Secunderabad, India
Secunderabad, India

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Prasad P.S.R.,CSIR - Central Electrochemical Research Institute | Chari V.D.,Mallareddy Engineering College
Journal of Natural Gas Science and Engineering | Year: 2015

The release of methane gas was compared in pure CH4 (sI) and mixed (sII) hydrates (with C4H8O - tetrahydrofuran and C3H8 - propane) having methane as dominant constituent. We report absence of the self preservation effect in mixed hydrates, having stiochiometric composition (sII) of larger guest molecules, and they populate the 51264 cages. Their dissociation behaviour is in accordance with the respective phase boundary curve. While a partial methane gas release was observed at 270K, particularly, in dilute systems. Further, excess gas release was at T>270K and complete methane release is governed by the thermodynamic stability of mixed hydrates. © 2015.


Swarupa P.G.,Koneru Lakshmaiah College of Engineering | Krishna D.R.,Mallareddy Engineering College | Prasad K.R.S.,Koneru Lakshmaiah College of Engineering | Babu K.S.,Mallareddy Engineering College
Oriental Journal of Chemistry | Year: 2015

The purpose of the investigation was to develop a new RP-HPLC Method for estimation of Rotigotine in pharmaceutical dosage forms. Chromatography was carried out on an BDS C-8 column (4.6 × 150mm, 5μ particle size) with a isocratic mobile phase composed of 0.01N Potassium dihydrogen Ortho phosphate (adjusted to pH 4.8 with OPA solution), Acetonitrile (45:55v/v) at a flow rate of 1 mL/min. The column temperature was maintained at 30°C and the detection was carried out using a PDA detector at 224 nm. Validation parameters such as system suitability, linearity, precision, accuracy, specificity, limit of detection (LOD), limit of quantification (LOQ), Stability of sample and standard stock solutions and robustness were studied as reported in the International Conference on Harmonization guidelines. The retention time for Rotigotine was 2.691 min. The percentage recoverie of Rotigotine was 100.33%. The relative standard deviation for assay of patch was found to be less than 2%. The Method was fast, accurate, precise and sensitive hence it can be employed for routine quality control of patchs containing both drugs in quality control laboratories and pharmaceutical industries.


Geetha Swarupa P.,Koneru Lakshmaiah College of Engineering | Lakshmana Rao K.,Mallareddy Engineering College | Prasad K.R.S.,Koneru Lakshmaiah College of Engineering | Suresh Babu K.,Mallareddy Engineering College
Asian Journal of Pharmaceutical and Clinical Research | Year: 2016

Objective: To develop accurate, fast, simple, and precise reversed-phase high-pressure liquid chromatography method for simultaneous determination of the binary mixture of metformin (MET) and empagliflozin (EMPA) in dosage forms. Methods: The method uses a mobile phase consisting of phosphate buffer, acetonitrile, methanol (15:80:5 v/v/v), an octadecyl silica C-18 column (4.6 mm × 250 mm, 5 μ particle size) in isocratic mode, detection wavelength of 227 nm, and a flow rate of 1 mL/minutes. Results: The measured retention times for MET and EMPA and were 2.528 and 4.140 minutes, respectively. The percentage recoveries of MET and EMPA were 101.12% and 100.55%, respectively. The relative standard deviation for assay of tablets was found to be <2%. The correlation coefficient for MET and EMPA was found to be 0.9990. The limit of detection and quantification for MET was 0.10 μg/mL and 0.31 μg/mL and for EMPA 0.01 μg/mL and 0.03 μg/mL. Conclusion: The method was fast, accurate, precise, and sensitive hence it can be employed for routine quality control of tablets containing both drugs in quality control laboratories and pharmaceutical industries. © 2016, Innovare Academics Sciences Pvt. Ltd. All rights reserved.

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