Sharma K.,Mahatma Gandhi Medical College |
Jain P.,Rajasthan Dental College |
Sharma A.,Rajasthan Dental College
Indian Journal of Pharmacology | Year: 2015
Objectives: This study aimed to identify the current knowledge, attitude, and perception (KAP) of the future prescribers about antimicrobial (AM) education so that the identified lacunae in the training curriculum can be effectively addressed. Materials and Methods: A questionnaire-based survey was carried out in the 2nd year students of medical and the dental undergraduate (UG) courses at a tertiary care teaching center in Jaipur. Each respondent completed the given questionnaire independently in the allocated time. A scoring system was used to rate the KAP of the respondents as poor, average, or good. Results: Statistically significant differences were found in the KAP of the medical and dental future prescribers (P = 0.0086, 0.0002, and <0.0001 for the KAP, respectively). Conclusion: The attitude of the UG students towards AM education is good, but the deficiencies in the knowledge and perception need to be improved further. Suitable interventions to address these lacunae must be planned. © 2015 Indian Journal of Pharmacology Published by Wolters Kluwer.
Sharma B.S.,SMS Medical College |
Gupta M.K.,Mahatma Gandhi Medical College |
Chandel R.,SMS Medical College
Indian Pediatrics | Year: 2012
A cross sectional survey of 3321 school going children (5-15 years) using modified ISAAC questionnaire in Jaipur city showed 7.59% children to have asthma (in last 12 months) and 8.4% wheezing in last 12 months. Only 5.3 % children had "physician diagnosed asthma ever" suggesting under diagnoses.
Bharadwaj A.,Mahatma Gandhi Medical College |
Khandelwal M.,SMS Medical College |
Bhargava S.K.,SK Soni Manipal Hospital
Indian Journal of Anaesthesia | Year: 2014
Paediatric patients undergoing surgical procedures commonly require some volume of blood or blood component replacement in the perioperative period. Paediatric patients undergoing major surgery associated with substantial blood loss should be evaluated pre-operatively. Pre-operative correction of anaemia may be done considering the age, plasma volume status, clinical status and comorbidities. Maximum allowable blood loss (MABL) for surgery must be calculated, and appropriate quantity of blood and blood components should be arranged. Intraoperative monitoring of blood loss should be done, and volume of transfusion should be calculated in a protocol based manner considering the volemia and the trigger threshold for transfusion for the patient and the MABL. Early haemostasis should be achieved by judicious administration of red blood cells, blood components and pharmacological agents. © 2014, Indian Society of Anaesthetists. All rights reserved.
Atal S.S.,Modern Institute of Medical science |
Atal S.,Mahatma Gandhi Medical College
Journal of Basic and Clinical Physiology and Pharmacology | Year: 2016
Despite significant improvements in medical and surgical management, multiple organ dysfunction syndrome (MODS) or multiple organ failure following conditions such as acute pancreatitis, severe sepsis, and traumatic, hemorrhagic, and endotoxin shocks is still accompanied with a high mortality rate. In light of the crucial role of immunologic derangement recently conceptualized in these conditions, ulinastatin, a urinary trypsin inhibitor, is considered as a potentially beneficial immunomodulator drug for MODS. Mechanisms involving protections against tissue organs and endothelial cell and anti-inflammatory effects by ulinastatin are dependent on the inhibition of polymorphonuclear leukocyte (PMN)-derived elastase, tumor necrosis factor α, and other pro-inflammatory cytokines and interleukins (IL-1, IL-6, and IL-8). Ulinastatin also suppresses the activation of PMN cells, macrophages, and platelets. Derived from these properties, ulinastatin has been investigated as a potential clinical therapy for indications including shock and pancreatitis and approved in Japan and China with ongoing clinical trials around the globe. Off-label potential uses of ulinastatin have been reported in preterm labor and hematological, hepatic, renal, and cardiovascular diseases including vasculitis syndromes such as Kawasaki disease. © 2016 by De Gruyter.
Bhargava J.,SMS Medical College |
Khan Z.Y.,Mahatma Gandhi Medical college
Journal of Clinical and Diagnostic Research | Year: 2012
Background: Anti-depressant drugs which are used in the Allopathic system of medicine for the treatment of depression have side effects. Studies which have compared the effcacy and the side effects of Allopathic and Ayurvedic drugs in the treatment of depression have not been reported. Aims: The aim of the present study was to compare the effcacy and the side effects of imipramine and sertraline which are the commonly prescribed drugs in the Allopathic system of medicine for the treatment of depression, with an Ayurvedic formulation. Settings and Design: This study was an open labeled randomized clinical trial which involved 90 depressive patients who were divided into three groups of 30 each, for the administration of imipramine, sertraline, and an Ayurvedic formulation respectively. HAM-D scoring was done and a side effect checklist was also prepared. Materials and Methods: The Ayurvedic formulation consisted of aqueous extracts of Brahmi, Shankhpuship, Malkangni and Jatamansi which were mixed in equal proportions (250 mg each). The Ayurvedic formulation was administered at a dose of 1000 mg orally in two divided doses; and imipramine and sertraline were administered at a dose of 150 mg each per day, to separate the groups of patients. The persons who abided by the inclusion and exclusion criteria were selected randomly. The effect of the treatments on the treated patients was repeatedly assessed at a continuous interval of two weeks for three months. Results: The Ayurvedic formulation had negligible side effects and it was found to be effective at par with imipramine and sertraline at the end of three months. Conclusions: The Ayurvedic formulation was found to be better as compared to imipramine and sertraline for the treatment of patients with mild to moderate depression, due to its lesser side effects.
Yadav D.,SMS Medical College |
Gupta M.,Mahatma Gandhi Medical College |
Mishra S.,SMS Medical College |
Sharma P.,All India Institute of Medical Sciences
Clinica Chimica Acta | Year: 2013
Objective: Lipid profile parameters are influenced by various factors like age, ethnicity, diet, genetic and gender differences hence it is essential to establish reference range of the values of serum lipids for a given population in India. We have planned this study to evaluate the reference values of lipid profile of a North Indian population according to the guidelines of the National Cholesterol Education Program (NCEP) of the USA. Design and methods: The present study was conducted on 2021 apparently healthy individuals of North Indian origin ranging in age from 15 to 60. years, who were selected randomly using defined criteria. Fasting samples were analyzed for total cholesterol, triglyceride, HDL-C and LDL-C. Data were analyzed for middle 95th percentile (2.5th-97.5th percentile), median and 95% confidence interval using SPSS software package version 10.0. Results: No substantial difference could be observed between male and female and vegetarian and non-vegetarian, in cholesterol, triglyceride and LDL-C levels. However HDL-C reported higher limit in female as compared to male (33-64 vs 32-58. mg/dl). Similarly upper limit of HDL-C in vegetarians were higher than non-vegetarian (value 32.8-64.92 vs 30.72-58.10. mg/dl). Median value for cholesterol, triglyceride, LDL-C progressively increased in different age groups (< 20, 20-40 and 41-60. years). No marked difference was observed in reference interval of these parameters in rural and urban populations. Conclusion: It can be suggested that lipid values obtained in this study can be used as the reference value, based on which clinical correlation can be made. © 2013.
Sharma A.,Mahatma Gandhi Medical College |
Mittal R.S.,Sawai Man Singh Medical College
Journal of Neurosciences in Rural Practice | Year: 2016
Cavernous malformations (CMs) are vascular anomalies with dilated spaces called caverns. These spaces are lined by endothelial cells and collage and devoid of smooth muscle or intervening neural tissue, and filled with blood at various stages of stasis, thrombosis, organization, and calcification. Most CMs are relatively small in size but when they are large enough they can produce sing of mass effect and may simulate neoplastic, vascular, inflammatory pathology. Giant CM (size >6 cm) are very rare lesions and very few cases are reported in world literature. We are reporting such a rare case of a 16 year male. Our case is also unique in the sense that it is the largest reported CM in Indian population. © 2016 Journal of Neurosciences in Rural Practice.
Gavaskar A.S.,Mahatma Gandhi Medical College |
Achimuthu R.,Government of Tamilnadu
Journal of Spinal Disorders and Techniques | Year: 2010
Study Design: Prospective, nonrandomised, single center. Objective: To study the clinico-radiologic and functional outcome after transfacetal screw fixation and fusion for low-grade degenerative spondylolisthesis of the lumbar spine. Summary of Background Data: Surgery for degenerative spondylolisthesis conventionally involves instrumented fusion using 3 column pedicle screw fixation systems. Recently transfacetal fusion techniques have been reported to produce good results without the surgical morbidity associated with posterolateral fusion and the neurologic complications associated with pedicle screw fixation. Methods: 30 patients with low-grade degenerative spondylolisthesis of the lumbar and lumbosacral spine underwent transfacetal fusion using 2 cortical screws and local cancellous bone grafts. Results: Clinical and radiologic evidence of fusion was obtained in 29 patients. One patient developed pseudoarthrosis with progression of slip and was reoperated. Quadruple visual analog scores and Oswestry disability assessment showed a significant improvement at 1-year follow-up. Conclusions: Degenerative spondylolisthesis with lower grade slips and normal anterior structures represent an ideal indication for transfacetal fusion. This is a simple and useful technique for short segment fusions of the lumbar spine. Copyright © 2010 by Lippincott Williams & Wilkins.
Sinha P.,Mahatma Gandhi Medical College |
Gupta S.,Mahatma Gandhi Medical College |
Dawra R.,Mahatma Gandhi Medical College |
Rijhawan P.,Mahatma Gandhi Medical College
Indian Journal of Medical Microbiology | Year: 2014
Background: Scrub typhus usually affects previously healthy active persons and if undiagnosed or diagnosed late, may prove to be life-threatening. Diagnosis of scrub typhus should be largely based on a high index of suspicion and careful clinical, laboratory and epidemiological evaluation. Objective: To describe the diverse clinical and laboratory manifestations of scrub typhus diagnosed in Mahatma Gandhi Medical College and Hospital, Jaipur. Materials and Methods: All cases of febrile illness diagnosed as scrub typhus over a period of 3 months were analysed. Diagnosis was based on ELISA test for antibody detection against 56 kDa antigen. Results: Forty-two cases of scrub typhus were seen over a period of 3 months (October, 2012-December, 2012). Common symptoms were high grade fever of 4-30 days duration, cough, haemoptysis and breathlessness. Eschar was not seen even in a single patient. Liver enzymes were elevated in nearly all cases (95.9%). Multiple organ dysfunction syndrome (MODS) was present in 16.66% of our patients (7 out of 42). Hypotension (6 patients, 14.2%), renal impairment (9 out of 15 patients, 60%), acute respiratory distress syndrome (4 patients, 9.52%) and meningitis (4 patients, 9.52%) were some of the important complications. There was a dramatic response to doxycycline in nearly all the patients, but initially when the disease was not diagnosed, seven patients had died. Conclusion: Scrub typhus has emerged as an important cause of febrile illness in Jaipur. Empirical treatment with doxycycline is justified in endemic areas.
Parthasarathy S.,Mahatma Gandhi Medical college
Sri Lankan Journal of Anaesthesiology | Year: 2011
In this prospective, randomized, double blind placebo controlled study, we investigated the postoperative analgesic efficacy of 1.5mg of intrathecal midazolam as an adjunct to bupivacaine for spinal anaesthesia in 100 patients undergoing abdominal hysterectomy. Patients were allocated randomly to 2 groups: Group B received intrathecal 3.5 ml of 0.5% heavy bupivacaine plus 0.3 ml of 0.9% saline; Group BM received 3.5 ml of 0.5% heavy bupivacaine plus 1.5 mg of preservative free midazolam (5 mg/ml). Onset of sensory analgesia, maximum level of sensory block, time to reach it, and time to two segment regression were similar between the two groups (p > 0.05). Blood pressure and heart rate were comparable between groups. The mean duration of postoperative analgesia was less in group B compared with group BM. Supplemental analgesic dose requirement with pentazocine was significantly less in Group BM compared with Group B. No neurological deficits were observed. Intraoperative sedation and oxygen desaturation was significantly higher but acceptable in Group BM. Conclusion: Intrathecal midazolam 1.5 mg when used as an adjunct to bupivacaine provides better intraoperative sedation and moderate prolongation of postoperative analgesia.