Maharaja Surajmal Institute of Pharmacy

Janakpuri, India

Maharaja Surajmal Institute of Pharmacy

Janakpuri, India
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Objective: synthesis of gold and silver nano-particles using leaf extracts of Catharanthus roseus, Datura metel and Azadirachta indica and Estimation of antimicrobial activity of silver nano-particles using disc diffusion method. Method: Green approach has been utilized for the synthesis of gold and silver nano-particles. Different aqueous plant extracts has been prepared which was then utilized for the biosynthesis of gold and silver nano-particles. Estimation for the synthesis of nano-particles were done using UV-Visible spectroscopy and Fourier-Transform infrared spectroscopy. Antimicrobial activity of silver nano-particles prepared using aqueous neem extract was investigated using disc diffusion method. Result: UV-Vis spectroscopy of prepared nano-particles was done which gave a peak at about 550 nm for gold nano-particles and around 430 nm for silver nano-particles. FTIR of collected nano-particles gave an idea about the type of bio-molecules which helped in the reduction of auric and silver salts into corresponding nano-particles. Anti-microbial activity of silver nano-particles showed that the nano-particles have better anti-microbial activity than 2% silver nitrate solution (kept as standard) when experiments were performed under similar conditions. Conclusion: Gold and silver nano-particles were successfully synthesized using greener approach and anti-microbial activity of silver nano-particles prepared using aqueous neem extract was estimated against 2% AgNO3solution. Nano-particles gave better anti-microbial activity than Silver nitrate solution. © 2014 Sarbjeet Singh Gujral et al, publisher and licensee IYPF.


Kumar S.,Uttrakhand Technical University | Kumar N.,P.A. College | Drabu S.,Maharaja Surajmal Institute of Pharmacy
Oriental Journal of Chemistry | Year: 2017

Thirteen new compounds belonging to series 2-amino-6-(5,10-dioxo-2,3-diphenyl-5,10-dihydrobenzo[g]quinoxalin-7-yl)-4-(substituted)phenylpyridine-3-carbonitrile (6a-m) were synthesized by multistep synthetic scheme. The newly synthesized compounds were screened for their antimycobacterial activity by L.J. Slope (Conventional) Method. Compound 6h with 4-N(CH3)2 group at phenyl ring of above mentioned position has been reported as most active antimycobacterial compound and compound 6k with 4-CH3 substitution at phenyl above mentioned position has been reported as the least active antimycobacterial compound. © 2017, Oriental Scientific Publishing Company. All rights reserved.


Pratibha N.,Maharaja Surajmal Institute of Pharmacy | Sushma D.,Maharaja Surajmal Institute of Pharmacy | Gupta Rajinder K.,Guru Gobind Singh Indraprastha University
International Journal of Drug Development and Research | Year: 2012

In the present study, sequential extracts of Camellia sinensis, Glycyrrhiza glabra, Calendula officinalis and Linum usitatissimum were analyzed for their antioxidant activity in different test systems. Phytochemical analysis indicated that amongst twelve test extracts, methanolic extract of Camellia sinensis was found to have the highest total phenolic content (104.93 ± 1.630 mg GAE /g) and FRAP value (1046.330±1.948 mg TE/g). Flavonoid content (115.503±2.984 mg RuE /g dry extract) of methanolic extract of Glycyrrhiza glabra was found to be superior among all the extracts. Highest DPPH scavenging (IC 50=44.03 ±1.784 μg/ml) effect was also observed in methanolic extracts of Camellia sinensis. In vitro antimicrobial screening indicated that methanolic extracts showed promising antimicrobial activity against Staphylococcus aureus, Staphylococcus epidermidis and Propionibacterium acnes. © 2010 IJDDR.


Kumar N.,Crossing tech | Chauhan A.,Crossing tech | Drabu S.,Maharaja Surajmal Institute of Pharmacy
Biomedicine and Pharmacotherapy | Year: 2011

A new series of substituted benzylidene acetophenone (Ia-Ih), 2-amino-4, 6- substituted diphenylpyridine-3-carbonitrile (IIa-IIh) and 4, 6-substituted diphenylpyrimidin-2-amine (IIId-IIIg) were synthesized and evaluated for anti-inflammatory and antimicrobial activities. Four compounds (Ie, If, IIh and IIId) have shown good anti-inflammatory activity when compared to standard drug indomethacin. Two compound (Ie and IIh) displayed significant activity against gram -ve bacteria (E. Coli) and three compounds (IId, IIf and IIIh) displayed good activity against gram +ve bacteria (S. aureus) on comparison with the standard drug ofloxacin. © 2011 Elsevier Masson SAS.


Chaturvedi S.,Maharaja Surajmal Institute of Pharmacy | Drabu S.,Maharaja Surajmal Institute of Pharmacy | Sharma M.,Jamia Hamdard University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2012

The methanolic extract from aerial parts of Tamarix gallica was investigated for anti-inflammatory and analgesic properties in animal models. The acute anti-inflammatory study was done using carrageenan and histaminehind paw edema method. The extract was tested at doses between 100 - 300 mg/kg body weight of rats to observe % inhibition of paw edema. The extract administered orally at doses of 100, 200 and 300 mg/kg p.o produced a significant (P < 0.05) dose dependent inhibition of edema formation due to carrageenan and histamine. The observed activity was found comparable to that of 10 mg/kg diclofenac that was used as a reference drug in the study. The Preliminary phytochemical screening conducted on Tamarix gallica confirmed the presence of tannins, flavonoids, alkaloid and saponins. The central and peripheral analgesic activity of T amarix gallica was also investigated by tail flick, hot plate and acetic acid induced writhing method on swiss albino mice. The analgesic activity of Tamarix gallica was detected by increase in the reaction time and by reduction in number of writhes. The methanol extract at the dose of 300 mg/kg/p.o showed 58.82 % inhibition against carrageenan induced rat paw edema while the standard drug Diclofenac showed 64.26% inhibition after 4 hrs of carrageenan injection. Tamarix gallica methanolic extract supports the folkloric use for management of inflammation and pain.


Nand P.,Maharaja Surajmal Institute of Pharmacy | Drabu S.,Maharaja Surajmal Institute of Pharmacy | Gupta R.K.,Guru Gobind Singh Indraprastha University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2012

In the present study, petroleum ether, dichloromethane and methanolic extracts of three medicinal plants namely Camellia sinensis, Glycyrrhiza glabra and Calendula officinalis were analyzed for their antibacterial and antioxidant activity in different test systems. Highest zone of inhibition (≥15) mm was observed with methanolic extract of Camellia sinensis using disc diffusion method. Phytochemical analysis indicated that amongst nine test extracts, methanolic extract of Camellia sinensis had the highest total phenolic content (104.93 ± 1.630 mg GAE /g). Flavonoid (115.503 ± 2.984 mg RuE /g dry extract) and flavonol content (574.446 ± 7.94mg RuE /g dry extract) of methanolic extract of Glycyrrhiza glabra was also found to be superior among all the extracts. Antioxidant assays revealed highest DPPH scavenging (IC 50=44.03 ± 1.784 μg/ml) and metal chelating (IC 50=234.64 ± 5.467 μg/ml) effect in methanolic extracts of Camellia sinensis. Similarly, methanolic extract of Glycyrrhiza glabra exhibited highest radical scavenging activity (IC 50=21.37 ± 1.422 μg/ml) when reacted with the ABTS +.


Drabu S.,Maharaja Surajmal Institute of Pharmacy | Chaturvedi S.,Maharaja Surajmal Institute of Pharmacy | Sharma M.,Jamia Hamdard University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

The use of plants as medicines predates written human history. The records show the study of herbs dates back over 5,000 years. The use of traditional medicine is globally expanding to newer horizons primarily due to low cost and less side effects associated. India is a vast repository of medicinal plants used in traditional medical treatments1. There are estimated to be around 25,000 effective plant-based formulations, used in folk medicine and known to rural communities in India2. It is estimated that there are over 7800 medicinal drug-manufacturing units in India, which consume about 2000 tonnes of herbs annually3. The various indigenous systems of medicine in India such as Siddha, Ayurveda, Unani and Allopathy have been using several plant species to treat different ailments4, 5. Taking these points in view Tamarix gallica plant is briefly reviewed in this article for its history, anatomy, phytochemical constituents and pharmacological activities.


Nand P.,Maharaja Surajmal Institute of Pharmacy | Drabu S.,Maharaja Surajmal Institute of Pharmacy | Gupta R.K.,Guru Gobind Singh Indraprastha University
Natural Product Communications | Year: 2011

Light petroleum, dichloromethane and methanolic extracts of Linum usitatissimum were investigated using GC/MS. The main components of three sequential extracts were methyl linolenate (11.9-33.9%) and methyl linoleate (3.4-9.1%). Components possessing antimicrobial activity against acne causing bacteria, namely α-linolenic acid (7.0 -7.1%), α-terpinene (1.7-3.1%), terpinen-4-ol (1.3-4.6%), 4-cymene (1.6-7.1%) and α-pinene (1.1%), were found in varying amounts. Antimicrobial screening indicated that the light petroleum extract was more active against aerobic and anaerobic test strains with a MIC value of 1.25 mg/mL and a MBC of 2.5 mg/mL against S. aureus and P. acnes. A MIC of 2.5 mg/mL was observed against S. epidermidis.


Nand P.,Maharaja Surajmal Institute of Pharmacy | Drabu S.,Maharaja Surajmal Institute of Pharmacy | Gupta R.K.,Guru Gobind Singh Indraprastha University
Indian Journal of Natural Products and Resources | Year: 2012

Extracts of Camellia sinensis Linn. leaves, Glycyrrhiza glabra Linn. roots and rhizome and Calendula officinalis Linn. flowers were screened for their in vitro antimicrobial activity using agar disc diffusion method. The antimicrobial activity of petroleum ether, dichloromethane and methanolic extracts of different parts of these plants were studied against acne causing bacteria, namely Staphylococcus aureus (MTCC 96), Staphylococcus epidermidis (MTCC 2639) and Propionibacterium acnes (MTCC *1951). Methanolic extract of C. sinensis leaves possessed highest antibacterial activity against S. epidermidis. Lowest minimum inhibitory concentration (0.625 mg/mL) and minimum bactericidal concentration (2.5 mg/mL) against S. epidermidis were also observed for methanolic extract of C. sinensis leaves. Phytochemical screening revealed the presence of alkaloids, flavonoids, glycosides and terpenoids which indicates that these phytoconstituents may be responsible for their anti-acne activity.


Sharma R.,JKK Nataraja Dental College and Hospital | Yasir M.,JKK Nataraja Dental College and Hospital | Gupta A.,Maharaja Surajmal Institute of Pharmacy
International Journal of ChemTech Research | Year: 2010

The aim of the present study was to formulate and evaluate the fast dissolving sublingual tablet of glipizide. Drug delivery system are becoming more complex as pharmaceutical scientist acquire better understanding of the physiochemical and biochemical parameters pertinent to their performance. Over the last decade, the demand of fast disintegrating tablet has been growing mainly for geriatric and pediatric patients, because of swallowing difficulties, the characteristics of fast disintegrating tablet for potential emergency treatment. The superdisintegrant used in this study was crospovidone. The tablets were evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, and disintegration time and dissolution study. The tablets were prepared by wet granulation procedure. Sublimation of naphthalene from tablets resulted in better tablets as compared to the tablets prepared from granules that were exposing to vacuum. The systematic formulation approach helped in understanding the effect of formulation processing variables.

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