Maharaja Surajmal Institute of Pharmacy

Janakpuri, India

Maharaja Surajmal Institute of Pharmacy

Janakpuri, India
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Singla C.,Maharaja Surajmal Institute of Pharmacy | Drabu S.,Maharaja Surajmal Institute of Pharmacy | Ali M.,Jamia Hamdard University
Proceedings - 2012 2nd International Conference on Advanced Computing and Communication Technologies, ACCT 2012 | Year: 2011

The present paper investigates the levels of heavy metal contamination i.e. lead, cadmium, mercury and arsenic in Urtica dioica aerial parts using automatic atomic absorption spectrophotometer (AAS) by computer plotting. The computer data system allows higher precision, higher sensitivity, and lower detection limits. The determination of heavy metals even in traces is of utmost importance as these metals are involved in biological cycles and their accumulation causes high toxicity. The paper compares the data of toxic metals with respect to permissible/acceptable limits of different countries. The level of heavy metals for Urtica dioica was found to be within the permissible limits for safe human use. © 2012 IEEE.


Drabu S.,Maharaja Surajmal Institute of Pharmacy | Chaturvedi S.,Maharaja Surajmal Institute of Pharmacy | Sharma M.,Jamia Hamdard University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

The use of plants as medicines predates written human history. The records show the study of herbs dates back over 5,000 years. The use of traditional medicine is globally expanding to newer horizons primarily due to low cost and less side effects associated. India is a vast repository of medicinal plants used in traditional medical treatments1. There are estimated to be around 25,000 effective plant-based formulations, used in folk medicine and known to rural communities in India2. It is estimated that there are over 7800 medicinal drug-manufacturing units in India, which consume about 2000 tonnes of herbs annually3. The various indigenous systems of medicine in India such as Siddha, Ayurveda, Unani and Allopathy have been using several plant species to treat different ailments4, 5. Taking these points in view Tamarix gallica plant is briefly reviewed in this article for its history, anatomy, phytochemical constituents and pharmacological activities.


Drabu S.,Maharaja Surajmal Institute of Pharmacy | Chaturvedi S.,Maharaja Surajmal Institute of Pharmacy | Sharma M.,Jamia Hamdard University
International Journal of Pharmacy and Technology | Year: 2011

The methanolic extract from aerial parts of Rhynchosia capitata DC Syn R. aurea DC was evaluated for analgesic activity on Swiss albino mice by three models, viz., acetic acid induced writhing response (chemical method), hot plate reaction time (thermal method), and tail flick assay (thermal method). The study found that methanolic extract from aerial parts of Rhynchosia Capitata DC shows significant analgesic activity comparable to that of standard drug Aspirin. The methanolic extract at 100, 200 and 300 mg/kg/p.o dose inhibited the abdominal constrictions induced by acetic acid and also increased the pain threshold of mice towards the thermal source in a dose-dependent manner. The pain and writhes in mice were significantly reduced (p < 0.001) as compared to the control. The study concludes that the methanolic extract from aerial parts of Rhynchosia Capitata possess analgesic activity at doses 100,200 and 300 mg/kg/p.o.


Sahni C.,Guru Gobind Singh Indraprastha University | Gupta R.K.,Guru Gobind Singh Indraprastha University | Nand P.,Maharaja Surajmal Institute of Pharmacy
Biomedicine and Preventive Nutrition | Year: 2014

Currently, there is an escalating demand of people for probiotic health-based products. Further, the survival of these bacteria in the human gastrointestinal system is questionable. Viability of probiotic in food and food products is a challenge for the food processing industry. Providing probiotic living cells with a physical barrier against adverse environmental conditions is therefore an approach currently receiving considerable interest to achieve longer shelf-life of the product. In the present study, skimmed milk powder along with probiotic ( Lactobacillus acidophilus) and prebiotic (Fructooligosaccharide) were used to make granules by wet granulation method and the viability of the granulated probiotic organism was investigated. Results indicated poor survival of the L. acidophilus after granulation. Physico-chemical characteristics of two optimised F1 and F2 formulations were assessed for pH, water holding capacity and moisture content determination. Major future challenges are also spotlighted. © 2014 Elsevier Masson SAS.


Nand P.,Maharaja Surajmal Institute of Pharmacy | Drabu S.,Maharaja Surajmal Institute of Pharmacy | Gupta R.K.,Guru Gobind Singh Indraprastha University
Natural Product Communications | Year: 2011

Light petroleum, dichloromethane and methanolic extracts of Linum usitatissimum were investigated using GC/MS. The main components of three sequential extracts were methyl linolenate (11.9-33.9%) and methyl linoleate (3.4-9.1%). Components possessing antimicrobial activity against acne causing bacteria, namely α-linolenic acid (7.0 -7.1%), α-terpinene (1.7-3.1%), terpinen-4-ol (1.3-4.6%), 4-cymene (1.6-7.1%) and α-pinene (1.1%), were found in varying amounts. Antimicrobial screening indicated that the light petroleum extract was more active against aerobic and anaerobic test strains with a MIC value of 1.25 mg/mL and a MBC of 2.5 mg/mL against S. aureus and P. acnes. A MIC of 2.5 mg/mL was observed against S. epidermidis.


Nand P.,Maharaja Surajmal Institute of Pharmacy | Drabu S.,Maharaja Surajmal Institute of Pharmacy | Gupta R.K.,Guru Gobind Singh Indraprastha University
Indian Journal of Natural Products and Resources | Year: 2012

Extracts of Camellia sinensis Linn. leaves, Glycyrrhiza glabra Linn. roots and rhizome and Calendula officinalis Linn. flowers were screened for their in vitro antimicrobial activity using agar disc diffusion method. The antimicrobial activity of petroleum ether, dichloromethane and methanolic extracts of different parts of these plants were studied against acne causing bacteria, namely Staphylococcus aureus (MTCC 96), Staphylococcus epidermidis (MTCC 2639) and Propionibacterium acnes (MTCC *1951). Methanolic extract of C. sinensis leaves possessed highest antibacterial activity against S. epidermidis. Lowest minimum inhibitory concentration (0.625 mg/mL) and minimum bactericidal concentration (2.5 mg/mL) against S. epidermidis were also observed for methanolic extract of C. sinensis leaves. Phytochemical screening revealed the presence of alkaloids, flavonoids, glycosides and terpenoids which indicates that these phytoconstituents may be responsible for their anti-acne activity.


Singh H.P.,University of Delhi | Gujral S.S,Maharaja Surajmal Institute of Pharmacy | Sharma S.K.,Maharaja Surajmal Institute of Pharmacy | Sharma R.K.,University of Delhi
Advanced Materials Letters | Year: 2015

In this work we have successfully prepared spherical and chain type silver nanoparticles of excellent size's homogeneity, reproducibility and stability using tannic acid. The synthesized nanometallic structures were characterized for their shape, size, thermal stability and crystalline nature. The mechanism for the formation of Ag NPs and shape evolution of the chain structure has been vividly explained. Further, these NPs were found to exhibit significant antibacterial activity against gram negative Escherichia coli bacteria but to different extend indicating the influence of particles morphology on their antibacterial behaviours. © 2015 VBRI Press.


Sharma R.,JKK Nataraja Dental College and Hospital | Yasir M.,JKK Nataraja Dental College and Hospital | Gupta A.,Maharaja Surajmal Institute of Pharmacy
International Journal of ChemTech Research | Year: 2010

The aim of the present study was to formulate and evaluate the fast dissolving sublingual tablet of glipizide. Drug delivery system are becoming more complex as pharmaceutical scientist acquire better understanding of the physiochemical and biochemical parameters pertinent to their performance. Over the last decade, the demand of fast disintegrating tablet has been growing mainly for geriatric and pediatric patients, because of swallowing difficulties, the characteristics of fast disintegrating tablet for potential emergency treatment. The superdisintegrant used in this study was crospovidone. The tablets were evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, and disintegration time and dissolution study. The tablets were prepared by wet granulation procedure. Sublimation of naphthalene from tablets resulted in better tablets as compared to the tablets prepared from granules that were exposing to vacuum. The systematic formulation approach helped in understanding the effect of formulation processing variables.


PubMed | Maharaja Surajmal Institute of Pharmacy
Type: Journal Article | Journal: Natural product communications | Year: 2012

Light petroleum, dichloromethane and methanolic extracts of Linum usitatissimum were investigated using GC/MS. The main components of three sequential extracts were methyl linolenate (11.9-33.9%) and methyl linoleate (3.4-9.1%). Components possessing antimicrobial activity against acne causing bacteria, namely alpha-linolenic acid (7.0 -7.1%), alpha-terpinene (1.7-3.1%), terpinen-4-ol (1.3-4.6%), 4-cymene (1.6-7.1%) and alpha-pinene (1.1%), were found in varying amounts. Antimicrobial screening indicated that the light petroleum extract was more active against aerobic and anaerobic test strains with a MIC value of 1.25 mg/mL and a MBC of 2.5 mg/mL against S. aureus and P. acnes. A MIC of 2.5 mg/mL was observed against S. epidermidis.


Kumar N.,Crossing tech | Drabu S.,Maharaja Surajmal Institute of Pharmacy | Mondal S.C.,Crossing tech
Arabian Journal of Chemistry | Year: 2013

Non-steroidal anti-inflammatory drugs act by inhibiting cyclooxigenase enzyme in the plasma membrane predominantly. Nowadays many researchers have observed a great involvement of these anti-inflammatory drugs in the cure of different types of cancers. This review shows the role of cyclooxigenase inhibitors specifically type-2 in cure or prevention of different types of cancers. © 2011.

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