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Kumar R.,National Institute of Pharmaceutical Education and Research | Trivedi V.,Mahavir Cancer Sansthan and Research Center | Murti K.,National Institute of Pharmaceutical Education and Research | Dey A.,National Institute of Pharmaceutical Education and Research | And 3 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2015

Cervical cancer is the second most common gynecological malignancy worldwide. According to HPV Information Centre, Spain (Aug'2014), in India approximately 1,22,844 women are diagnosed with the disease every year and of them 67,477 die due to the disease. CaCx is said to be mediated by HPV but recent data published reveal the role of Oxidative Stress in different Cancers. Arsenic is also one of the agents for causing Oxidative Stress. Arsenic has been linked with different types of cancer. Arsenic is considered responsible for generation of free radicals and eventually for apoptosis. Early diagnosis of CaCx is presently a matter of concern and clinical presentation in advanced stages become difficult for complete clinical response. For determination of oxidative stress, Malondialdehyde (MDA) was taken as an identifier and arsenic estimation was performed with the help of Atomic Absorption Spectrometer (AAS). RBC count and Haemoglobin levels were performed according to standard protocol. MDA was in direct proportion with arsenic concentration and inversely proportional to RBC and Haemoglobin in CaCx patients. Arsenic is one of the major causative agents for oxidative stress and hence may be a risk factor leading to cancer including CaCx.

Nath A.,Mahavir Cancer Sansthan and Research Center | Priyanka,Mahavir Cancer Sansthan and Research Center | Singh J.K.,Mahavir Cancer Sansthan and Research Center | Singh S.,Mahavir Cancer Sansthan and Research Center | And 5 more authors.
Journal of Ecophysiology and Occupational Health | Year: 2014

Oral cancer is the most common form of cancer and cancer-related deaths among Indian males. 70-75% of these cases are due to chewing tobacco. Estrogen and testosterone both are an important hormone for male and female. Estrogen has an important role in the development of breast cancer, ovarian cancer etc. There are very few studies available which describe the increased oral cancer incidence and level of estrogen in male oral cancer patients and use of smokeless tobacco consumption among the same type of cancer patients. Therefore, the present study has been aimed to find out the prevalence of oral cancer due to consumption of smokeless tobacco, sub-site distribution and level of estrogen in the oral cancer patients in Bihar. In the present study 126 patients suffering from oral cancer were selected randomly. The background data obtained were categorized into sex-wise as well as age-wise oral cancer incidence, carcinoma site, frequency of oral cancer and the type of tobacco addiction among the surveyed oral cancer patients. Estrogen level in male oral cancer patients was assessed by ELISA-kit method. Addiction of khaini among all of the smoke and smokeless tobacco consuming persons in Bihar was found higher. Prevalence of oral cancer was four times higher in male patients than the female and the level of estrogen hormone in male oral cancer patients were found elevated. In conclusion, high oral cancer incidence has been observed among people of Bihar. Most popular form of smokeless tobacco is khaini mainly used by illiterate people. Elevated level of estrogen hormone in male oral cancer patients may be associated with the increased incidence of oral cancer among people of Bihar. It may further provide some evidence to understand the whole mechanism of oral cancer. © 2014 The Academy of Environmental Biology, India.

Singh T.,Bra Bihar University | Sinha N.,Bra Bihar University | Singh A.,Mahavir Cancer Sansthan and Research Center
Indian Journal of Pharmacology | Year: 2013

Background: Limited data is available about the toxicity of herbal remedies used for self-medication. Since a popular medicinal plant Ecliptaalba contains various bioactive molecules, the present study aimed to observe the biochemical and histological changes in liver associated with acute oral toxicity (LD 50 ) of aqueous extract of E. alba (L.) Hassk. in female Swiss albino mice. Materials and Methods: For the acute oral toxicity study, the animals were divided into six groups of 6 mice each. Group-I was normal control and the treatment groups were administered aqueous leaf extract of E. alba orally at different doses of 500 mg (group-I),1750 mg (group-III), 2000 mg (group-IV), 2500 mg (group-V) and 3000 mg/kg/b.wt.(group-VI) for seven consecutive days. The mice were sacrificed on the eighth day and blood was collected for the analysis of ALP (alkaline phosphatase), SGPT (serum glutamic pyruvic transferase), total protein and albumin. The liver was dissected, weighed, and processed for histopathological analysis. Results: The LD 50 was found to be 2316.626 mg/kg/body weight in female mice. Serum SGPT, total protein and albumin increased in treated group-IV (P < 0.05), V (P < 0.01), and VI (P < 0.01) as compared to the control (group-I). ALP level significantly decreased in the treated group-IV (P < 0.05), V (P < 0.01) and VI (P < 0.01). Histopathological changes were observed at dose of 2000 mg (group-IV), 2500 mg (group-V) and 3000 mg (group-VI). Conclusion: It was concluded that oral administration of aqueous leaf extract of E. alba had detrimental effects on biochemical parameters and induced histopathological alterations in liver of female Swiss albino mice at doses higher than 2000 mg/kg/day indicating that its indiscriminate use should be avoided.

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