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Rangan S.,Malladi Drugs and Pharmaceuticals Ltd. No. 788 1 | Rangan S.,Presidency College at Chennai | Antony S.A.,Presidency College at Chennai | Kandhaswamy A.,Malladi Drugs and Pharmaceuticals Ltd. No. 788 1 | And 2 more authors.
Arkivoc | Year: 2014

A concise and novel approach for the synthesis of (1R ,2R)-1-alkyl-1-phenyl-2-methylaminopropanes by dehydroxylation of corresponding (1 S,2R)-1-phenyl-1-alkyl-2-methylamino-propan-1-ols, which were prepared by the asymmetric induction through Grignard reaction of optically active α-aminoketones. These efficient preparations resulted in compounds with very good yields and high diastereoselectivity. The stereochemistry involved in the synthesis was described with justification on absolute configuration of the compounds.

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