Mangalore, India
Mangalore, India

Mangalore University is a public university in Konaje, Mangalore, Karnataka, India. MU has jurisdiction over the districts of Dakshina Kannada, Udupi and Kodagu. The university imparts higher education in field of arts, commerce, science, law and management. Wikipedia.

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Sheik S.,Mangalore University | Chandrashekar K.R.,Mangalore University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

The present study deals with the investigation on the in vitro antimicrobial, antioxidant, and antiarthritic activity in the dried extracts of leaf and stem of Pscychotria flavida Talbot. The study revealed that plant contains several physiologically active phytochemicals such as phenols, saponins, flavonoids, tannins, steroids and glycosides. Crude methanol, ethyl acetate and aqueous extracts of the leaf and stem were evaluated for antimicrobial activity by disc diffusion method, antioxidant activity by DPPH and reducing power assay, antiarthritic activity by anti protein denaturation and proteinase inhibition method. A high linear correlation between phenols and DPPH antioxidant activity/reducing power assay was observed. Flavonoids correlated only with reducing power. Methanol extract of both leaf and stem exhibited higher antibacterial activity which is correlated to the presence of higher amount of phenols. Methanol extract of leaf and ethyl acetate of stem showed on par antifungal activity against Candida albicans which is comparable to that of standard Nystatin. The extract also showed significant inhibition of protein denaturation and proteinase inhibition.

Shetty R.A.,Mangalore University | Sadananda M.,Mangalore University
Behavioural Brain Research | Year: 2017

In order to understand links that exist between inherited risk or predisposition, brain and behavioural development, endocrine regulation and social/environmental stimuli, animal models are crucial. The Wistar-Kyoto (WKY) rat has been shown to have validity as a model of adult and adolescent depression. While sex- and age-specific differences in some of the face, predictive and construct validities of the model such as depression-like behaviours have been established, anhedonia and anxiety using other induced anxiety paradigms such as elevated plus maze remain equivocal. First, post-weaning social isolation effects on inherent and induced anxiety behaviours were tested during two critical time periods, early- and mid-adolescence. Isolation induced immediate effects on novel environment-induced hyperactivity and anxiety-related behaviours. Adolescent WKYs demonstrated reduced 50-kHz ultrasonic vocalizations suggesting agoraphobia-like behaviours. Second, isolated rats, despite being subsequently social-/group-housed demonstrated longer lasting effects on social interaction measures and anhedonia. This establishes that the depression-like profile observed during early- and mid-adolescence persists into late adolescence and early adulthood in WKY. Further, that interventions at a later stage during adolescence may not be able to reverse early adolescent effects in the context of pre-disposition, thus highlighting the irreversibility of being double-hit during critical time periods of brain and behavioural development and maturation. © 2016 Elsevier B.V.

Karun N.C.,Mangalore University | Sridhar K.R.,Mangalore University
Data in Brief | Year: 2017

The edible wild mushrooms are most important in food security of ethnic groups and tribals throughout the world. Various indigenous strategies are followed to trace wild mushrooms suitable for human consumption. Data presented in this article projects ethnic knowledge on 51 edible wild mushrooms (in 23 genera) in the Western Ghats region of India. Information collected with support of ethnic groups/tribals pertains to habitats, substrates, mutualistic association, extent of availability, extent of edibility and method of processing of wild mushrooms. Extensive field visits and interactions with ethnic groups were performed to collect the data on each mushroom. Initially, most of these mushrooms were identified based on the indigenous methods and designated with vernacular names (Are-Gowda, Kodava and Tulu). Based on macromorphology (in field) and micromorphology (in laboratory), each mushroom was identified with its systematic name. Among the 51 wild mushrooms irrespective of extent of availability, the most preferred include Astraeus hygrometricus, Clitocybe infundibuliformis, Fistulina hepatica, Lentinus sajor-caju, Pleurotus (5 spp.) and Scleroderma citrinum and Termitomyces (18 spp.). This data forecasts the importance of documentation of traditional knowledge, protection of habitats, management of resources (tree species and substrates) and sustainable exploitation of wild mushrooms. © 2017

Manjunatha J.G.G.,Mangalore University
Journal of Food and Drug Analysis | Year: 2017

The electrochemical behavior of indigo carmine (IC) at poly (glycine) modified carbon paste electrode (PGMCPE) was investigated by cyclic and differential pulse voltammetry. The oxidation peak of IC was observed in phosphate buffer of pH 6.5. The influence of different pH, scan rate, and concentration were analyzed. The probable reaction mechanism involved in the oxidation of IC was also proposed. Results showed that PGMCPE a remarkable electrocatalytic activity for the oxidation of IC under optimal conditions. The electrocatalytic response of the sensor was proportional to the IC concentration in the range of (2 × 10-6-1 × 10-5 M) and (1.5 × 10-5-6 × 10-5 M) with a limit of detection 11 × 10-8 M and limit of quantification 3.6 × 10-7 M. The modified electrode demonstrated many advantages such as simple preparation, high sensitivity, low detection of limit, excellent catalytic activity, short response time, and remarkable antifouling property toward IC and its oxidation product. © 2017.

Venkatesh T.,NITTE University | Suresh P.S.,Mangalore University | Tsutsumi R.,Tokushima University
Molecular and Cellular Endocrinology | Year: 2015

A significant fraction of the human genome is transcribed as non-coding RNAs (ncRNAs). This non-coding transcriptome has challenged the notion of the central dogma and its involvement in transcriptional and post-transcriptional regulation of gene expression is well established. Interestingly, several ncRNAs are dysregulated in cancer and current non-coding transcriptome research aims to use our increasing knowledge of these ncRNAs for the development of cancer biomarkers and anti-cancer drugs. In endocrine-related cancers, for which survival rates can be relatively low, there is a need for such advancements. In this review, we aimed to summarize the roles and clinical implications of recently discovered ncRNAs, including long ncRNAs, PIWI-interacting RNAs, tRNA- and Y RNA-derived ncRNAs, and small nucleolar RNAs, in endocrine-related cancers affecting both sexes. We focus on recent studies highlighting discoveries in ncRNA biology and expression in cancer, and conclude with a discussion on the challenges and future directions, including clinical application. ncRNAs show great promise as diagnostic tools and therapeutic targets, but further work is necessary to realize the potential of these unconventional transcripts. © 2015 Elsevier Ireland Ltd.

Chethan P.D.,Mangalore University | Vishalakshi B.,Mangalore University
Carbohydrate Polymers | Year: 2013

Selective modification of chitosan has been achieved by incorporating ethylene-1,2-diamine molecule in a regioselective manner using N-phthaloylchitosan and chloro-6-deoxy N-phthaloylchitosan as precursors. The present modification results in additional nitrogen centres which function as potential binding sites during adsorption of metal ions. The derivative ethylene-1,2-diamine-6-deoxy-chitosan and its pthaloylated precursor have been evaluated for divalent metal ion removal. The former is found to have higher capacity for adsorption due to the presence of additional NH2 group. The samples exhibited highest affinity for Cu and least for Zn. About 80% of the adsorbed metal ions could be stripped in a solution of pH 1.2. The interaction between acidic metal centres and basic nitrogen centres on surface of the adsorbent appears to govern adsorption. Intrachain and interchain co-ordinate bonding involving NH and NH2 groups is proposed to be the mechanism of formation of metal-adsorbent complex. The adsorption process is described by Langmuir model. © 2013 Elsevier Ltd. All rights reserved.

Ramaprasad A.T.,Mangalore University | Rao V.,Mangalore University
Sensors and Actuators, B: Chemical | Year: 2010

A new processable and humidity sensitive chitin-polyaniline blend has been developed. Polyaniline is blended with chitin by solution blending method. The free standing films of blends are stable under ambient condition. The characterization of the blends is done by UV-vis absorption spectrum, FTIR, conductivity studies, thermogravimetric analysis and SEM. Conductivity of the self-doped blends increases from less than ≈10 -7 S/cm to 2.15 × 10 -5 S/cm, depending on the percentage of polyaniline in the blend. When these blends are doped with HCl conductivity rises to ≈9.68 × 10 -2 S/cm. Spectroscopic analysis shows interaction between chitin and polyaniline and the electronic states are similar to those of the emeraldine and protonically doped forms of polyaniline. These blend films are used for the construction of resistive based humidity sensor. A linear response of resistance with humidity is observed. It shows a small hysteresis and its response is stable even after 75 cycles of humidity exposure. Effect of electron beam irradiation on the humidity response has also been studied. Sensitivity is improved upon irradiation and doping. Further effect of thickness and electrode separation on humidity response is also studied. Response time for the humidity sensor is less than 30 s. The constructed humidity sensor shows good results in the 10-100% humidity and in the temperature range of 20-60 °C. © 2010 Elsevier B.V.

Parashar P.,Mangalore University
Journal of Materials Science: Materials in Electronics | Year: 2012

Polystyrene (PS) and Poly (2-vinylpyridine) (P2VP) was melt blended. The compatibility of PS/P2VP was investigated by differential scanning calorimetry (DSC), Fourier transmission Infrared (FTIR) and scanning electron microscopy (SEM). The results indicated the single glass transition temperature for the blend. Results of the studies carried out on the electrical behaviour of silver island films deposited on the composite of PS and P2VP are presented here. The substrates were held at 457 K, much above the glass transition temperature of the polymers to ensure sufficient polymer fluidity during deposition, to obtain a sub-surface particulate film. A constant deposition rate of 0.4 nm/s was used through out the study. Silver films deposited on softened PS give rise to a very high room temperature resistance approaching that of the substrate resistance due to the formation of a highly agglomerated structure. On the other hand, films on softened P2VP gives rise to a room temperature resistance in the range of tens to a few hundred MΩ/□ which is desirable for device applications. The composite of PS and P2VP show resistances at room temperature. The films show an increase in resistance, when they are exposed to atmosphere. This is attributed to the oxidation of silver islands. The film resistances in the desired range could be obtained even, after exposure to atmosphere with PS concentration of 50%. © 2011 Springer Science+Business Media, LLC.

Bhat S.P.,Mangalore University
Indian Journal of Plastic Surgery | Year: 2013

Introduction: Viscoelastic properties of skin in coloured ethnic groups are less favourable compared to Caucasians for executing Keystone flaps. Keystone flaps have so far been evaluated and reported only in Caucasians. The potential of Keystone flaps in a coloured ethnic group is yet unknown. Aim: This article reviews the experience to reconstruct skin defects presenting in a coloured ethnic group, by using Keystone flaps, with a review of existing literature. Design: Uncontrolled case series. Materials and Methods: This retrospective review involves 55 consecutive Keystone flaps used from 2009 to 2012, for skin defects in various locations. Patient demographic data, medical history, co-morbidity, surgical indication, defect features, complications, and clinical outcomes are evaluated and presented. Results: In this population group with Fitzpatrick type 4 and 5 skin, the average patient age was 35.73. Though 60% of flaps (33/55) in the series involved specific risk factors, only two flaps failed. Though seven flaps had complications, sound healing was achieved by suitable intervention giving a success rate of 96.36%. Skin grafts were needed in only four cases. Conclusions: Keystone flaps achieve primary wound healing for a wide spectrum of defects with an acceptable success rate in a coloured skin population with unfavorable biophysical properties. By avoiding conventional local flaps and at times even microsurgical flaps, good aesthetic outcome is achieved without additional skin grafts or extensive operative time. All advantages seen in previous studies were verified. These benefits can be most appreciated in coloured populations, with limited resources and higher proportion of younger patients and unfavorable defects.

Rao P.K.,Mangalore University
Journal of Cancer Research and Therapeutics | Year: 2010

Background and Objectives: Oral submucous fibrosis (OSF) is a chronic irreversible condition of the oral mucosa with proven malignant potential. However, till date, there has been a dearth of effective management strategies. This study used alpha lipoic acid, an antioxidant, in oral form to determine if it could be useful in managing OSF patients. Materials and Methods: A case-control study was conducted on 18 patients of OSF (9 cases and 9 controls). The case group was treated using alpha lipoic acid in addition to the intralesional steroid and hyaluronidase injections used in the control group. Results: The cases in the alpha lipoic acid group exhibited better relief of symptoms such as burning sensation of the mucosa and mouth opening, as compared to the controls. The use of alpha lipoic acid along with intralesional steroids and hyaluronidase caused reversal of higher clinical stages to lower ones. Conclusion: The use of an antioxidant, alpha lipoic acid, along with conventional therapy of intralesional steroid injections definitely seems to have a beneficial impact in the management of OSF.

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