Huntington, WV, United States

Marshall University

www.marshall.edu
Huntington, WV, United States

Marshall University is a coeducational public research university in Huntington, West Virginia, United States founded in 1837, and named after John Marshall, the fourth Chief Justice of the United States.The university is currently composed of nine undergraduate colleges: College of Business , College of Education and Professional Development , College of Arts and Media , College of Health Professions , Honors College, College of Information Technology and Engineering , College of Liberal Arts , College of Science , and University College ; three graduate colleges, the general Graduate College, the School of Pharmacy, and the Joan C. Edwards School of Medicine, a regional center for cancer research which has a national reputation for its programs in rural healthcare delivery. The forensic science graduate program is one of nearly twenty post-graduate-level academic programs in the United States accredited by the American Academy of Forensic science. The University's digital forensics program is the first program in the world to receive accreditation in digital forensics from the Forensic Science Education Programs Accreditation Commission . The College of Business has achieved AACSB accreditation.Marshall University has a non-residential branch campus, focused on graduate education, in South Charleston, the Marshall University - South Charleston Campus, which also offers classes throughout the southern half of the state, including at the Erma Byrd Higher Education Center in Beckley. It also offers undergraduate courses, under three "centers", the Southern Mountain Center, operating on the campuses of the Southern West Virginia Community College in Logan and Williamson and at the YMCA in Gilbert; the Mid-Ohio Valley Center in Point Pleasant and the Teays Valley Center in Hurricane. Marshall University also operates the Robert C. Byrd Institute, with operations on both the Huntington and South Charleston campuses, as well as in Fairmont, West Virginia, and Rocket Center, West Virginia. The goal of the Institute is the transfer of technology from the academic departments to private industry to support job development in the region. Wikipedia.


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News Article | May 17, 2017
Site: news.yahoo.com

In this April 27, 2017 photo, Maurice Cooley, right, Associate Vice President of Intercultural Affairs at Marshall University, presents Demetrius Miller with his Kente cloth during Marshall's spring Donning of the Kente ceremony in Huntington, W. Va. Harvard will join a growing number of universities when it holds its first "Black Commencement" on May 23 to recognize the accomplishments of black students and faculty. Organizers said it isn't meant to replace the traditional graduation but to add something that was missing. (Sholten Singer/The Herald-Dispatch via AP) BOSTON (AP) — Black students at Harvard University are organizing a graduation ceremony of their own this year to recognize the achievements of black students and faculty members some say have been overlooked. More than 700 students and guests are registered to attend Harvard's Black Commencement, which will take place two days before the school's traditional graduation events. It isn't meant to replace the existing ceremony, student organizers say, but rather to add something that was missing. "We really wanted an opportunity to give voice to the voiceless at Harvard," said Michael Huggins, president of the Harvard Black Graduate Student Alliance, a campus group that is planning the ceremony. "So many students identify with the African diaspora but don't necessarily feel welcome as part of the larger community, and they don't feel like their stories are being shared." Harvard joins a growing number of universities that have added graduation events for students of different ethnicities. Some have offered black commencement ceremonies for years, including Stanford University, Marshall University and the University of Washington. Some have added them more recently, and are also adding events for a variety of cultural groups. Black undergraduates at Harvard have held similar graduation events in the past, but student organizers say the new ceremony is the first that's open to students across the university. The May 23 event at Harvard will feature four student speakers discussing the hurdles they faced on the way to graduation. Every student will receive a stole made of traditional African kente cloth, meant to symbolize their shared heritage and to be worn with their cap and gown at the university's graduation. Students have raised $35,000 for the event, mostly from schools within the university. Organizers say some university deans and professors have agreed to attend. A Harvard spokesman declined to comment. "This event is truly open for everyone," said Huggins, who is graduating with a master's in public policy this month. "We really want this to be an open affair where people can learn about some experiences that often go unnoticed." Students at Harvard also started an annual Latino graduation ceremony in 2015, and the school hosts a separate event for LGBT students, known as a "lavender graduation." Many other colleges have been adding similar events in recent years. The University of Delaware held its first LGBT ceremony this year, joining dozens of others across the country. Along with its traditional commencement, Virginia Commonwealth University added new ceremonies for black students, Latinos and military veterans last year. "They're small affairs, but they're meaningful," said Michael Porter, a spokesman for Virginia Commonwealth University. "It's really a social event, and one more time to get together as you wind down the college career." Cultural graduation events are typically started by students, experts say, and often by those who feel marginalized on their campuses. They can be particularly important for black students, many of whom are the first in their families to graduate from college, said M. Evelyn Fields, president of the American Association of Blacks in Higher Education. "When you're a little speck of pepper in a sea of salt, you can get lost," said Fields, who is also a professor of early childhood education at South Carolina State University. "They don't want to just be lost in the sea. They want the recognition that they believe they deserve, for the work that they've done." Black students at Harvard represent 5 percent of the overall student body, compared with whites, who make up 43 percent, according to federal education data. Campus tensions at the Ivy League school have been heightened over the past two years after a series of racially charged episodes. Harvard police called it a hate crime when framed portraits of several black law professors were defaced in 2015. No suspect was found. Months later, the law school agreed to abandon its official coat of arms after student activists protested the symbol's ties to an 18th-centry slave owner. Organizers of the Black Commencement say it's partly meant to highlight racial disparities on campus. But ultimately it's a celebration of achievement, said Jillian Simons, a law student and president-elect of the Harvard Black Graduate Student Alliance. "We want to acknowledge how far we've come," Simons said. "We want to say that there is a time to be jubilant and to acknowledge something that is positive instead of something that is causing heartache."


Patent
Marshall University | Date: 2017-02-08

Non-naturally occurring peptides are provided that act as a Src SH2 domain antagonist of cardiotonic steroids. Pharmaceutical compositions comprising the peptides are also provided along with vectors encoding the peptides. Methods of treating a Src-associated disease and reducing Src activity in a cell are further provided and include administering or contacting a cell with an effective amount of the peptide.


News Article | April 17, 2017
Site: www.prweb.com

LearnHowToBecome.org, a leading resource provider for higher education and career information, has released its list of West Virginia’s best colleges for 2017. 17 four-year schools were highlighted, with West Virginia Wesleyan College, Bethany College, Wheeling Jesuit University, West Virginia University Institute of Technology and West Virginia University scoring in the top five. Of the 10 two-year schools included in the ranking, Cabell County Career Technology Center, West Virginia Northern Community College, Blue Ridge Community and Technical College, Mountwest Community and Technical College and Southern West Virginia Community and Technical College were the top five. A full list of winning schools is included below. “These West Virginia schools have created a culture of both academic and career success,” said Wes Ricketts, senior vice president of LearnHowToBecome.org. “When we look at measures of alumni success next to each school’s quality of education, these are the clear leaders in the state.” To be included on West Virginia’s “Best Colleges” list, schools must be regionally accredited, not-for-profit institutions. Each college is also scored on more than a dozen additional data points including diversity of program offerings, career services, educational counseling, financial aid availability, graduation rates and student/teacher ratios. Complete details on each college, their individual scores and the data and methodology used to determine the LearnHowToBecome.org “Best Colleges in West Virginia” list, visit: The Best Four-Year Colleges in West Virginia for 2017 include: Alderson Broaddus University Bethany College Bluefield State College Concord University Davis & Elkins College Fairmont State University Glenville State College Marshall University Ohio Valley University Shepherd University University of Charleston West Liberty University West Virginia State University West Virginia University West Virginia University Institute of Technology West Virginia Wesleyan College Wheeling Jesuit University The Best Two-Year Colleges in West Virginia for 2017 include: Ben Franklin Career Center Blue Ridge Community and Technical College BridgeValley Community & Technical College Cabell County Career Technology Center Eastern West Virginia Community and Technical College Mountwest Community and Technical College New River Community and Technical College Pierpont Community and Technical College Southern West Virginia Community and Technical College West Virginia Northern Community College ### About Us: LearnHowtoBecome.org was founded in 2013 to provide data and expert driven information about employment opportunities and the education needed to land the perfect career. Our materials cover a wide range of professions, industries and degree programs, and are designed for people who want to choose, change or advance their careers. We also provide helpful resources and guides that address social issues, financial aid and other special interest in higher education. Information from LearnHowtoBecome.org has proudly been featured by more than 700 educational institutions.


CHARLESTON, W. Va.--(BUSINESS WIRE)--City Holding Company (“Company” or “City”) (NASDAQ:CHCO), a $4.1 billion bank holding company headquartered in Charleston, WV, held its annual meeting of shareholders today on the campus of Marshall University in Huntington, WV, as part of what City has termed its “City on Campus” program. The first program was held on the campus of Shenandoah University in Winchester, Virginia in April 2016. To maximize student involvement in the City on Campus program, City has moved its annual meetings up by a week. As a result, City has not released its earnings for the first quarter of 2017 – a topic which is normally reviewed by management with shareholders in attendance at the annual meeting. City will release its earnings next week on Tuesday, April 25, 2017. However, City’s management did provide some information at today’s meeting, which began at 2:30 p.m., regarding earnings for the first quarter of 2017. Highlights of the Company’s discussion about expected first quarter performance included the following: In addition, the Company noted that it had sold 441,000 common shares at a weighted average price of $64.48 per share, net of broker fees, during the quarter ended March 31, 2017. Through April 18, 2017, the Company had sold approximately 548,000 shares at a weighted average price of $64.82 per share, net of broker fees. City Holding Company is the parent company of City National Bank of West Virginia. City National Bank operates 85 branches across West Virginia, Virginia, Kentucky and Ohio. This news release contains certain forward-looking statements that are included pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Such information involves risks and uncertainties that could result in the Company's actual results differing materially from those projected in the forward-looking statements. Important factors that could cause actual results to differ materially from those discussed in such forward-looking statements include, but are not limited to, (1) the Company may incur additional loan loss provision due to negative credit quality trends in the future that may lead to a deterioration of asset quality; (2) the Company may incur increased charge-offs in the future; (3) the Company could have adverse legal actions of a material nature; (4) the Company may face competitive loss of customers; (5) the Company may be unable to manage its expense levels; (6) the Company may have difficulty retaining key employees; (7) changes in the interest rate environment may have results on the Company’s operations materially different from those anticipated by the Company’s market risk management functions; (8) changes in general economic conditions and increased competition could adversely affect the Company’s operating results; (9) changes in other regulations and government policies affecting bank holding companies and their subsidiaries, including changes in monetary policies, could negatively impact the Company’s operating results; (10) the Company may experience difficulties growing loan and deposit balances; (11) the current economic environment poses significant challenges for us and could adversely affect our financial condition and results of operations; (12) deterioration in the financial condition of the U.S. banking system may impact the valuations of investments the Company has made in the securities of other financial institutions resulting in either actual losses or other than temporary impairments on such investments; (13) the effects of the Wall Street Reform and Consumer Protection Act (the “Dodd-Frank Act”) and the regulations promulgated and to be promulgated thereunder, which may subject the Company and its subsidiaries to a variety of new and more stringent legal and regulatory requirements which adversely affect their respective businesses; (14) the impact of new minimum capital thresholds established as a part of the implementation of Basel III; and (15) other risk factors relating to the banking industry or the Company as detailed from time to time in the Company’s reports filed with the Securities and Exchange Commission, including those risk factors included in the disclosures under the heading “ITEM 1A Risk Factors” of the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2016. Forward-looking statements made herein reflect management's expectations as of the date such statements are made. Such information is provided to assist stockholders and potential investors in understanding current and anticipated financial operations of the Company and is included pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The Company undertakes no obligation to update any forward-looking statement to reflect events or circumstances that arise after the date such statements are made. Further, the Company is required to evaluate subsequent events through the filing of its March 31, 2017 Form 10-Q. The Company will continue to evaluate the impact of any subsequent events on the preliminary March 31, 2017 results and will adjust the amounts if necessary.


Patent
Marshall University | Date: 2015-04-02

Non-naturally occurring peptides are provided that act as a Src SH2 domain antagonist of cardiotonic steroids. Pharmaceutical compositions comprising the peptides are also provided along with vectors encoding the peptides. Methods of treating a Src-associated disease and reducing Src activity in a cell are further provided and include administering or contacting a cell with an effective amount of the peptide.


T helper type 2 (Th2) cells are critical to host defence against helminth infection and the pathogenesis of allergic diseases. The differentiation of Th2 cells from naive CD4 T cells is controlled by intricate transcriptional mechanisms. At the precursor stage of naive CD4 T cells, transcriptional mechanisms maintain the potential and in the meantime prevent spontaneous differentiation to Th2 fate. In addition, intrachromosomal interactions important for co-ordinated expression of Th2 cytokines pre-exist in naive CD4 T cells. Upon T-cell receptor (TCR) engagement, naive CD4 T cells are induced by polarizing signals of the interleukin-4/Stat6 and Jagged/Notch pathways to up-regulate the expression of GATA-3. Once up-regulated, GATA-3 drives Th2 and suppresses Th1 differentiation in a cell autonomous fashion. In this stage of differentiation, the Th2 cytokine locus, as well as the interferon-γ locus, undergoes chromatin remodelling and epigenetic modifications that contribute to the somatic memory of Th2 cytokine gene expression pattern. Once differentiated, Th2 effector cells promptly produce Th2 cytokines upon TCR stimulation, which is regulated by concerted actions of GATA-3, TCR signalling, enhancers and the Th2 locus control region. This review provides a detailed account of the transcriptional regulatory events at these different stages of Th2 differentiation. © 2013 John Wiley & Sons Ltd.


Hardman W.E.,Marshall University
Journal of Nutrition | Year: 2014

Cancer may not be completely the result of novel or inherited genetic mutations but may in fact be a largely preventable disease. Researchers have identified biochemicals, including n-3 (ω-3) fatty acids, tocopherols, β-sitosterol, and pedunculagin, that are found in walnuts and that have cancer-prevention properties. Mouse studies in which walnuts were added to the diet have shown the following compared with the control diet: 1) the walnut-containing diet inhibited the growth rate of human breast cancers implanted in nudemice by ̃80%; 2) the walnut-containing diet reduced the number of mammary gland tumors by ̃60% in a transgenicmousemodel; 3) the reduction in mammary gland tumors was greater with whole walnuts than with a diet containing the same amount of n-3 fatty acids, supporting the idea that multiple components in walnuts additively or synergistically contribute to cancer suppression; and 4) walnuts slowed the growth of prostate, colon, and renal cancers by antiproliferative and antiangiogenic mechanisms. Cell studies have aided in the identification of the active components in walnuts and of their mechanisms of action. This review summarizes these studies and presents the notion that walnuts may be included as a cancer-preventive choice in a healthy diet. © 2014 American Society for Nutrition.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: EXP PROG TO STIM COMP RES | Award Amount: 508.71K | Year: 2016

Proposal: 1553667 -

PI: Spitzer, Nadia Ph.D.

Consumers today are in contact with hundreds of products that boast antimicrobial properties because they contain manufactured silver nanoparticles. These products include wound dressings, food containers, toys, toothbrushes, clothing, cosmetics, and household appliances. The silver nanoparticles may be shed from these products resulting in exposure. The antibacterial properties of silver have been recognized since before modern medicine; however, the specific shape and size of silver nanoparticles make them act differently than larger forms of silver. Specifically, they may cross barriers that other forms of silver cannot, following repeated exposures. This project examines the responses of brain cells to low-levels of silver nanoparticles such as those that might result from daily exposure. The PI use a special type of brain cell, adult neural cells. The results of this research will improve our understanding of the impact of widespread incorporation of silver nanoparticles in consumer products. It will also contribute to regulatory policies.

The proposed work will investigate the cellular and molecular effects of chronic low-level exposures to silver nanoparticles (AgNPs) on neural physiology and development. It utilizes adult neural cells as a model to test the effects of low levels of AgNPs on neural cell physiology in identified cells in vitro and in vivo. In vitro studies
will identify the intracellular signaling pathways targeted by AgNP exposure to mediate deficits
in cytoskeletal structure and function. This will be assessed by combining pharmacology with immunocytochemistry, immunoblot, and time-lapse microscopy of differentiating adult neural cells in culture. The passive and active membrane properties of living cells exposed to low-level AgNPs will be measured by patch clamp electrophysiology to quantify effects on cell physiology during differentiation. Building on in vitro findings, neurogenesis in the brain after chronic, sub-lethal oral AgNP exposure will be investigated using rats. This work represents a critical step towards understanding the cellular targets of sub-lethal AgNPs on neural cells with respect to the physiological mechanisms operating in individual cells. The proposed work includes a significant public education effort that involves undergraduate students in bringing science to elementary schools throughout rural West Virginia. Children will learn scientific concepts in fun interactive ways and meet accessible role models for choosing careers in science or technology.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: Campus Cyberinfrastrc (CC-NIE) | Award Amount: 499.86K | Year: 2015

Marshall University is improving and expanding its campus research network to offer high-performance end-to-end network connectivity between research facilities by implementing: a) Science DMZ to provide a dedicated network with configuration and policies optimized for scientific applications. b) a dedicated data transfer node to offer a high-speed storage server with adequate data store to host large data sets and 10G transfer rate on the Science DMZ and c) high performance network improvement supporting 10-40 Gb/s connectivity between research facilities, laboratories and the campus core network/data center. The end-to-end network performance measurement is based on the perfSONAR framework allowing constant monitoring of performance and latency.

The improved network infrastructures provides support to advanced data-intensive scientific research by enhancing data transfer from the end points at the researcher locations to the main campus research facilities including the Robert C Byrd Biotechnology Science Center, Genomics & Bioinformatics Core Facility (GABC), Arthur Weisberg Family Applied Engineering Complex, Visualization Lab, and Big Green XSEDE-compatible High Performance Computing cluster in University data center and the backup facility.

The new network capabilities enable faster data transfer for intra-campus connectivity and remove the bottleneck in external connectivity to foster collaboration with other institutions over the Internet2 national network. The project aligns with the institutions cyberinfrastructure plan in achieving the goal of creating a scalable network design that supports current and future science requirements to advance scientific research.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: BIOMEDICAL ENGINEERING | Award Amount: 349.68K | Year: 2015

PI: Price, Elmer M.
Proposal Number: 1511928

Recent evidence indicates that there exist locations in the adult brain that constantly generate new cells that migrate into specific regions involved in olfaction, memory and learning. This project aims to provide new information regarding the mechanisms that are responsible for this important and complex process. The PI also plans to use this knowledge to bioengineer structures which, when implanted into brain, will form new migratory paths that will deliberately target new neurons into specific regions of the brain. When delivered to areas impacted by injury or disease, these new neurons are anticipated to restore lost function.

During adult neurogenesis, a large number of molecules participate in complex signaling, which requires precise spatial and temporal control. Although several of these neurotrophic ligands and cognate receptors have been identified, many questions remain regarding the molecular mechanisms by which these components function. The goals of this project are to characterize the mechanism by which specific factors mediate neurogenesis using an in vitro system and then use this information to bioengineer cylindrical fibrin-based implants which will generate new neural migratory paths in vivo. The project involves in vitro and complementary in vivo aims. The premise of the in vitro studies is that neural stem cells receive neurotrophic signals in a particular order and one role of each ligand is to induce the expression of the receptor for the next ligand. The in vivo experiments will exploit novel, readily bioengineered fibrin cylinders that will be implanted into the brain in order to recruit endogenous neural progenitor cells from their usual niche and target them into non-neurogenic regions. The project will use time-lapse microscopy, fluorescence microscopy, immunochemistry, and animal behavioral studies to accomplish the aims. Undergraduate researchers will participate in this research through a program dubbed FIRE (Full Immersion Research Experience), where the students will be involved in all aspects of a research program, including literature evaluation, grant writing, technical and presentation skill development, and preparation for graduate school application.

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