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Kuala Selangor, Malaysia

Sambanthamurthi R.,Malaysian Palm Oil Board | Tan Y.,Malaysian Palm Oil Board | Sundram K.,Malaysian Palm Oil Council | Abeywardena M.,CSIRO | And 7 more authors.
British Journal of Nutrition | Year: 2011

Waste from agricultural products represents a disposal liability, which needs to be addressed. Palm oil is the most widely traded edible oil globally, and its production generates 85 million tons of aqueous by-products annually. This aqueous stream is rich in phenolic antioxidants, which were investigated for their composition and potential in vitro biological activity. We have identified three isomers of caffeoylshikimic acid as major components of oil palm phenolics (OPP). The 2,2-diphenyl-1-picrylhydrazyl assay confirmed potent free radical scavenging activity. To test for possible cardioprotective effects of OPP, we carried out in vitro LDL oxidation studies as well as ex vivo aortic ring and mesenteric vascular bed relaxation measurements. We found that OPP inhibited the Cu-mediated oxidation of human LDL. OPP also promoted vascular relaxation in both isolated aortic rings and perfused mesenteric vascular beds pre-contracted with noradrenaline. To rule out developmental toxicity, we performed teratological studies on rats up to the third generation and did not find any congenital anomalies. Thus, these initial studies suggest that OPP is safe and may have a protective role against free radical damage, LDL oxidation and its attendant negative effects, as well as vascular constriction in mitigating atherosclerosis. Oil palm vegetation liquor thus represents a new source of phenolic bioactives. © 2011 The Authors.

Ng W.P.Q.,University of Nottingham Malaysia Campus | Lam H.L.,University of Nottingham Malaysia Campus | Ng F.Y.,Malaysian Palm Oil Council | Kamal M.,University of Technology Malaysia | Lim J.H.E.,Synergy Global
Journal of Cleaner Production | Year: 2012

This paper gives an overview of the green potential of the palm biomass industry, which contributes to Malaysia's economic and sustainable development. An overall picture of the green development indicators of the country is provided based on the authors' experiences in policy making, research and business development. The emerging palm biomass industry in Malaysia is foreseen to dominate the country's directional development in the coming years, particularly when the sustainability issue is raised globally. With the increasing volume of palm oil residue accumulation due to palm oil production, palm biomass is gaining significant attention and being increasingly utilised to produce various green products as well as highly valuable biochemicals, such as bioethanol, vitamins, etc. The palm oil industry has been identified as the key industry for expansion to achieve economic advancement along with the development of greener production processes in the country. Research on palm biomass, which is actively being carried out by both private and public institutions, is categorised. Furthermore, actions and policies to promote the implementation of green technology in Malaysia, while simultaneously defending both environmental and ecological health and promoting technology transformation, are summarised. Challenges and concerns over the green future of the country are discussed, as well as the business trend in the Malaysian palm biomass industry. Copyright © 2012 Published by Elsevier Ltd. All rights reserved.

Patten G.S.,CSIRO | Abeywardena M.Y.,CSIRO | Sundram K.,Malaysian Palm Oil Council | Tan Y.A.,Malaysian Palm Oil Board | Sambanthamurthi R.,Malaysian Palm Oil Board
Journal of Functional Foods | Year: 2015

The effects of a novel water soluble polyphenolics preparation (oil palm phenolics; OPP) on whole gastrointestinal transit, ex vivo proximal and distal colonic contractility and intact expulsion time in the distal colon were examined. Nine weeks of dietary supplementation with OPP at 50 mg gallic acid equivalents (GAE)/rat per day had no effect on gastric emptying compared to the control (AIN-93M), but 30% substituted high amylose maize starch (HAMS) used as a positive resistant starch control, had significantly higher gastric emptying compared to both control and OPP. OPP increased distal colonic contractile response to KCl, PGE2 and angiotensin I compared with the control, whilst HAMS also had similar increased contractile responses. This correlated with faster distal colonic expulsion rates for OPP and HAMS compared with the control. The present study revealed that OPP, like resistant starch, has positive effects on distal colonic contractility and motility with potential putative roles in bowel function and health. © 2015 Elsevier Ltd.

Sambanthamurthi R.,Malaysian Palm Oil Board | Tan Y.,Malaysian Palm Oil Board | Sundram K.,Malaysian Palm Oil Council | Hayes K.C.,Brandeis University | And 9 more authors.
British Journal of Nutrition | Year: 2011

It is well established that plant phenolics elicit various biological activities, with positive effects on health. Palm oil production results in large volumes of aqueous by-products containing phenolics. In the present study, we describe the effects of oil palm phenolics (OPP) on several degenerative conditions using various animal models. OPP reduced blood pressure in a NO-deficient rat model, protected against ischaemia-induced cardiac arrhythmia in rats and reduced plaque formation in rabbits fed an atherogenic diet. In Nile rats, a spontaneous model of the metabolic syndrome and type 2 diabetes, OPP protected against multiple aspects of the syndrome and diabetes progression. In tumour-inoculated mice, OPP protected against cancer progression. Microarray studies on the tumours showed differential transcriptome profiles that suggest anti-tumour molecular mechanisms involved in OPP action. Thus, initial studies suggest that OPP may have potential against several chronic disease outcomes in mammals. © 2011 The Authors.

Leow S.-S.,Malaysian Palm Oil Board | Sekaran S.D.,University of Malaya | Sundram K.,Malaysian Palm Oil Council | Tan Y.,Malaysian Palm Oil Board | Sambanthamurthi R.,Malaysian Palm Oil Board
Journal of Nutrigenetics and Nutrigenomics | Year: 2014

Background/Aim: Plant phenolics can inhibit, retard or reverse carcinogenesis, and may thus help prevent or treat cancer. Oil palm phenolics (OPP) previously showed anti-tumour activities in vivo via a cytostatic mechanism at 1,500 ppm gallic acid equivalent. Here, we report other possible molecular mechanisms by which this extract attenuates cancer, especially those concerning the immune response. Methods: We subcutaneously injected J558 myeloma cells in BALB/c mice and supplemented OPP orally at 1,500 ppm gallic acid equivalent. We observed the physiology parameters of these animals and harvested their spleens and livers after 18 h, 1 week and 4 weeks for microarray gene expression analysis using Illumina MouseRef-8 BeadChips. Results: Time course microarray analysis on spleens after injecting J558 myeloma cells in mice revealed that the immune response of tumour-bearing mice supplemented with OPP was lower compared to controls, thus suggesting delayed inflammation in response to OPP. In livers, cholesterol biosynthesis genes were upregulated while inflammatory genes were downregulated through time, further suggesting attenuation of systemic inflammation and cachexia. These effects correlated with the delayed in vivo development of syngeneic tumours in mice given OPP. Conclusions: This study suggests the possible utilisation of OPP as an anti-tumour and anti-cachexia agent. © 2014 S. Karger AG, Basel.

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