Yonovitz D.,MAR Systems |
Yonovitz A.,University of Montana
41st International Congress and Exposition on Noise Control Engineering 2012, INTER-NOISE 2012 | Year: 2012
In the United States hearing loss affects approximately 35 million people. Occupational noise exposure, the most common cause of noise-induced hearing loss fNIHL) is nearly 100 percent preventable. Estimates of compensation for NIHL are estimated at 20 billion dollars, making NIHL the costliest environmental and medical-legal problem in the United States. Technology may now be utilized to extend federal and state requirements for the preservation of hearing for those who are exposed to levels that may be injurious to hearing. While noise dosimetry has been routinely utilized to measure workplace exposure, the levels of noise exposure no longer should be predicted but actually measured from personal noise monitoring. Very compact devices with long battery life, high memory capacity to store over 3 months of daily exposure data, USB and automatic RF download capability have been implemented in a prototype device. The personal noise monitor records percentage of noise exposure integrated over a work day, decibel A-weighted levels, peak levels and the frequency spectrum of noise exposure. Signaling indicators to the wearer as well as acknowledgement of high exposure are part of the personal noise monitor. Trials have been very encouraging and will be reported. Source
MAR Systems | Date: 2015-07-17
A system for reducing a level of metallic contaminants from an aqueous stream is described, including at least one of an aluminum oxide sorption media and an ion exchange media (media
MAR Systems | Date: 2013-09-09
Chemicals for the treatment of water and wastewater; Chemicals for use in purification of water; Chemicals in the nature of sorbents; Mineral substances in the nature of sorbents; Waste water treatment chemicals for industrial use.
MAR Systems | Date: 2014-03-11
Techniques for reduction of copper from aqueous streams using an iron promoted activated alumina are disclosed. An adsorbent media composition that reduces copper levels in an aqueous feed stream includes an iron containing activated alumina. A process for reducing copper levels in an aqueous fluid using an iron promoted activated alumina sorption media includes contacting the aqueous fluid containing a copper contaminant with the iron promoted activated alumina to achieve reductions in copper from the aqueous fluid.
Vinals X.,University Pompeu Fabra |
Moreno E.,Research Center Biomedica en Red sobre Enfermedades Neurodegenerativas |
Moreno E.,University of Barcelona |
Lanfumey L.,University of Paris Descartes |
And 20 more authors.
PLoS Biology | Year: 2015
Activation of cannabinoid CB1 receptors (CB1R) by delta9-tetrahydrocannabinol (THC) produces a variety of negative effects with major consequences in cannabis users that constitute important drawbacks for the use of cannabinoids as therapeutic agents. For this reason, there is a tremendous medical interest in harnessing the beneficial effects of THC. Behavioral studies carried out in mice lacking 5-HT2A receptors (5-HT2AR) revealed a remarkable 5-HT2AR-dependent dissociation in the beneficial antinociceptive effects of THC and its detrimental amnesic properties. We found that specific effects of THC such as memory deficits, anxiolytic-like effects, and social interaction are under the control of 5- HT2AR, but its acute hypolocomotor, hypothermic, anxiogenic, and antinociceptive effects are not. In biochemical studies, we show that CB1R and 5-HT2AR form heteromers that are expressed and functionally active in specific brain regions involved in memory impairment. Remarkably, our functional data shows that costimulation of both receptors by agonists reduces cell signaling, antagonist binding to one receptor blocks signaling of the interacting receptor, and heteromer formation leads to a switch in G-protein coupling for 5-HT2AR from Gq to Gi proteins. Synthetic peptides with the sequence of transmembrane helices 5 and 6 of CB1R, fused to a cell-penetrating peptide, were able to disrupt receptor heteromerization in vivo, leading to a selective abrogation of memory impairments caused by exposure to THC. These data reveal a novel molecular mechanism for the functional interaction between CB1R and 5-HT2AR mediating cognitive impairment. CB1R-5-HT2AR heteromers are thus good targets to dissociate the cognitive deficits induced by THC from its beneficial antinociceptive properties. © 2015 Viñals et al. Source