University of Bari and Marche Polytechnic University | Date: 2016-04-14
Object of the present invention is the use of Irisin for the treatment and/or prevention of osteoporosis. In particular, the present invention refers to the use of recombinant irisin for the treatment and/or prevention of osteoporosis.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC5-07-2015 | Award Amount: 6.65M | Year: 2016
The project MERCES is focused on the restoration of different degraded marine habitats, with the aim of: 1) assessing the potential of different technologies and approaches; 2) quantifying the returns in terms of ecosystems services and their socio-economic impacts; 3) defining the legal-policy and governance frameworks needed to optimize the effectiveness of the different restoration approaches. Specific aims include: a) improving existing, and developing new, restoration actions of degraded marine habitats; b) increasing the adaptation of EU degraded marine habitats to global change; c) enhancing marine ecosystem resilience and services; d) conducting cost-benefit analyses for marine restoration measures; e) creating new industrial targets and opportunities. To achieve these objectives MERCES created a multi-disciplinary consortium with skills in marine ecology, restoration, law, policy and governance, socio-economics, knowledge transfer, dissemination and communication. MERCES will start from the inventory of EU degraded marine habitats (WP1), conduct pilot restoration experiments (WP2, WP3, WP4), assess the effects of restoration on ecosystem services (WP5). The legal, policy and governance outputs will make effective the potential of marine restoration (WP6) and one dedicated WP will assess the socio-economic returns of marine ecosystems restoration (WP7). The transfer of knowledge and the links with the industrial stakeholders will be the focus of WP8. The results of MERCES will be disseminated to the widest audience (WP9). The project will be managed through a dedicated management office (WP10). MERCES will contribute to the Blue Growth by: i) improving the EU scientific knowledge on marine restoration, ii) contributing to EU Marine Directives; iii) implementing the Restoration Agenda, iv) enhancing the industrial capacity in this field, v) increasing the competitiveness of EU in the world market of restoration, and vi) offering new employment opportunities.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-14-2015 | Award Amount: 5.78M | Year: 2016
Asbestos is one of the major occupational carcinogens. The European Union has an extensive history of protecting workers and consumers against asbestos and even adopted a resolution 2012/2065(INI) on asbestos related occupational health threats and prospects for abolishing all existing asbestos last year. Although asbestos is banned, it is still massively present in the built environment. Millions of workers & consumers in the EU were, and still are, for many years exposed to asbestos fibres, despite all measures. Inhalation of even very low quantities of asbestos fibres tremendously increases the risk of developing Malignant Mesothelioma (MM). The IARC reported 8.100 MM deaths in 2010 in the EU. Despite all EU actions, MM incidence is still increasing. MM is a highly fatal disease with a poor median survival time from first signs of illness to death around 12 months despite aggressive treatments. To date there is no curative therapy for MM. MM is considered as an extremely therapy-resistant disease. Chemotherapy consisting of a combination of pemetrexed and cisplatin is considered standard of care with a median survival increase of 3 months (9-12 months). The department of pulmonary diseases of the Erasmus MC, Rotterdam, The Netherlands, in collaboration with international partners, have developed a promising personalised immunotherapy for MM with very limited adverse effects. The first clinical results show a considerably prolonged average survival with limited adverse events (24 months, twice as long). The EMA and the FDA granted this therapy Orphan Designation: autologous dendritic cells pulsed with allogeneic tumour cell lysate for the treatment of malignant mesothelioma (EU: 16 January 2014 - EU/3/13/1229; FDA US: 06 May 2014). The objective for the project is to deliver the scientific & registration package for market approval by the EMA of a novel immuno therapeutic approach to treat MM. This includes the execution of a phase II/III clinical trial.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-05-2015 | Award Amount: 5.14M | Year: 2016
The main objective of GoodBerry is to provide the necessary knowledge and procedures to facilitate the development of highly productive and top quality berry fruits, even under multiple suboptimal growth conditions, at a competitive cost. The project is based on an integrative multi-actor approach, from cultivation techniques to molecular studies, aiming the development and validation of a range of tools to improve competitiveness of European berry production, and eventually the attraction and confidence of consumers. The selection of the model species can be considered as strategic since strawberry is the most important berry crop in Europe and the production of raspberry and blackcurrant are increasing strongly in recent years. The project will apply the most recent technical advances in: a) The identification of berry germplasm exhibiting advantageous balance of production vs nutritional quality throughout the EU, b) The search of innovative production systems to maintain high yield in a range of European-wide environments, c) The development of standardized and reliable analytical tools to evaluate berry production and fruit quality. As result, it is expected: a) the implementation of modern breeding strategies to accelerate the release of new berry cultivars; b) The adoption by EU-growers of high quality production systems to improve fruit quality. The proposal establishes as obligatory to disseminate and communicate the results to the scientific community, industry, the broad public and interested stakeholders user. The final impact will be to consolidate the emerging needs of high-quality berries, and to boost consumer and market confidence supported by an improved competitiveness of producers. It is a multidisciplinary, collaborative project based on complementary expertise and skills of internationally recognized berry research institutions, and highly involved key berry SMEs that will combine their effort to secure the robustness of the results.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-01c-2015 | Award Amount: 7.00M | Year: 2016
iSAGE will enhance the sustainability, competitiveness and resilience of the European Sheep and Goat sectors through collaboration between industry and research. iSAGE have a powerful consortium with 18 industry representatives from various EU production systems and socio-economic contexts. The sheep and goat sector will be investigated because it is sensitive to general socio-economic, demographic, and ecological and market challenges; nevertheless, the projects approach and results will be made available and disseminated to other EU livestock industries. Therefore, at the core of iSAGE is a participatory approach centered on a multi-actor internal and external communication (WP) to build the project from the farmer level. This approach will ensure relevant issues are addressed and the project outcomes are applicable in practice and create a farm-level observatory and knowledge exchange network on the sustainability of livestock. This WP will also assist three assessment work packages that will deal with the sustainability assessment of sheep and goat farm systems and related supply chains, with socio-economic demographic and consumer trend analyses, and with the impacts of climate change. Assessment WPs will inform action WPs that will: (1) redesign holistic farming systems to best reconcile the various demands concerning productivity, sustainability and societal values. (2) identify industry solutions that aim to improve sustainability and productivity of sheep and goat systems through breeding, including new phenotypes linked to sustainable animal productivity. iSAGE, together with stakeholders and end-users, will draft a roadmap for further research and policy making. The stakeholder groups will be the key players in disseminating project outputs through case studies and demonstrations to act as a blueprint to other producers across Europe and create networks to assist wider implementation of iSAGE outputs.
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: FETOPEN-02-2016 | Award Amount: 670.00K | Year: 2017
This FET-open Coordination and Support Action is called Nanoarchitectronics (NTX) to denote a new interdisciplinary research area at the crossroad of Electromagnetics and Nanoelectronics. NTX It is a new technology aimed at conceiving, designing and developing reconfigurable, adaptive and cognitive structures, sensorial surfaces and functional skins with unique physical properties, and engineering applications in the whole electromagnetic spectrum; through assembling building blocks at nanoscale in hierarchical architectures. The conception of this new area responds to the need of unifying concepts, methodologies and technologies in Communications, Environment Sensing Systems, Safety and Security, Bio-Sensing Systems and Imaging Nanosystems, within a wide frequency range. This FET project proposal gathers thirteen universities, research centers and high-tech industries, belonging to eight European countries. According to the FET work-program, the major objective of Nanoarchitectronics is to boost the future application-driven research through the establishment of an accepted language among physicists and engineers, a shared way of thinking, a common theoretical foundation and a common strategy for the future. Therefore, the project aims at laying the foundation for an ever-increasing synergy and progress of Nanoarchitectronics. To achieve these objectives, Nanoarchitectronics is structured in four main activities. The Concept activity is devoted to establish and define the concepts of Nanoarchitectronics and its boundaries with respect to other disciplines and to the activity carried out by other consortia. The Strategy activity identifies the policy dialogue and the strategic view of the consortium in terms of position, impact and vision. The Virtual Networking serves to internal web communication (private), and for dissemination (public). The Dissemination and Exploitation activity is carried out mainly by the industrial partners of the consortium
Agency: European Commission | Branch: H2020 | Program: IA | Phase: FOF-03-2016 | Award Amount: 5.03M | Year: 2016
Multi-stage manufacturing, which is typical in important industrial sectors such as automotive, house hold appliance and semiconductor manufacturing just to name few, is inherently complex. The main idea of GO0D MAN project is to integrate and combine process and quality control for a multi stage manufacturing production into a distributed system architecture built on agent-based Cyber-Physical Systems (CPS) and smart inspection tools designed to support Zero-Defect Manufacturing (ZDM) strategies. Data analytics tools provide a mean for knowledge build-up, system control and ZDM management. Real time and early identification of deviations and trends, performed at local level, allow to prevent the generation of defects at single stage and their propagation to down-stream processes, enabling the global system to be predictive (early detection of process faults) and proactive (self-adaptation to different conditions). The GO0D MAN project is based on the results of previous successful EU projects and integrates them to realize and deploy a Zero Defect Manufacturing framework for multi-stage production lines, in collaboration with industry partners, a system integrator, two technology providers and three end users. The use cases are representative of key European industrial sectors and have different types of multi-stage production systems: the first use case concerns highly automated serial mass production of automotive components, the second use case is about batch production of high precision mechanical components for automotive electro valves, the third use case produces professional customized products such as ovens for restaurants. Successful completion of this project will provide a replicable system architecture for ZDM. The results will be broadly applicable in a variety of industries to improve the overall quality and productivity of production systems.
Agency: European Commission | Branch: H2020 | Program: IA | Phase: EE-10-2016 | Award Amount: 5.32M | Year: 2016
P2Endure aims to provide scalable, adaptable and ready-to-implement prefabricated Plug-and-Play (PnP) systems for deep renovation of building envelopes and technical systems. These innovative solutions will be used to transform non-functioning or sub-optimal public and historic buildings into dwellings, and applicable for the widest range of building typologies, i.e. public buildings, residential buildings, and transformation projects. The main innovation of P2Endure comprises PnP prefab systems enabled by 3D printing, laser and thermal scanning integrated with Building Information Model (BIM). The promoted solutions are SME-driven and geared to rapid and low-disturbance on-site assembly processes for deep renovation. P2Endure presents a proof-of-performance of the optimised PnP renovation techniques by implementing 10 large-scale and live demonstration projects that represent the main deep renovation typologies and real market demand in 4 EU geo-clusters. This will be done through progressive steps known as 4M: Mapping Modelling Making Monitoring throughout a 4-year project duration. These demonstration cases give evidence of the achieved 60% energy saving after deep renovation along with 15% cost saving and 50% time saving at renovation, and high indoor environmental quality. The P2Endure project leverage in total primary energy saved is: 19.121 GWh/y. Wider impacts on replication and market upscaling are guaranteed by a Technology Commercialization Platform (TCP). On this platform P2Endure builds up a critical mass of building owners and their projects, local authorities, supply-chain actors, including leading industrial players in prefab building and technical systems that provide the necessary vehicle for innovative SMEs to enlarge their EU and global market shares through P2Endure solutions.
Agency: European Commission | Branch: H2020 | Program: IA | Phase: EEB-01-2016 | Award Amount: 6.68M | Year: 2016
We will validate an affordable (28% reduction of total costs) and lightweight (35% weight reduction) solution for envelope insulation to bring existing curtain wall buildings to nearly zero energy standards while complying with the structural limits of the original building structure and national building codes. Two key commercial insulating products: Highly insulating mono-component and environmentally friendly spray foam, EENSULATE foam, for the cost-effective automated manufacturing and insulation of the opaque components of curtain walls as well as for the significant reduction of thermal bridges during installation (SELENA and EVONIK in cooperation with ULSTER); Lightweight and thin double pane vacuum glass, EENSULATE glass, for the insulation of the transparent component of curtain walls, manufactured through an innovative low temperature process using polymeric flexible adhesives and distributed getter technology, thus allowing to use both annealed and tempered glass as well as low emissivity coatings (AGC, SAES and TVITEC in cooperation with ULSTER and UNIVPM ). A multi-functional thermo-tunable coating will allow for dynamic solar gain control as well as anti-fogging and self-cleaning properties (AGC in cooperation with UCL). They will enable insulating solutions that Focchi, DAPP and Unstudio will promote with two different levels of performance: EENSULATE Basic curtain wall modules where the thermal and acoustic insulation will be provided by the novel EENSULATE glass and EENSULATE foam in the spandrel combined with state of the art low-e coated glass; EENSULATE Premium modules integrating the thermo-chromic coated glass with additional self-cleaning and anti-fogging functionalities. BGTEC will exploit the limited thickness and high insulating properties of the EENSULATE glass to introduce in their range innovative solutions for the fenestration challenges in historical buildings, compatible with the original window frames and sash designs.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETOPEN-1-2014 | Award Amount: 2.92M | Year: 2016
This project is at the intersection of photonics, RF signal processing and phononics, aiming to achieve an all-optical phononic circuit using coherent phonons as the state variable. The concept is based on cavity optomechanics (OM) to develop GHz- frequency in-chip phononic circuits for room temperature operation. The circuits will integrate OM-pumped phonon sources and detectors as well as phonon processing components (waveguides, splitters, memories, photonic RF signal processing) to process information with phonons outside the cavity. The project seeks to prove two concepts. One is the efficient generation of GHz to tens of GHz coherent phonons, coupling them efficiently into a waveguide, engineering their propagation with low losses and detecting them at room temperature. The other is the synchronisation of two or more self-sustained OM cavities, which relies on the integration of several phononic components. Phonon-based processing will enable on-chip synchronisation and transfer of information carried between optical channels by phonons, which could eventually serve as a future scalable platform for, e.g., practical information processing with phonons. The technical work is organised in three work-packages: Theory, Components and Integration. The consortium is made up by three leading research institutes, three universities with an internationally recognised track-record in their respective areas of expertise and an industrial partner bringing their photonics, phononics, optomechanics, electrical engineering, integration, nanofabrication, theory, multi-physics/multi-scale modelling, instrumentation and application of detectors to the project.