Begum N.,Manarat International University |
Nakanishi T.,Hiroshima University |
Sadiah S.,Hiroshima University |
Islam M.E.,Jahangirnagar University
Proceedings - 2016 4th International Symposium on Computing and Networking, CANDAR 2016 | Year: 2016
A group signature scheme allows a user to anonymously sign a message on behalf of a group. One of important issues in group signature schemes is the user revocation. Previously, Libert et al. proposed an elegant revocable group signature scheme with O(1) signing/verification costs, O(1) signature size, O(1) membership certificate size, and O(logN) public key size, where N is the number of group members. However, the revocation list (RL) size is O(R), where R is the number of revoked members. Due to O (R) signatures in the RL, the RL size amounts to 8 MB in case of R = 10, 000. Then, a revocable group signature scheme with O(R/T) RL size was previously proposed for an integer parameter T, by accumulating T entries in the RL. Thus, we can expect that the delay time for a signer to fetch the RL is reduced in mobile environment. As the trade-off, the signing cost is increased by O(T). However, this scheme with the compact RL has not been implemented yet, and the practicality on the computation times for concrete T is unknown. In this paper, we implemented the scheme with the compact RL, and explore the practicality, where the signing time is greatly reduced by the technique to reduce the witness computation for the accumulator shown in the previous paper. From the experimental results, the signing and verification times are less than 500 ms and 900 ms even for T = 100, and thus we can confirm that the implemented scheme is practical, and the accumulating technique in the implemented scheme is sufficiently effective. © 2016 IEEE.
PubMed | Northern University of Bangladesh, Manarat International University, Chemical Research Division and Atish Dipankar University of Science and Technology
Type: | Journal: Evidence-based complementary and alternative medicine : eCAM | Year: 2015
Cnicus arvensis is used by many ethnic groups for inflammation, pain, and other ailments. In this study, reducing sugar, carbohydrate, alkaloid, steroid, tannin, flavonoid, and saponin groups were identified using standard chromogenic method. In high-performance liquid chromatography, vanillic acid and epicatechin were identified in the extract. Antinociceptive test by acetic acid induced writhing inhibition resulted 43.17 and 95.08% inhibition for 100 and 200mg/kg body weight, comparing with standard diclofenac Na with 74.86% inhibition for 25mg/kg body weight. In formalin induced paw licking test for antinociceptive activity, the extract inhibited 69.87 and 75.55% licking for 150 and 300mg/kg body weight comparing with the inhibition (68.56%) of diclofenac Na for 10mg/kg body weight at first phase. At late phase, the extract showed 73.12 and 87.46% licking comparing with licking inhibition (71.69%) by diclofenac Na at the same dose. In open field test for CNS depressant activity, the extract showed depression of locomotor activity for 150 and 300mg/kg body weight comparing with diazepam for 10mg/kg body weight. All results were statistically significant (P < 0.01). The identified polyphenols are reputed for antinociceptive and CNS depressant activity. The present findings support the use of this plant in pain.
Zahan R.,Atish Dipankar University of Science and Technology |
Badrul Alam M.,Atish Dipankar University of Science and Technology |
Saiful Islam M.,International Islamic University Chittagong |
Sarker G.C.,Square Pharmaceuticals Ltd |
And 5 more authors.
International Journal of Cancer Research | Year: 2011
The research study was conducted to determine the antitumor effect of the flower of Alangium salvifolium (crude extract and diethylether fractions) against Ehrlich Ascites Carcinoma (EAC) in mice at the doses of 10 mg kg-1 body weight intraperitoneally. Extract/fractions was administered for nine consecutive days. Twenty-four hours of last dose and 18 h of fasting, the mice were sacrificed and antitumor effect was assessed by evaluating tumor volume, viable and nonviable tumor cell count, tumor weight and hematological parameters of EAC bearing host. Significant (p<0.001) increases of survival times 30±0.96 and 25±0.40 days for crude extract and diethylether fraction of the A. salvifolium (10 mg kg-1) treated tumor bearing mice, respectively were confirmed with respect to the control group (20±0.13 days). The extract/fraction also decreased the body weight of the EAC tumor bearing mice. Hematological studies reveal that the heamoglobin (Hb) content was decreased in EAC treated mice whereas restoration to near normal levels was observed in extract treated animals. There was a significant (p<0.001) decrease in RBC count and increase in WBC counts in extract/fraction treated animals when compared to EAC treated animals. From the result it was showed that the extract has significant anticancer activity and that is comparable to that of Bleomycin. © 2011 Academic Journals Inc.
Dey S.K.,Khulna University |
Hira A.,Khulna University |
Ahmed A.,Khulna University |
Howlader S.I.,World University of Bangladesh |
And 3 more authors.
International Journal of Applied Research in Natural Products | Year: 2013
Entada scandens (E. scandens) (family. Mimosaceae) is a widely used medicinal plant has been traditionally used by the folklore medicinal practitioners of Bangladesh to treat pain, cancer, gastrointestinal disorders where antinociceptive, cytotoxic and anti-diarrheal medications are implicated. Therefore, phytochemical groups and antinociceptive, cytotoxic, and anti-diarrheal activities of ethanol extract of seed of E. scandens were investigated by using acetic acid induced writhing model in mice, brine shrimp lethality bioassay and castor oil induced diarrheal model in mice. Phytochemical study of the extract indicated the presence of alkaloids, glycosides, tannins, flavonoids and saponins. At the doses of 250 and 500 mg/kg body weight, the extract showed a significant antinociceptive activity showing 60.61 and 72.73% inhibition respectively (P<0.001) comparable to that produced by Diclofenac Na (80.30%) used as standard drug. The extract showed significant toxicity in the brine shrimp lethality bioassay (LC50. 20μg/ml & LC90. 80μg/ml). While evaluating anti-diarrheal activity, the extract inhibited the mean number of defecation which were 13.21% (P<0.01) and 22.64 % (P<0.001) at the doses of 250 and 500mg/kg respectively. The latent period for the extract treated group was (p<0.01) increased as compared to control group. In addition, antimicrobial study was carried out by disc diffusion assay, but no significant inhibition was found against Escherichia coli, Pseudomonas aureus, Plesiomonas shigelloides, Salmonella typhi, S. paratyphi, Shigella dysenteriae, S. flexneri, S. boydii, S. sonnei, Proteus vulgaris, Enterococcus faecalis, Staphylococcus saprophyticus, S. aureus, S. epidermidis and Streptococcus pyogenes. The study tends to suggest the antinociceptive, cytotoxic and antidiarrheal activities of the crude ethanol extract of the seed of E. scandens and justify its use in folkloric remedies. Industrial relevance. Medicinal plants can form an excellent source for derivation of lead compounds or newer drugs. The knowledge base of folk medicinal practitioners can in this instance form an invaluable source on which further scientific studies may be based, for the folk medicinal practices of the Kavirajes date back to centuries ago. They also have proved to be a rich source of new active compounds which are less toxic and less costly when compared to the synthetic drugs. The present study will help the industry to produce herbal drug with less side effect, economically affordable and more effective in the treatment of pain, diarrhea and inflammation processes. Finally the phytochemical screening from the plant would be effective drug for the antinociceptive, cytotoxic and antidiarrheal activities of the crude ethanol extract of the seed of E. scandens. © 2008-2013. IJARNP-HS Publication.
Khatun A.,Manarat International University |
Rahman M.,Northern University of Bangladesh |
Jahan S.,Manarat International University
Oriental Pharmacy and Experimental Medicine | Year: 2014
The methanol extract of leaves of traditionally used medicinal plant Murraya exotica Linn. (Family: Rutaceae) was evaluated for possible cytotoxic, thrombolytic and antioxidant activities in this study. The extract was tested for phytochemical group test by standard method using chromogenic reagents, in vivo brine shrimp lethality assay using Artemia salina, thrombolytic effect by using the standard streptokinase and antioxidant activity by using 2,2-diphenyl-1-picryl-hydrazyl (DPPH). The study revealed the presence of reducing sugars, tannins, saponins and alkaloids. The extract showed statistically significant (p < 0.01) potent cytotoxic effect in brine shrimp lethality bioassay where the value of LC50 and LC90 were 1.27 μg/ml and 5.09 μg/ml respectively compared with the standard vincristine sulphate with the value of LC50 and LC90 0.09 μg/ml and 4.83 μg/ml respectively after 24 h. The study gave a significant indication to the use of the plant extract as a potential source for cytotoxic compounds. The extract showed mild thrombolytic effect of 15.78 % thrombolytic activity whereas the standard streptokinase showed 76.50 ± 0.82 %. In the antioxidant activity study, the extract showed free radical scavenging activity where IC50 = 1.25 μg/ml and IC90 = 4.4 μg/ml, compared with the standard ascorbic acid showing IC50 = 0.01 μg/ml and IC90 = 3.58 μg/ml. Based on the findings of phytochemical, toxicological and anti-oxidative activity, it is evident that the plant may contain some novel compounds that possess potent anti-mutagenic and anti-oxidative activities. The obtained results support the use of this plant in traditional medicine. © 2014 Institute of Korean Medicine, Kyung Hee University.
PubMed | University of Rajshahi and Manarat International University
Type: Journal Article | Journal: Pakistan journal of pharmaceutical sciences | Year: 2015
In order to introduce an easily applicable, removable, painless and long-term drug delivery system for non-insulin dependent diabetes mellitus (NIDDM), hydroxyl propyl methyl cellulose with polyvinyl alcohol (HPMC-PVA) blend patches of metormin HCl were evaluated in vitro and in vivo. A suitable patch of metformin 800 mg with HPMC-PVA blend were used, following a three cycle freeze-thaw technique. Drug release kinetic profiles were performed in both patch and swim bladder. Albino mice were artificially generated as NIDDM mice by alloxan insertion i.p and after then treated with the therapeutic patch. Blood glucose was estimated by commercially available glucose kit based on glucose oxidase method. Drug release parameters from the patch and swim bladder were typical non-Fickian diffusion and both have the same kinetic constant, revealing its possible diffusion through stratum corneum. Hypoglycemia was observed in treatment of normal mice with TDDS of metformin HCl within 4 hours i.e. 25 2.13 mg/dl and within 16 hours in diabetic rats blood glucose level returned to normal level i.e. from 360 3.3 mg/dl (NIDDM level) to 105 2.5 mg/dl (Normal level). The TDS-patch has got the same kinetic simulation with that of swim-bladder, which might be a prediction for in vivo application. Here metformin was delivered to diabetic mice and has got significant anti-diabetic effect can be considered as a kind of patch for NIDDM just like wearing and taking off a hand watch because hypoglycaemia can be removed by just taking off the patch.
PubMed | University of Auckland, University of Science and Technology Beijing, Massey University and Manarat International University
Type: Journal Article | Journal: Journal of water and health | Year: 2016
This short communication provides insights into water, sanitation and hygiene (WASH) for homeless people through a scoping study conducted in Dhaka, Bangladesh. It investigates homeless access to WASH through the lens of a rights-based approach. It demonstrates that homeless peoples denial of their right to WASH reflects their marginal position in society and an unequal distribution of power and opportunities. The study ultimately suggests a rights-based approach to work toward dealing with the root causes of discrimination and marginalisation rather than just the symptoms. For the homeless, who not only lack substantive rights, but also the means through which to claim their rights, an integrated rights-based approach to WASH offers the possibility for social inclusion and significant improvements in their life conditions. Given the unique deprivation of homelessness it is argued that in addressing the lack of access to adequate WASH for homeless people the immediate goal should be the fulfilment and protection of the right to adequate shelter.
Uddin N.,University of Dhaka |
Hossain M.K.,Manarat International University |
Haque M.R.,Manarat International University |
Hasan C.M.,Manarat International University
Asian Journal of Chemistry | Year: 2013
Chemical investigation on the methanol extract of Paederia foetidae, using vacuum liquid chromatography resulted in the isolation of ethyl p-methoxy-trans-cinnamate. The structure was established by extensive spectral analysis (PMR, CMR, 2D NMR and MS etc.) and comparing with the published data. This is the first report of this compound from Rubiaceae family.
Polyphenols content, cytotoxic, membrane stabilizing and thrombolytic activities of Sarcolobus globosus: A medicinal plant from Sundarban forest [Contenido de polifenoles, citotoxicidad, estabilizante de membranas y actividades tromboliticas de Sarcolobus globosus. Una planta medicinal de la Foresta Sundarban]
Kuddus M.R.,Manarat International University |
Aktar F.,University of Dhaka |
Miah M.K.,University of Dhaka |
Baki M.A.,University of Dhaka |
Rashid M.A.,University of Dhaka
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas | Year: 2011
The crude methanolic extract of the bark of Sarcolobus globosus (Family-apocynaceae) and its different organic soluble Kupchan fractions were screened for total phenol content (TPC), cytotoxic, membrane stabilizing and thrombolytic activities. The polyphenol content was determined colorimetrically using Folin-Ciocalteu method and expressed in gallic acid equivalent. The chloroform soluble Kupchan fraction (CSF) exhibited higher level of Total Polyphenol Contents (TPC, 54.21 gm of GAE/100 gm of dried extract). In the brine shrimp lethality bioassay, the crude methanolic extract (MEBP) exhibited significant cytotoxicity. The membrane stabilizing activity was assessed by using erythrocyte in hypotonic solution and was compared with acetyl salicylic acid. The hexane soluble Kupchan fraction (HSF) produced 52.73 % inhibition of hemolysis of RBC as compared to 65.38 % revealed by acetyl salicylic acid (0.10 mg/mL). In thrombolytic study screening, the crude methanolic extract demonstrated significant thrombolytic activity in human blood specimen. © 2011 Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas.
PubMed | Bangabandhu Sheikh Mujibur Rahman Agricultural University, Manarat International University and Korea Advanced Institute of Science and Technology
Type: Journal Article | Journal: Bioorganic & medicinal chemistry letters | Year: 2015
The motility of zoospores is critical in the disease cycles of the peronosporomycetes that cause devastating diseases in plants, fishes, vertebrates, and microbes. In the course of screening for secondary metabolites regulating the motility of zoospores of Phytophthora capsici, we discovered two new inhibitors from the ethyl acetate extract of the fermentation broth of a marine-derived strain Bacillus sp. 109GGC020. The structures of these novel metabolites were elucidated as new cyclic lipopeptides and named gageopeptins A (1) and B (2) by spectroscopic analyses including high resolution MS and extensive 1D and 2D NMR. The stereoconfigurations of 1 and 2 were assigned based on the chemical derivatization studies and reviews of the literature data. Although compounds 1 and 2 impaired the motility of zoospores of P. capsici in dose- and time-dependent manners, compound 1 (IC50 = 1 g/ml) was an approximately 400-fold stronger motility inhibitor than 2 (IC50 = 400 g/ml). Interestingly, the zoospores halted by compound 1 were subsequently lysed at higher concentrations (IC50 = 50 g/ml). Compounds 1 and 2 were also tested against some bacteria and fungi by broth dilution assay, and exhibited moderate antibacterial and good antifungal activities.