Maharanis Science College for Women

Bangalore, India

Maharanis Science College for Women

Bangalore, India
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Girish K.,Maharanis Science College For Women
Asian Journal of Pharmaceutical and Clinical Research | Year: 2017

Herbal drugs are the potential sources of therapeutic aid for the treatment and prevention of number of ailments as recognized very early by Ayurveda, Unani, and traditional folk - medical practitioners. The rich biodiversity of plants makes them a treasure house for obtaining new and novel compounds either themselves as drugs or lead molecules for drugs with different mechanisms of action. Lantana camara L. belonging to the family Verbenaceae and universally known as wild or red sage is the most widespread species of the genus. It occurs in most parts of the world as an evergreen notorious weed species. It is also considered as an ornamental garden plant. It is widely used in different traditional medical practices for treating various health problems. Different parts of the plant are used in treating various human ailments. The plant extracts and essential oil of L. camara possess various bioactivities including antimicrobial activities. The therapeutic potential of the plant is due to the occurrence of many bioactive phytocompounds. In last decade, scientists and researchers around the globe have elaborately studied the chemical composition of the whole plant of L. camara as well as its biological activities. This article reviews the antimicrobial activities of L. camara. © 2017 The Authors.


Gowda B.G.,Maharanis Science College for Women
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Objective: A simple, rapid, precise and accurate high performance liquid chromatography (HPLC) method has been developed for the estimation of colchicine (COLC) in bulk drug, pharmaceutical formulations and biological fluids. Methods: The developed HPLC method involves the using of a mixture of acetonitrile: methanol: water (32:48:20 v/v) as a mobile phase. The pH of the mobile phase was adjusted to 5.2 with phosphoric acid. A CLC C18 column (5 μm, 25 cm x 4.6 mm i.d.) was used for the elution. The flow rate of the mobile phase was set to 1.2 ml/min. Injection volume was set at 20 μl and the detection of the analyte was done at 254 nm. Results: The linear regression analysis data for calibration curve showed a good relationship with correlation coefficient of 0.9997. The concentration range was 7-130 μg/ml. The percentage recovery of COLC was found to be 99.87 %. The limits of detection and quantification are also reported. This selective method is found to be accurate, precise and effectively used for the determination of COLC in various pharmaceutical formulations and biological fluids with better chromatographic conditions. Conclusions: The method was successfully applied to the assay of COLC in pharmaceutical formulations and biological fluids and the results were statistically compared with those of the reference method by applying Student's t-test and F-test. No interference was observed from the common tablet excipients. The accuracy of the method was further ascertained by performing recovery studies via standard-addition method.


Farahani M.R.,Iran University of Science and Technology | Rajesh Kanna M.R.,Maharanis Science College For Women
Journal of Chemical and Pharmaceutical Research | Year: 2015

Let G=(V,E) be a simple connected graph. The sets of vertices and edges of G are denoted by V=V(G) and E=E(G), respectively. A topological index of a graph is a number related to a graph which is invariant under graph automorphisms. In chemical graph theory, we have many invariant polynomials and topological indices for a molecular graph. In 1972, Gutman and Trinajstić introduced the First and Second Zagreb topological indices of molecular graphs. The First and Second Zagreb indices are equal to M1(G)= ΣvεV(G) dv 2 and M2(G)= ΣvεE(G) (du×dv), respectively. These topological indices are useful in the study of anti-inflammatory activities of certain chemical instances, and in elsewhere. In this paper, we focus on the structure of V-Phenylenic Nanotubes and Nanotori and compute the Generalized Zagreb index of these Nanostructures. © 2015, Journal of Chemical and Pharmaceutical Research. All Rights Reserved.


Farahani M.R.,Iran University of Science and Technology | Rajesh Kanna M.R.,Maharanis Science College For Women
Journal of Chemical and Pharmaceutical Research | Year: 2015

Let G be a simple molecular graph without directed and multiple edges and without loops, the vertex and edge-sets of which are represented by V(G) and E(G), respectively. A topological index of a graph G is a numeric quantity related to G which is invariant under automorphisms of G. A new counting polynomial, called the Omega polynomial, was recently proposed by Diudea on the ground of quasi-orthogonal cut "qoc" edge strips in a polycyclic graph. Another new counting polynomial called the Pi polynomial. The Omega and Pi polynomials are equal to Ω(G,x)= Σcm(G,c)xc and ∏(G,x)= Σcm(G,C).C.x|E(G)|-c, respectively. In this paper, the Pi polynomial and the Pi Index of Polycyclic Aromatic Hydrocarbons PAHk are computed. © 2015, Journal of Chemical and Pharmaceutical Research. All Rights Reserved.


Padmanabha B.,Maharanis Science College for Women
Research Journal of Chemistry and Environment | Year: 2015

The major ion concentration data has been processed using the HYCH-basic Computer programme. In this computer programme, the estimation of Sodium Adsorption Ratio (SAR), Residual Sodium Carbonate (RSC), Corrosivity Ratio (CR), USSL classification of water for salinity and sodium hazards and Permeability Index (PI) are employed. This study suggests that Sodium Percentage, Residual Sodium Carbonate (RSC) recorded higher in the Kamana lake than in the Dalvoi lake. Sodium Adsorption Ratio and Corrosivity ratio documented higher in Dalvoi lake than Kamana lake. The water of Kamana lake is noncorrosive and in Dalvoi lake it is corrosive. According to USSL classification, the water of these two lakes indicated low salinity with high or very high sodium hazard. Permeability index recorded higher in the Kamana than in the Dalvoi lake. Permeability index documented highest during winter season followed by monsoon and lowest in the summer season. Influx of large quantity of domestic sewage decreased water level and increased dissolved solids might have decreased the permeability index in the summer season.


Basha P.M.,Bangalore University | Rai P.,Bangalore University | Begum S.,Maharanis Science College for Women
Biological Trace Element Research | Year: 2011

Multigenerational evaluation was made in rats on exposure to high fluoride (100 and 200 ppm) to assess neurotoxic potential of fluoride in discrete areas of the brain in terms of lipid peroxidation and the activity of antioxidant enzyme system. The rats were given fluoride through drinking water (100 and 200 ppm) and maintained subsequently for three generations. Fluoride treatment significantly increased the lipid peroxidation and decreased the activity of antioxidant enzymes viz, catalase, superoxide dismutase, glutathione peroxidase, glutathione S-transferase, and glutathione level in first-generation rats and these alterations were more pronounced in the subsequent second and thirdgeneration rats in both the doses tested. Decreased feed and water consumption, litter size and organ (brain) somatic index, marginal drop in body growth rate and mortality were observed in all three generations. Decreased antioxidant enzyme activity and increased malondialdehyde levels found in the present study might be related to oxidative damage that occurs variably in discrete regions of the brain. Results of this study can be taken as an index of neurotoxicity in rats exposed to water fluoridation over several generations. © Springer Science+Business Media, LLC 2010.


Siddheshwar P.G.,Bangalore University | Vanishree R.K.,Maharanis Science College for Women | Melson A.C.,Maharanis Science College for Women
Transport in Porous Media | Year: 2012

The effects of temperature-dependent viscosity, gravity modulation and thermo-mechanical anisotropies on heat transport in a low-porosity medium are studied using the Ginzburg-Landau model. The effect of gravity modulation is to decrease the Nusselt number, Nu and variable viscosity leads to increase in Nu. The thermo-mechanical anisotropies have opposite effect on Nu with thermal anisotropy decreasing the heat transport. © 2011 Springer Science+Business Media B.V.


Basha P.M.,Bangalore University | Rai P.,Bangalore University | Begum S.,Maharanis Science College for Women
Biological Trace Element Research | Year: 2011

High-fluoride (100 and 200 ppm) water was administered to rats orally to study the fluoride-induced changes on the thyroid hormone status, the histopathology of discrete brain regions, the acetylcholine esterase activity, and the learning and memory abilities in multigeneration rats. Significant decrease in the serum-free thyroxine (FT4) and free triiodothyronine (FT3) levels and decrease in acetylcholine esterase activity in fluoridetreated group were observed. Presence of eosinophilic Purkinje cells, degenerating neurons, decreased granular cells, and vacuolations were noted in discrete brain regions of the fluoride-treated group. In the T-maze experiments, the fluoride-treated group showed poor acquisition and retention and higher latency when compared with the control. The alterations were more profound in the third generation when compared with the first-and second-generation fluoride-treated group. Changes in the thyroid hormone levels in the present study might have imbalanced the oxidant/antioxidant system, which further led to a reduction in learning memory ability. Hence, presence of generational or cumulative effects of fluoride on the development of the offspring when it is ingested continuously through multiple generations is evident from the present study. © Springer Science+Business Media, LLC 2011.


Vanishree R.K.,Maharanis Science college for Women | Siddheshwar P.G.,Bangalore University
Transport in Porous Media | Year: 2010

A linear stability analysis is performed for mono-diffusive convection in an anisotropic rotating porous medium with temperature-dependent viscosity. The Galerkin variant of the weighted residual technique is used to obtain the eigen value of the problem. The effect of Taylor-Vadasz number and the other parameters of the problem are considered for stationary convection in the absence or presence of rotation. Oscillatory convection seems highly improbable. Some new results on the parameters' influence on convection in the presence of rotation, for both high and low rotation rates, are presented. © Springer Science+Business Media B.V. 2009.


Vanishree R.K.,Maharanis Science college for Women
Journal of Applied Fluid Mechanics | Year: 2014

A linear stability analysis is performed to study the effects of through-flow and internal heat generation on the preferred mode of stationary thermal convection in a variable viscosity liquid saturating an anisotropic porous medium. The Rayleigh-Ritz technique is used to obtain the eigenvalue of the problem. The influence of porous parameter, mechanical anisotropy parameter, Peclet number, thermal anisotropy parameter, Brinkman number and variable viscosity parameter on the stability of the system is analyzed. The problem suggests another method of controlling convection by externally controlling porous media damping and shear. This is in addition to the through-flow mechanism of regulating convection.

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