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Kundariya D.S.,Maharaja Shree Mahendrasinhji Science College | Rupala R.G.,Maharaja Shree Mahendrasinhji Science College | Patel P.K.,Maharaja Shree Mahendrasinhji Science College
Asian Journal of Chemistry | Year: 2012

New series of methyl-4-(4,5-dihydro-5-[(Z)phenyl]-1H-pyrazol-3-yl)-2- methylbenzohydrazide were synthesized by cyclisization of chalcones, methyl 4-((E)-3-((Z)phenyl)acryloyl)-2-methylbenzoate with hydrazine hydrate in presence of basic media. The chalcones were synthesized starting from 4-acetyl-2-methylbenzoic acid in 2 step. The structures of the synthesized compounds have been established on the basis of physical and spectral data and are screened for antimicrobial activity. Some of them exhibited significant activity. Source

Joshi N.K.,Maharaja Shree Mahendrasinhji Science College | Kundariya D.S.,Maharaja Shree Mahendrasinhji Science College | Parmar J.M.,Maharaja Shree Mahendrasinhji Science College
International Journal of ChemTech Research | Year: 2012

Ethyl 2-(4-(2,3-dichlorophenyl)piperazin-1-yl)acetate 2 was prepared by the condensation of ethyl bromoacetate with 1-(2,3-dichlorophenyl)piperazine 1. The reaction of 2 with hydrazine hydrate furnished 2-[4-(2,3-dichlorophenyl)piperazin-1-yl]acetohydrazide 3, which on cyclisation with substituted aromatic carboxylic acids in the presence of phosphorous oxychloride give 1-(2,3-dichlorophenyl)-4-((5- aryl-1,3,4-oxadiazol-2-yl)methyl)piperazine 4. The newly synthesized compounds have been characterized by IR, 1H NMR, mass spectral data and elemental analysis. The synthesized compounds were screened for in vitro antimicrobial activity. The purity of synthesized compounds was confirmed by TLC. Source

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