Mahavir Cancer Institute and Research Center

Patna, India

Mahavir Cancer Institute and Research Center

Patna, India
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Kumar A.,Mahavir Cancer Institute and Research Center | Rahman M.S.,Mahavir Cancer Institute and Research Center | Iqubal M.A.,Mahavir Cancer Institute and Research Center | Ali M.,Mahavir Cancer Institute and Research Center | And 5 more authors.
International Journal of Preventive Medicine | Year: 2016

Background: In the present times, arsenic poisoning contamination in the ground water has caused lots of health‑related problems in the village population residing in middle Gangetic plain. In Bihar, about 16 districts have been reported to be affected with arsenic poisoning. For the ground water and health assessment, Simri village of Buxar district was undertaken which is a flood plain region of river Ganga. Methods: In this study, 322 water samples were collected for arsenic estimation, and their results were analyzed. Furthermore, the correlation between arsenic contamination in ground water with depth and its distance from river Ganga were analyzed. Results are presented as mean ± standard deviation and total variation present in a set of data was analyzed through one‑way analysis of variance. The difference among mean values has been analyzed by applying Dunnett’s test. The criterion for statistical significance was set at P < 0.05. Results: This study shows novel findings ever done in this area. Halwa Patti and Doodhi Patti strips were the most affected strips with high‑arsenic concentration in hand pumps. Furthermore, a correlation between the arsenic concentration with the depth of the hand pumps and the distance from the river Ganga was also a significant study. Conclusions: The present study concludes that in Simri village there is high contamination of arsenic in ground water in all the strips. Such a huge population is at very high risk leading the village on the verge of causing health hazards among them. Therefore, an immediate strategy is required to combat the present problem. © 2016 International Journal of Preventive Medicine.


Joshi D.,Jiwaji University | Joshi D.,Gorakhpur University | Mittal D.K.,Jiwaji University | Kumar R.,Mahavir Cancer Institute and Research Center | And 2 more authors.
Toxicological and Environmental Chemistry | Year: 2013

Mercury (Hg) is a potent nephrotoxin. The aim of this study was to investigate the protective role of Curcuma longa extract and curcumin against HgCl2-induced nephrotoxicity. Male Sprague Dawley rats were administered HgCl2 (12 μmol kg-1, ip; once only) followed by treatment of Curcuma longa extract (200 mg kg-1, po) and curcumin (80 mg kg-1, po) for three days after 24 h of HgCl2 administration. The present results showed that mercuric chloride administration caused an impairment of renal function system which was evident from significant increase in urea, creatinine, uric acid, and blood urea nitrogen concentration in serum. In addition, the swelling in glomerulus and degenerated renal tubules with obstructed lumen was also observed by acute mercuric chloride administration. Treatment with Curcuma longa extract and curcumin was effective in restoring all variables of kidney functions near to control group, which was consistent with kidney histoarchitecture. In conclusion, these results suggest that Curcuma longa extract and curcumin protect against HgCl2-induced nephrotoxicity. This study could be important for the further understanding of mercury toxicity in renal tissues and in the development of better treatments for people and/or animals exposed to the metal. © 2014 Taylor & Francis.


Singh J.K.,Mahavir Cancer Institute and Research Center | Nath A.,Mahavir Cancer Institute and Research Center | Mishra M.,Mahavir Cancer Institute and Research Center | Kumar A.,Mahavir Cancer Institute and Research Center | And 2 more authors.
Academic Journal of Cancer Research | Year: 2011

It is generally accepted that intercourse and childbearing are in some way associated with the occurrence of cervical cancer. Cervical cancer is predominantly a disease of married life, associated with women who have given birth to 1 or more children. In order to analyse the respective relationship between male and female child ratio and risk of cervix cancer, the present study was undertaken. For this purpose epidemiological study of 400 cases of cervix cancer patient of Mahavir Cancer Institute and Research Centre between 2008 and 2009 with parity and number of male and female child were reviewed. In this study, it was observed that mean number of male child was 2.44, mean number of female child was 1.74 while average parity was 4.64 in all patients. Ratio of male/female child was 1.41 in cervix cancer patients group. Thus it was concluded that microchimer of Y chromosome persist in female body up to many decades, which finally causes cervix cancer. If ratio of male vs. female child is more than one there may be increased chances of cervix cancer in mother. © IDOSI Publications, 2011.


Agrawal P.,Mahavir Cancer Institute and Research Center | Garg N.,Mahavir Cancer Institute and Research Center | Pandey B.B.,Mahavir Cancer Institute and Research Center
Cancer Treatment Communications | Year: 2016

Primary leiomyosarcoma (LMS) of breast is a very rare neoplasm of breast. Less than forty cases have been reported so far. Clinical presentation of this entity simulates other benign and malignant lesion of mesenchymal tumors of breast. Histopathological examination remains the goldstandard but application of ancillary techniques helps in further confirmation of the diagnosis. Herein we presented two case-reports of the primary LMS of breast. One of the cases was reported to have the axillary metastasis too. Though the optimal management followed for this entity is tumor excision with clear margins, the multi-disciplinary team performed Modified Radical Mastectomy (MRM) with axillary node dissection. © 2016.


Kumar A.,Mahavir Cancer Institute and Research Center | Ali Md.,Mahavir Cancer Institute and Research Center | Kumar R.,Mahavir Cancer Institute and Research Center | Nath A.,Mahavir Cancer Institute and Research Center | Singh J.K.,Mahavir Cancer Institute and Research Center
One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment | Year: 2014

In India, arsenic poisoning in groundwater in Gangetic basin, especially the districts adjoining the Ganges river, right from Eastern Uttar Pradesh, Bihar to West Bengal are the major problem of concern and where major health related problems are arising. To combat the present problem and because there are no antidotes against arsenic poisoning, a pre-clinical study on Charles foster rats was done. Sodium arsenite was administered to the rats for 60 days and upon this arsenic pretreated rats, Withania somnifera and Pteris longifolia plant extracts of Himalayan sub-region were selected and administered for 45 days to study the antidote effects. In in-vivo conditions, these plants played the vital role to combat the arsenic induced toxicity completely proving to be the best antidote. The plants not only eliminated the effects of arsenic but also reversed the normal physiological activity in the animal, having the best antidote activity against arsenic induced toxicity. © 2014 Taylor & Francis Group.


Sharma B.,Cmj University | Sharma B.,Institute of Management Sciences | Suhail M.,Cmj University | Suhail M.,Institute of Management Sciences | And 3 more authors.
International Journal of Pharma and Bio Sciences | Year: 2013

The aim of the present study was to investigate the effects of Mangifera indica leaves extract on the kidney function parameters in alloxan induced diabetic Swiss albino mice. Forty five albino mice (weighing 28 to 32 g) were randomly divided into control, alloxan treated and Mangifera indica treated mice group. Diabetes was induced in mice by injectingintraperitoneally alloxan monohydrate at dose of 150 mg/kg body weight. Ethanolic extracts of Mangifera indica leaves atdose of 80 mg/kg body weight were given orally in diabetic mice daily for four weeks after established LD50 value. Results and discussion: In diabetic mice, serum urea, uric acid, creatinine and glucose levels were significantly increased but level of serum albumin was decreased in comparison with the control group. Diabetic mice group, treated with ethanolic extract of Mangifera indica leaves (80 mg/kg b.w), on comparison with diabetic group showed a significant decrease in these biochemical parameters such as urea, uric acid creatinine and glucose level. However, the serum albuminlevel got increased as compared to diabetic mice. The results suggested that ethanolic extract of Mangifera indica leaves possesses protective effect against alloxan induced diabetic mice.


PubMed | National Institute of Pharmaceutical Education and Research, Mahavir Cancer Institute and Research Center and Rajendra Memorial Research Institute of Medical Sciences
Type: Journal Article | Journal: Journal of research in pharmacy practice | Year: 2014

Chronic myeloid leukemia (CML) is a clonal hematopoietic disorder caused by acquired genetic defect in pluripotent stem cells characterized by acquisition of the philadelphia chromosome. The aim of this study was to compare the efficacy, safety and quality of life (QoL) in CML patients treated with imatinib or hydroxyurea.A prospective observational study was conducted on 40 patients with pathologically confirmed CML in an in-patient department of Mahavir Cancer Sansthan and Research Centre (tertiary care cancer hospital) in India. Patients were divided into two groups (group A: Imatinib consuming patients and group B: Hydroxyurea consuming patients). Complete blood count was done every month to assess the efficacy and safety/toxicity profile of these drugs. The results were analyzed 12 months after completion of treatment. QoL was assessed by The European Organization for Research and Treatment of Cancer QoL Questionnaire core 30. Hematological response was analyzed using kaplan-meier survival analysis. Chi-square test was applied to assess the association of two regimens with complete hematological response, hematological and non-hematological toxicity. White blood cell (WBC) was noted each month in every patient of each group and analyzed by generalized linear mode (repeated measures) analysis of variance (ANOVA). Independent t-test was used to compare changes in QoL between treatment groups.At the end of treatment, significant improvement (P = 0.001) in hematological response was observed in the group A (95%) compared to group B (30%). WBC count analyzed at each month of treatment by ANOVA achieved better results for patients treated with imatinib (P = 0.0001). The hematological toxicity was higher in imatinib group while non-hematological toxicity was higher in the hydroxyurea group; however only little toxicities such as nausea and constipation were statistically significant. QoL assessment of patients related to functional scale showed significantly better results in group A (P = 0.046).The study showed that imatinib has better profile compared to hydroxyurea, with siginificant statistical differences in terms of efficacy, non-hematological toxicity and QoL in CML patients. Even with such better efficacy and safety profile, pharmacoeconomic evaluation needs to be done to justify and support the use of imatinib for CML patients in India.


PubMed | Mahavir Cancer Institute and Research Center
Type: | Journal: International journal of preventive medicine | Year: 2016

In the present times, arsenic poisoning contamination in the ground water has caused lots of health-related problems in the village population residing in middle Gangetic plain. In Bihar, about 16 districts have been reported to be affected with arsenic poisoning. For the ground water and health assessment, Simri village of Buxar district was undertaken which is a flood plain region of river Ganga.In this study, 322 water samples were collected for arsenic estimation, and their results were analyzed. Furthermore, the correlation between arsenic contamination in ground water with depth and its distance from river Ganga were analyzed. Results are presented as mean standard deviation and total variation present in a set of data was analyzed through one-way analysis of variance. The difference among mean values has been analyzed by applying Dunnetts test. The criterion for statistical significance was set at P < 0.05.This study shows novel findings ever done in this area. Halwa Patti and Doodhi Patti strips were the most affected strips with high-arsenic concentration in hand pumps. Furthermore, a correlation between the arsenic concentration with the depth of the hand pumps and the distance from the river Ganga was also a significant study.The present study concludes that in Simri village there is high contamination of arsenic in ground water in all the strips. Such a huge population is at very high risk leading the village on the verge of causing health hazards among them. Therefore, an immediate strategy is required to combat the present problem.

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