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Gurgaon, India

Bhavsar J.,IMT Manesar | Bhashkar B.,IMT Manesar | Kumar A.,Mankind Research Center
Oriental Journal of Chemistry | Year: 2013

A simple, highly rapid, efficient and eco friendly process for Racemisation of (1R, 6S)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0] nonane in various halogenated solvents has been carried out as a base catalysed reaction to afford racemic mixture in excellent yields (80-95%) at temperature of or below 40°C. The base catalysed racemisation in halogenated solvent has an advantage of simple workup procedure, and use of less volume of halogenated solvent irrespective of type of solvent used in the reaction system. Source


The present invention provides novel indoline compounds, derivatives of Formula 1 and salts thereof; which can be effectively used for the preparation of a1-adrenoceptor antagonists, Silodosin and its pharmaceutically acceptable salts.


Patent
Mankind Research Center | Date: 2013-11-21

The present invention relates to an improved and industriously advantageous process by means of providing coupling/condensing of wet mass of (1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid-O


Kumar A.,Mankind Research Center | Bhashkar B.,Mankind Research Center | Kumar H.,Mankind Research Center | Singh G.,Mankind Research Center
Asian Journal of Chemistry | Year: 2015

The present work is focused on improved process of preparation of fexofenadine which is achieved by regio-selective synthesis of intermediate; 1-oxoalkoxy-2-methyl-2-[4-(4-chloro-1-oxobutyl)phenyl]propane. The said intermediate is prepared in good yields and with greater purity wherein the synthesis of side products like 1-oxoalkoxy-2-methyl-2-[3-(4-chloro-1-oxobutyl)phenyl]propane (metaisomer) is reduced to a great amount. The intermediate, 1-oxoalkoxy-2-methyl-2-[4-(4-chloro-1-oxobutyl)phenyl]propane (para-isomer) where, alkyl group is selected from C2-5 carbon chain, is synthesized through preparation of 1-chloro-2-methyl-2-phenylpropane which upon reaction with potassium salt of aliphatic carboxylic acid followed by Friedel-Crafts acylation with 4-chlorobutyrylchloride results into desired intermediate, 1-oxoalkoxy-2-methyl-2-[4-(4-chloro-1-oxobutyl)phenyl]propane and a side impurity, 1-oxoalkoxy-2-methyl-2-[3-(4-chloro-1-oxobutyl)phenyl]propane (meta-isomer) in the ratio of 1:0.09-0.15. The above said mixture can be directly used for the synthesis of fexofenadine and has an advantage of eliminating the purification process at intermediate stage and use of less volume of expensive solvents. Source


Kumar A.,Mankind Research Center | Bhashkar B.,Mankind Research Center | Bhavsar J.,Mankind Research Center | Singh A.,Mankind Research Center
Der Pharma Chemica | Year: 2015

Current study describes a methodfor the preparation of chiral (3R)-azepan-3-amine(Compound 2)with high purity and yield, which may useas an intermediate or starting material to synthesize one of the most popular antibioticbesifloxacin hydrochloride. Chiral moiety of (3R)-azepan-3-amine (Compound 2)is prepared from (3R)-aminoazepan-2-one(Compound 1)by reducing it with novel reducing agent viz. NaBH4/AlCl3, NaBH4/CaCl2, NaBH4/DMS, NaBH4/BF3 or LiAlH4 using appropriate solvents viz. tetrahydrofuran (THF), isopropylether (IPE), toluene or acetonitrile (ACN).Purity and yield of furnished chiral amine is very highcompared to reported methods. The method is cost effective and commercial applicable. Source

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