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Kottayam, India

Mahatma Gandhi University, also known as M G University, was established on 2 October 1983 in Kottayam. Mahatma Gandhi University , has been accredited by the National Assessment and Accreditation Council, India. The university has 10 affiliated colleges spread over five districts in central Kerala.The University Grants Commission of India does not believe that the names of Indian universities should be unique, so another UGC-recognized government-run Mahatma Gandhi University was established in 2007 in Andhra Pradesh and was not challenged by the older Mahatma Gandhi University. Similarly another university named Mahatma Gandhi University was also established through Meghalaya State legislative Act, 2010 in Meghalaya and through Uttarakhand State legislative act, 2007 in Uttarakhand. Wikipedia.

Mathews V.V.,Mahatma Gandhi University
European review for medical and pharmacological sciences | Year: 2013

Arsenic trioxide (As2O3) is an environmental toxicant as well as an effective anti cancer agent against many types of cancers. It is a promising drug for patients with relapsed acute promyelocytic leukaemia (APL), but its clinical efficacy is burdened by the serious cardiac toxicities. The present study was designed to investigate the toxic mechanism of arsenic in cardiac tissue at its clinically relevant concentrations. Experimental rats were administered with As2O3 2, 4 and 8 mg/kg body weight, orally for a period of 45 days. Cardiac toxicities were recorded by lipid peroxidation, activities of glutathione dependent antioxidant and antiperoxidative enzymes, cardiac arsenic accumulation and histopathological changes. In vivo studies revealed a significant rise in lipid peroxidation, decline in reduced glutathione, glutathione dependent antioxidant enzymes and antiperoxidative enzymes in the cardiac tissue of arsenic treated rats. The extent of free radical production was found increased with periodic rise in the arsenic concentration. The experimental group which received 8 mg/kg body weight of arsenic exhibited the highest deposition of arsenic in cardiac tissue. Light microscopic examination of cardiac tissues in arsenic treated rats has showed increased structural abnormalities like myocardial fibre swelling, capillary congestion and micro-haemorrhages. The study concludes that the mechanism of arsenic induced cardiac toxicity is associated with the accumulation of arsenic in tissue and the extent of free radical production. Source

Recent measurements have demonstrated unprecedented increase in atmospheric deposition of nutrients in many parts of India. To determine whether atmospheric nutrient inputs would increase phytoplankton growth and catchment dissolved organic carbon (DOC) flushing to constrain benthic algae, we analyzed NO3 - and PO4 -3 in atmospheric deposits; nutrients and DOC in runoff and lake water and standing crop biomass of phytoplankton and periphyton at Jaisamand Lake of Rajasthan, India. Atmospheric deposition of NO3 - (7. 18-29. 95 kg ha-1year-1) and PO4 -3 (0. 56-2. 15 kg ha-1year-1) showed a consistently rising trend across the year. Microbial biomass and activity in catchment increased in response to atmospheric deposition. Lake DOC and nutrients showed strong coherence with their terrestrial and atmospheric fluxes. Phytoplankton development showed significant linearity with atmospheric input of nutrients. Air-driven input appeared to have compensated the nutrient constraints to phytoplankton during drought. The N:P stoichiometry of deposition and that of lake water indicated that, although there was a seasonal switchover to N- or P-limitation, phytoplankton were mainly co-limited by N and P due probably to the synergistic effects of combined N + P enrichment in the pelagic zone of the lake. Periphyton standing crop showed inverse relationship with phytoplankton and lake DOC. The study indicated that enhanced phytoplankton development and terrestrial DOC flushing in response to atmospheric nutrient input attenuated light penetration to constrain algal periphyton. We suggests that data on these issues may be considered in developing aquatic ecosystem models to establish future links between changing air-water-land interactions and associated shifts in lake ecosystem functioning for more accurately predicting climate change drivers and designing integrated lake basin management strategies. © 2012 Springer Science+Business Media B.V. Source

Joseph S.,St Georges College | Mathew B.,Mahatma Gandhi University
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2015

(Graph Presented) Herein, we report a simple microwave assisted method for the green synthesis of silver and gold nanoparticles by the reduction of aqueous metal salt solutions using leaf extract of the medicinal plant Aerva lanata. UV-vis., FTIR, XRD, and HR-TEM studies were conducted to assure the formation of nanoparticles. XRD studies clearly confirmed the crystalline nature of the synthesized nanoparticles. From the HR-TEM images, the silver nanoparticles (AgNPs) were found to be more or less spherical and gold nanoparticles (AuNPs) were observed to be of different morphology with an average diameter of 18.62 nm for silver and 17.97 nm for gold nanoparticles. In order to evaluate the effect of microwave heating upon rate of formation, the synthesis was also conducted under ambient condition without the assistance of microwave radiation and the former method was found to be much faster than the later. The synthesized nanoparticles were used as nanocatalysts in the reduction of 4-nitrophenol to 4-aminophenol by NaBH4. © 2014 Elsevier B.V. All rights reserved. Source

Joseph S.,Stgeorges College | Mathew B.,Mahatma Gandhi University
Journal of Molecular Liquids | Year: 2014

A simple, fast, efficient and cost effective synthetic strategy based on microwave irradiation is described for the preparation of silver nanoparticles in aqueous medium using hexamine as the reducing agent and agar as the stabilizer. The formation of nanoparticles is confirmed using UV-vis., XRD, EDX, and HR-TEM analysis. TEM images suggest that the nanoparticles are of spherical shape with an average diameter of 10.16 nm. The agar stabilized silver nanoparticles show excellent catalytic activity for the reduction of methyl orange in the presence of NaBH4 in aqueous medium. The reaction follows pseudo-first order kinetics, and the reaction rate increases with increase in amount of the catalyst. The synthesized silver nanoparticles are expected to be promising material for the application in environmental protection. They also show very good antibacterial activity against Staphylococcus aureus (Gram positive) and Salmonella typhi (Gram negative). © 2014 Elsevier B.V. Source

Kanthraj G.R.,Mahatma Gandhi University
Indian Journal of Dermatology, Venereology and Leprology | Year: 2015

Recent teledermatology practice has been focused on different models made possible by robust advances in information technology leading to consistent interaction between the patient and health care professionals. Patient-assisted teledermatology practice also called patient-enabled teledermatology or home based teledermatology is one such novel model. There is a lack of scientific literature and substantive reviews on patient-assisted teledermatology practice. The present article reviews several studies and surveys on patient-assisted teledermatology practice and outlines its advantages and barriers to clinical utility and analyses the potentiality of this concept. Incorporating patient-assisted teledermatology practice as a novel model in the revised classification of teledermatology practice is proposed. In patient-assisted teledermatology, the patient can upload his/her clinical images as a first contact with the dermatologist or an initial face-to-face examination can be followed by teledermatology consultations. The latter method is well suited to chronic diseases such as psoriasis, vitiligo, and leg ulcers, which may need frequent follow-up entailing significant costs and time, particularly in the elderly. Teledermatology may also be used by the treating dermatologist to seek expert opinion for difficult cases. Studies have demonstrated the importance and usability of the concept of patient-assisted teledermatology practice. Various teledermatology care models are available and the appropriate model should be chosen depending on whether the clinical situation is that of easily diagnosed cases ("spotters"), chronic cases or doubtful cases and difficult-to-manage cases. Source

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