Lussac-les-Châteaux, France
Lussac-les-Châteaux, France

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Lefebvre E.,Cergy-Pontoise University | Lequeux I.,CNRS Polymers, Biopolymer and Surfaces Laboratory | Vighetto C.,Cergy-Pontoise University | Fromantin I.,University Pierre and Marie Curie | And 13 more authors.
IRBM | Year: 2014

The PANSaBIO project aims to evaluate the prevalence of biofilms on a large panel of chronic wounds (more than 100 samples) and relate its presence to the type and history of the wound and its microbiology. A large file computing all the data is under construction. Moreover, several strategies to prepare an innovative anti-biofilm dressing have been developed. On one hand, antimicrobial peptides were grafted to gelatin; the modified protein can be used to prepare an active dressing. Second, various antiseptics were entrapped in a gelatin gel. An adaptation was necessary to obtain the convenient mechanical properties of the gel. Then this preparation was turned to a dressing. A first generation of dressings efficient against biofilms of Pseudomonas aeruginosa and Staphylococus aureus is available today. © 2014 Elsevier Masson SAS.

Klak M.-C.,Cergy-Pontoise University | Picard J.,Maia Woundcare | Giraudier S.,Maia Woundcare | Larreta-Garde V.,Cergy-Pontoise University
Soft Matter | Year: 2012

Biogels are useful reservoirs for molecular delivery as they can entrap a large variety of compounds in their liquid phase. The delivery kinetics of these molecules is dictated by diffusion laws and thus depends on their molecular size. An original strategy to accelerate the release of large molecules from a gelatin gel is here described. The gel solid network is progressively degraded by enzymes which allows for the delivery of large to very large molecules in a well-controlled way. Diffusion by burst is thus made possible even for very large molecules. Finally, a mathematical model is elaborated to predict the diffusion of molecules entrapped inside a gel undergoing a gel-sol transition. © 2012 The Royal Society of Chemistry.

Ma.I.A Woundcare | Date: 2013-05-30

Body care products and substances for cosmetic use; skin care substances for cosmetic use; beauty products and substances, namely products and substances for toilet purposes, cosmetic products and substances. Medical plasters for wound care and for wound prevention, medical plasters for skin care, medical substances and preparations for skin care; materials for dressings as well as antiseptic cleansing tissues.

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