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Kozhikode, India

Ekambaramgnanadesigan,Annamalai University | Balumahendran K.,Annamalai University | Gnanagurudasan E.,Malabar Medical College | Santhosh Kumar N.,Shridevi Institute of Medical science and Research Hospital
International Journal of Pharma and Bio Sciences

Selenium (Se) is considered to be one of the most controversial trace elements. Se deficiency is a global health problem related to an increased susceptibility to various diseases of animals and humans particularly male infertility. This review covers particularly the current knowledge of selenium in the reproductive system. Nowadays, infertility is one of the most stressful conditions amongst married couples. Male factor infertility is implicated in almost half of these cases. Recent advances in the field of reproductive medicine have focused the role of selenium concentration in relation with male fertility. The main aim of the present review was to provide further data on the distribution of this metal throughout the human male reproductive tract. Source

Deshpande G.S.,Hassan Institute of Medical science | Deshpande S.R.,Malabar Medical College | Nalini G.K.,Hassan Institute of Medical science
Journal of Clinical and Diagnostic Research

Though the budgeting for health has increased in recent times and we see a robust network of quality public and private health centres across the nation, the budgeting for e-Health technologies have not received the Indian health planners adequate attention. The heart of e-Health efforts should be an efficient mobile based short messaging network which is very much available at a common mans price. A back up network of call centres like Project M of Africa will not be difficult for a nation that provides call centre back -up and technologies to the world. Convergence E-Health Services under a Unified National Health Grid hold good prospects for a big overpopulated country like India, with a poor and inefficient health infrastructure. Source

Padma Priya S.,Ajman University for Science and Technology | Higuchi A.,National Central University | Higuchi A.,King Saud University | Higuchi A.,National Health Research Institute | And 10 more authors.
Laboratory Investigation

The ultimate goal of dental stem cell research is to construct a bioengineered tooth. Tooth formation occurs based on the well-organized reciprocal interaction of epithelial and mesenchymal cells. The dental mesenchymal stem cells are the best explored, but because the human odontogenic epithelium is lost after the completion of enamel formation, studies on these cells are scarce. The successful creation of a bioengineered tooth is achievable only when the odontogenic epithelium is reconstructed to produce a replica of natural enamel. This article discusses the untapped sources of odontogenic epithelial stem cells in humans, such as those present in the active dental lamina in postnatal life, in remnants of dental lamina (the gubernaculum cord), in the epithelial cell rests of Malassez, and in reduced enamel epithelium. The possible uses of these stem cells in regenerative medicine, not just for enamel formation, are discussed. © 2015 USCAP, Inc All rights reserved. Source

Meenakshi S.R.,Malabar Medical College | Agarwal R.,M S Ramaiah Medical College
Journal of Clinical and Diagnostic Research

Background and Objectives: Nitric Oxide (NO), the L-arginine derivative, is tonically synthesised by the endothelium within the kidney and it plays a crucial role in the regulation of the blood pressure and the renal blood flow. NO regulates the renal function through the modulation of the vascular tone and sodium handling. With the progressive development of the renal insufficiency, it remains unclear whether the endogenous NO production is increased or decreased in the kidney. This study was carried out to determine whether there were any changes in the levels of NO and teir correlation with the routine parameters of the renal dysfunction in the patients of Chronic Renal Failure (CRF), as the disease progresses in conjunction with poor renal functions. Methods: Thirty patients with chronic renal disease which was caused by chronic glomerulonephritis and hypertension, who were on Maintenance Haemodialysis (MHD) with serum creatinine levels of > 2.5 mg/dl, were included in this study. Thirty healthy voluntary blood donors were taken as the controls. NO was estimated by a spectrophotometric method by using cadmium reduction. The routine renal function tests, BUN and Creatinine were performed by the standard clinical chemistry procedures. Results: The serum NO levels were found to be significantly increased (p < 0.01) in the CRF on MHD (98.77 ± 35.40 μmol/l) as compared to the controls (22.03 ± 7.23 μmol/l). The NO output correlated with the serum creatinine (r = 0.8123, p < 0.01) and the urea concentration (r = 0.5166, p = <0.01) in the CRF group. Conclusion: The NO levels were markedly enhanced in the CRF patients who were on MHD. This was due to the dialysis procedure itself, which led to the stimulation of cytokine induced NO synthase and also due to the platelets which generated more NO due to uraemia. At high concentrations, NO is a cytotoxic molecule which is responsible for the complications of dialysis and it results in Nitrosative Stress in these patients, as it is a highly reactive free radical. Since the no output correlated with the serum creatinine and urea concentrations, a higher no production probably indicated insufficient blood purification, due to the common effect on their elimination pathways via the renal tract. Therefore, the alterations of the renal function, that are reflected in the changes of the creatinine concentration, will be accompanied by the changes in the serum NO. Thus, the determination of the NO levels in the peripheral blood may be useful in the assessment of the dialysis and they can also be used as markers in the follow up and the prognosis in these type of patients. Source

Kashinatha Shenoy M.,Malabar Medical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences

Epidemic keratoconjunctivitis is commonly associated with type 8 & 9 strains of adenovirus which are responsible for epidemics in India and elsewhere [1]. The patients are highly contagious for up to 2 weeks and the incubation period for the virus is 2-14 days, the affected person being infectious for 10-14 days after symptoms [2,3]. Epidemic keratoconjunctivitis (EKC) is characterized by conjunctivitis with acute onset of watering, redness, foreign body sensation, discharge and discomfort. Both eyes are affected in 60% of the cases [4]. Ophthalmic examination shows lid oedema, a follicular response which is frequently associated with a preauricular adenopathy; subconjunctival hemorrhages' and pseudo membranes may rarely develop in unusual instances. Corneal involvement causes intense photophobia due to punctate epithelial lesions. Later, sub epithelial infiltrates appear at the level of Bowman membrane as a hypersensitivity reaction to viral antigen [3,4]. We herewith report a rare case of pseudo membrane covering both eyes, attended by difficulty to open both the eyes. Source

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