Maharishi Markandeshwar University Mullana

Ambāla, India

Maharishi Markandeshwar University Mullana

Ambāla, India
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Yildirim H.,Istanbul University | Bayrak N.,Istanbul University | Tuyun A.F.,Istanbul University | Kara E.M.,Istanbul University | And 2 more authors.
RSC Advances | Year: 2017

Antibacterial and antifungal organic compounds are becoming increasingly important for biomedical applications. This study deals with the synthesis, characterization of structures, in silico PASS prediction, and the discovery of antibacterial and antifungal properties based on new sulfanyl-1,4-naphthoquinone derivatives containing an arylamine with a trifluoromethyl group at different positions, which can be further applied in drug discovery and development. The in vitro antimicrobial potential of the newly synthesized compounds was evaluated in a panel of seven bacterial strains (three Gram-positive and four Gram-negative bacteria) and one yeast, with an additional study on antibiofilm activities. The compounds (5b and 5e) were identified as having strong antibacterial efficiency against the human-originated pathogen S. epidermidis, with minimal inhibitory concentration values (4.88 and 2.44 μg mL-1, respectively). The toxicity of both compounds (5b and 5e) was studied in detail to compare these compounds with Cefuroxime (a clinically proven drug). The antibacterial activity of the compound 5f was equal to that of Cefuroxime. Moreover, three compounds (5b, 5e, and 5f) exhibited excellent antibacterial activity, and 5b and 5e were two and four times more active than the reference antimicrobial compound (Cefuroxime), respectively. For this reason, these three compounds (5b, 5e, and 5f) are being considered as promising antibacterial agents. In addition, docking studies were used to better rationalize the action and prediction of the binding modes of these compounds. © The Royal Society of Chemistry 2017.


Khare R.,Maharishi Markandeshwar University Mullana | Sethi P.,Maharishi Markandeshwar University Mullana
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2015

Objective: The metal complexes of 1-(Phenylamino)-4, 4, 6-trimethyl-3, 4-dihydropyrimidine-2-(1H)-thione: preparation, physical and spectroscopic studies and preliminary antibacterial properties. Methods: Complexes of bidentate ligand containing N, S-bridge [M(pmpt)2(H2O)n] (M(II) = Cu, Mn, Ni, Co; n = 2 and M(II) = Zn, Cd, Pd; n = 0) derived from the reaction of Hpmpt ligand with metals (M(II) = Cu, Mn, Ni, Co, Zn, Cd, Pd) and characterized by various physico-chemical techniques. From magnetic moment studies, square planar geometry is suggested for Zn(II), Cd(II), Pd(II) complexes, octahedral geometry is proposed for Co(II), Ni(II) and Mn(II) and distorted octahedral for Cu(II) complexes. Thermo gravimetric (TG) curves indicate the decomposition of complexes in four to five steps. The presence of coordinated water in metal complexes was confirmed by thermal, elemental analysis and IR data. Free ligand and its complexes were assayed in vitro for their antibacterial activity against gram positive and gram negative bacteria using chloramphenicol as a standard market-drug. Results: The reported complexes were synthesized through greener protocol that is grindstone method by mixing the ligand and metal salts in 2:1 molar ratio. Products were obtained in good yield with sharp melting point. Conclusion: Studies have indicated that such complexes can be prepared by environment friendly approach which requires less time, simple workup for isolation and purification with good yield. The [Ni(pmpt)2(H2O)2] complex showed excellent antibacterial activity while other reported metal complexes showed weak antibacterial activity. © 2015, International Journal of Pharmacy and Pharmaceutical Science. All right resurved.


Gupta V.,Maharishi Markandeshwar University Mullana | Ramandeep,Maharishi Markandeshwar University Mullana | Mani N.,Lovely Professional University | Tripathi A.K.,Maharishi Markandeshwar University Mullana
Procedia Computer Science | Year: 2016

Fixed point theory is very wide field, which have many applications in different areas. The concept of altering distance to find fixed point results have been explored by many authors. In the present paper, we achieve unique common fixed point results for two self-mappings using a generalization of altering distance and a rational type contractive condition. An example has also been given in support of our result. © 2016 The Authors.


Jain A.K.,Maharishi Markandeshwar University | Chargolra V.,Maharishi Markandeshwar University | Prasad D.,Maharishi Markandeshwar University Mullana
Proceedings of the 2015 IEEE 3rd International Conference on MOOCs, Innovation and Technology in Education, MITE 2015 | Year: 2015

One of the significant constraints of sensor nodes is their limited battery power due to which they are prone to fail. The sensor nodes may also get damaged due to various natural hazards or other reasons. Due to these constraints the wireless sensor networks become unreliable. This paper proposes a distributed clustering approach with state-full architecture; a protocol, RS-HEED (Reliable, State-full Hybrid Energy Efficient Distributed clustering) for increasing the lifetime and reliability- of a network. RS-HEED periodically does clustering to select cluster heads on the basis of residual energy as primary parameter and communication cost as secondary parameter. RS-HEED b a query driven model and employs a connection setup phase to deliver data reliably from sensor node to base station. © 2015 IEEE.


Khanna R.,Maharishi Markandeshwar University Mullana | Singh H.,National Institute of Technology Kurukshetra
Proceedings of the Institution of Mechanical Engineers, Part L: Journal of Materials: Design and Applications | Year: 2016

Cryo process is the process of treating work-pieces to cryogenic temperatures (i.e. -184 °C) to remove residual stresses and improve wear resistance of steels. It improves the surface properties of the materials. Aerospace and tool industries use this treatment to enhance the dimensional stability and wear resistance. In this research paper, a comparison has been presented for normal and cryogenic-treated high carbon high chromium cold alloy tool (D-3) steel. The response variables namely cutting rate, metal removal rate, and surface roughness are considered for experimentations and six input process parameters like pulse width, time between two pulses, servo reference mean voltage, short pulse time, maximum feed rate, and wire mechanical tension were used for optimization on wire electric discharge machine. Grey relational analysis has been applied to calculate the grey relational coefficients and grey relational grade. ANOVA is also performed to know the significant factors for multi-response optimization. © IMechE 2015.


Jain A.,Maharishi Markandeshwar University Mullana | Panwar S.,Maharishi Markandeshwar University Mullana | Kang T.W.,Dongguk University | Jeon H.C.,Dongguk University | And 2 more authors.
Journal of Materials Science: Materials in Electronics | Year: 2014

In the present work, we have prepared zinc sulphide (ZnS:Mn)/zinc oxide (ZnO) core-shell nanostructures by a chemical precipitation method and observed the effect of ZnO concentration on the fluorescent nanoparticles. Change in the morphological and optical properties of core-shell nanoparticles have been observed by changing the concentration of ZnO in a core-shell combination with optimum value of Mn to be 1 % in ZnS. The morphological studies have been carried out using X-ray diffraction (XRD) and transmission electron microscopy. It was found that diameter of ZnS:Mn nanoparticles was around 4-7 nm, each containing primary crystallites of size 2.4 nm which was estimated from the XRD patterns. The particle size increases with the increase in ZnO concentration leading to the well-known ZnO wurtzite phase which was coated on the FCC phase of ZnS:Mn. Band gap studies were performed by UV-visible spectroscopy and a red shift in absorption spectra have been observed with the addition of Mn as well as with the capping of ZnO on ZnS:Mn. The formation of core-shell nanostructures have been also confirmed by FTIR analysis. Photoluminescence studies show that emission wavelength is red shifted with the addition of ZnO layer on ZnS:Mn(1 %). These core-shell ZnS:Mn/ZnO nano-composites will be a very suitable material for specific kind of tunable optoelectronic devices. © 2014 Springer Science+Business Media New York.


Shikha D.,Maharishi Markandeshwar University Mullana | Shikha D.,Sri Guru Teg Bahadur Khalsa College | Mehta V.,Sri Guru Teg Bahadur Khalsa College | Sharma J.K.,Maharishi Markandeshwar University Mullana | Sharma J.,Sri Guru Granth Sahib World University
Optoelectronics and Advanced Materials, Rapid Communications | Year: 2016

The structural, optical and electrical properties of ZnSe films deposited by chemical bath deposition method were investigated as a function of pH(11.0 to13.0). XRD studies showed that films deposited were polycrystalline in nature with zinc-blende structure and a strong [111] texture. The grain size increases as pH increases. From the optical studies the band gap is obtained and showed that it varies inversely with pH and in electrical studies it was observed that both dark and photoconductivity increases as the particle size increases. © 2016, National Institute of Optoelectronics. All rights reserved.


Thakur R.,Biochemical Research Laboratory | Jain N.,Biochemical Research Laboratory | Pathak R.,Biochemical Research Laboratory | Sandhu S.S.,Maharishi Markandeshwar University Mullana
Evidence-based Complementary and Alternative Medicine | Year: 2011

Wounds are the result of injuries to the skin that disrupt the other soft tissue. Healing of a wound is a complex and protracted process of tissue repair and remodeling in response to injury. Various plant products have been used in treatment of wounds over the years. Wound healing herbal extracts promote blood clotting, fight infection, and accelerate the healing of wounds. Phytoconstituents derived from plants need to be identified and screened for antimicrobial activity for management of wounds. The in vitro assays are useful, quick, and relatively inexpensive. Small animals provide a multitude of model choices for various human wound conditions. The study must be conducted after obtaining approval of the Ethics Committee and according to the guidelines for care and use of animals. The prepared formulations of herbal extract can be evaluated by various physicopharmaceutical parameters. The wound healing efficacies of various herbal extracts have been evaluated in excision, incision, dead space, and burn wound models. In vitro and in vivo assays are stepping stones to well-controlled clinical trials of herbal extracts. © 2011 Rupesh Thakur et al.


Kumar S.,Maharishi Markandeshwar University Mullana | Singh S.,Maharishi Markandeshwar University Mullana | Sharma J.K.,Maharishi Markandeshwar University Mullana | Goel A.,Amity University | Kalra K.,Amity University
Pramana - Journal of Physics | Year: 2016

The signature splittings inKπ =1+: 7/2[404]π⊗9/2[624]ν , Kπ =0-: 9/2[514]π⊗9/2[624]ν bands of 180Ta and Kπ = 0-: 7/2[404]π⊗7/2[503]ν , Kπ = 1-: 5/2[402]π⊗3/2[512]ν , Kπ = 1+: 7/2[404]π⊗9/2[624]ν bands of 182Ta are analysed within the framework of two-quasiparticle rotor model. The phase as well as magnitude of the experimentally observed signature splitting in Kπ = 1+ band of 180Ta, which could not be explained in earlier calculations, is successfully reproduced. The conflict regarding placement of a 12+ level in Kπ = 1+: 7/2+[404]π⊗9/2+[624]ν ground-state rotational band of 180Ta is resolved and tentative nature of Kπ = 0-: 7/2[404]π⊗7/2[503]ν , Kπ = 1+: 7/2[404]π⊗9/2[624]ν bands observed in 182Ta is confirmed. As a future prediction for experimentalists, these two-quasiparticle structures observed in 180Ta and 182Ta are extended to higher spins. © 2016 Indian Academy of Sciences.


Khanna A.,Maharishi Markandeshwar University Mullana | Sharma A.K.,Manav Bharti University
Journal of Applied Science and Engineering | Year: 2013

In the modern technology, the plates of variable thickness are widely used in engineering applications i.e. nuclear reactor, aeronautical field, naval structure, submarine etc. In this paper, effect of thermal gradient on vibration of square plate of varying thickness is studied. Thermal effect and thickness of plate vary bi-parabolic i.e. parabolic in x-direction and parabolic in y-direction. Rayleigh Ritz technique is used to calculate the fundamental frequencies. The frequencies corresponding to the first two modes of vibrations are obtained for a square plate for different values of taper constant and thermal gradient. Results are presented in Table and Graphical form.

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