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Abbulu K.,Malla Reddy Institute of Pharmaceutical science
Research Journal of Pharmacy and Technology | Year: 2011

The objective of the present study was to prepare ketorolac loaded conventional liposomes containing natural phospholipid, Soy phosphatidyl choline by optimizing various process and formulation related variables such as drug - lipid ratio, cholesterol content, vacuum, speed of rotation, hydration medium and hydration time. Effects of charges over the vesicles were studied by incorporating dicetylphosphate and stearylamine. Various liposomal batches were prepared by thin film hydration technique and they were characterterized for drug encapsulation %, chemical interaction of the components, vesicle size profile, drug release profile in vitro and stability using specified methods. The best ketorolac loaded liposome was composed of SPC/Cholesterol/stearyl amine group of 4:1:0.7%w/w/w. It was found to have greater stability, higher drug encapsulation % and lower drug release in vitro compared to the others. The drug encapsulation efficiency of optimum formulation was 84% and it could retain 36% of the drug even after 24h. FTIR study indicated that there is no significant chemical interaction between the components. SEM photograph confirmed that vesicles were homogenous and spherical in shape. Stability studies showed that the vesicles were stable in refrigerated temperature for nearly one month without significant difference in drug entrapment. The present study has given us knowledge also that liposomes with low amount of cholesterol are better candidate for ketorolac liposomes. © RJPT All right reserved.


Gundamaraju R.,Malla Reddy Institute of Pharmaceutical science
Asian Pacific Journal of Tropical Disease | Year: 2014

Liver fluke disease is a chronic parasitic inflammatory disease of the bile ducts which is highly prominent in the tropical regions. Infection occurs through ingestion of fluke-infested fresh-water raw fish. Opisthorchis viverrini is the biggest causative organism for this disease. Adult flukes get into the body of humans and settle in the small intrahepatic bile ducts, and then they live there for few decades. The long-lived flukes cause long-lasting chronic inflammation of the bile ducts, and this produces epithelial hyperplasia, periductal fibrosis and bile duct dilatation. Major complications of the disease also include pancreatitis, bile duct obstruction etc. The majority of patients are asymptomatic, but the patients with heavy infection suffer from lassitude and nonspecific abdominal complaints. Approximately 35 million people are infected with liver flukes throughout the world and the exceptionally high incidence of cholangiocarcinoma in some endemic areas is closely related with a high prevalence of liver fluke infection. Considering the appulse of this food-borne malady on accessible bloom and the astringent accessible analytic consequences, alarmist accident infection should not be abandoned or neglected. This review acts as a complete picture in elucidating the information regarding the parasite and disease condition thereby supporting the researchers worldwide. © 2014 Asian Pacific Tropical Medicine Press.


Khatry S.,Dev Bhoomi Institute of Pharmacy and Research | Abbulu K.,Malla Reddy Institute of Pharmaceutical science
International Journal of Pharmacy and Technology | Year: 2011

Extrusion processing has been a preferred mode of fabrication in the plastics industry for nearly a century. Interest in the pharmaceutical applications is growing rapidly and is evident from the increasing number of patents and publications. Hot melt extrusion is a well recognized technology in pharmaceutical industry today and is used in the preparation of variety of dosage forms and drug delivery systems. The types of extruders currently available for hot melt extrusion are single and twin-screw extruders. Depending on the geometric design and function, the screw is generally composed of three different sections: feeding section, melting section, and the metering section. This paper highlights the advantages, applications of hot melt extrusion technology and the optimization of HME process through which product quality and performance is assured. Equipment parameters like screw configuration and screw speed, process parameters like temperature, melt viscosity, flow and melt pressure and the formulation parameters like physicochemical properties of the polymer and drug, drug-polymer miscibility and compatibility, glass transition temperature of the polymers, type of plasticizer and the desired drug release from dosage forms have a strong impact on the product and its performance. Optimization of HME process by proper selection of polymers, plasticizers, processing conditions and parameters plays a crucial role in the product performance. Key words: Hot Melt Extrusion, Solid dispersions, Solubility enhancement; Thermal analysis, Glass transition temperature, Solubility parameters, Rheology, Sustained release.


Gundamaraju R.,Malla Reddy Institute of Pharmaceutical science
Asian Pacific Journal of Tropical Disease | Year: 2013

Objective: To evaluate the anti-helmintic activity of Ferula foetida " Hing" against helmintic (Pheretima postuma). Methods: Aqueous extracts from the Ferula foetida resin was investigated for its anthelmintic activity against Pheretima posthuma. Three concentrations (25, 50 and 100 mg/mL) of extract were studied in activity, which involved the determination of time of paralysis and time of death of the worm. Results: The extract has exhibited significant anti-helmintic activity at the highest concentration of 100 mg/mL. Infact, the extract has shown better significant activity than the standard drug. Piperazine citrate in the same concentration as that of extracts was included as standard reference and distilled water as control. Conclusions: It was concluded from the present study that the plant revealed significant anthelmintic activity. © 2013 Asian Pacific Tropical Medicine Press.


Gundamaraju R.,Malla Reddy Institute of Pharmaceutical science | Mulaplli S.B.,Malla Reddy Institute of Pharmaceutical science | Ramesh C.,GSN Pharmaceuticals Pvt.Ltd.
International Journal of Pharmacognosy and Phytochemical Research | Year: 2013

The anti-obesic activity of Lantana camara was studied on progesterone induced models of hyperlipedemia in mice. Hyperlipidemia condition established by progesterone, which changed various parameters in the body. An increase in food consumption and water consumption usually accompanies the body weight gain, which is the characteristic nature of progesterone stimulation. Increased consumption of food and water generally leads to elevated parameters like LDL, VLDL, serum cholesterol etc. Accumulation of fat in areas like inguinal, epididymal, neck etc. was observed. Ethanobotanical knowledge of medicinal plants is one of the most prominent source of new drugs and has shown potential results for treatment of obesity. Preliminary phytochemical analysis of Lantana camara revealed the presence of phyto constituents such as steroids, flavinoids, alkaloids, etc.


Krishna Chaitanya B.,Malla reddy institute of pharmaceutical science
Journal of Applied Pharmaceutical Science | Year: 2012

The traditional medicinal plant Basella alba belongs to Basellaceae. Earlier folklore claims reports that the plant is used in inflammatory conditions. Inflammation is the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. The present work was focused to evaluate anti inflammatory activity by cotton pellet granuloma method. The Basella alba leaves were subjected to cold maceration process by using solvent, 50% ethanol for 48hrs. The extract was obtained by filtration. The filtrate was freeze dried to get the powder product. The extract was mixed with 2% gum acacia to prepare suspension for oral dose. Sub acute inflammation was produced by cotton pellet granuloma. Sterile cotton (50+1mg) soaked in 0.2 ml of distilled water containing penicillin (0.1mg) and streptomycin (0.13mg) was implanted subcutaneously by incision on the back under ether anesthesia. Drugs were orally administered for 6days, the animal was sacrificed on seventh day and granuloma was dissected out, dried in oven for 24 hrs and weighed. The percentage inhibition was determined. To test the anti inflammatory activity phenyl butazone was taken as standard. Effect of different treatment (control, phenyl butazone, BLE-1, BLE-2) in sub acute inflammatory models in rats was studied and percentage inhibition of inflammation of standard and drug extract was compared in the present study. As the availability, cost and side effect of synthetic drugs impact on health as well as economy, mankind should go for natural treatment should go for natural treatment prior to synthetic drug.


Sangeetha J.,Malla Reddy Institute of Pharmaceutical science | Soundarya K.,Malla Reddy Institute of Pharmaceutical science | Santhosh K.,Malla Reddy Institute of Pharmaceutical science | Sindhura C.,Malla Reddy Institute of Pharmaceutical science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2010

The objective of this work is to determine the anti-helmenthic activity of Passiflora edulis Linn, using ethanol and water extracts of leaves at different concentrations (50, 75 and 100mg/ml). The evaluation of in-vitro anthelmentic activity is done on adult earthworms due to its anatomical similarity with the intestinal parasite. The reaction time is noted as paralysis time and death time for all the concentrations and compared with standard albendazole.


Aishwarya J.,Malla Reddy Institute of Pharmaceutical science | Srinivas N.,Malla Reddy Institute of Pharmaceutical science
International Journal of Pharma and Bio Sciences | Year: 2015

The present study is to establish bi-layer tablets of Glimepiride and Captopril, of which Glimepiride as immediate release and Captopril as sustained release layers. Immediate release layer was prepared by direct compression method by using cross povidone as disintegrant and sustained release layer was prepared by direct compression method by using HPMC K4 as polymer. Both powder blends of immediate and sustained release layers were evaluated for Bulk density, Tapped density, Compressibility index, Hausner ratio and Angle of repose. All the values were found within limit of standard. In vitro release studies were carried out by USP type 2 paddle apparatus. The result showed that polymer HPMC K4 in sustained layer controlled the release of drug. The formulation (F4) having immediate release layer produced immediate effect showing 99.6%drug release within 30minutes, followed by sustained release effect showing 96.8% drug release upto 12 hours. The present study concluded that Bilayer tablets of Glimepiride and Captopril can be a better alternative to conventional dosage form for providing immediate and sustained drug delivery.


PubMed | Netaji Subhas Institute of Technology, University of Malaya and Malla Reddy Institute of Pharmaceutical science
Type: Journal Article | Journal: Pharmacognosy research | Year: 2014

The plant Albizia amara (Roxb.) Boiv. bark was used in traditional medical practices of India to treat cardiovascular diseases. Hyperlipidemia is the greatest risk factor of coronary heart disease.The objective of this study was to screen the potential of A. amara against the condition of hyperlipidemia in rats.The antihyperlipidemic activity of A. amara ethanolic extract (AAEE) was studied on Triton X-100 induced model of hyperlipidemia in rats. Hyperlipidemia in experimental rats was evidenced by an enhancement in the levels of serum cholesterol, triglycerides (TGs), low density lipoprotein (LDL), very LDL (VLDL) and decrease in high density lipoprotein (HDL).AAEE showed significant antihyperlipidemic effect by lowering the serum levels of biochemical parameters such as a significant reduction in the level of serum cholesterol, TG (104.1 3.39), LDL (48.2 2.19), VLDL (20.81 0.67) and increase in HDL (47.25 2.05) level with an increase in a dose of AAEE (41.39 1.24) < (47.25 2.05), which was similar to the standard drug atorvastatin. The results of serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase also revealed that the plant extract was found to be safe on liver. Histopathological evaluation also revealed the positive effect of the plant extract. Preliminary phytochemical analysis revealed the presence of phytoconstituents such as saponins, glycosides and tannins. The preliminary chemical constituents stood as a strong evidence for the study.Summing up the evidences of the pragmatic study, we can conclude that the extract of A. amara (Roxb.) Boiv. Bark aids in declining the condition of hyperlipidemia in rats.


PubMed | University of Malaya and Malla Reddy Institute of Pharmaceutical science
Type: Journal Article | Journal: Pharmacognosy research | Year: 2014

Ulcerations have been effecting humans and causing major damage in the gastro intestinal tract. A need for development of a flawless anti-ulcer medication was always in the agenda. Thus, the need to conduct a study was provoked.The major objective of the present study is to screen the antiulcer activity of the ethanolic extract of Talinum portulacifolium (Forsk) plant.The antiulcer activity of the ethanolic extract of T.Z portulacifolium was performed on albino rats. Gastric ulcers were induced by ethanol, pylorus ligated aspirin and histamine induced ulcer models. Omeprazole was used as a standard drug for comparison.Treatment with the T. portulacifolium plant extract significantly protected the ulceration induced by the three models. The gastric volume, pH of gastric juice, total acidity, free acidity and ulcer index were the parameters estimated and did show significant results. 800 mg/kg extracts of T. portulacifolium did show high significant results as that of standard drug. Percentage protection of 800 mg/kg was 79.9% and the standard drug-treated group did show 84%. So was with total acidity (38.1 + 1.45) and free acidity (16.5 + 0.76).The ethanolic extract of T. portulacifolium plant was found to possess a significant antiulcer activity.

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