Time filter

Source Type

Rangan S.,Malladi Drugs and Pharmaceuticals Ltd. No. 788 1 | Rangan S.,Presidency College at Chennai | Antony S.A.,Presidency College at Chennai | Kandhaswamy A.,Malladi Drugs and Pharmaceuticals Ltd. No. 788 1 | And 2 more authors.

A concise and novel approach for the synthesis of (1R ,2R)-1-alkyl-1-phenyl-2-methylaminopropanes by dehydroxylation of corresponding (1 S,2R)-1-phenyl-1-alkyl-2-methylamino-propan-1-ols, which were prepared by the asymmetric induction through Grignard reaction of optically active α-aminoketones. These efficient preparations resulted in compounds with very good yields and high diastereoselectivity. The stereochemistry involved in the synthesis was described with justification on absolute configuration of the compounds. Source

Discover hidden collaborations