Mandom Corporation

Ōsaka, Japan

Mandom Corporation

Ōsaka, Japan
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Patent
Mandom Corporation | Date: 2017-02-01

Provided are a deodorant composition that can dramatically improve the remaining performance of a bactericide on an application object after application and a deodorant product comprising the deodorant composition. The deodorant composition according to the present invention comprises ethanol, a bactericide, a hydrophobized hydroxyalkyl cellulose, and an ester compound having a molecular weight of 150 or more; and the deodorant product according to the present invention comprises a container and the deodorant composition filled in the container.


Patent
Mandom Corporation | Date: 2016-11-08

The present invention provides a body odor suppressing agent that contains activated carbon and that has excellent body odor suppressing effects, causes no black soiling on an object to be coated, and has excellent practical aptitude. The present invention also provides a body odor suppressing agent having an excellent feeling of use when the agent is applied to the skin. The present invention further provides a body odor suppressing agent capable of preventing nozzles from clogging when the agent is packed into a spray container and used. The body odor suppressing agent of the present invention includes a titanium oxide-coated activated carbon including an activated, carbon having an average particle diameter of 15 to 50 m and a titanium oxide present over the surface of the activated carbon.


Fujita F.,Okazaki Institute for Integrative Bioscience | Fujita F.,Mandom Corporation | Uchida K.,Okazaki Institute for Integrative Bioscience | Uchida K.,National Institute for Physiological science | And 8 more authors.
Journal of Neuroscience | Year: 2013

Cold sensation is an important and fundamental sense for animals and it is known to be affected by ambient temperature. Transient Receptor Potential Melastatin 8 (TRPM8), a nonselective cation channel expressed in a subset of peripheral afferent fibers, acts as a cold sensor, having an activation threshold of ~28°C. Although the cold temperature threshold of TRPM8 is affected by menthol or pH, ambient temperature has not been reported to affect it. Because the cold temperature threshold was thought to be unchanged by alterations in ambient temperature, the relativity of temperature sensing in different ambient temperatures could not be understood at the level of molecular function of thermosensitive TRP channels. Here, we show that ambient temperature changed the temperature threshold for activation of human and rat TRPM8 in a heterologous expression system and cold responses in mouse DRG neurons. Moreover, reducing the level of cellular phosphatidylinositol 4,5-bisphosphate (PIP2) attenuated changes in the cold temperature threshold after alterations in ambient temperature. A single amino acid mutation at position 1008 in the C terminus of TRPM8 (arginine to glutamine) also attenuated changes in the cold temperature threshold induced by ambient temperature. These findings suggest that ambient temperature does affect the temperature threshold for TRPM8 activation through interaction of PIP2. © 2013 the authors.


Kasahara K.,Mandom Co.
Nihon Reoroji Gakkaishi | Year: 2013

Rheological characteristics of stringy cosmetic emulsions that contain different ingredients and have different firmness was determined by a stress-controlled rheometer. Although the measurement of steady flow showed the first normal stress difference [N1] increase and viscosity [η] decrease with increase in shearing speed, there was no correlation between both parameters and the sensory evaluation score which indicates the degree of the stringiness. But it was found that new parameter ([N1]/[η]) has a strong correlation with the sensory evaluation score(r > 90) within a range of 300 - 1000S-1. © 2013, The Society of Rheology, Japan. All rights reserved.


Hara T.,Mandom Corporation | Matsui H.,Mandom Corporation | Shimizu H.,Mandom Corporation
PLoS ONE | Year: 2014

Diacetyl (2,3-butanedione) is a key contributor to unpleasant odors emanating from the axillae, feet, and head regions. To investigate the mechanism of diacetyl generation on human skin, resident skin bacteria were tested for the ability to produce diacetyl via metabolism of the main organic acids contained in human sweat. L-Lactate metabolism by Staphylococcus aureus and Staphylococcus epidermidis produced the highest amounts of diacetyl, as measured by highperformance liquid chromatography. Glycyrrhiza glabra root extract (GGR) and &alpha-tocopheryl- L-ascorbate-2-O-phosphate diester potassium salt (EPC-K1), a phosphate diester of&alpha-tocopherol and ascorbic acid, effectively inhibited diacetyl formation without bactericidal effects. Moreover, a metabolic flux analysis revealed that GGR and EPC-K1 suppressed diacetyl formation by inhibiting extracellular bacterial conversion of L-lactate to pyruvate or by altering intracellular metabolic flow into the citrate cycle, respectively, highlighting fundamentally distinct mechanisms by GGR and EPC-K1 to suppress diacetyl formation. These results provide new insight into diacetyl metabolism by human skin bacteria and identify a regulatory mechanism of diacetyl formation that can facilitate the development of effective deodorant agents. ©2014 Hara et al. Financial support for this research was provided by Mandom Corp. The authors' employer (Mandom Corp.) played no role in the study design, data acquisition, or decision to publish.


Patent
Mandom Corporation | Date: 2015-02-20

Provided are a deodorant composition that can dramatically improve the remaining performance of a bactericide on an application object after application and a deodorant product comprising the deodorant composition. The deodorant composition according to the present invention comprises ethanol, a bactericide, a hydrophobized hydroxyalkyl cellulose, and an ester compound having a molecular weight of 150 or more; and the deodorant product according to the present invention comprises a container and the deodorant composition filled in the container.


Patent
Mandom Corporation | Date: 2013-12-04

The present invention provides a body odor suppressing agent that contains activated carbon and that has excellent body odor suppressing effects, causes no black soiling on an object to be coated, and has excellent practical aptitude. The present invention also provides a body odor suppressing agent having an excellent feeling of use when the agent is applied to the skin. The present invention further provides a body odor suppressing agent capable of preventing nozzles from clogging when the agent is packed into a spray container and used. The body odor suppressing agent of the present invention includes a titanium oxide-coated activated carbon including an activated carbon having an average particle diameter of 15 to 50 m and a titanium oxide present over the surface of the activated carbon.


The present invention provides a powdery solid hair cosmetic that enables easy hairdressing, enables hairdressing into an intended hairstyle without sticky feeling, can impart a natural texture, and has an unprecedented, novel form. The powdery solid composition for hair of the present invention is in a powdery solid form, is used for hair, and contains a powder and an oil.


Patent
Mandom Corporation | Date: 2015-10-14

The present invention provides a body odor suppressing agent that contains activated carbon and that has excellent body odor suppressing effects, causes no black soiling on an object to be coated, and has excellent practical aptitude. The present invention also provides a body odor suppressing agent having an excellent feeling of use when the agent is applied to the skin. The present invention further provides a body odor suppressing agent capable of preventing nozzles from clogging when the agent is packed into a spray container and used. The body odor suppressing agent of the present invention includes a titanium oxide-coated activated carbon including an activated carbon having an average particle diameter of 15 to 50 pm and a titanium oxide present over the surface of the activated carbon.


The present invention provides a powdery solid hair cosmetic that enables easy hairdressing, enables hairdressing into an intended hairstyle without sticky feeling, can impart a natural texture, and has an unprecedented, novel form. The powdery solid composition for hair of the present invention is in a powdery solid form, is used for hair, and contains a powder and an oil.

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