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Majeed T.A.,Mahavir Cancer Sansthan | Deshpande R.K.,Asian Institute of Oncology | Upadhaya S.,Asian Institute of Oncology | Deshmukh S.A.,Asian Institute of Oncology
Indian Journal of Surgical Oncology | Year: 2010

Internal jugular vein is one of the major contributors to the venous drainage from the intracranial structures. Neck dissections which necessitates ligation of internal jugular vein leads to significant alteration of cerebrospinal fluid pressures in the range of three times for unilateral ligation to five times in cases of bilateral ligation. Agenesis of internal jugular vein merits concern prior to central venous cannulation and ligation during radical neck dissection for metastatic nodes in head and neck cancers. © 2011 Indian Association of Surgical Oncology. Source

Singh J.K.,Ss Hospital And Research Center | Chauhan R.,Mahavir Cancer Sansthan
Reviews on Recent Clinical Trials | Year: 2015

Cervical cancer has a major impact on the lives of Indian women with an estimated 122, 844 new cases of cervical cancer in the year 2012. About 80% of these cases present in a locally advanced stage leading to high morbidity and mortality. Because of lack of public awareness and infrastructure for screening and early detection in developing countries, this late presentation is likely to continue in the coming years. Radiation therapy has been the treatment of choice for patients with locally advanced cancer cervix. Many clinical trials and meta-analyses have shown a significant improvement in overall and progression-free survival with decreased local and distant recurrences with the use of concurrent chemotherapy with radiation. Most of these trials have been done in women from developed countries where the patient and disease profile are entirely different from ours. Recently, few trials from India have also shown promising results in locally advanced cancer cervix with concurrent chemoradiotherapy but toxicities remain a major concern. Further exploration is required for the use of concurrent chemo radiation prior to incorporating it into routine clinical practice. © 2015 Bentham Science Publishers. Source

Heroor A.,Head Surgical Oncology | Panjwani G.,Mahavir Cancer Sansthan | Chaskar R.,KDA Hospital
Indian Journal of Surgery | Year: 2015

This study aims to document demographic and intraoperative variables and short-term postoperative outcomes in patients being operated by laparoscopy-assisted colorectal surgeries and assessing the magnitude of impact of the learning curve on surgical results. This study included 101 patients with colonic or rectal pathology getting operated for laparoscopy-assisted colorectal surgeries carried out by the same surgeon over 5 years (2008 to 2013). The patient data was retrospectively analyzed for pre-decided variables. Also, comparison was made between the surgeries performed during the learning curve of initial 30 cases with subsequent operations. Laparoscopic colorectal surgeries give satisfactory results in terms of intraoperative parameters like surgical duration, blood loss, and clinico-pathologic parameters like lymph nodal resection and distal and circumferential margins. Patients undergoing laparoscopic colorectal surgeries fare better in short-term postoperative period while early long-term outcomes appear similar as compared to the standard open colorectal surgeries. The surgical outcomes, both intraoperative and early postoperative, improve significantly once the learning curve is negotiated. Laparoscopic Surgery can be safely used as an alternative to conventional open colorectal surgeries without compromising on oncological principles. © 2015, Association of Surgeons of India. Source

Reena S.,Patna Medical College and Hospital | Reecha S.,Patna Medical College and Hospital | Kaushal K.,Danapur Railway Hospital | kumar V.P.,MahavirCancer Sansthan | Singh J.K.,Mahavir Cancer Sansthan
Journal of Clinical and Diagnostic Research | Year: 2014

Laryngeal squamous cell carcinoma (SCC) in adolescents is a rare clinical entity and behaves aggressively. The mechanism of laryngeal oncogenesis is complex. Further studies need to be done to know the role that human papilloma virus plays in laryngeal SCC in adolescents.We report a rare case of laryngeal SCC in a 12-year-old boy presenting with cutaneous forehead metastasis. Source

Anjali S.,Mahavir Cancer Sansthan | Tanuja,B M D College | Nath A.,Mahavir Cancer Sansthan | Singh J.K.,Mahavir Cancer Sansthan | Ravish K.,Mahavir Cancer Sansthan
Research Journal of Biotechnology | Year: 2011

The purpose of this study was to investigate the effects of corn oil on histological and biochemical parameter of kidney of Female Swiss albino mice. Mice were administered corn oil at the dose of 10 ml/kg body weight for the period of six weeks. No morphological alterations were observed. But fur soiling was observed among few mice of treated groups during the experimental period. Histological examination of kidney of female mice revealed mild alterations like tubular disarrangement. Few foci of hemorrhage and fatty degeneration were observed only in four weeks and six weeks corn oil treated groups. Mice of one week and two weeks group showed neither abnormal condition nor any severe lesions in the kidney. Comparative study of treated groups of mice with control group of mice was done. The serum biochemical test or kidney function test (Urea and creatinine) were estimated by Fully Automated Biochemistry Analyzer (Model No.-Selectra- E" (Vita lab) by Merck. These data showed that corn oil at the rate of 10 ml/kg body weight can be used as a vehicle for toxicological studies but may cause adverse effects on the renal tubules if used for prolonged periods. Source

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