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Tantradi P.,Maratha Mandals Ngh Institute Of Dental Science And Research Center | Sreenivasan V.,Subharati Dental College | Kadaganche H.,Vaidik Dental College
Indian Journal of Dental Research | Year: 2010

Context: Caries epidemiological studies based on clinical examination alone tend to underestimate proximal caries. Aims: This study aims to determine the additional value of radiographic examination (bitewings) compared to clinical examination in assessing posterior proximal caries. It also aims to determine the radiographic multiplication /adjusting / correction factors by which a clinical decayed surface (D-S) and decayed-missing-filled surfaces (DMFS) score could be multiplied, to obtain an actual D-S and DMFS score Materials and Methods: Two groups of 100 subjects each, in the age range of 16-20 years, were examined clinically for caries and their DMFS index recorded. Both groups were subjected to bitewing radiographs to detect the clinically undiagnosed posterior proximal caries. The radiographic adjusting factors were determined for group A. To check its repeatability and thus its usefulness, radiographic correction factor was determined for Group B. Statistical Analysis: The results were statistically analyzed with the use of means, standard deviations, regression equation and "Z" test. Level of significance was determined at P > 0.05. Results: A significant number of clinically undetected proximal caries was diagnosed with the help of bitewing radiographs. The difference between the radiographic adjusting/correction factor for D-S and DMFS score for the two groups was statistically not significant (P > 0.05) thus verifying the repeatability of the radiographic correction factors. Conclusion: The radiographic correction factors can be used to obtain a more precise estimate of true caries prevalence in a particular study population without having to subject all individuals to radiographic examination.


D'souza R.S.,Maratha Mandals Ngh Institute Of Dental Science And Research Center | Bhat K.G.,Maratha Mandals Ngh Institute Of Dental Science And Research Center | Sailaja D.,Gokaraju Rangaraju Institute of Engineering and Technology | Babji D.V.,Maratha Mandals Ngh Institute Of Dental Science And Research Center | And 2 more authors.
Journal of Clinical and Diagnostic Research | Year: 2013

Introduction: Toll-like receptors (TLRs) are an important component of immune system. Among them, TLR-2 plays a dominant role in the oral tissues in initiating inflammation in chronic periodontitis. Not many studies have been done on quantitative expression of TLR-2 by using immunofluorescent techniques (IFT) in oral tissues. In this study, the expression and localisation of TLR-2 were detected in gingival tissues of chronic periodontitis patients and healthy individuals. Material and Methods: Immuno Fluorescent Technique (IFT) was used for the expression and localization of TLR-2 in gingival tissue samples from 25 chronic periodontitis patients and from 25 healthy controls. Haematoxylin and Eosin staining was also done for all the samples to determine the histological characteristics of the gingival tissue samples. Result: Both healthy and periodontitis gingival tissues expressed TLR-2. We found that the expression level of TLR-2 was higher in all the periodontitis patients than in healthy individuals. We also found out that the expression of TLR-2 was higher in the epithelial cells than in the connective tissue cells. Conclusion: These data suggest a definite involvement of TLR-2 in initiating an inflammatory response in periodontal tissues. More studies are required to define the mechanisms and expression levels of TLR-2 in oral health and diseases.


Ajeesh Kumar A.K.,Anthem Biosciences Pvt. Ltd. and 49 | Nair K.B.,Anthem Biosciences Pvt. Ltd. and 49 | Bodke Y.D.,Kuvempu University | Sambasivam G.,Anthem Biosciences Pvt. Ltd. and 49 | Bhat K.G.,Maratha Mandals Ngh Institute Of Dental Science And Research Center
Monatshefte fur Chemie | Year: 2016

Abstract: A series of novel carboxamides, sulfonamides, ureas, and thioureas derived from 1,2,4-oxadiazol-3-ylmethyl-piperazin-1-yl substituted with pyrazolo[1,5-a]pyrimidine analog were designed and synthesized. The newly synthesized compounds were characterized by 1H NMR, 13C NMR, ESI–MS, and IR and were tested for their in vitro antiproliferative activity by MTT assay. Out of these twenty derivatives, five compounds showed good anticancer activity against HeLa cell line. These are superior with less than 10 µg/cm3 of IC50 when compared to the marketed anticancer drug paclitaxel with 30 µg/cm3 of IC50 against Hela cell line. Graphical abstract: [Figure not available: see fulltext.] © 2016 Springer-Verlag Wien


Nayak A.,Maratha Mandals Ngh Institute Of Dental Science And Research Center | Nayak R.,Maratha Mandals Ngh Institute Of Dental Science And Research Center | Bankur P.K.,Guru Gobind Singh Dental College
Journal of Clinical and Diagnostic Research | Year: 2015

Background: The dimensions of gingiva and different parts of the masticatory mucosa have become a subject of considerable interest in Periodontics. Studies assessing the thickness of the facial gingiva are often seen in the literature. The thickness of the palatal gingiva is a subject still less researched in periodontal therapy and implantology. Objectives: To measure the thickness of the palatal gingiva using an ultrasound device ‘Biometric A- Scan’ and to evaluate the variation in the thickness of the palatal gingiva at the sites examined. Materials and Methods: In the 50 subjects examined, the thickness of the palatal gingiva was assessed at the maxillary anteriors, premolars and molars by an ultrasound device ‘Biometric A-Scan’. The results were subjected to statistical analysis using one-way ANOVA test and Newman-Keuls multiple post hoc procedure. Results: Statistically significant variations existed in the palatal gingival thickness. The thickness was highest at the lateral incisor region, followed by canine, premolars, molars and central incisor. Interpretation and Conclusion: In the subjects assessed, the thickness of the palatal gingiva at the lateral–canine area was the highest followed by the premolar area. In periodontal root coverage procedures and during implant therapy, we suggest the inclusion of the lateral incisor area, apart from the canine and premolar area, as a potential donor site for harvesting soft tissue grafts from the palatal area. However, the effect of several factors like age and sex of the patient, the anatomy of the palatal area, the influence of rugae patterns and racial and geographical differences should be taken into consideration prior to harvesting a graft from these sites. Apart from this, the study suggests that, the ultrasonographic measurements provide an elegant means of obtaining the measurements of gingival and mucosal tissues rapidly, accurately and non-invasively. Our endeavour in this research project attempts to open more avenues for studies in the field of advanced periodontal diagnosis, with the use of ultrasound, and expand the horizons of periodontal plastic surgery and implant therapy as well. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.

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