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Thiruvananthapuram, India

Joseyphus R.S.,Mar Ivanios College Autonomous | Israr-Ul-Hassan,Dhofar University | Naikoo G.A.,Dhofar University
Asian Journal of Chemistry | Year: 2016

A series of cobalt(II), nickel(II), copper(II) and zinc(II) complexes were synthesized with a newly prepared Schiff base ligand. The ligand was prepared by the condensation of indole-3-carboxaldehyde with 2-amino-3-carboxyethyl-4,5-dimethylthiophene (1:1 molar ratio). The complexes were characterized by elemental analysis, molar conductance, magnetic moment, UV-visible, IR, 1H NMR and mass spectrometric techniques. From the results of physico-chemical and spectral techniques, tetrahedral and square planar geometry have been proposed for these metal complexes. The crystallinity and surface morphologies of the metal-complexes were examined by powder XRD and SEM. Antibacterial and antifungal activities of the metal-complexes were screened by Kirby-Bauer disk diffusion method. DNA cleavage was investigated using the Gel-electrophoresis method. The super oxide anion scavenging and anticancer activities of the metal-complexes against HeLa cell line were determined using MTT assay. Source


Dhanaraj C.J.,Anna University | Hassan I.U.,Dhofar University | Johnson J.,Anna University | Joseph J.,Noorul Islam University | Joseyphus R.S.,Mar Ivanios College Autonomous
Journal of Photochemistry and Photobiology B: Biology | Year: 2016

The ligand, N2,N3-bis(3-nitrophenyl)quinoxaline-2.3-diamine was prepared by the condensation of quinoxaline-2.3(1,4H)-dione with 3-nitroaniline. It was treated with Co(II), Ni(II), Cu(II) and Zn(II) acetates to form the metal complexes. These were characterized by elemental analysis, molar conductance, magnetic moment, UV–Vis., IR, 1H NMR, ESR and mass spectral data. Octahedral geometry has been assigned to Co(II), Ni(II) and Zn(II) complexes, whereas Cu(II) complex has distorted octahedral geometry. From the powder XRD data, crystallite size and unit cell parameters were calculated. The surface morphology of the synthesized compounds were determined using SEM analysis. The antimicrobial activity of the compounds against some bacterial species viz. Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeuruginosa and Staphylococcus aureus; also the fungal species, Aspergillus niger, and Candida albicans were done by disc diffusion method. DNA binding, cleavage and super oxide anion scavenging activities were also evaluated. The DNA binding activity of the compounds were identified using electronic absorption titrations and DNA cleavage was determined using gel electrophoresis. The anticancer activities of the compounds against HeLa cell line were determined using MTT assay. The highly potent compound among the five against HeLa cell line is subjected to molecular docking study against human papilloma virus receptor molecule and ATP binding site of telomerase. © 2016 Source


Selwin Joseyphus R.,Mar Ivanios College Autonomous | Shiju C.,Mar Ivanios College Autonomous | Joseph J.,Anna University | Justin Dhanaraj C.,Noorul Islam University | Bright K.C.,St Johns College
Der Pharma Chemica | Year: 2015

The Schiff base ligand, derived from imidazole-2-carboxaldehyde with L-phenylalanine and the Co(II), Ni(II), Cu(II) and Zn(II) complexes were synthesized. The synthesized ligand and its complexes were characterized by elemental analysis, molar conductance, magnetic moment, 1H NMR, 13C NMR, IR, UV-Vis., ESR, mass spectra, TGA, CV and powder XRD. The analytical data shows that the metal to ligand ratio is 1:1. The molar conductance data reveal that all the complexes are non-electrolytes. The results show that the ligands act as a tridentate monobasic donor coordinating through the azomethine nitrogen, imidazole nitrogen and carboxylato oxygen atoms. The TGA data indicates the presence of coordinated water molecules in these complexes. The crystallinity of these compounds was proved by the powder XRD pattern. Antimicrobial studies indicate that the complexes exhibit more activity than the ligand. Source


George M.,Mar Ivanios College Autonomous | Josekumar V.S.,Mar Ivanios College Autonomous
Indian Journal of Natural Products and Resources | Year: 2016

The present study was carried out to identify the phytochemical profile, heavy metal content and cytotoxicity of the epiphytic fern, Acrostichum heterophyllum L., which is a herb used in many traditional and tribal systems of medicine. Preliminary scientific evaluation towards the possibility of this species as a potential bioactive agent is attempted here. Three different extracts in hexane, ethyl acetate and methanol were prepared sequentially and obtained a percentage yield of 2.714, 3.82 and 8.058, respectively. Phytochemical screening revealed presence of flavonoids, alkaloids, sugars, glycosides, phenolics and tannins as major components of ethyl acetate and methanol extracts. All the heavy metals analyzed were found to be below the permissible limits. MTT assay using L929 cell line identified IC50 value of hexane, ethyl acetate and methanolic extracts as 254.18, 266.99 and 191.93 μg/mL, respectively. High IC50 values reported in the present study suggests low toxicity of the extracts. The brine shrimp lethality assay also revealed the nontoxic nature of the extracts upto concentrations of 1000 μg/mL. The results indicate the suitability of A. heterophyllum as herbal a drug resource. © 2016, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved. Source


Rahim S.,St Johns College | Antony A.,St Johns College | Lukose G.,Mar Ivanios College Autonomous | Mohanan K.,Kerala University | And 2 more authors.
Oriental Journal of Chemistry | Year: 2015

Metal chelates of Schiff base derived from thiophene-2-aldehyde with 4-aminoantipyrine have been synthesized. The ligand and the complexes have been characterized by IR, molar conductance, magnetic moments, EPR, cyclic voltammetry, XRD and SEM measurements. Computational studies were also carried out. The geometry of the complexes was investigated by electronic spectral data and magnetic moment measurements. The metal complexes exhibit higher antibacterial activity than the free ligand. Source

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