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Nemes R.-M.,Marius Nasta Institute of Pulmonology | Postolache P.,Grigore T. Popa University of Medicine and Pharmacy | Olaru M.,Constantin Brancusi University | Todea D.,University of Medicine and Pharmacy, Cluj-Napoca | Cojocaru D.-C.,Grigore T. Popa University of Medicine and Pharmacy
2013 E-Health and Bioengineering Conference, EHB 2013 | Year: 2013

Chronic obstructive pulmonary disease (COPD) currently occupies sixth place in the list of morbidity causes in the world adult population and is catching third in 2020; smoking is the most important cause. COPD mortality reaches 200-300%ooo for the age group 45-64 years, 6% of deaths in men and 4% of deaths in women. Mortality from the disease is increasing at 3rd place in 2020, the disease having higher mortality statistics as expected. Positive diagnosis of COPD is given by objectifying functional bronchial obstruction by performing spirometry in a patient who is smoker or exposed to pollutants. Investigation of the respiratory function in patients with COPD is essential. Spirometry is considered to be the most reproducible, inexpensive, and the routine test for measuring airflow limitation. © 2013 IEEE.


Postolache P.,Grigore T. Popa University of Medicine and Pharmacy | Cojocaru D.-C.,Grigore T. Popa University of Medicine and Pharmacy | Olaru M.,Constantin Brancusi University | Todea D.,University of Medicine and Pharmacy, Cluj-Napoca | Nemes R.-M.,Marius Nasta Institute of Pulmonology
2013 E-Health and Bioengineering Conference, EHB 2013 | Year: 2013

Smoking is a major public health problem with medical, social, and financial implications. We conducted a retrospective analysis of data resulting from enrollment and completion of a smoking cessation program of a number of 399 subjects of both gender, who presented consecutively in 2009 to the Smoking Cessation Counseling Medical Office of the Iasi Clinical Rehabilitation Hospital. The treatment for smoking cessation was represented either by bupropion or varenicline, administered by the usual scheme. Smoking severity was quantified by pack - years, determining the carbon monoxide in the exhaled air, both at baseline and at the end of the treatment period, and by Fagerström test for nicotine dependence. In female patients, the severity of smoking was significantly lower (P = 0.000) but their male counterparts responded better to treatment. Also, varenicline seemed to have a stronger therapeutic effect then bupropion while their adverse effects were similar. © 2013 IEEE.


Nemes R.M.,Marius Nasta Institute of Pulmonology | Ianosi E.S.,University of Medicine and Pharmacy of Targu Mures | Pop C.S.,University of Bucharest | Postolache P.,Grigore T. Popa University of Medicine and Pharmacy | And 4 more authors.
Romanian Journal of Morphology and Embryology | Year: 2015

Tuberculosis (TB) of the tongue is not a common finding diagnosis, even if consider endemic areas. Tuberculosis of the tongue sometimes can mimic lingual neoplasm. Oral tuberculosis is rarely primary as mechanism, and frequently secondary to pulmonary tuberculosis. There are many suspect lesions that can be classified as tuberculosis, such as tumor mass, ulcerative lesion or fissure. It is very important for diagnosis to perform histopathological examination of the biopsy. We present here the case of a 74-year-old man who developed lingual tuberculosis with a tumor aspect concomitant with pulmonary tuberculosis. Histopathological and immunohistochemical examinations established the diagnosis of lingual tuberculosis. © 2015, Editura Academiei Romane. All rights reserved.


Bumbacea R.S.,Dermatology and Allergology Clinic | Bumbacea R.S.,Carol Davila University of Medicine and Pharmacy | Petrutescu B.,Dermatology and Allergology Clinic | Bumbacea D.,Carol Davila University of Medicine and Pharmacy | And 2 more authors.
Pneumologia | Year: 2013

Used since 1929 in medical practice, nowadays four chemical varieties of intravascular iodine based radiocontrast media (I-RCM) are available: ionic monomers with high osmolarity, ionic dimers with low osmolarity, non-ionic monomers with low osmolarity and non-ionic iso-osmolar dimers. Increasing prescription of I-RCMs augments the number of reported hypersensitivity reactions. I-RCM induced hypersensitivity reactions can be clasified in two types: immediate hypersensitivity reactions (IHRs - occurring within the first hour) and delayed hypersensitivity reactions (DHRs - occurring between 1 hour and 7 days). IHRs usually present as urticaria and angioedema but may associate severe respiratory and cardiovascular symptoms. Risk factors for an IHRs include a prior immediate reaction, personal history of atopic diseases (mainly asthma) and treatment with beta blocking agents. Diagnostic tests for IHRs include blood tests (serum tryptase) and skin tests (prick and intradermal) performed 2 to 6 months after IHR. High osmolarity of the I-RCM is the factor most strongly associated with IHRs. Primary prevention of IHRs involves the use of non-ionic low-osmolar or iso-osmolar agents for all intravascular procedures. DHRs are usually mild to moderate in severity, transient and self-limiting, presenting as maculopapular rash in more than 50% of cases. As with IHRs, the most important risk factor for DHRs is a previous reaction to I-RCM. Assessment of DHRs includes skin prick tests, intradermal and patch tests. Due to extensive cross-reactivity between I-RCM, a change of product is no guarantee against a repeated reaction. Current premedication procedures in patients with previous severe reactions can reduce symptoms, but may not prevent recurrent reactions.


Migliori G.B.,Care and Research Institute | Zellweger J.P.,Competence Center | Abubakar I.,Public Health England | Ibraim E.,Marius Nasta Institute of Pulmonology | And 30 more authors.
European Respiratory Journal | Year: 2012

The European Centre for Disease Prevention and Control (ECDC) and the European Respiratory Society (ERS) jointly developed European Union Standards for Tuberculosis Care (ESTC) aimed at providing European Union (EU)-tailored standards for the diagnosis, treatment and prevention of tuberculosis (TB). The International Standards for TB Care (ISTC) were developed in the global context and are not always adapted to the EU setting and practices. The majority of EU countries have the resources and capacity to implement higher standards to further secure quality TB diagnosis, treatment and prevention. On this basis, the ESTC were developed as standards specifically tailored to the EU setting. A panel of 30 international experts, led by a writing group and the ERS and ECDC, identified and developed the 21 ESTC in the areas of diagnosis, treatment, HIV and comorbid conditions, and public health and prevention. The ISTCs formed the basis for the 21 standards, upon which additional EU adaptations and supplements were developed. These patient-centred standards are targeted to clinicians and public health workers, providing an easy-to-use resource, guiding through all required activities to ensure optimal diagnosis, treatment and prevention of TB. These will support EU health programmes to identify and develop optimal procedures for TB care, control and elimination.

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