Hamzah Y.B.,Makmal Nanoteknologi |
Hamzah Y.B.,University of Technology Malaysia |
Hashim S.,University of Technology Malaysia |
Rahman W.A.W.A.,University of Technology Malaysia
Journal of Polymer Research | Year: 2017
Nanogels have become an important topic of interdisciplinary research, especially in the fields of polymer chemistry, physics, materials science, pharmacy, and medicine where their small dimensions prove highly advantageous. One of the most important areas of research and development concerning these gels is in drug delivery applications. Nanogels could potentially revolutionize conventional therapy and diagnostic methods because of their superior effectiveness over their macro-sized counterparts in almost all therapeutic areas. Current strong interests in this class of material have driven many studies to discover novel production methods and new areas of application in this area. Therefore, it is important to keep abreast of the development of these gels. In this review, we aim to cover the basic aspects of organic nanogels including their definition, classification, and synthesis methods. © 2017, Springer Science+Business Media B.V.
Hamzah M.Y.,Makmal Nanoteknologi |
Isa N.M.,Malaysian Nuclear Agency |
Napia L.M.A.,Malaysian Nuclear Agency
AIP Conference Proceedings | Year: 2014
The use of microemulsion in the development of nanosized gels based on polyethylene glycol diacrylate (PEGDA) is demonstrated. PEGDA was solubilized in n-heptane with use of sodium docusate (AOT) at 0.15M concentration to form reverse micelles. These micelles were than irradiated at 5, 10, 15, 20 and 25 kGy using electron beam (EB) to crosslink the entrapped polymer in the micelles. Ionizing radiation was imparted to the emulsions to generate crosslinking reaction in the micelles formed. The nanosized gels were evaluated in terms of particle diameter using dynamic light scattering (DLS) and the images of the nanosized gels were studied using transmission electron microscopy (TEM). Results show that the size and shape of the particles are influenced by concentration of PEGDA and radiation dose. This study showed that this method can be utilized to produce nanosized gels. © 2014 AIP Publishing LLC.
Hamzah Y.,Makmal Nanoteknologi |
Yunus W.M.Z.W.,Makmal Nanoteknologi |
Isa N.M.,Makmal Nanoteknologi |
Tajau R.,Makmal Nanoteknologi |
And 2 more authors.
E-Polymers | Year: 2012
The purpose of the work described here was to prepare covalently crosslinked nanogel from polyethylene glycol diacrylate (PEGDA) using an inverse micelle system as a template for irradiation via electron beam. Inverse micelles were formed by addition of sodium dioctyl sulfosuccinate (AOT) in n-heptane above its critical micelle concentration. These nano sized micelles were used to trap PEGDA in its water phase. Irradiation of the PEGDA containing micelles leads to formation of many radicals and recombinations thus forming crosslinked nanogel.
Yusof H.,Makmal Nanoteknologi |
Naurah M.I.,ALURTRON |
Advanced Materials Research | Year: 2014
Micro sized gels have been widely used as drug carriers due to their compatibility in blood. Among the important properties are round small dimensions and large surface area. These properties allow for better attachment of ligand and higher stability in the blood stream. In this study, microgels from polyethylene glycol diacrylate (PEGDA) were prepared from microemulsions using electron beam with energy of 3 MeV at different irradiation dose of 0 to 25 kGy. Dynamic light scattering (DLS) study revealed that gel with diameter of 70-100 nm with a narrow size distribution was obtained at 5 kGy and 400-550 nm with a broad size distribution at 25 kGy. The molecular weight obtained from GPC-MALLS for the minimum practical dose irradiated has resulted in more than 4.22 × 105 g/mol as compared to7.75 × 102 g/mol for nonirradiated polymer. The increase of size and its distribution as well as its molecular weight over the elevation dose were suspected to be due to diffusion of micelles that leads to recombination of macro radicals from different micelles during longer irradiation period at higher doses. Overall findings from this study have proven that PEGDA microgels can be prepared via electron beam radiation with emulsions as templates for polymerization. © (2014) Trans Tech Publications, Switzerland.