Maharashtra Udaygiri Mahavidyalaya

Udgīr, India

Maharashtra Udaygiri Mahavidyalaya

Udgīr, India
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Birajdar S.S.,Maharashtra Udaygiri Mahavidyalaya | Hatnapure G.D.,Maharashtra Udaygiri Mahavidyalaya | Keche A.P.,Maharashtra Udaygiri Mahavidyalaya | Kamble V.M.,Maharashtra Udaygiri Mahavidyalaya | Kamble V.M.,The Institute of Science
Journal of Chemical and Pharmaceutical Research | Year: 2013

We report synthesis of novel series of amino alcohol derivatives of 2-methyl benzimidazole. These compounds have been synthesized by epoxide ring opening of 2-methyl benzimidazole with different substituted cyclic amines. These synthesized compounds have been characterized using IR, 1H NMR and ES-MS spectral data together with their melting point. These compounds (4a-4o) were evaluated for their preliminary in-vitro antibacterial activity against Gram +ve (Staphylococcus aureus) and Gram -ve (Escherichia coli) pathogens. Out of all tested compounds, the compounds 4c, 4j, 4n and 4o showed moderate to good activity compared to standard drugs Ciprofloxacin and Norfloxacin. Further, these compounds were screened for their antitubercular activity against Mycobacterium tuberculosis H37Rv strain by MABA method. The compound 4c and 4o were found to exhibit moderate antimycobacterial activity compared to standard Isoniazid.


Birajdar S.S.,Maharashtra Udaygiri Mahavidyalaya | Hatnapure G.D.,Maharashtra Udaygiri Mahavidyalaya | Keche A.P.,Maharashtra Udaygiri Mahavidyalaya | Kamble V.M.,Maharashtra Udaygiri Mahavidyalaya | Kamble V.M.,The Institute of Science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

Benzimidazole ring is a useful synthon in medicinal chemistry and is a part of many biologically active compounds. This communication reports a mild and efficient approach for the synthesis of benzimidazole ring through oxidative cyclization of o-phenylenediamine and different aldehydes using dioxane dibromide, as a user-friendly reagent. This is a new, convenient and facile methodology for the synthesis of 2-substituted-1H-benzo[d]imidazoles.


Hallale S.N.,Maharashtra Udaygiri Mahavidyalaya | Allapure R.B.,Maharashtra Udaygiri Mahavidyalaya
Pollution Research | Year: 2012

In the present investigation, an attempt has been made to investigate the pollution status of domestic sewage near fort area at Udgir. The Study of Physico-chemical parameters viz. Temperature, pH, Electrical conductivity (EC), Total Dissolved Solids (TDS), Total hardness (TH), Dissolved Oxygen (DO), Sodium, Potassium, Sulphate and Phosphates were investigated. Result show considerable seasonal variation in physico-chemical parameters. Copyright © EM International.

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