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Secunderabad, India

Prasad P.S.R.,CSIR - Central Electrochemical Research Institute | Chari V.D.,Mallareddy Engineering College
Journal of Natural Gas Science and Engineering | Year: 2015

The release of methane gas was compared in pure CH4 (sI) and mixed (sII) hydrates (with C4H8O - tetrahydrofuran and C3H8 - propane) having methane as dominant constituent. We report absence of the self preservation effect in mixed hydrates, having stiochiometric composition (sII) of larger guest molecules, and they populate the 51264 cages. Their dissociation behaviour is in accordance with the respective phase boundary curve. While a partial methane gas release was observed at 270K, particularly, in dilute systems. Further, excess gas release was at T>270K and complete methane release is governed by the thermodynamic stability of mixed hydrates. © 2015. Source

Swarupa P.G.,Koneru Lakshmaiah College of Engineering | Krishna D.R.,Mallareddy Engineering College | Prasad K.R.S.,Koneru Lakshmaiah College of Engineering | Babu K.S.,Mallareddy Engineering College
Oriental Journal of Chemistry | Year: 2015

The purpose of the investigation was to develop a new RP-HPLC Method for estimation of Rotigotine in pharmaceutical dosage forms. Chromatography was carried out on an BDS C-8 column (4.6 × 150mm, 5μ particle size) with a isocratic mobile phase composed of 0.01N Potassium dihydrogen Ortho phosphate (adjusted to pH 4.8 with OPA solution), Acetonitrile (45:55v/v) at a flow rate of 1 mL/min. The column temperature was maintained at 30°C and the detection was carried out using a PDA detector at 224 nm. Validation parameters such as system suitability, linearity, precision, accuracy, specificity, limit of detection (LOD), limit of quantification (LOQ), Stability of sample and standard stock solutions and robustness were studied as reported in the International Conference on Harmonization guidelines. The retention time for Rotigotine was 2.691 min. The percentage recoverie of Rotigotine was 100.33%. The relative standard deviation for assay of patch was found to be less than 2%. The Method was fast, accurate, precise and sensitive hence it can be employed for routine quality control of patchs containing both drugs in quality control laboratories and pharmaceutical industries. Source

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