OF THE CELLULAR CAROTENOIDS; OPTIMIZE GROWTH CONDITIONS AND DETERMINE OVERALL CAROTENOID PRODUCTIVITIES; EXTRACT THE CAROTENOIDS IN PREPARATIVE QUANTITIES FOR TESTING; OPTIMIZE THE EXTRACTION PROCEDURE TOGIVE THE HIGHEST RECOVERY COMMENSURATE WITH SPEED AND LOW COST; QUANTITATE THE COST FACTORS INVOLVED IN THIS NOVEL SUPPLY SOURCE; BEGIN ISOLATION OF HERBICIDE (NORFLUORAZONE) RESISTANT ALGAE THAT MAY CONTAIN ELEVATED LEVELS OF CAROTENOIDS.


Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 47.80K | Year: 1993

N/A


Grant
Agency: National Science Foundation | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 40.00K | Year: 1985

N/A


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: KBBE-2007-2-2-01 | Award Amount: 7.99M | Year: 2008

Current evidence on the effect of diet on mental performance (MP) is largely based on animal, retrospective studies, and short-term nutritional intervention studies in humans. NUTRIMENTHE will significantly improve this knowledge through studying the role, mechanisms, risks & benefits of specific nutrients & food components to respond to specific needs and improve the MP of children. The research will include quantification of the nutrient effects of early programming on later cognitive and mental disorders, effects of food on mental state and MP such as mood, activation, attention, motivation, effort, perception, memory & intelligence and the effects of food on mental illness. NUTRIMENTHE will establish: A team of leading international scientists (paediatricians, neurospsychologists, psychiatrics) from top academic centres and a leading Food Multinational, providing a critical mass of experts in the effect of diet on childrens MP Epidemiologic studies to analyse the long-term effects of pre- & early postnatal diet on childrens mental performance & illness Follow-up of randomised clinical intervention trials with specific nutrients initiated during pregnancy, infancy & childhood Quantitative requirements of n-3 LCPUFAs in children with restricted diet Quantitative assessment of the interaction between nutrition & genetic variation with respect to MP Development of a neuropsychological battery for an EU common assessment of MP Consistent & clear pan-European recommendations on dietary requirement for children An increase the EU public knowledge, specifically parents, teachers & industry, laying the basis for appropriate health claims about how diet influences MP in children Establish the economic opportunity for further product development within EU Development of a professional & public engaging dissemination programme, to increase excellence & innovation potentials & training in nutrition research linked to cognitive- & neuroscience

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