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Joshi D.,Jiwaji University | Joshi D.,Gorakhpur University | Mittal D.K.,Jiwaji University | Kumar R.,Mahavir Cancer Institute and Research Center | And 2 more authors.
Toxicological and Environmental Chemistry | Year: 2013

Mercury (Hg) is a potent nephrotoxin. The aim of this study was to investigate the protective role of Curcuma longa extract and curcumin against HgCl2-induced nephrotoxicity. Male Sprague Dawley rats were administered HgCl2 (12 μmol kg-1, ip; once only) followed by treatment of Curcuma longa extract (200 mg kg-1, po) and curcumin (80 mg kg-1, po) for three days after 24 h of HgCl2 administration. The present results showed that mercuric chloride administration caused an impairment of renal function system which was evident from significant increase in urea, creatinine, uric acid, and blood urea nitrogen concentration in serum. In addition, the swelling in glomerulus and degenerated renal tubules with obstructed lumen was also observed by acute mercuric chloride administration. Treatment with Curcuma longa extract and curcumin was effective in restoring all variables of kidney functions near to control group, which was consistent with kidney histoarchitecture. In conclusion, these results suggest that Curcuma longa extract and curcumin protect against HgCl2-induced nephrotoxicity. This study could be important for the further understanding of mercury toxicity in renal tissues and in the development of better treatments for people and/or animals exposed to the metal. © 2014 Taylor & Francis. Source


Sharma B.,Cmj University | Sharma B.,Institute of Management Sciences | Suhail M.,Cmj University | Suhail M.,Institute of Management Sciences | And 3 more authors.
International Journal of Pharma and Bio Sciences | Year: 2013

The aim of the present study was to investigate the effects of Mangifera indica leaves extract on the kidney function parameters in alloxan induced diabetic Swiss albino mice. Forty five albino mice (weighing 28 to 32 g) were randomly divided into control, alloxan treated and Mangifera indica treated mice group. Diabetes was induced in mice by injectingintraperitoneally alloxan monohydrate at dose of 150 mg/kg body weight. Ethanolic extracts of Mangifera indica leaves atdose of 80 mg/kg body weight were given orally in diabetic mice daily for four weeks after established LD50 value. Results and discussion: In diabetic mice, serum urea, uric acid, creatinine and glucose levels were significantly increased but level of serum albumin was decreased in comparison with the control group. Diabetic mice group, treated with ethanolic extract of Mangifera indica leaves (80 mg/kg b.w), on comparison with diabetic group showed a significant decrease in these biochemical parameters such as urea, uric acid creatinine and glucose level. However, the serum albuminlevel got increased as compared to diabetic mice. The results suggested that ethanolic extract of Mangifera indica leaves possesses protective effect against alloxan induced diabetic mice. Source


Agrawal P.,Mahavir Cancer Institute and Research Center | Garg N.,Mahavir Cancer Institute and Research Center | Pandey B.B.,Mahavir Cancer Institute and Research Center
Cancer Treatment Communications | Year: 2016

Primary leiomyosarcoma (LMS) of breast is a very rare neoplasm of breast. Less than forty cases have been reported so far. Clinical presentation of this entity simulates other benign and malignant lesion of mesenchymal tumors of breast. Histopathological examination remains the goldstandard but application of ancillary techniques helps in further confirmation of the diagnosis. Herein we presented two case-reports of the primary LMS of breast. One of the cases was reported to have the axillary metastasis too. Though the optimal management followed for this entity is tumor excision with clear margins, the multi-disciplinary team performed Modified Radical Mastectomy (MRM) with axillary node dissection. © 2016. Source


Kumar A.,Mahavir Cancer Institute and Research Center | Ali Md.,Mahavir Cancer Institute and Research Center | Kumar R.,Mahavir Cancer Institute and Research Center | Nath A.,Mahavir Cancer Institute and Research Center | Singh J.K.,Mahavir Cancer Institute and Research Center
One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment | Year: 2014

In India, arsenic poisoning in groundwater in Gangetic basin, especially the districts adjoining the Ganges river, right from Eastern Uttar Pradesh, Bihar to West Bengal are the major problem of concern and where major health related problems are arising. To combat the present problem and because there are no antidotes against arsenic poisoning, a pre-clinical study on Charles foster rats was done. Sodium arsenite was administered to the rats for 60 days and upon this arsenic pretreated rats, Withania somnifera and Pteris longifolia plant extracts of Himalayan sub-region were selected and administered for 45 days to study the antidote effects. In in-vivo conditions, these plants played the vital role to combat the arsenic induced toxicity completely proving to be the best antidote. The plants not only eliminated the effects of arsenic but also reversed the normal physiological activity in the animal, having the best antidote activity against arsenic induced toxicity. © 2014 Taylor & Francis Group. Source


Singh J.K.,Mahavir Cancer Institute and Research Center | Nath A.,Mahavir Cancer Institute and Research Center | Mishra M.,Mahavir Cancer Institute and Research Center | Kumar A.,Mahavir Cancer Institute and Research Center | And 2 more authors.
Academic Journal of Cancer Research | Year: 2011

It is generally accepted that intercourse and childbearing are in some way associated with the occurrence of cervical cancer. Cervical cancer is predominantly a disease of married life, associated with women who have given birth to 1 or more children. In order to analyse the respective relationship between male and female child ratio and risk of cervix cancer, the present study was undertaken. For this purpose epidemiological study of 400 cases of cervix cancer patient of Mahavir Cancer Institute and Research Centre between 2008 and 2009 with parity and number of male and female child were reviewed. In this study, it was observed that mean number of male child was 2.44, mean number of female child was 1.74 while average parity was 4.64 in all patients. Ratio of male/female child was 1.41 in cervix cancer patients group. Thus it was concluded that microchimer of Y chromosome persist in female body up to many decades, which finally causes cervix cancer. If ratio of male vs. female child is more than one there may be increased chances of cervix cancer in mother. © IDOSI Publications, 2011. Source

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