PubMed | University Pompeu Fabra, Center for Research in Environmental Epidemiology, Polytechnic University of Catalonia and MAR Systems
Type: Journal Article | Journal: eNeuro | Year: 2016
Intellectual disability in Down syndrome (DS) is accompanied by altered neuro-architecture, deficient synaptic plasticity, and excitation-inhibition imbalance in critical brain regions for learning and memory. Recently, we have demonstrated beneficial effects of a combined treatment with green tea extract containing (-)-epigallocatechin-3-gallate (EGCG) and cognitive stimulation in young adult DS individuals. Although we could reproduce the cognitive-enhancing effects in mouse models, the underlying mechanisms of these beneficial effects are unknown. Here, we explored the effects of a combined therapy with environmental enrichment (EE) and EGCG in the Ts65Dn mouse model of DS at young age. Our results show that combined EE-EGCG treatment improved corticohippocampal-dependent learning and memory. Cognitive improvements were accompanied by a rescue of cornu ammonis 1 (CA1) dendritic spine density and a normalization of the proportion of excitatory and inhibitory synaptic markers in CA1 and dentate gyrus.
Reverter-Branchat G.,IMIM Hospital del Mar Medical Research Institute |
Bosch J.,IMIM Hospital del Mar Medical Research Institute |
Vall J.,IMIM Hospital del Mar Medical Research Institute |
Farre M.,MAR Systems |
And 8 more authors.
Clinical Chemistry | Year: 2016
BACKGROUND: Although it is being increasingly applied, blood collection for drug testing in sport presents some logistic issues that complicate full applicability on a large scale. The use of dried blood spots (DBS) could benefit compliant blood testing considerably owing to its simplicity, minimal invasiveness, analyte stability, and reduced costs. The aim of this study was to evaluate the applicability of DBS to the methodology approved by the World Anti-Doping Agency (WADA) for detection of doping by recombinant human growth hormone (rhGH) in serum. METHODS: A protocol for a single DBS analysis using the hGH isoforms differential immunoassays (kit 1 and kit 2) was developed and validated. A clinical study with healthy volunteers injected for 3 consecutive days with a low subcutaneous dose (0.027 mg · kg-1 · day-1 · person-1) of rhGH was conducted. Finger prick DBS and paired-time serum samples from arm venipuncture were compared. RESULTS: The analysis of the DBS-based protocol indicated that with only a single blood spot it was possible to detect positivity for growth hormone abuse. In spite of the low rhGH dose administered and independently of the kit used, the window of detection for DBS was confirmed in all analyzed samples up to 8 h after rhGH administration and extended up to 12 h in 50% of the cases. Serum positivity was detected in all studied samples for 12 h after administration. CONCLUSIONS: These results support the usefulness of DBS as a biological matrix for testing recent growth hormone abuse. © 2016 American Association for Clinical Chemistry.
MAR Systems | Date: 2016-01-14
Waterproofing system comprised primarily of waterproofing membranes for foundations of buildings and also including waterproofing chemical compositions for construction.
MAR Systems | Date: 2016-11-08
MAR Systems | Date: 2013-09-09
Chemicals for the treatment of water and wastewater; Chemicals for use in purification of water; Chemicals in the nature of sorbents; Mineral substances in the nature of sorbents; Waste water treatment chemicals for industrial use.
MAR Systems | Date: 2014-03-11
Techniques for reduction of copper from aqueous streams using an iron promoted activated alumina are disclosed. An adsorbent media composition that reduces copper levels in an aqueous feed stream includes an iron containing activated alumina. A process for reducing copper levels in an aqueous fluid using an iron promoted activated alumina sorption media includes contacting the aqueous fluid containing a copper contaminant with the iron promoted activated alumina to achieve reductions in copper from the aqueous fluid.
MAR Systems | Date: 2013-05-10
Sorption media for removal of contaminants from fluid streams are provided. The sorption media comprise an active compound bound or linked to a support substrate or matrix. Support substrates can include iron- and alumina-based materials. A method for making sorption media for the removal of contaminants from fluid streams is also described. The method includes selecting a support substrate, and, optionally, providing a doping mixture comprising an active compound. The selected support substrate can be contacted with the doping mixture to form a doped mixture. The doped mixture can be reacted at a predetermined temperature and atmospheric environment for a predetermined duration to form an active media, wherein the active compound is bound or linked to the support substrate.
MAR Systems | Date: 2015-07-17
A system for reducing a level of metallic contaminants from an aqueous stream is described, including at least one of an aluminum oxide sorption media and an ion exchange media (media 1) and a functionalized activated alumina media (media 2), wherein the system is configured to:
MAR Systems | Date: 2015-04-30
The invention relates to the proppants and proppant substrates treated with active compounds that reduce the presence of contaminants in fluids, methods of using those materials, as well as methods of making those materials. The invention further provides that the contaminated fluids are associated with wells, including oil and gas wells.