andhra Pradesh, India
andhra Pradesh, India

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Srinivasa Rao Y.,Maharajahs Post Graduate College | Surya Mohana Rao N.,Maharajahs Post Graduate College | Sreerama Murthy B.,Maharajahs Post Graduate College | Pavan Kumar G.V.S.R.,Maharajahs Post Graduate College
Journal of the Indian Chemical Society | Year: 2012

A direct spectrophotometric method was developed by the authors, for the detection and determination of metronidazole and ornidazole in pure form, as well in pharmaceutical formulations in the form of tablets and capsules. The method was based on the formation of an instantaneous, clear, stable, reddish-purple colour, due to the diazotization reaction between the nitro group of the drug sample, sulphanilamide and NEDA. The drug sample, dissolved in hot water, followed by the addition of 2 ml of each 0.5% sulphanilamide and 0.3% NEDA, exhibited a stable reddish purple colour, which showed a maximum absorbance at 540 nm. Beer's law was found to be obeyed in the range of 200-600 μg ml, -1 for metronidazole and 100-300 μg mL -1 for ornidazole with a limit of detection of 0.01 μg mL -1 and 0.02 μ,g mL -1 respectively. The method was found to be simple, accurate and recommended for rapid analysis.


Sreerama Murthy B.,Maharajahs Post Graduate College | Pavan Kumar G.V.S.R.,Maharajahs Post Graduate College | Ramana P.,Maharajahs Post Graduate College | Sravanthi N.,Maharajahs Post Graduate College
Journal of the Indian Chemical Society | Year: 2011

A simple and accurate method was developed for the detection and determination of paracetamol by spectrophotometry in pharmaceutical formulations in the form of tablets. Paracetamol, was dissolved in 4 M sulphuric acid and treated with 1% aqueous sodium vanadate solution in the presence of 1 M hydrochloric acid. It exhibited a stable bluish-violet colour. The coloured compound showed λ max at 560 nm. This method is also recommended as a spot test for paracetamol. It is also precise and found to be accurate for qualitative and quantitative determinations of paracetamol.


Bhargavi V.,Maharajahs Post Graduate College | Anil K.,Maharajahs Post Graduate College | Anil Kumar Ch.,Maharajahs Post Graduate College | Lakshmi K.V.V.,Maharajahs Post Graduate College
Journal of Pure and Applied Microbiology | Year: 2011

Food handlers with poor hygiene working in food service establishments act as potential sources of infection due to pathogenic microorganisms. The study was undertaken to determine the prevalence of gram negative enteropathogens among the food handlers working in food establishments in Vizianagaram, Andhrapradesh, India. Randomly 10 food establishments were selected and samples were taken from finger nails and palms of food handlers and also from utensils used for serving food by swabbing method. Most Prevalent organisms identified were Klebsiellaspp.,(31.5%) followed by Vibriospp., (15.7%), and other members of enterobacteriacea family. Antimicrobial susceptibility was evaluated for all the identified isolates. Imepenem was found to be most effective antibiotic while other antibiotics showed high to moderate activity. The study showed the poor hygiene condition and lack of awareness on hygienic practices in food handlers. An effective means for preventing the transmission of pathogens from handlers to consumer is strict adherence to good personnel hygiene and practice hygiene food handling procedures.

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