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Jain A.K.,Maharishi Markandeshwar University | Chargolra V.,Maharishi Markandeshwar University | Prasad D.,Maharishi Markandeshwar University Mullana
Proceedings of the 2015 IEEE 3rd International Conference on MOOCs, Innovation and Technology in Education, MITE 2015 | Year: 2015

One of the significant constraints of sensor nodes is their limited battery power due to which they are prone to fail. The sensor nodes may also get damaged due to various natural hazards or other reasons. Due to these constraints the wireless sensor networks become unreliable. This paper proposes a distributed clustering approach with state-full architecture; a protocol, RS-HEED (Reliable, State-full Hybrid Energy Efficient Distributed clustering) for increasing the lifetime and reliability- of a network. RS-HEED periodically does clustering to select cluster heads on the basis of residual energy as primary parameter and communication cost as secondary parameter. RS-HEED b a query driven model and employs a connection setup phase to deliver data reliably from sensor node to base station. © 2015 IEEE.

Khanna R.,Maharishi Markandeshwar University Mullana | Singh H.,National Institute of Technology Kurukshetra
Proceedings of the Institution of Mechanical Engineers, Part L: Journal of Materials: Design and Applications | Year: 2016

Cryo process is the process of treating work-pieces to cryogenic temperatures (i.e. -184 °C) to remove residual stresses and improve wear resistance of steels. It improves the surface properties of the materials. Aerospace and tool industries use this treatment to enhance the dimensional stability and wear resistance. In this research paper, a comparison has been presented for normal and cryogenic-treated high carbon high chromium cold alloy tool (D-3) steel. The response variables namely cutting rate, metal removal rate, and surface roughness are considered for experimentations and six input process parameters like pulse width, time between two pulses, servo reference mean voltage, short pulse time, maximum feed rate, and wire mechanical tension were used for optimization on wire electric discharge machine. Grey relational analysis has been applied to calculate the grey relational coefficients and grey relational grade. ANOVA is also performed to know the significant factors for multi-response optimization. © IMechE 2015.

Thakur R.,Biochemical Research Laboratory | Jain N.,Biochemical Research Laboratory | Pathak R.,Biochemical Research Laboratory | Sandhu S.S.,Maharishi Markandeshwar University Mullana
Evidence-based Complementary and Alternative Medicine | Year: 2011

Wounds are the result of injuries to the skin that disrupt the other soft tissue. Healing of a wound is a complex and protracted process of tissue repair and remodeling in response to injury. Various plant products have been used in treatment of wounds over the years. Wound healing herbal extracts promote blood clotting, fight infection, and accelerate the healing of wounds. Phytoconstituents derived from plants need to be identified and screened for antimicrobial activity for management of wounds. The in vitro assays are useful, quick, and relatively inexpensive. Small animals provide a multitude of model choices for various human wound conditions. The study must be conducted after obtaining approval of the Ethics Committee and according to the guidelines for care and use of animals. The prepared formulations of herbal extract can be evaluated by various physicopharmaceutical parameters. The wound healing efficacies of various herbal extracts have been evaluated in excision, incision, dead space, and burn wound models. In vitro and in vivo assays are stepping stones to well-controlled clinical trials of herbal extracts. © 2011 Rupesh Thakur et al.

Khanna A.,Maharishi Markandeshwar University Mullana | Sharma A.K.,Manav Bharti University
Journal of Applied Science and Engineering | Year: 2013

In the modern technology, the plates of variable thickness are widely used in engineering applications i.e. nuclear reactor, aeronautical field, naval structure, submarine etc. In this paper, effect of thermal gradient on vibration of square plate of varying thickness is studied. Thermal effect and thickness of plate vary bi-parabolic i.e. parabolic in x-direction and parabolic in y-direction. Rayleigh Ritz technique is used to calculate the fundamental frequencies. The frequencies corresponding to the first two modes of vibrations are obtained for a square plate for different values of taper constant and thermal gradient. Results are presented in Table and Graphical form.

Tuli H.S.,Maharishi Markandeshwar University Mullana | Kumar G.,Kurukshetra University | Sandhu S.S.,Rani Durgavati University | Sharma A.K.,Maharishi Markandeshwar University Mullana | Kashyap D.,Jawaharlal Institute of Postgraduate Medical Education & Research
Turkish Journal of Biology | Year: 2015

Cordycepin, an active ingredient in the insect fungus Cordyceps militaris, is in a category of compounds that exhibit significant therapeutic activity. The aim of the present study was to investigate the effect of cordycepin on cell proliferation, apoptosis, and cell cycle in A549 human lung cancer cells. MTT assay was used to evaluate the cytotoxic effect of cordycepin on A549 cell growth. Apoptotic effect was observed using cell morphology, DAPI staining, and DNA fragmentation studies. Flow cytometry (FCM) analysis was used to analyze cell cycle status after cordycepin treatment. Furthermore, apoptosis was assayed using annexin V-Alexa Fluor 488. Results of MTT assay showed that cordycepin significantly inhibited cell proliferation with an IC50 value of 64 µg/mL. The number of rounding-up cells increased with cordycepin treatment and changes in cellular morphology were seen. In DNA fragmentation studies, a typical ladder pattern was observed on agarose gel and formation of apoptotic bodies was further confirmed using DAPI staining. The FCM analysis of cordycepin-treated cells showed that apoptosis rate increased with the increase in dosage. In conclusion, cordycepin induces apoptosis in A549 human lung cancer cell line and could be a potential therapeutic candidate for lung cancer treatment. © TÜBİTAK.

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