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Abbulu K.,Malla Reddy Institute of Pharmaceutical science
Oriental Journal of Chemistry | Year: 2012

A reverse phase high performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of Sitagliptin phosphate and Metformin hydrochloride in marketed tablet formulations is developed. The determination was carried out on an XTerraC8 (4.6 × 100 mm, 3 urn) column using a mobile phase of pH-9 phosphate buffer solution: acetonitrile: methanol in the ratio of 35:45:20. The flow rate was 0.6 ml/min. The analyte was monitored using UV detector at 260 nm. The retention time for Sitagliptin phosphate was 3.056 mins and for Metformin hydrochloride 2.420 mins. Linearity of Sitagliptin and Metformin were found in the range of 50 ppm to 150 ppm. Percentage recoveries were obtained in the range of for Sitagliptin 99.5% and for Metformin 100.4%. The proposed method is precise, accurate, selective, robust, reproducible and rapid for the simultaneous estimation of Sitagliptin phosphate and Metformin hydrochloride in tablet dosage forms.

Khatry S.,Dev Bhoomi Institute of Pharmacy and Research | Abbulu K.,Malla Reddy Institute of Pharmaceutical science
International Journal of Pharmacy and Technology | Year: 2011

Extrusion processing has been a preferred mode of fabrication in the plastics industry for nearly a century. Interest in the pharmaceutical applications is growing rapidly and is evident from the increasing number of patents and publications. Hot melt extrusion is a well recognized technology in pharmaceutical industry today and is used in the preparation of variety of dosage forms and drug delivery systems. The types of extruders currently available for hot melt extrusion are single and twin-screw extruders. Depending on the geometric design and function, the screw is generally composed of three different sections: feeding section, melting section, and the metering section. This paper highlights the advantages, applications of hot melt extrusion technology and the optimization of HME process through which product quality and performance is assured. Equipment parameters like screw configuration and screw speed, process parameters like temperature, melt viscosity, flow and melt pressure and the formulation parameters like physicochemical properties of the polymer and drug, drug-polymer miscibility and compatibility, glass transition temperature of the polymers, type of plasticizer and the desired drug release from dosage forms have a strong impact on the product and its performance. Optimization of HME process by proper selection of polymers, plasticizers, processing conditions and parameters plays a crucial role in the product performance. Key words: Hot Melt Extrusion, Solid dispersions, Solubility enhancement; Thermal analysis, Glass transition temperature, Solubility parameters, Rheology, Sustained release.

Gundamaraju R.,Malla Reddy Institute of Pharmaceutical science
Asian Pacific Journal of Tropical Disease | Year: 2014

Liver fluke disease is a chronic parasitic inflammatory disease of the bile ducts which is highly prominent in the tropical regions. Infection occurs through ingestion of fluke-infested fresh-water raw fish. Opisthorchis viverrini is the biggest causative organism for this disease. Adult flukes get into the body of humans and settle in the small intrahepatic bile ducts, and then they live there for few decades. The long-lived flukes cause long-lasting chronic inflammation of the bile ducts, and this produces epithelial hyperplasia, periductal fibrosis and bile duct dilatation. Major complications of the disease also include pancreatitis, bile duct obstruction etc. The majority of patients are asymptomatic, but the patients with heavy infection suffer from lassitude and nonspecific abdominal complaints. Approximately 35 million people are infected with liver flukes throughout the world and the exceptionally high incidence of cholangiocarcinoma in some endemic areas is closely related with a high prevalence of liver fluke infection. Considering the appulse of this food-borne malady on accessible bloom and the astringent accessible analytic consequences, alarmist accident infection should not be abandoned or neglected. This review acts as a complete picture in elucidating the information regarding the parasite and disease condition thereby supporting the researchers worldwide. © 2014 Asian Pacific Tropical Medicine Press.

Krishna Chaitanya B.,Malla Reddy Institute of Pharmaceutical science
Journal of Applied Pharmaceutical Science | Year: 2012

The traditional medicinal plant Basella alba belongs to Basellaceae. Earlier folklore claims reports that the plant is used in inflammatory conditions. Inflammation is the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. The present work was focused to evaluate anti inflammatory activity by cotton pellet granuloma method. The Basella alba leaves were subjected to cold maceration process by using solvent, 50% ethanol for 48hrs. The extract was obtained by filtration. The filtrate was freeze dried to get the powder product. The extract was mixed with 2% gum acacia to prepare suspension for oral dose. Sub acute inflammation was produced by cotton pellet granuloma. Sterile cotton (50+1mg) soaked in 0.2 ml of distilled water containing penicillin (0.1mg) and streptomycin (0.13mg) was implanted subcutaneously by incision on the back under ether anesthesia. Drugs were orally administered for 6days, the animal was sacrificed on seventh day and granuloma was dissected out, dried in oven for 24 hrs and weighed. The percentage inhibition was determined. To test the anti inflammatory activity phenyl butazone was taken as standard. Effect of different treatment (control, phenyl butazone, BLE-1, BLE-2) in sub acute inflammatory models in rats was studied and percentage inhibition of inflammation of standard and drug extract was compared in the present study. As the availability, cost and side effect of synthetic drugs impact on health as well as economy, mankind should go for natural treatment should go for natural treatment prior to synthetic drug.

Gundamaraju R.,Malla Reddy Institute of Pharmaceutical science
Asian Pacific Journal of Tropical Disease | Year: 2013

Objective: To evaluate the anti-helmintic activity of Ferula foetida " Hing" against helmintic (Pheretima postuma). Methods: Aqueous extracts from the Ferula foetida resin was investigated for its anthelmintic activity against Pheretima posthuma. Three concentrations (25, 50 and 100 mg/mL) of extract were studied in activity, which involved the determination of time of paralysis and time of death of the worm. Results: The extract has exhibited significant anti-helmintic activity at the highest concentration of 100 mg/mL. Infact, the extract has shown better significant activity than the standard drug. Piperazine citrate in the same concentration as that of extracts was included as standard reference and distilled water as control. Conclusions: It was concluded from the present study that the plant revealed significant anthelmintic activity. © 2013 Asian Pacific Tropical Medicine Press.

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