Mar Thoma College

Tiruvalla, India

Mar Thoma College

Tiruvalla, India
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Anzar S.,Government Medical College | Koshy C.,Regional Cancer Center | Abraham K.M.,Mar Thoma College
Indian Journal of Palliative Care | Year: 2017

Objective: The Self-administered Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) is a 7-item self-report scale developed to identify pain which is of predominantly neuropathic origin. The aim of this study was to develop a Malayalam version of the LANSS and to test its validity and reliability in chronic pain patients. Methodology: We enrolled 101 Malayalam-speaking chronic pain patients who visited the Division of Palliative Medicine, Regional Cancer Centre, Thiruvananthapuram, Kerala, India. The translated version of S-LANSS was constructed by standard means. Fifty-one neuropathic pain and fifty nociceptive pain patients were identified by an independent pain physician and were subjected to the new pain scale by a palliative care nurse who was blinded to the diagnosis. The 'gold standard diagnosis' is what the physician makes after clinical examination. Its validation, sensitivity, specificity, and positive and negative predictive values were determined. Results: Fifty-one neuropathic pain and fifty nociceptive pain patients were subjected to the Malayalam version of S-LANSS pain scale for validity testing. The agreement by Cohen's Kappa 0.743, Chi-square test P < 0.001, sensitivity 89.58, specificity 84.91, positive predictive value 84.31, negative predictive value 90.00, accuracy by 87.13, and likelihood ratio 5.94. Conclusion: The Malayalam version of S-LANSS pain scale is a validated screening tool for identifying neuropathic pain in chronic pain patients in Malayalam-speaking regions. © 2017 Indian Journal of Palliative Care | Published by Wolters Kluwer - Medknow.


Mariamma K.C.,Mes College | Varghese H.T.,Fatima Mata National College | John K.,Mar Thoma College | Vinsova J.,Charles University | Van Alsenoy C.,University of Antwerp
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2013

The optimized molecular structure, vibrational frequencies and corresponding vibrational assignments of 5-Chloro-2-[4-(trifluoromethyl) phenylcarbamoyl]phenyl acetate have been investigated experimentally and theoretically using Gaussian09 software package. Potential energy distribution of the normal modes of the vibrations was done using GAR2PED program. The HOMO and LUMO analysis is used to determine the charge transfer within the molecule. The stability of the molecule arising from hyper conjugative interaction and charge delocalization have been analyzed using NBO analysis. The calculated geometrical parameters are in agreement with that of similar derivatives. The calculated first hyperpolarizability is comparable with the reported values of similar derivatives and is an attractive object for future studies of nonlinear optics. The red shift of the NH stretching wave number in the IR spectrum with a strong intensity from the computed wave number indicates the weakening of the NAH bond resulting in proton transfer to the neighboring oxygen. © 2013 Elsevier B.V. All rights reserved.


Varghese H.T.,Fatima Mata National College | Mariamma K.C.,M E S College | John K.,Mar Thoma College | Mathew S.,Mar Thoma College | And 3 more authors.
Journal of Raman Spectroscopy | Year: 2010

The Fourier transform Raman(FT-Raman)and Fourier transform infrared (FT-IR) spectraof2-[acetyl(4-bromophenyl)carbamoyl]-4-chlorophenyl acetate were studied. The vibrational wavenumbers were examined theoretically using the Gaussian03 set of quantum chemistry codes, and the normal modes were assigned by potential energy distribution (PED) calculations. The simultaneous Raman and infrared (IR) activations of the C=O stretching mode in the carbamoylmoiety show a charge transfer interaction through a π-conjugated path. From the optimized structure, it is clear that the hydrogen bonding decreases the double bond character of the C=O bond and increases the double bond character of the C-N bonds. The first hyperpolarizability and predicted IR intensities are reported. The calculated first hyperpolarizability is comparable with the reported values of similar structures, which makes this compound an attractive object for future studies of nonlinear optics.Optimized geometrical parameters of the compound are in agreement with similar reported structures. © 2009 John Wiley & Sons, Ltd.


PubMed | Armed Forces Medical College AFMC, Guru Gobind Singh Indraprastha University, Hindu Rao Hospital, Mar Thoma College and 4 more.
Type: Journal Article | Journal: Pregnancy hypertension | Year: 2016

Cell free fetal DNA (cffDNA) and its hypermethylated RASSF1A gene signify a recent advancement in non-invasive prenatal diagnosis of feto-placental anomalies like pre-eclampsia. The study uses hypermethylated RASSF1A gene to quantify cffDNA and to assess its relationship with placental and urine proteins in pre-eclampsia cases.DNA was isolated from plasma samples of clinically diagnosed cases of pre-eclampsia (n=103) and normal pregnancy (n=616) from 21weeks of gestation. Through methylation sensitive enzyme (BstUI) digestion; followed by real time-polymerase chain reaction (RT-PCR), quantification of hypermethylated RASSF1A was done. Immunoassays determined: placental protein-13 (pp-13) and pregnancy associated plasma protein A (PAPP-A) and pyrogallol red molybdate assay for 24h urine protein.Highly significant differences between control and pre-eclampsia cases for hypermethylated RASSF1A concentrations were found; Group I: 337.35 vs 74.4616.71, Group II: 53.7516.65 vs 244.2235.68, Group III: 93.2519.08 vs 412.3180.18, Group IV: 144.3018.13 vs 1056.89153.78, Group V: 307.5540.76 vs 2763.76259.76copies/ml. Multivariate Pearsons correlation analysis of hypermethylated RASSF1A with pp-13, PAPP-A and urine proteins showed positive and very highly significant (P<0.001) associations.Diagnostic potential of fetal specific, hypermethylated RASSF1A was evaluated. Its positive relationship with placental and urine proteins submit the case for considering it as a reliable marker for pre-eclampsia.


PubMed | Guru Gobind Singh Indraprastha University, Hindu Rao Hospital, Mar Thoma College, Institute of Nuclear Medicine and Allied Sciences and 2 more.
Type: | Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians | Year: 2016

To quantify cell free fetal DNA (cffDNA) with fetal specific epigenetic marker, hypermethylated RASSF1A, in maternal plasma of normal pregnant women from 20 weeks of gestation and to assess its relationship with maternal age, height, pre-pregnancy weight and body mass index (BMI).Hundred normal pregnant women within the gestational age of 21-40 weeks were randomly selected and grouped into five (n=20). Group 1: 21-24, Group 2: 25-28, Group 3: 29-32, Group 4: 33-36 and Group 5: 37-40 weeks. Maternal plasma DNA was extracted, digested with methylation-sensitive restriction enzyme, BstUI and the fetal specific DNA (cffDNA) was quantified by Real-time polymerase chain reaction (qRT-PCR).The mean hypermethylated RASSF1A concentrations in different gestational groups were Group 1: 30.114.9, Group 2: 52.622.18, Group 3: 93.219.08, Group 4: 172.826.81 and Group 5: 337.852.9 copies/ml. Pearsons correlation analysis showed highly significant positive correlation between cffDNA and gestational age (r=0.899, p<0.001). BMI was also found to be positively related to cffDNA (r=0.217, p<0.05). However, it did not show any correlation with maternal age, height and pre-pregnancy weight.The gestational age-dependent increase of hypermethylated RASSF1A; the fetal specific epigenetic marker in maternal plasma was demonstrated, in an Indian study group of normal pregnant women. Findings would form the basis of future studies involving pregnancy complications that would aid in the early diagnosis of placental pathologies with hypermethylated RASSF1A.


Parameswaranpillai J.,Cochin University of Science and Technology | Joseph G.,Cochin University of Science and Technology | Chellappan R.V.,Cochin University of Science and Technology | Zahakariah A.K.,Mar Thoma College | Hameed N.,Deakin University
Journal of Polymer Research | Year: 2015

Polypropylene (PP) and polystyrene (PS) blends were prepared by melt processing in a haake at 180 °C. PP/PS blends are immiscible and the blend morphologies were characterized by scanning electron microscopy. The viscoelastic properties were characterized using dynamic mechanical analysis (DMA) with reference to blend ratio. The blend morphologies such as matrix droplet and phase inverted morphologies were observed. The storage modulus of the blends increased with increase in PS content and the value was maximum for neat PS. DMA showed changes in the polystyrene glass transition temperatures (Tg) over the entire composition range. There was a sharp increase in the Tg of PS with increasing PP content in the blend and a 12 °C elevation in Tg was observed. The increase in Tg was explained by proposing a new model based on the physical interaction between the blend components. It is assumed that the different effects by the PP phase resulted in the formation of constrained PS chains leading to high Tg values. The addition of PP-g-MAH has a positive effect on the morphology, increases the storage modulus, and decreases the Tg till 80/20 blends. However, for PP/PS blends with higher concentrations of PS, the PP-g-MAH has little effect or adverse effect on the morphology, and storage modulus, but decreases the Tg. © 2015, Springer Science+Business Media Dordrecht.


Thomas R.,Mar Thoma College | Boudenne A.,University Paris Est Creteil | Ibos L.,University Paris Est Creteil | Candau Y.,University Paris Est Creteil | Thomas S.,Mahatma Gandhi University
Journal of Applied Polymer Science | Year: 2010

Thermal conductivity and diffusivity of carboxyl-terminated copolymer of polybutadiene and acrylonitrile (CTBN) and hydroxyl-terminated polybutadiene (HTPB) liquid rubber- modified epoxy blends were investigated. A good agreement was observed between the calculated values of the specific heat estimated from thermal conductivity, diffusivity, and density measurements and the DSC results. Measurements of the thermal conductivity values of HTPB/Epoxy blends were in good agreement with three simple theoretical models, which have been used thereafter for the estimation of the unknown value of the thermal conductivity of CTBN (kCTBN = 0.24 Wm-1K-1). The morphology of the rubber-modified epoxy blends has been quantified and indicate a tendency towards co-continuous phase upon the inclusion of higher weight percentage of rubber (-30 wt %). Moreover, we notice a significant enhancement of the thermal conductivity during this morphological shift. © 2010 Wiley Periodicals, Inc.


Kumar C.V.A.,Indian Institute of Space Science and Technology | Eapen S.,Mar Thoma College
Journal of Geophysical Research: Space Physics | Year: 2013

In this paper, we compare the local and global dynamics of total electron content (TEC) by analyzing Lyapunov exponents and correlation dimensions. The internal structure of the underlying system is studied using TEC data from the solar minimum years 2007-2008. The mutual information, false nearest neighbors, and space-time separation of both local and global snapshots are estimated and analyzed. It indicates that although the internal dynamics changes with season, the pattern of variation over the seasons remains identical for both the years, suggesting that the characteristics of these changes might be predictable. We report the evidence of a linear scaling with slope 0.00187 and a periodicity with period of 1 year on measures of global and local scale complexities of TEC dynamics. This behavior appears to be a universal phenomenon unaffected by change of cycles and amount of information influencing the complexity, since they are almost constant over the 2 years. The global Lyapunov exponent increases linearly over a year, whereas the local Lyapunov exponent increases up to the middle of the year, attains greatest local complexity, and then decreases. This suggests that local prediction is more reliable than the global one. The estimated invariants characterize the complex dynamics as it evolve from local time to global time and also provide information to the system's heterogeneity. The features such as presence of multiple attractors, linear scaling, and nearly regular seasonal periodicity may have practical consequences and could yield insights into the internal dynamics of TEC and the modeling of its variations. Key PointsEvidence of a novel scaling and periodicity of global and local complexitiesLyapunov exponent characterises complexity evolving from local to global in timePhenomenon are unaffected by change of cycles, amount of information © 2013. American Geophysical Union. All Rights Reserved.


Idicula M.,Mar Thoma College | Joseph K.,SB College | Thomas S.,Mahatma Gandhi University
Journal of Reinforced Plastics and Composites | Year: 2010

Short randomly oriented banana and sisal hybrid fiber reinforced polyester composites, banana/polyester composites and sisal/polyester composites were fabricated at different fiber loading say, 0.20 to 0.50 Vf. Composites were prepared by varying the relative volume fraction of the two fibers at each fiber loading. When the fiber loading was increased; tensile, flexural, and impact properties increased. Better performance was shown by composites having volume fraction, 0.40 Vf. Tensile strength, tensile modulus, flexural strength, and flexural modulus showed a positive hybrid effect when the volume ratio of the fiber was varied in the hybrid composites at each fiber loading. Maximum tensile strength was observed in composites having volume ratio of banana and sisal 3:1. When the volume ratio of sisal was increased, the impact strength of the composite increased. Different layering patterns were tried at 0.40 Vf, keeping the volume ratio of fibers 1:1. Tensile properties were slightly greater in the trilayer composite with banana as the skin material. Bilayer composites showed higher flexural and impact property. SEM studies were carried out to evaluate fiber/matrix interactions. Experimental results were compared with theoretical predictions. © 2010 SAGE Publications.


Thomas R.,Mar Thoma College | Sinturel C.,CNRS Center for Research on Divided Matter | Pionteck J.,Leibniz Institute of Polymer Research | Puliyalil H.,Mahatma Gandhi University | Thomas S.,Mahatma Gandhi University
Industrial and Engineering Chemistry Research | Year: 2012

The in-situ cure and cure kinetics of an epoxy resin based on diglycidyl ether of bisphenol A (DGEBA) polymerized with an anhydride hardener and its mixtures with a liquid polybutadiene rubber having hydroxyl functionality (HTPB) were studied using Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) in an isothermal mode. The cure reaction was monitored in-situ by FTIR spectroscopy by observing variation in intensity of epoxy, anhydride, and ester bands. The cure reaction mechanisms by which the network structure of epoxy was developed were discussed. Isothermal mode DSC measurements were performed at selected temperatures. The reaction followed an autocatalytic mechanism, and kinetic analysis was done by a phenomenological model developed by Kamal. Good fits were obtained between the autocatalytic model and the experimental data up to the vitrification state. Afterward, the reaction became diffusion controlled. The reaction during the later stages of cure was explained by introducing a diffusion factor, which agreed well with the kinetic data. The nature of the developing morphology of modified epoxies was analyzed by optical microscopy (OM) and small angle laser light scattering (SALLS) technique. The ultimate morphology of the cured blends was analyzed using scanning electron microscopy (SEM). The cure kinetics has been correlated with the developed morphology to get insight into the mechanism of reaction-induced microphase separation. © 2012 American Chemical Society.

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