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Gāndhī Nagar, India

Gavaskar A.S.,Mahatma Gandhi Medical College | Achimuthu R.,Government of Tamilnadu
Journal of Spinal Disorders and Techniques

Study Design: Prospective, nonrandomised, single center. Objective: To study the clinico-radiologic and functional outcome after transfacetal screw fixation and fusion for low-grade degenerative spondylolisthesis of the lumbar spine. Summary of Background Data: Surgery for degenerative spondylolisthesis conventionally involves instrumented fusion using 3 column pedicle screw fixation systems. Recently transfacetal fusion techniques have been reported to produce good results without the surgical morbidity associated with posterolateral fusion and the neurologic complications associated with pedicle screw fixation. Methods: 30 patients with low-grade degenerative spondylolisthesis of the lumbar and lumbosacral spine underwent transfacetal fusion using 2 cortical screws and local cancellous bone grafts. Results: Clinical and radiologic evidence of fusion was obtained in 29 patients. One patient developed pseudoarthrosis with progression of slip and was reoperated. Quadruple visual analog scores and Oswestry disability assessment showed a significant improvement at 1-year follow-up. Conclusions: Degenerative spondylolisthesis with lower grade slips and normal anterior structures represent an ideal indication for transfacetal fusion. This is a simple and useful technique for short segment fusions of the lumbar spine. Copyright © 2010 by Lippincott Williams & Wilkins. Source

Philip N.I.,Mahatma Gandhi Medical College | Prabhakar M.,Desh Bhagat Dental College | Arora D.,Christian Dental College | Chopra S.,Christian Dental College
American Journal of Orthodontics and Dentofacial Orthopedics

Introduction: The Moyers mixed dentition space analysis method is among the most commonly used in clinical practice for detecting tooth size-arch length discrepancies. In view of reported secular trends, racial, and sex differences in tooth sizes, the purposes of this study were to evaluate the applicability of Moyers probability tables in a contemporary orthodontic population of India and to formulate more accurate mixed dentition prediction aids. Methods: Odontometric data were collected from 300 male and 300 female subjects of Indian descent, who had fully erupted mandibular permanent incisors and maxillary and mandibular canines and premolars. We measured the mesiodistal crown widths with vernier scale dial calipers. The odontometric values obtained were then subjected to statistical and linear regression analysis. Results: All tooth groups showed significant differences (P <0.001) between mesiodistal widths of male and female subjects. Regression equations for the maxillary arch (males, Y = 7.15 + 0.67X; females, Y = 7.44 + 0.65X) and the mandibular arch (males, Y = 5.55 + 0.71X; females, Y = 6.15 + 0.67X) were used to develop new probability tables on the Moyers pattern. Significant differences (P <0.05) were found between our predicted widths and the Moyers tables at almost all percentile levels, including the recommended 75% and 50% levels. Conclusions: We believe that these new prediction aids could be considered for a more precise mixed dentition space analysis in Indian children. Copyright © 2010 by the American Association of Orthodontists. Source

Bhargava J.,SMS Medical College | Khan Z.Y.,Mahatma Gandhi Medical College
Journal of Clinical and Diagnostic Research

Background: Anti-depressant drugs which are used in the Allopathic system of medicine for the treatment of depression have side effects. Studies which have compared the effcacy and the side effects of Allopathic and Ayurvedic drugs in the treatment of depression have not been reported. Aims: The aim of the present study was to compare the effcacy and the side effects of imipramine and sertraline which are the commonly prescribed drugs in the Allopathic system of medicine for the treatment of depression, with an Ayurvedic formulation. Settings and Design: This study was an open labeled randomized clinical trial which involved 90 depressive patients who were divided into three groups of 30 each, for the administration of imipramine, sertraline, and an Ayurvedic formulation respectively. HAM-D scoring was done and a side effect checklist was also prepared. Materials and Methods: The Ayurvedic formulation consisted of aqueous extracts of Brahmi, Shankhpuship, Malkangni and Jatamansi which were mixed in equal proportions (250 mg each). The Ayurvedic formulation was administered at a dose of 1000 mg orally in two divided doses; and imipramine and sertraline were administered at a dose of 150 mg each per day, to separate the groups of patients. The persons who abided by the inclusion and exclusion criteria were selected randomly. The effect of the treatments on the treated patients was repeatedly assessed at a continuous interval of two weeks for three months. Results: The Ayurvedic formulation had negligible side effects and it was found to be effective at par with imipramine and sertraline at the end of three months. Conclusions: The Ayurvedic formulation was found to be better as compared to imipramine and sertraline for the treatment of patients with mild to moderate depression, due to its lesser side effects. Source

Atal S.S.,Modern Institute of Medical science | Atal S.,Mahatma Gandhi Medical College
Journal of Basic and Clinical Physiology and Pharmacology

Despite significant improvements in medical and surgical management, multiple organ dysfunction syndrome (MODS) or multiple organ failure following conditions such as acute pancreatitis, severe sepsis, and traumatic, hemorrhagic, and endotoxin shocks is still accompanied with a high mortality rate. In light of the crucial role of immunologic derangement recently conceptualized in these conditions, ulinastatin, a urinary trypsin inhibitor, is considered as a potentially beneficial immunomodulator drug for MODS. Mechanisms involving protections against tissue organs and endothelial cell and anti-inflammatory effects by ulinastatin are dependent on the inhibition of polymorphonuclear leukocyte (PMN)-derived elastase, tumor necrosis factor α, and other pro-inflammatory cytokines and interleukins (IL-1, IL-6, and IL-8). Ulinastatin also suppresses the activation of PMN cells, macrophages, and platelets. Derived from these properties, ulinastatin has been investigated as a potential clinical therapy for indications including shock and pancreatitis and approved in Japan and China with ongoing clinical trials around the globe. Off-label potential uses of ulinastatin have been reported in preterm labor and hematological, hepatic, renal, and cardiovascular diseases including vasculitis syndromes such as Kawasaki disease. © 2016 by De Gruyter. Source

Sharma A.,Mahatma Gandhi Medical College | Mittal R.S.,Sawai Man Singh Medical College
Journal of Neurosciences in Rural Practice

Cavernous malformations (CMs) are vascular anomalies with dilated spaces called caverns. These spaces are lined by endothelial cells and collage and devoid of smooth muscle or intervening neural tissue, and filled with blood at various stages of stasis, thrombosis, organization, and calcification. Most CMs are relatively small in size but when they are large enough they can produce sing of mass effect and may simulate neoplastic, vascular, inflammatory pathology. Giant CM (size >6 cm) are very rare lesions and very few cases are reported in world literature. We are reporting such a rare case of a 16 year male. Our case is also unique in the sense that it is the largest reported CM in Indian population. © 2016 Journal of Neurosciences in Rural Practice. Source

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