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Roy A.,North Bengal Medical College and Hospital | Samanta T.,NRS Medical College and Hospital | Purkait R.,NRS Medical College and Hospital | Mukherji A.,NRS Medical College and Hospital | Ganguly S.,Malda Medical College and Hospital
Journal of the College of Physicians and Surgeons Pakistan | Year: 2013

Objective: To determine the etiology, clinical spectrum and outcome of metabolic liver diseases (MLD) in children admitted in a tertiary care hospital of Eastern India. Study Design: An observational study. Place and Duration of Study: Paediatric Liver Clinic and Paediatrics Inpatient Department of Nilratan Sircar Medical College and Hospital, Kolkata, Eastern India, from April 2009 to March 2011. Methodology: All children aged 0 - 12 years having characteristic clinical features along with diagnostic hallmark of any MLDs were included in this study and data were collected on a pre-designed proforma. After appropriate management and discharge, all patients were followed-up for next 6 months. Results: Fifty one children with mean age 4.34 ± 3.78 years (range 2 days - 12 years), male: female ratio 1.55:1, were studied. The etiologies were Wilson's disease (33.33%, n = 17); glycogen storage disorder (23.53%, n = 12); galactosemia (19.61%, n = 10); non-alcoholic fatty liver disease (11.76%, n = 6); Gaucher disease (5.88%, n = 3); mucopolysaccharidoses (3.92%, n = 2) and familial hyperlipoproteinemia type-I (1.96%, n = 1). Jaundice (n = 24) and hepatomegaly (n = 47), was the commonest symptom and sign respectively. Of the 17 non-responders, most were Wilson's disease (n = 7) cases. There was statistical difference in outcome with respect to INR > 1.3 at diagnosis (p = 0.026). Conclusion: High index of suspicion, early detection and screening, simple dietary modification and cost effective drugs along with good compliance are sufficient to treat and even prevent evolution of most causes of the MLDs. © 2013 College of Physicians and Surgeons Pakistan. Source

Mukherjee B.,Malda Medical College and Hospital
Advances in Intelligent Systems and Computing | Year: 2016

Parkinson’s disease is a degenerative neurological disorder which severely affects the ability to move, speak and behave. Parkinsonism is clinically diagnosed but the laboratory confirmation is hard to obtain and needs very sophisticated investigations with high economic burden. In this work a fuzzy based approach is adapted for efficient and proper detection of Parkinson’s disease using biomedical measurements of voice which is cheap and cost effective. The proposed system can also be utilised as a supplementary test to confirm the clinical diagnosis of Parkinson’s disease in a remote place using the telephony system to track the voice signal. Moreover, it can be used as a guide for the treatment of Parkinson’s disease as it gives a quantitative measure to signify the extent of the disease. The model is constructed using a Sugeno-Takagi Fuzzy Inference System (FIS) based on Fuzzy C-Means clustering. The result shows that the detection accuracy of the system is up to 96-97 percent with a reasonable efficiency. The study also compares the results with the Subtractive Clustering based Fuzzy Inference System. The accuracy of the Fuzzy C-Means based Fuzzy Inference System is found to be higher than the other one. © Springer International Publishing Switzerland 2016. Source

Jain P.,Medical College | Mondal S.K.,Medical College | Sinha S.K.,Medical College | Mukhopadhyay M.,Sagar Dutta Medical College | Chakraborty I.,Malda Medical College and Hospital
Journal of Natural Science, Biology and Medicine | Year: 2014

Colorectal carcinoma (CRC) is the fourth most commonly diagnosed malignant disease worldwide, with over 1 million new cases and approximately 5,00,000 deaths each year. Aims and Objectives: This prospective observational study was done to study the clinicopathological characteristics of CRC including mucin stains and correlate the preoperative serum carcinoembryonic antigen (CEA) and cancer antigen (CA)-125 levels with the prognosis. Materials and Methods: A total of 90 CRCs were included from December 2010 to June 2013. Detailed history and relevant clinical/radiological findings were noted in all clinically and/or radiologically suspected cases of CRC. Preoperative blood samples were collected for serum CEA and CA-125 level estimation. The mucin expression was evaluated with special stains. Results: The combined Alcian blue-periodic acid Schiff (PAS) staining was positive for both stains in 68.88% cases indicating that both neutral and acidic mucins are increased in CRC. High preoperative serum CEA levels were seen in 82.22% cases, whereas preoperative serum CA-125 levels showed an increase in 20% cases. Higher levels of these tumor markers corresponded with higher TNM stage. Conclusions: Mucin evaluation in CRCs remains one of the valuable methods as mucinous variants correlate with worse prognosis. Preoperative serum CEA level assessment is an indispensible adjunct to the diagnosis and prognosis of CRC. However, preoperative serum CA-125 level measurement is not an efficient tool for prognostication in CRC and should not be recommended for routine use. © Journal of Natural Science, Biology and Medicine. Source

Kar C.,Malda Medical College and Hospital | Das S.,NRS Medical College and Hospital | Roy A.,NRS Medical College and Hospital
Indian Journal of Dermatology | Year: 2014

Background: There are very little elaborative studies in India about various patterns of skin diseases and various factors those influence the diseases in a tertiary institution. Aims: To find out the various patterns of skin diseases in relation to age, sex, occupation, and socio-economic status. To find out the magnitude of skin diseases and compare with other similar studies. Materials and Methods: Collection of data of all new skin cases in a specified period of one year and put on proforma for diagnosis. Few investigations were done for correct diagnosis. Results: It was found that skin OPD patients (new) were 4.16% of total new OPD patients, and male female ratio was 1.1:1. Among all patients (12910), infection was commonest (39.54%), followed by allergic skin disorder (29.20%). 25.05% patients were housewives, followed by students (23.21%). Study showed that 33.28% patients had per capita income of ' 361-720/month, and 22.35% patients were educated and/or studied up to class V. Conclusion: Pattern of skin diseases are mostly depend not only on environmental factors but also on occupation, socio-economic status, literacy, and age of the patients. Source

Chaudhuri A.D.,Rg Kar Medical College And Hospital | Nandi S.,Malda Medical College and Hospital | Bhuniya S.,Midnapore Medical College and Hospital | Tapadar S.R.,Rg Kar Medical College And Hospital | Saha M.,Rg Kar Medical College And Hospital
Lung India | Year: 2013

Context: Non-resolving pneumonia is often an area of concern for pulmonologists. Fiber optic bronchoscopy (FOB) may have a special role in etiologic evaluation of non-resolving pneumonias. There is paucity of recent studies in this field. Aims: This study aimed to assess the patients of non-resolving or slowly resolving pneumonia with special emphasis on efficacy of FOB and computed tomography (CT)-guided fine needle aspiration cytology (FNAC) in diagnosis. Settings and Design: Prospective, observational study conducted in a tertiary care institute over a period of one year. Materials and Methods: After fulfilling the definition of non-resolving pneumonia by clinical and radiological parameters, patients were evaluated by FOB with relevant microbiological, cytological, histopathological investigations and CT scan of thorax. CT-guided FNAC was done in selected cases where FOB was inconclusive. Results: Sixty patients were enrolled in the study. Mean age was 51.33 ± 1.71 years with male to female ratio 2:1. Right lung was more commonly involved (65%), and right upper lobe was the commonest site (25%). Pyogenic infection was the commonest etiology (53.3%), bronchogenic carcinoma and tuberculosis accounted for 26.7% and 16.7% cases, respectively. Both, FOB (85.7%) and CT-guided FNAC (91.67%) were very useful for etiological diagnosis of non-resolving pneumonia. Both the procedures were safe, and no major complication was observed. Conclusions: Because of the high yield of FOB, it is very useful and safe diagnostic tool for evaluation of non-resolving pneumonia. CT-guided FNAC also gives good yield when cases are properly selected. Source

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