Kerala, India
Kerala, India

Time filter

Source Type

Padma Priya S.,Ajman University for Science and Technology | Higuchi A.,National Central University | Higuchi A.,King Saud University | Higuchi A.,National Health Research Institute | And 10 more authors.
Laboratory Investigation | Year: 2015

The ultimate goal of dental stem cell research is to construct a bioengineered tooth. Tooth formation occurs based on the well-organized reciprocal interaction of epithelial and mesenchymal cells. The dental mesenchymal stem cells are the best explored, but because the human odontogenic epithelium is lost after the completion of enamel formation, studies on these cells are scarce. The successful creation of a bioengineered tooth is achievable only when the odontogenic epithelium is reconstructed to produce a replica of natural enamel. This article discusses the untapped sources of odontogenic epithelial stem cells in humans, such as those present in the active dental lamina in postnatal life, in remnants of dental lamina (the gubernaculum cord), in the epithelial cell rests of Malassez, and in reduced enamel epithelium. The possible uses of these stem cells in regenerative medicine, not just for enamel formation, are discussed. © 2015 USCAP, Inc All rights reserved.

PubMed | Co operative Hospital and Malabar Medical College
Type: Journal Article | Journal: Journal of orthopaedic case reports | Year: 2016

Anterior dislocation of hip associated with fracture of proximal femur is an uncommon injury. Only very few cases are reported in the literature. We report such an unusual and previously not described case of anterior dislocation of hip associated with fracture of trochanter and neck of the femur in an elderly lady.A 60 year old lady was presented to our casualty following a fall at home. She complained of pain in the left hip with deformity and inability to move the limb. The hip was externally rotated and clinical examination revealed anterior dislocation of the hip. X-ray showed associated fracture of the proximal femur extending between base of greater trochanter and head of the femur. Cemented Hemiarthroplasty was done under regional anesthesia.Anterior dislocation of hip with extensive fracture of proximal femur, though a rare condition may present because of associated twisting force at the time of the fall. If operated with cemented prosthetic replacement of the head, patient can be mobilized early.

Meenakshi S.R.,Malabar Medical College | Agarwal R.,M S Ramaiah Medical College
Journal of Clinical and Diagnostic Research | Year: 2013

Background and Objectives: Nitric Oxide (NO), the L-arginine derivative, is tonically synthesised by the endothelium within the kidney and it plays a crucial role in the regulation of the blood pressure and the renal blood flow. NO regulates the renal function through the modulation of the vascular tone and sodium handling. With the progressive development of the renal insufficiency, it remains unclear whether the endogenous NO production is increased or decreased in the kidney. This study was carried out to determine whether there were any changes in the levels of NO and teir correlation with the routine parameters of the renal dysfunction in the patients of Chronic Renal Failure (CRF), as the disease progresses in conjunction with poor renal functions. Methods: Thirty patients with chronic renal disease which was caused by chronic glomerulonephritis and hypertension, who were on Maintenance Haemodialysis (MHD) with serum creatinine levels of > 2.5 mg/dl, were included in this study. Thirty healthy voluntary blood donors were taken as the controls. NO was estimated by a spectrophotometric method by using cadmium reduction. The routine renal function tests, BUN and Creatinine were performed by the standard clinical chemistry procedures. Results: The serum NO levels were found to be significantly increased (p < 0.01) in the CRF on MHD (98.77 ± 35.40 μmol/l) as compared to the controls (22.03 ± 7.23 μmol/l). The NO output correlated with the serum creatinine (r = 0.8123, p < 0.01) and the urea concentration (r = 0.5166, p = <0.01) in the CRF group. Conclusion: The NO levels were markedly enhanced in the CRF patients who were on MHD. This was due to the dialysis procedure itself, which led to the stimulation of cytokine induced NO synthase and also due to the platelets which generated more NO due to uraemia. At high concentrations, NO is a cytotoxic molecule which is responsible for the complications of dialysis and it results in Nitrosative Stress in these patients, as it is a highly reactive free radical. Since the no output correlated with the serum creatinine and urea concentrations, a higher no production probably indicated insufficient blood purification, due to the common effect on their elimination pathways via the renal tract. Therefore, the alterations of the renal function, that are reflected in the changes of the creatinine concentration, will be accompanied by the changes in the serum NO. Thus, the determination of the NO levels in the peripheral blood may be useful in the assessment of the dialysis and they can also be used as markers in the follow up and the prognosis in these type of patients.

Ekambaramgnanadesigan,Annamalai University | Balumahendran K.,Annamalai University | Gnanagurudasan E.,Malabar Medical College | Santhosh Kumar N.,Shridevi Institute of Medical science and Research Hospital
International Journal of Pharma and Bio Sciences | Year: 2013

Selenium (Se) is considered to be one of the most controversial trace elements. Se deficiency is a global health problem related to an increased susceptibility to various diseases of animals and humans particularly male infertility. This review covers particularly the current knowledge of selenium in the reproductive system. Nowadays, infertility is one of the most stressful conditions amongst married couples. Male factor infertility is implicated in almost half of these cases. Recent advances in the field of reproductive medicine have focused the role of selenium concentration in relation with male fertility. The main aim of the present review was to provide further data on the distribution of this metal throughout the human male reproductive tract.

Deshpande G.S.,Hassan Institute of Medical science | Deshpande S.R.,Malabar Medical College | Nalini G.K.,Hassan Institute of Medical science
Journal of Clinical and Diagnostic Research | Year: 2010

Though the budgeting for health has increased in recent times and we see a robust network of quality public and private health centres across the nation, the budgeting for e-Health technologies have not received the Indian health planners adequate attention. The heart of e-Health efforts should be an efficient mobile based short messaging network which is very much available at a common mans price. A back up network of call centres like Project M of Africa will not be difficult for a nation that provides call centre back -up and technologies to the world. Convergence E-Health Services under a Unified National Health Grid hold good prospects for a big overpopulated country like India, with a poor and inefficient health infrastructure.

Pandit D.,Malabar Medical College
Indian Journal of Rheumatology | Year: 2011

Brucellosis commonly presents as pyrexia of unknown origin. However, it can also present with the involvement of reticular-endothelial or skeletal system wherein sacroilitis, spondylitis, arthritis, and osteomyelitis are the common presentations. Osteoarticular manifestations are often under diagnosed due to a low index of suspicion, and temporary response to symptomatic treatment. This can lead to a chronic incapacitating disease. Being treatable, it is important to identify them early and institute appropriate therapy. Diagnosis can be achieved by bacterial isolation and/or serology. New culture methods and molecular techniques can be useful whenever available. Treatment with antibiotics and surgery when indicated can help prevent the incapacitation and crippling, which otherwise results due to progressive disease. Elimination of animal brucellosis is the only way of prevention of human brucellosis. A safe and effective vaccine for human use is the future hope. © 2011 Indian Rheumatology Association.

Naik G.,Malabar Medical College | Deshpande S.R.,Malabar Medical College
Journal of Clinical and Diagnostic Research | Year: 2011

The Human immunodeficiency virus infection is essentially an infection of the immune system, with progressive and profound defects in the cell mediated immune response. The pathogenesis of the Human immunodeficiency virus infection is a multifactorial process, consisting of aberrant cellular activation and the disregulation of nearly every aspect of the immune system. The lentivirus subverts the immune system by infecting the CD4+Tcells that normally orchestrate immune responses and by activating the immune system and inducing a cytokine milieu that the virus uses to its own replication advantage. The disease outcome depends on the innate immune response, the adaptive immune response, the host genetic factors and the differences in viral pathogenicity.

Naik G.,Malabar Medical College | Deshpande S.R.,Malabar Medical College
Journal of Clinical and Diagnostic Research | Year: 2011

Objective: To study the prevalence of Staphylococcus aureus and Methicillin-Resistant Staphylococcus Aureus (MRSA) in surgical site infections (SSIs) in referral hospitals at the coastal city of Mangalore, India. Materials and Methods: This study was conducted on 300 patients who underwent surgery in the obstetrics and gynaecology, orthopaedic and surgical departments which were attached to the referral hospitals which were attached to Kasturba Medical College, Mangalore. Pus samples were collected with two sterile swabs and processed in the Microbiology department. Results: Of the 300 pus samples, 216(72%) showed growth. 258 aerobic bacteria were isolated. The most common organism which was isolated was Staphylococcus aureus, with 83(32.2%) isolates. Of these, 8 (9.6%) were Methicillin Resistant Staphylococcus Aureus (MRSA). Conclusions: Indian clinicians and infectious disease specialists in the coastal areas are facing formidable challenges from Methicillin Resistant Staphylococcus aureus. Despite the best surgical practices, nearly a tenth of all the SSIs cases could be caused by MRSA. Routine screening for these multidrug resistant organisms in the hospital staff, especially in the surgical departments and pre-surgical screening of the patients could help in reducing the incidence of MRSA.

Kashinatha Shenoy M.,Malabar Medical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

Epidemic keratoconjunctivitis is commonly associated with type 8 & 9 strains of adenovirus which are responsible for epidemics in India and elsewhere [1]. The patients are highly contagious for up to 2 weeks and the incubation period for the virus is 2-14 days, the affected person being infectious for 10-14 days after symptoms [2,3]. Epidemic keratoconjunctivitis (EKC) is characterized by conjunctivitis with acute onset of watering, redness, foreign body sensation, discharge and discomfort. Both eyes are affected in 60% of the cases [4]. Ophthalmic examination shows lid oedema, a follicular response which is frequently associated with a preauricular adenopathy; subconjunctival hemorrhages' and pseudo membranes may rarely develop in unusual instances. Corneal involvement causes intense photophobia due to punctate epithelial lesions. Later, sub epithelial infiltrates appear at the level of Bowman membrane as a hypersensitivity reaction to viral antigen [3,4]. We herewith report a rare case of pseudo membrane covering both eyes, attended by difficulty to open both the eyes.

Liji K.,Malabar Medical College | Warrier P.K.,MES Medical College | Deshpande S.R.,Malabar Medical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

To study the acid-base status of the malayalee patients admitted in Medical Intensive care Unit with metabolic encephalopathy, to know about the most common underlying disease, to understand the prevalent metabolic disorder among nonvegetarian patients in the Malappuram region of Kerala state, India. Estimation of acid base parameters and electrolytes (Na+, K+, and Cl-) in intensive care unit patients with metabolic encephalopathy were done in a total of 43 adults admitted with metabolic encephalopathy. Simultaneously, age and sex matched 25 non vegetarian malayalee of control group were also studied. Most of the ICU admitted nonvegetarian malayalee patients showed significant acid base and electrolyte balance disorders. Most cases of metabolic encephalopathy had an identifiable precipitating factor. Disorders like Hyponatremia require timely recognition and can often be reversed with appropriate intervention and treatment of underlying predisposing factors. Early diagnosis of hyponatremia, and electrolyte imbalances, in the ICU admitted patient may prove life saving in a nonvegetarian malayalee patient.

Loading Malabar Medical College collaborators
Loading Malabar Medical College collaborators