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Cannanore, India

Vijayan A.,Sri Hasanamba Dental College and Hospital | Vijayan A.,Al Azhar Dental College | Asha M.L.,Sri Hasanamba Dental College and Hospital | Asha M.L.,Dr Shamala Reddy Dental College Hospital And Research Center | And 2 more authors.
Clinical Oncology | Year: 2014

Aims: To evaluate the effectiveness of transcutaneous electrical nerve stimulation (TENS) delivered using an extra-oral device in patients with radiation-induced xerostomia. Materials and methods: Thirty oral cavity and oropharyngeal cancer patients post-adjuvant (. n=26) or definitive radiotherapy (. n=4) were enrolled in this study. The TENS electrode pads were placed externally on the skin overlying the parotid glands. Unstimulated whole saliva was collected for 5min into graduated tubes using the low forced spitting method. The TENS unit was then activated and stimulated saliva was collected for an additional 5min. The difference between unstimulated and stimulated saliva output was measured using the paired t-test. Linear regression was used to determine factors significantly influencing the improvement in salivary output. Results: Twenty-nine of 30 patients showed increased saliva flow during stimulation. A statistically significant improvement in saliva production (. P<0.05) during stimulation was noted. The mean unstimulated saliva flow was 0.056ml/min and the mean stimulated saliva flow was 0.12ml/min with a median increase of 0.06ml/min. The interval to the application of TENS after radiotherapy significantly influenced the improvement in salivary flow. Conclusion: Extra-oral application of TENS is effective in increasing the whole salivary flow in most of the post-radiated oral cavity/oropharyngeal cancer patients with xerostomia. TENS therapy may be useful as an effective supportive treatment modality in post-radiated oral cancer patients. © 2014 The Royal College of Radiologists.

Interest in survival analysis is to look and capture the information about the occurrence of events, i.e., death. In human life different types of events may happen at the same time. Sometimes, few events completely interrupt or make subtle changes on the occurrence of an event of interest. The method to capture information about the specific event of interest along with other events is known as competing risk modeling. This paper is dedicated to explore the application of competing risk model in oncology practice. It is aimed in near future that more and more survival analysis will be performed through application of competing risk modeling instead of traditional survival analysis to generate robust statistical inference. © 2014 Indian Journal of Cancer | Pulished by Wolters Kluwer - Medknow.

Alora Veedu R.,P.A. College | Balan A.,Government Dental College | Sankar S P.,Malabar Cancer Center
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology | Year: 2015

Objective Numerous treatment modalities for oral submucous fibrosis (OSF) have been advocated over the years. However, its medical treatment is not yet fully standardized. This randomized double-blind trial assessed and compared the effects of two commonly used drugs, independently and in combination. Methods Forty-five patients were staged clinically and histopathologically for OSF and were randomly divided into three groups of 15 each by permuted block randomization. Each group received biweekly submucosal injections of hyaluronidase (1500 IU), dexamethasone (8 mg) or a combination of both (750 IU and 4 mg), respectively, for a period of 5 weeks. Improvement in pain upon opening, burning sensation, and tightness of mucosa as perceived by the patient, as well as improvement in mouth opening measured clinically were determined at the end of week 2, months 1, 2, 3, and 6 after the final injection. Results were compared and statistically analyzed using analysis of variance. Results Submucosal injection of hyaluronidase gave a quicker and better improvement of measured symptoms. Conclusions Biweekly submucosal injection of hyaluronidase over a period of 5 weeks appears to be a viable treatment option for OSF. © 2015 Elsevier Inc.

Babu S.,The Surgical Center | B S.,The Surgical Center | M G.,Malabar Cancer Center | Salih S.,The Surgical Center
World Journal of Surgical Oncology | Year: 2011

Squamous cell carcinoma of lip is a common malignancy in Indian subcontinent. Metastatic spread is infrequent. Although advanced tumours spread to lymph nodes in the neck, it does not typically present with lung metastasis or with lymphangitic carcinomatosis. We describe a patient who developed cough and increasing dyspnoea while on treatment for carcinoma of lip. Chest x-ray and computed tomography were consistent with lymphangitic carcinomatosis. Lymphangitic carcinomatosis occurs with many different primary tumours and can rarely occur in oral cancers. This is the first report from carcinoma of lip. © 2011 Babu et al; licensee BioMed Central Ltd.

Shanju S.,Malabar Cancer Center | Sangeetha K.,Malabar Cancer Center | Nair C.K.,Malabar Cancer Center | Satheesan B.,The Surgical Center
Research Journal of Biotechnology | Year: 2013

Stem cells are unique cells, having the property of self renewal characteristics and differentiation. Protein antigen markers in surface of cells are generally used to identify stem cell population. Cancer stem cells or tumor initiating cells generally occur within tumor cells causing cancer. Cell surface antigen markers on the stem cells are not able to identify the specific type of cancer. Further research on tumor suppressor genes, signaling pathways during stem cell differentiation would be able to combat the disease.

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