Mahatma Gandhi Memorial Medical College

Indore, India

Mahatma Gandhi Memorial Medical College

Indore, India
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Malviya S.,Modern Institute of Pharmaceutical science MIPS | Jain S.,Modern Institute of Pharmaceutical science MIPS | Vyas S.,Mahatma Gandhi Memorial Medical College
Andrologia | Year: 2016

Male sexual dysfunction is a common disorder that appears to be a consequence of a wide range of physical and psychological conditions. Due to mental stress, insufficient physical exercise and various aetiological factors, human being's life is becoming less pleasant, which leads to incapability to have sexual pleasure. The allopathic drugs used for sexual dysfunction are believed to produce a variety of side effects and affect other physiological processes and, ultimately, general health. Therefore, the search for natural supplement from medicinal plants is being intensified probably because of less side effects availability and affordability. Ethnobotanical surveys have indicated a large number of plants traditionally used as aphrodisiacs but only few of them are scientifically validated for the management and treatment of male sexual dysfunction. This article has summarised the medicinal plants traditionally recommended and scientifically validated for the management and treatment of male sexual dysfunction. © 2016 Blackwell Verlag GmbH


PubMed | Modern Institute of Pharmaceutical science MIPS and Mahatma Gandhi Memorial Medical College
Type: Journal Article | Journal: Andrologia | Year: 2016

Male sexual dysfunction is a common disorder that appears to be a consequence of a wide range of physical and psychological conditions. Due to mental stress, insufficient physical exercise and various aetiological factors, human beings life is becoming less pleasant, which leads to incapability to have sexual pleasure. The allopathic drugs used for sexual dysfunction are believed to produce a variety of side effects and affect other physiological processes and, ultimately, general health. Therefore, the search for natural supplement from medicinal plants is being intensified probably because of less side effects availability and affordability. Ethnobotanical surveys have indicated a large number of plants traditionally used as aphrodisiacs but only few of them are scientifically validated for the management and treatment of male sexual dysfunction. This article has summarised the medicinal plants traditionally recommended and scientifically validated for the management and treatment of male sexual dysfunction.


Varma P.,Mahatma Gandhi Memorial Medical College | Walia S.,Mahatma Gandhi Memorial Medical College | Manglawat R.,Mahatma Gandhi Memorial Medical College
Indian Journal of Ophthalmology | Year: 2014

Fibrous histiocytomas (FHs) are mesenchymal tumors that may be benign or malignant. Ocular involvement by FHs is infrequent and primarily limited to the orbit. Rarely, FHs can also involve the conjunctiva and perilimbal area. We report the case of a 38-year-old male with lid, conjunctival, and neck FHs. The diagnosis was confirmed by histopathology. © 2005 - Indian Journal of Ophthalmology.


Gajbhiye S.,Mahatma Gandhi Memorial Medical College | Agrawal R.P.,Mahatma Gandhi Memorial Medical College | Atal S.,Mahatma Gandhi Memorial Medical College | Tiwari V.,Mahatma Gandhi Memorial Medical College | Phadnis P.,Mahatma Gandhi Memorial Medical College
Journal of Pharmacology and Pharmacotherapeutics | Year: 2015

We report a rare case of exercise-induced anaphylaxis (EIA), occurring exclusively with exercise, without any other associated trigger, detected in the prodromal phase, and prevented from additional anaphylaxis episodes by treatment with cetirizine and 10 mg daily of antileukotriene montelukast to date. EIA is a syndrome in which patients experience a spectrum of the symptoms of anaphylaxis ranging from mild cutaneous signs to severe systemic manifestations such as hypotension, syncope, and even death after increased physical activity. Many people have triggers, such as, a variety of foods, various medications, alcohol, cold weather, humidity, and seasonal and hormonal changes along with exercise that cause the symptoms. Typically, either exercise or the specific trigger alone will rarely cause symptoms. It is differentiated from cholinergic urticaria by the absence of response to passive body warming and emotional stress.


Sutter R.W.,World Health Organization | John T.J.,India Expert Advisory Group on Polio Eradication | Jain H.,Mahatma Gandhi Memorial Medical College | Agarkhedkar S.,Dr D y Patil Medical College | And 10 more authors.
The Lancet | Year: 2010

Poliovirus types 1 and 3 co-circulate in poliomyelitis-endemic countries. We aimed to assess the immunogenicity of a novel bivalent types 1 and 3 oral poliovirus vaccine (bOPV). We did a randomised, double-blind, controlled trial to assess the superiority of monovalent type 2 OPV (mOPV2), mOPV3, or bOPV over trivalent OPV (tOPV), and the non-inferiority of bivalent vaccine compared with mOPV1 and mOPV3. The study was done at three centres in India between Aug 6, 2008, and Dec 26, 2008. Random allocation was done by permuted blocks of ten. The primary outcome was seroconversion after one monovalent or bivalent vaccine dose compared with a dose of trivalent vaccine at birth. The secondary endpoints were seroconversion after two vaccine doses compared with after two trivalent vaccine doses and cumulative two-dose seroconversion. Parents or guardians and study investigators were masked to treatment allocation. Because of multiple comparisons, we defined p≤0·01 as statistically significant. This trial is registered with Current Controlled Trials, ISRCTN 64725429. 900 newborn babies were randomly assigned to one of five vaccine groups (about 180 patients per group); of these 70 (8) discontinued, leaving 830 (92) for analysis. After the first dose, seroconversion to poliovirus type 1 was 20 for both mOPV1 (33 of 168) and bOPV (32 of 159) compared with 15 for tOPV (25 of 168; p>0·01), to poliovirus type 2 was 21 (35 of 170) for mOPV2 compared with 25 (42 of 168) for tOPV (p>0·01), and to poliovirus type 3 was 12 (20 of 165) for mOPV3 and 7 (11 of 159) for bOPV compared with 4 (7 of 168) for tOPV (mOPV3 vs tOPV p=0·01; bOPV vs tOPV; p>0·01). Cumulative two-dose seroconversion to poliovirus type 1 was 90 (151 of 168) for mOPV1 and 86 (136 of 159) for bOPV compared with 63 (106 of 168) for tOPV (p<0·0001), to poliovirus type 2 was 90 (153 of 170) for mOPV2 compared with 91 (153 of 168) for tOPV (p>0·01), and to poliovirus type 3 was 84 (138 of 165) for mOPV3 and 74 (117 of 159) for bOPV compared with 52 (87 of 168) for tOPV (p<0·0001). The vaccines were well tolerated. 19 serious adverse events occurred, including one death; however, these events were not attributed to the trial interventions. The findings show the superiority of bOPV compared with tOPV, and the non-inferiority of bOPV compared with mOPV1 and mOPV3. GAVI Alliance, World Health Organization, and Panacea Biotec. © 2010 Elsevier Ltd.


Saklani R.,University of Delhi | Gupta S.K.,University of Delhi | Mohanty I.R.,Mahatma Gandhi Memorial Medical College | Kumar B.,Tufts University | And 2 more authors.
Molecular and Cellular Biochemistry | Year: 2016

Diabetic cardiomyopathy (DCM) is a dreadful complication of diabetes responsible for 80 % mortality in diabetic patients, but unfortunately its pharmacotherapy is still incomplete. Rutin is a naturally occurring flavonoid having a long history of use in nutritional supplements for its action against oxidative stress, inflammation, and hyperglycemia, the key players involved in the progression of DCM, but remains unexplored for its role in DCM. This study was conducted to address this lacuna. It was performed in 4-week-old Streptozotocin-induced (45 mg/kg) diabetic rats for a period of 24 weeks to mimic the cardiotoxic effect of chronic hyperglycemia in diabetic patient’s heart and to investigate the effect of rutin (50 mg/kg/day) in ameliorating these effects. Heart of the diabetic rats showed altered ECG parameters, reduced total antioxidant capacity, increased inflammatory assault, and degenerative changes. Interestingly, rutin treatment significantly ameliorated these changes with decrease in blood glucose level (p > 0.001), % HbA1c (p > 0.001) and reduced expression of TNF-α (p < 0.001), CRP (p < 0.001), and BNP (p < 0.01) compared to diabetic control rats. In addition, rutin provided significant protection against diabetes associated oxidative stress (p < 0.05), prevented degenerative changes in heart, and improved ECG parameters compared to diabetic control rats. The heart-to-body weight ratio was significantly reduced in rutin treatment group compared to diabetic control rats (p < 0.001). In conclusion, this study implicates that oxidative stress and inflammation are the central players involved in the progression of DCM and rutin ameliorates DCM through its antioxidant and anti-inflammatory actions on heart. © 2016 Springer Science+Business Media New York


Atal S.,Mahatma Gandhi Memorial Medical College | Phadnis P.,Bundelkhand Medical College | Vyas S.,Mahatma Gandhi Memorial Medical College | Gudsurkar G.,Mahatma Gandhi Memorial Medical College | Churihar R.,Mahatma Gandhi Memorial Medical College
Asian Journal of Pharmaceutical and Clinical Research | Year: 2016

Objective: To evaluate the effect of piperine on the antidepressant activity of sertraline and analgesic activity of pentazocine and to explore the effect of using oral and parenteral routes of administration on the possible interactions. Methods: Piperine was isolated from commercially obtained Piper nigrum extract. Swiss albino mice of either sex were divided into 8 groups (n=6) receiving: 2% gum acacia (oral, intraperitoneally [i.p.]), standard drug (oral, i.p.), standard drug + piperine (oral, i.p.), piperine (oral, i.p.). Tail suspension test (TST) was used for antidepressant effect and Eddy’s hot plate method for analgesic effect. Sertraline and pentazocine were used as standard drugs (5 mg/kg) and piperine at 10 mg/kg. Result: In the TST, piperine alone (both routes) decreased immobility time, but the effect was statistically insignificant. Both combination groups (oral and i.p.) showed significantly better activity compared to sertraline oral and i.p. groups, respectively (p<0.05). Oral combination showed activity comparable to i.p. combination (p>0.05). Piperine did not show any analgesic activity of its own (both routes). Piperine with pentazocine orally showed significantly better activity compared to pentazocine (oral) at 1, 2, and 4 hrs, and analgesia at 0.5 hr which pentazocine oral did not. Parenteral combination was significantly better than pentazocine (i.p.) group at 2 and 4 hrs and better than oral combination at 4 hrs. Conclusion: Piperine has potential to be used in combination with pentazocine due to its bioenhancing effect and with sertraline due to a potentiating/ additive effect which can help reduce dose and adverse effects of these drugs. © 2016, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.


PubMed | Tufts University, Mahatma Gandhi Memorial Medical College and University of Delhi
Type: Journal Article | Journal: Molecular and cellular biochemistry | Year: 2016

Diabetic cardiomyopathy (DCM) is a dreadful complication of diabetes responsible for 80% mortality in diabetic patients, but unfortunately its pharmacotherapy is still incomplete. Rutin is a naturally occurring flavonoid having a long history of use in nutritional supplements for its action against oxidative stress, inflammation, and hyperglycemia, the key players involved in the progression of DCM, but remains unexplored for its role in DCM. This study was conducted to address this lacuna. It was performed in 4-week-old Streptozotocin-induced (45mg/kg) diabetic rats for a period of 24weeks to mimic the cardiotoxic effect of chronic hyperglycemia in diabetic patients heart and to investigate the effect of rutin (50mg/kg/day) in ameliorating these effects. Heart of the diabetic rats showed altered ECG parameters, reduced total antioxidant capacity, increased inflammatory assault, and degenerative changes. Interestingly, rutin treatment significantly ameliorated these changes with decrease in blood glucose level (p>0.001), % HbA1c (p>0.001) and reduced expression of TNF- (p<0.001), CRP (p<0.001), and BNP (p<0.01) compared to diabetic control rats. In addition, rutin provided significant protection against diabetesassociated oxidative stress (p<0.05), prevented degenerative changes in heart, and improved ECG parameters compared to diabetic control rats. The heart-to-body weight ratio was significantly reduced in rutin treatment group compared to diabetic control rats (p<0.001). In conclusion, this study implicates that oxidative stress and inflammation are the central players involved in the progression of DCM and rutin ameliorates DCM through its antioxidant and anti-inflammatory actions on heart.


PubMed | Mahatma Gandhi Memorial Medical College
Type: Review | Journal: Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine | Year: 2016

Nasal intubation technique was first described in 1902 by Kuhn. The others pioneering the nasal intubation techniques were Macewen, Rosenberg, Meltzer and Auer, and Elsberg. It is the most common method used for giving anesthesia in oral surgeries as it provides a good field for surgeons to operate. The anatomy behind nasal intubation is necessary to know as it gives an idea about the pathway of the endotracheal tube and complications encountered during nasotracheal intubation. Various techniques can be used to intubate the patient by nasal route and all of them have their own associated complications which are discussed in this article. Various complications may arise while doing nasotracheal intubation but a thorough knowledge of the anatomy and physics behind the procedure can help reduce such complications and manage appropriately. It is important for an anesthesiologist to be well versed with the basics of nasotracheal intubation and advances in the techniques. A thorough knowledge of the anatomy and the advent of newer devices have abolished the negative effect of blindness of the procedure.


PubMed | Mahatma Gandhi Memorial Medical College
Type: Journal Article | Journal: Journal of pharmacology & pharmacotherapeutics | Year: 2015

We report a rare case of exercise-induced anaphylaxis (EIA), occurring exclusively with exercise, without any other associated trigger, detected in the prodromal phase, and prevented from additional anaphylaxis episodes by treatment with cetirizine and 10 mg daily of antileukotriene montelukast to date. EIA is a syndrome in which patients experience a spectrum of the symptoms of anaphylaxis ranging from mild cutaneous signs to severe systemic manifestations such as hypotension, syncope, and even death after increased physical activity. Many people have triggers, such as, a variety of foods, various medications, alcohol, cold weather, humidity, and seasonal and hormonal changes along with exercise that cause the symptoms. Typically, either exercise or the specific trigger alone will rarely cause symptoms. It is differentiated from cholinergic urticaria by the absence of response to passive body warming and emotional stress.

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