Istanbul, Turkey
Istanbul, Turkey

Marmara University is a public university in the Fatih district of Istanbul, in Turkey. Marmara University has succeeded in becoming the second largest university in the country. The university's mission is to impart and promote knowledge and values consistent with universal standards; to meet the technological, social and cultural challenges of a global society; to contribute to the creation of an informed society, which learns about and shares this knowledge and values; and to emphasize the European dimension in the delivery of education opportunities. The rector of Marmara University is Prof. Dr. M. Zafer Gül who has held this position since July 2010. Wikipedia.


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Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FoF-08-2015 | Award Amount: 4.15M | Year: 2015

The rise of the system complexity, the rapid changing of consumers demand require the European industry to produce more customized products with a better use of resources. The main objective of IMPROVE is to create a virtual Factory of the Future, which provides services for user support, especially on optimization and monitoring. By monitoring anomalous behaviour will be detected before it leads to a breakdown. Thereby, anomalous behaviour is detected automatically by comparing sensor observation with an automatically generated model, learned out of observations. Learned models will be complemented with expert knowledge because models cannot learn completely. This will ensure and establish a cheap and accurate model creation instead of manual modelling. Optimization will be performed and results will be verified through simulations. Therefore, the operator has a broad decision basis as well as a suggestion of a DSS (Decision Support System), which will improve the manufacturing system. Operator interaction will be done by a new developed HMI (Human Machine Interface) providing the huge amount of data in a reliable manner. To reach this aim, every step of the research process is covered by a minimum of two experienced consortium partners, who conclude the results of the project using four demonstrators. The basis for IMPROVE are industrial use-cases, which are transferable to various industrial sectors. Main challenges are reducing ramp-up phases, optimizing production plants to increase the cost-efficiency, reducing time to production with condition monitoring techniques and optimise supply chains including holistic data. Consequently, the resource consumption, especially the energy consumption in manufacturing activities, can be reduced. The optimized plants and supply chains enhance the productivity of the manufacturing during different phases of production. Furthermore, the industrial competitiveness and sustainability in EU will be strengthened.


The weld strength of thermoplastics, such as high density polyethylene and polyprophylene sheets are influenced by friction stir welding parameters. The determination of the welding parameters plays an important role for the weld strength. For the influential use of the thermoplastics joints, the weld should have adequate strength. The quality of the joint was evaluated by examining the characteristics of the joint efficiency as a result of ultimate tensile strength. In this study, the Taguchi approach of parameter design was used as a statistical design of experiment technique to set the optimal welding parameters. The experiments were arranged by using Taguchi's L9 orthogonal array. The signal-to-noise ratio and the analysis of variance were utilized to obtain the influence of the friction stir welding parameters on the weld strength. Finally, the results were confirmed by further experiments. © 2011 Elsevier Ltd.


Background: Non-alcoholic fatty liver disease (NAFLD) is currently conceptualised as a clinical spectrum that results from a 'multiple-hit' process which begins with simple steatosis and subsequently renders the hepatocytes susceptible to a variety of insults. Ultimately, more serious liver injuries like non-alcoholic steatohepatitis (NASH) and cirrhosis may develop. Although the metabolic syndrome is considered the crucial player in the pathogenesis of NAFLD, recent studies have highlighted novel pathophysiological mechanisms in this clinical entity. Aim: To discuss the pathophysiology of NAFLD based on the hypothesis that simple steatosis and NASH are discrete entities rather than two points on a spectrum. Methods: A literature search was conducted in August 2012 on PubMed, Ovid Embase, Ovid Medline and Scopus using the following search terms: steatosis, non-alcoholic steatohepatitis, pathophysiology, fatty liver, natural history and genetics. Results: Simple steatosis and NASH appear as two distinct pathophysiological entities and progression from pure fatty liver to NASH appears to be so rare as to warrant publication. The possible pathogenetic pathways specifically related to NASH are highlighted. Conclusions: Although simple steatosis and non-alcoholic steatohepatitis are currently viewed as two histological subtypes of the unique spectrum of non-alcoholic fatty liver disease, the two conditions are likely distinct not only from a histological but also from a pathophysiological standpoint. Efforts to distinguish simple steatosis from non-alcoholic steatohepatitis using non-invasive modalities should be informed by the current pathophysiology of these two clinical entities. © 2012 Blackwell Publishing Ltd.


Yavuz I.,Marmara University
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2013

We theoretically investigate the boosts in high-order harmonic generation using fabricated nanostructures and determine that the distribution of an ensemble of gas atoms in the vicinity of nanostructures is substantial for the evaluation of harmonic emission. The distributional behavior is mimicked by a single-atom response as well as by allowing the target atoms to reside in different positions inside the nanogap. For a given population distribution, a maximum photon energy of ∼25 eV could be observed in qualitative agreement with experiment. © 2013 American Physical Society.


Yilmaz Y.,Marmara University
Alimentary Pharmacology and Therapeutics | Year: 2012

Background The role of excess fructose intake in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) has recently received increasing attention, but the pathophysiology of this relationship has been only partly elucidated. Aim To provide an overview of the potential role played by fructose in the pathogenesis of NAFLD by focusing on both indirect and direct harmful effects. Methods Experimental and clinical studies which investigated the relation of fructose with NAFLD are reviewed. Results Several factors may potentially contribute to fructose-induced NAFLD, including the induction of the metabolic syndrome, copper deficiency, bacterial translocation from the gut to the liver, the formation of advanced glycation endproducts and a direct dysmetabolic effect on liver enzymes. Conclusions Experimentally-increased fructose intake recapitulates many of the pathophysiological characteristics of the metabolic syndrome in humans, which may in turn lead to NAFLD. However, the majority of experimental studies tend to involve feeding excessively high levels of fructose (60-70% of total energy intake) which is not reflective of average human intake. Hopefully, the combination of in vivo, in vitro and genetic research will provide substantial mechanistic evidence into the role of fructose in NAFLD development and its complications. © 2012 Blackwell Publishing Ltd.


Yavuz I.,Marmara University
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2012

We address an efficient scheme to generate a broadband extreme-ultraviolet (xuv) continuum from high-order harmonic generation emerging from the concept of plasmonic field enhancement in the vicinity of metallic nanostructures. Based on the numerical solution of a time-dependent Schrödinger equation, for moderate field intensities and depending on the inhomogeneity of the field, we are able to increase the plateau region roughly by a factor of two and generate a broadband xuv continuum. The underlying physics of the plasmon enhancement in harmonic generation is investigated in terms of the semiclassical trajectories of strong field-electron dynamics, and perfect consistency is found between quantum mechanical simulations. It is found that the field inhomogeneity plays a critical role in quantum path selection. After a critical value, we observe a systematic suppression in the long trajectories, suggesting the generation of a single isolated attosecond pulse. Finally, we investigate the dependence of cutoff position on the order of field inhomogeneity and find a β2.3 0.2 scaling. © 2012 American Physical Society.


In the present study, hazelnut (Corylus avellana L.) kernel oil was transesterified with methanol using potassium hydroxide as catalyst to obtain biodiesel and a comprehensive experimental investigation of combustion (cylinder gas pressure, rate of pressure rise, ignition delay) and heat release (rate of heat release, cumulative heat release, combustion duration and center of heat release) parameters of a direct injection compression ignition engine running with biodiesel and its blends with diesel fuel was carried out. Experiment parameters included the percentage of biodiesel in the blend, engine load, injection timing, injection pressure, and compression ratio. Results showed that hazelnut kernel oil methyl ester and its blends with diesel fuel can be used in the engine without any modification and undesirable combustion and heat release characteristics were not observed. The modifications such as increasing of injection timing, compression ratio, and injection pressure provided significant improvement in combustion and heat release characteristics. © 2009 Elsevier Ltd. All rights reserved.


In this study, the effects of methanol-diesel (M5, M10) and ethanol-diesel (E5, E10) fuel blends on the performance and exhaust emissions were experimentally investigated. For this work, a single cylinder, four-stroke, direct injection, naturally aspirated diesel engine was used. The tests were performed by varying the engine speed between 1000 and 1800 rpm while keeping the engine torque at 30 Nm. The results showed that brake specific fuel consumption and emissions of nitrogen oxides increased while brake thermal efficiency, smoke opacity, emissions of carbon monoxide and total hydrocarbon decreased with methanol-diesel and ethanol-diesel fuel blends. © 2010 Elsevier Ltd. All rights reserved.


Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that have been associated with an increased risk of developing nonalcoholic fatty liver disease (NAFLD). Insulin resistance and central obesity are the key components of MetS, ultimately leading to liver fat accumulation and the subsequent development of necroinflammatory liver injury. However, the origin and nature of the metabolic stressors responsible for stimulating the progression of simple steatosis to nonalcoholic steatohepatitis (NASH) remain to be clearly identified. In addition, epidemiologic research on the association between MetS and NAFLD has provided only limited information to guide the development of targeted interventions, in particular, nutrition and pharmacologic prevention programs. This review summarizes the evidence supporting the proposal that NAFLD is not invariably associated with the presence of MetS, and mechanisms other than insulin resistance may contribute to the chronic inflammatory processes that underpin the development of liver fat accumulation and the subsequent architectural distortion of the liver. A special focus is given to increased hemoglobin as a risk factor for the development of NAFLD in the absence of MetS. © 2012 by Thieme Medical Publishers, Inc.


Yilmaz Y.,Marmara University
Alimentary Pharmacology and Therapeutics | Year: 2012

Background Low bone mineral density (BMD) has been reported in both paediatric and adult patients with non-alcoholic fatty liver disease (NAFLD). The mechanisms behind the reduced BMD in NAFLD are still not completely understood. Aim To provide a critical overview of the pathophysiological pathways linking NAFLD, reduced BMD and osteoporosis, with a special focus on the alterations of soluble mediators which could link fat accumulation in the liver with bone health. The MEDLINE database was searched by a combination of keywords: non-alcoholic fatty liver disease OR hepatic steatosis OR metabolic syndrome OR insulin resistance AND bone mineral density OR osteoporosis OR bone AND biomarkers OR serum marker. Results Several factors that may influence bone mineralisation and the increased risk of osteoporosis in NAFLD can be discussed. These include the release of cytokines from the inflamed liver which may influence the bone microenvironment, vitamin D deficiency, and limited physical activity. Circulating markers of bone metabolism, including osteopontin, osteoprotegerin, osteocalcin and fetuin-A, have been found to be altered in patients with NAFLD. Conclusion A better understanding of the mechanisms that link bone metabolism and the liver may open a new frontier to fight two highly prevalent conditions like NAFLD and osteoporosis. © 2012 Blackwell Publishing Ltd.

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